Latest studies
- RecruitingNot Applicable
A multi-centre study testing a new imaging app to help diagnose systemic sclerosis using nailfold capillaroscopy
This study tests a new app called CapilyticsAcquisition to help doctors diagnose conditions like Raynaud's and systemic sclerosis. It takes pictures of tiny blood vessels near fingernails to assist with earlier and more accurate diagnosis. Participants are adults and children aged 6+.
Systemic sclerosis spectrum disordersScotland - Recruiting
SMILE: Supporting mental health in young people: integrated methodology for clinical decisions and evidence-based interventions
The SMILE study helps young people (10-24) with anxiety or depression. It uses a fun online game and activities to build resilience and improve mental health. The study runs from February 2025 to July 2026 across seven countries, including the UK.
Depression and anxiety in children and young peopleScotland - CompletedPhase III
A study to assess the safety of using 100 mg methotrexate for the treatment of an unruptured ectopic pregnancy
This study aims to see if a standard 100mg dose of methotrexate is safe and effective for women with a stable ectopic pregnancy. This could help make treatment quicker and simpler, avoiding individual dose calculations and long waiting times.
Ectopic pregnancyScotland - Completed
Understanding corridor care in UK emergency departments
This study looks at how many patients are cared for in places like hospital corridors when emergency departments are busy. It wants to understand who these patients are and why they're there, to help improve emergency care across the UK.
UK Emergency Department use of escalation areasScotland - RecruitingPhase III
IIH-Advance: A randomised clinical trial to determine the effects of weight loss, induced by a weight loss drug (Tirzepatide), in adults with active idiopathic intracranial hypertension
This study looks at whether a weight loss drug, Tirzepatide, can help adults with a condition called Idiopathic Intracranial Hypertension (IIH). IIH causes high pressure in the head, leading to headaches and eye problems. We want to see if losing weight with this drug can improve these symptoms.
Idiopathic intracranial hypertensionScotland - RecruitingPhase III
Investigating whether prolonged antibiotics can prevent permanent Pseudomonas infection in bronchiectasis
This study looks at whether early, strong antibiotic treatment can stop a lung infection called Pseudomonas from becoming permanent in people with bronchiectasis. We hope to reduce flare-ups and improve health.
BronchiectasisScotland - CompletedPhase I
A Phase I trial of LY3143921 hydrate in solid tumours
This study looks at a new drug, LY3143921 hydrate, for advanced solid cancers. It aims to find a safe dose and understand its effects, especially in cancers where usual treatments haven't worked or aren't suitable. This is the first time it’s being tested in people.
Colorectal Cancer (CRC), High Grade Serous Ovarian Cancer (HGSOC), Non-Small Cell Lung Cancer (NSCLC; Squamous Cell Variant), Squamous Carcinoma of the Oesophagus, Squamous Carcinoma of the Head and Neck (Human Papillomavirus Negative), Urothelial Cancer, Breast Cancer (Triple Negative Type), Pancreatic CancerScotland - RecruitingPhase I/II
A two-part study to investigate the effects in adults of two doses of golexanolone in patients with primary biliary cholangitis with fatigue and cognitive dysfunction
This study looks at a new drug, golexanolone, for people with a liver condition called Primary Biliary Cholangitis (PBC) who also feel very tired and have trouble thinking clearly. Researchers want to see if it's safe, how it works in the body, and if it helps these symptoms.
Patients with primary biliary cholangitis with fatigue and cognitive dysfunctionScotland - Recruiting
A study to find out if a new blood test (microRNA) can be used to monitor people after surgery for seminoma or dysgerminoma cancer
This study looks at a new blood test to see if cancer has come back in people treated for specific early-stage cancers like seminoma or dysgerminoma. It aims to reduce the need for scans by seeing if a simple blood test can do the job and help find cancer recurrence earlier.
Seminoma and dysgerminomaScotland - Recruiting
Pancreas lipotoxicity in type 2 diabetes: Edinburgh Diabetes Remission Study (EDRS)
This study, the Edinburgh Diabetes Remission Study (EDRS), is looking at how fat in the pancreas affects type 2 diabetes. It wants to see if losing weight can reverse the condition. Participants will follow a special low-calorie diet to help researchers understand these changes.
Type 2 diabetesScotland - CompletedNot Applicable
Usability and accuracy of the Hormona at-home perimenopause test kit and mobile app
This study looks at how well women aged 40-55 can use the Hormona app and at-home test kit to understand their changing hormones during perimenopause. It aims to make the system easy to use and accurate.
Perimenopause and menopauseScotland - Recruiting
Timing of nutrition in emergency laparotomy
This study looks at the best time to give special liquid food directly into a vein to adults having urgent belly surgery. It aims to see if starting this feeding early helps reduce problems and speeds up recovery after the operation.
Hospital complications in adults undergoing emergency laparotomyScotland - Completed
Assessing the feasibility of using nicotine replacement therapy (NRT) to enable disadvantaged parents to create a smoke-free home
This study helps parents in Scotland create smoke-free homes by testing if nicotine patches or gum (NRT) can reduce children's exposure to smoke. It looks at how well this approach works and if people find it easy to use.
Children's exposure to second-hand smoke in the homeScotland - Recruiting
Using high flow moist oxygen early to treat acute severe asthma in children
This study looks at whether giving children high-flow, warm, moist oxygen early can help them recover faster from severe asthma attacks. It aims to see if this treatment reduces the need for stronger medicines given into a vein. Children aged 2 to 18 with acute severe asthma are being invited to take part.
Acute severe asthma in childrenScotland - Recruiting
Pharmacogenetics to avoid loss of hearing UK
This study uses a quick genetic test to protect newborn babies from hearing loss. Some babies given a common antibiotic, gentamicin, can become deaf if they have a certain gene. This test identifies those babies quickly so they can receive a safer treatment. It's being tested across the UK.
Use of a genetic test to detect the m.1555A>G variant associated with aminoglycoside-induced hearing loss in neonatal care unitsScotland - RecruitingNot Specified
Study of whether radiotherapy after surgery to treat a weakened or broken bone caused by cancer helps to reduce pain and improve quality of life
This study looks at whether radiation treatment after surgery for cancer-related broken bones helps with pain and quality of life. Some people will get radiation, others won't immediately, to see if it makes a difference and if it's truly needed after surgery.
Bone metastasesScotland - RecruitingPhase I
18F-LW223: A new tool for detecting inflammation in the body
This study is testing a new scan called 18F-LW223 PET to find inflammation in the body. It involves healthy men aged 18-55 having one scan and blood tests. We want to see how safe the new scan is and how well it shows inflammation.
Radiotracer to detect regional tissue inflammationScotland - Recruiting
Investigating the use of a breathing device in older people with broken ribs
This study looks at a breathing device for older people with broken ribs. It aims to see if an incentive spirometer can help prevent chest infections and other problems, making recovery smoother after a rib injury.
Rib fracturesScotland - Recruiting
Disease in the small blood vessels, heart failure and diabetes
This study looks at how heart failure, diabetes (type 1 and type 2), and high blood pressure are connected. Researchers want to understand heart problems in people with diabetes, especially type 1, to find better ways to prevent and treat them in the future.
People with heart failure, diabetes and/or hypertensionScotland - Completed
Evaluating CBT Bytesize: a mixed-methods feasibility trial of a blended digital CBT intervention for adolescent anxiety and low mood
This study tested a new digital programme called CBT Bytesize for young people aged 11-17 with anxiety. It combines online learning with therapist support to see if it helps reduce anxiety and is easy to use.
Anxiety disorders in children and young peopleScotland - RecruitingPhase I/II
5G: A next generation agile genomically guided glioma modular platform for proof-of-concept molecular hypothesis testing in patients with malignant brain tumours
This study is testing a new drug called paxalisib with a standard treatment (temozolomide) for glioblastoma, a type of brain tumour. It aims to see if this combination is safe and effective, especially for patients whose tumours might respond well to paxalisib.
GlioblastomaScotland - Recruiting
A study evaluating whether immobilisation or no immobilisation affects pain scores in toddlers fractures
This study looks at how best to treat toddlers' shin bone breaks. It compares using a cast or boot with no cast, to see which helps children with pain, convenience, and recovery. It aims to find the safest and most practical approach for families and the NHS.
Toddler's fractures - non-displaced spiral fractures of the tibiaScotland - RecruitingPhase II
ENDOCAN-1: A study to see if CBD (cannabinoid) can help with endometriosis-related pain
This study, called ENDOCAN-1, is looking into whether a special liquid medicine called MRX1, which contains a part of cannabis called CBD but without the 'high' effects, can help women with endometriosis pain. It aims to find new pain relief options.
EndometriosisScotland - Recruiting
Improving epilepsy and pregnancy care
This study aims to improve care for pregnant women with epilepsy. It tests a new approach, called the 'EpiSafe bundle,' in maternity units to ensure women get specialised epilepsy care early in pregnancy. This can help reduce risks for both mothers and babies.
Pregnant women with epilepsyScotland - Recruiting
A pilot study to develop a new treatment for people living with Parkinson’s who have difficulties with producing and understanding language
This study looks into developing a new online therapy for people with Parkinson's disease who struggle with language. It's a pilot project to see if the therapy helps with daily conversations and if it's practical to offer more widely.
Parkinson's diseaseScotland - Not yet recruiting
A healthy volunteer imaging study to test two new tablet formulations designed to release in the duodenum (the first part of the small intestine)
This study looks at new dummy tablets designed to release medicine in the first part of your small intestine. Researchers use special scans to track them, hoping to improve how some drugs work. It involves healthy volunteers and helps develop future medicines.
Duodenal drug deliveryScotland - RecruitingPhase I
Participants undergoing coronary artery bypass graft will receive veins removed from legs treated with gene therapy and a placebo for grafting. Vein segments are treated at random with either gene therapy or a placebo.
This study is testing a new gene therapy to help keep leg veins open after a heart bypass operation. We're looking at its safety and the best dose. Patients will receive both the gene therapy and a dummy treatment (placebo) on different vein sections.
Vein graft blocking in those having a Heart Bypass Surgery to address Heart Disease symptoms, such as chest pain and shortness of breathScotland - Recruiting
Buried versus exposed wires in hand and wrist fractures
This study looks at the best way to use wires (K-wires) to fix broken hand or wrist bones. It compares leaving the wire ends outside the skin versus burying them underneath to see which method leads to fewer infections and if there's a difference in healing.
MusculoskeletalScotland - RecruitingNot Applicable
Biomarkers for RAtional Investigation for Neurological Decision Support in traumatic brain injury (BRaINS-TBI): cohort study with a nested pragmatic randomised controlled trial
This study looks at a new blood test for people with head injuries in A&E. It aims to see if this test can help doctors make better decisions, reduce unnecessary scans, and improve care. It involves blood samples and follow-up.
Traumatic brain injuryScotland - RecruitingNot Applicable
Studying how healthy skin reacts to a new LED light device
This study is testing a new, quicker, and cheaper light device to see how healthy skin reacts. It involves shining different lights on your back to understand normal skin responses. This information will help doctors better diagnose and treat skin conditions in the future.
Erythema reaction of non-photosensitive individuals to various wavelengths of LED lightScotland - RecruitingPhase IV
A platform trial to identify the best treatments for critically ill children admitted to paediatric intensive care
This study is looking for better ways to care for very sick children in intensive care. We are testing common treatments to see which ones work best and are safest, hoping to improve their recovery and future well-being.
Critical illnessScotland - RecruitingPhase I
First-in-human study of RO7812653
This study is testing a new medicine, RO7812653, for early Alzheimer's disease. We want to see if it's safe, how it works in the body, and if it could help. Some people will get the medicine, others a dummy treatment (placebo), given by injection into the lower back.
Early symptomatic Alzheimer’s disease (eAD)Scotland - RecruitingPhase III
A study comparing JNJ-79635322 and an anti-B-cell maturation antigen (BCMA)xCD3 bispecific antibody in participants with relapsed or refractory multiple myeloma (Trilogy-4)
This study looks at a new injection called JNJ-79635322 for multiple myeloma that has come back or isn't responding to treatment. We're comparing it to another approved drug, teclistamab, to see if it helps patients aged 18 and over who have tried other therapies.
Relapsed or refractory multiple myelomaScotland - Recruiting
GendAge weight loss study: sex hormones as regulators of the age- and sex-dependent benefits of caloric restriction
This study looks at how age and sex hormones, like oestrogen, affect weight loss from dieting. It aims to create better, personalised diet advice for everyone who is overweight or obese, regardless of their age or gender.
Overweight and/or obesityScotland - Recruiting
A population-based digital study offering people testing for cancer genes, to identify people at increased risk of cancer so they can take steps to prevent it or detect it early
This study offers a genetic test for cancer risk to people in the UK. It uses a saliva sample to check for genes linked to breast, ovarian, bowel, and womb cancers. The aim is to find people at higher risk so they can take steps to prevent cancer or detect it early.
CancerScotland - Recruiting
Cauda equina syndrome early recognition study
This study looks into Cauda Equina Syndrome (CES), a serious spinal condition. It aims to find better ways for doctors in A&E to quickly identify who has CES and who doesn't, to make sure people get the right treatment when they need it most.
Cauda equina syndrome (CES)Scotland - Recruiting
A UK study of minimally invasive emergency treatment of sudden bleeding from the lower bowel
This study looks back at records of patients in the UK and other countries who had a special X-ray guided procedure called embolisation to stop sudden bleeding from their bowel. It aims to understand how well this treatment works and to improve care for similar cases in the future.
Patients who have undergone angiography +/- embolisation for acute non-variceal lower GI haemorrhage.Scotland - Completed
The impact of trainer behaviour on trainee cognitive load and performance during vascular surgery simulation
This study looks at how a trainer's behaviour affects surgical trainees learning. It compares supportive trainers to rude ones in a simulated operating room. The goal is to improve training and patient safety by understanding this impact.
Surgical trainee intraoperative cognitive load, technical skills and non-technical skillsScotland - RecruitingPhase II
MonoGerm: A trial to test if using one chemotherapy drug is as good as using three chemotherapy drugs before radiotherapy for patients with germinoma brain tumours
The MonoGerm trial is testing if one chemotherapy drug works as well as three for a type of brain tumour called germinoma. We want to see if one drug has fewer side effects and improves quality of life before standard radiotherapy.
Intracranial germinomaScotland - Recruiting
How does undergraduate experiential learning shape the transition from pharmacy student to trainee pharmacist: a qualitative study
This study looks at how training in real healthcare settings helps pharmacy students in Scotland become qualified pharmacists. It asks trainee pharmacists about their experiences and ideas for making these training placements even better for future students by exploring what helped and what could be improved.
Undergraduate pharmacy experiential learningScotland - Recruiting
Impact of having a long lie after a fall
This study looks into what happens when someone falls and can't get up for a long time. It aims to improve how we help people waiting for assistance, making things better for patients, ambulance services, and care homes.
Specialty: Trauma and Emergency Care, Primary sub-specialty: Pre-hospital; Health Category: Disputed Aetiology and OtherScotland - RecruitingNot Specified
Trialling a blood test for Alzheimer’s disease in UK memory services
This study is testing a new blood test for earlier and more accurate Alzheimer's disease diagnosis in UK memory clinics. It aims to see if this test can help doctors make a quicker diagnosis for people aged 50 and over who have memory problems.
Alzheimer’s diseaseScotland - RecruitingPhase III
A Phase III randomized, open-label study of pasritamig (JNJ-78278343), a T-cell-redirecting agent targeting human kallikrein 2, with docetaxel versus docetaxel for metastatic castration-resistant prostate cancer
This study is testing a new drug, pasritamig, with an existing treatment for advanced prostate cancer called docetaxel. It aims to see if combining them works better than docetaxel alone for men whose cancer has spread and is resistant to hormone treatment.
Metastatic castration-resistant prostate cancer (mCRPC)Scotland - Recruiting
Treatment preferences for irreversible pulpitis
This study looks at how best to help adults understand and choose treatments for a painful dental problem called irreversible pulpitis. It compares two tools, one with comics, to see which helps patients make better decisions about their care.
Management of severe or irreversible pulpitisScotland - Completed
NHS and third sector homelessness worker outreach for people experiencing homelessness, to reduce the risk of street drug overdose
This study helps homeless adults who have used street drugs and been in trouble with the police. It offers weekly visits from an NHS health worker and a homelessness charity worker to improve health, reduce overdoses, and find safe housing. Half get these visits, half get usual care.
Prevention of overdose and emergency healthcare use in people experiencing homelessness with additional severe disadvantages e.g. previous overdose and criminal justice encountersScotland - Recruiting
Can we safely reduce the number of days of radiotherapy needed to treat people with breast cancer who need boost treatment?
This study looks at whether we can safely give breast cancer patients who need an extra 'boost' of radiotherapy a shorter 5-day treatment instead of the usual 15 days. It compares two different 5-day boost doses with the standard 15-day boost.
Breast cancerScotland - Not yet recruiting
Understanding the role of neutrophil enzymes in a type of asthma with low inflammation
This study is looking into a difficult-to-treat type of asthma called Type 2-low asthma. Researchers want to see if certain immune cells called neutrophils and their proteins are higher in people with this type of asthma. The goal is to find new ways to treat it and improve lives.
Type 2 inflammatory asthmaScotland - Recruiting
Investigating the root cause of strabismus in children
This study looks into why some children have a squint, or crossed eyes. We're checking if their brain's sense of eye position is working correctly. This could help us develop better treatments for children with squints in the future.
Strabismus (squint or crossed eyes), specifically Partially Accommodative Esotropia (PAE) and Fully Accommodative Esotropia (FAE).Scotland - CompletedNot Applicable
Post-market surveillance study of the ADAPTIS Total Ankle Replacement with EVERLAST polyethylene insert
This study looks at a new type of ankle replacement called INFINITY™ with ADAPTIS™ and EVERLAST™. The goal is to see how well it works and if it helps patients move better and have less pain. It's for people needing their first ankle replacement.
INFINITY™ with ADAPTIS™ and EVERLAST™ Technology with Poly Insert for patients requiring primary total ankle replacement/arthroplasty (TAR/TAA) across up to 10 UK NHS Hospital Trusts regularly performing TAA/TAR.Scotland - Recruiting
Evaluating the role of IL-17 as an orchestrator of peripheral-central cross talk in depressive symptoms
This study looks at how a medicine blocking IL-17, used for skin and joint conditions, might help improve depression in people with these conditions. It uses brain scans to see if reducing inflammation in the body also affects the brain and mood.
Depressive symptoms in people with active psoriatic disease and how IL-17 inhibition affects inflammation in brain and immune processes.Scotland