Latest studies
- CompletedPhase I
A study evaluating the interaction of the body with (pharmacokinetics), clinical activity, and safety of RO6870810 and atezolizumab (PD-L1 Antibody) in participants with advanced ovarian cancer or triple-negative breast cancer
This study looks at a new drug called RO6870810 given alongside an immunotherapy drug called atezolizumab. Researchers want to find the safest dose and see if this combination helps treat adults with advanced ovarian cancer or triple-negative breast cancer who have limited standard treatment options.
Advanced ovarian cancer, triple negative breast cancerScotland - CompletedNot Applicable
Can we predict which patients with psoriatic arthritis will respond to treatment using precision medicine?
This UK study looks at whether a simple blood test can help doctors choose the best biologic medicine for people with psoriatic arthritis. By checking specific immune cells before treatment starts, researchers hope to match each person to the right drug first time, helping relieve joint pain and swelling much faster.
Arthritis that affects some people with the skin condition psoriasisScotland - CompletedNot Applicable
The iHOLDS Trial: High Or Low Dose Syntocinon for induction of labour
Around one in three first-time mothers have their labour started artificially (induced). Many need a hormone drip called oxytocin. This UK study compares the standard dose of oxytocin with a higher dose to see if it safely helps women give birth vaginally and reduces the need for an unplanned caesarean section.
Induction of labourScotland - CompletedPhase I/II
A trial of the synthetic cannabinoid ART27.13 to stimulate appetite in patients with cancer anorexia and weight loss
This clinical trial is testing a new medicine called ART27.13 to see if it can help improve appetite and prevent weight loss in people with cancer. Researchers want to find the safest, most effective dose and see if it helps patients regain muscle and body weight.
Cancer patients with anorexia and weight lossScotland - RecruitingPhase II/III
A trial assessing preoperative chemotherapy in patients with locally advanced but operable colon cancer
The FOxTROT trials look at whether giving bowel cancer treatments, such as chemotherapy or immunotherapy, before surgery helps shrink tumours and stops cancer returning. The study tests this approach in people of different ages, fitness levels, and tumour types to see who benefits the most.
Locally advanced but operable colon cancerScotland - Completed
A trial comparing the effectiveness of an online sleep behavioural intervention versus standard care in children with rolandic epilepsy
This UK study tests whether an online sleep programme can help children with epilepsy sleep better. Children aged 4 to 12 who have sleep issues take part completely from home. Half use an online sleep programme alongside standard care, while half continue with their usual NHS care alone.
Sleep quality in children with rolandic epilepsyScotland - Completed
Remote rehabilitation after intensive care
Leaving intensive care can be tough, leaving people physically weak and emotionally drained. This UK study tests a six-week online rehabilitation programme designed to help people recover at home. Researchers want to see if regular remote support, gentle exercises, and recovery advice improve quality of life compared to standard NHS care.
Any condition requiring admission to intensive care and 48 hours of invasive mechanical ventilationScotland - CompletedNot Applicable
Investigating the use of lenzilumab for acute graft versus host disease (when transplanted stem cells attack the body’s cells)
This UK clinical trial is testing a new drug called lenzilumab for acute graft versus host disease (GvHD). GvHD happens when transplanted donor cells attack the patient's body. Researchers want to see if adding lenzilumab to standard steroid treatment is safe and helps patients who have a higher risk of severe illness.
Graft versus host disease following allogeneic stem cell transplantationScotland - Completed
AFTER – Ankle fracture treatment: enhancing rehabilitation trial
The AFTER study explores the best way to help people aged 50 and over recover from a broken ankle. It compares doing exercises at home using a guide and website against having four to six one-to-one sessions with an NHS physiotherapist, to see which approach works best.
Ankle fractureScotland - CompletedPhase II
A comparison of response to treatment in patients with Myelodysplastic Syndrome/Myeloproliferative Neoplasm (MDS/MPN) Overlap Syndromes taking ASTX727 versus best supportive care
This UK clinical trial is testing a new tablet called ASTX727 for adults with rare bone marrow cancers called MDS/MPN overlap syndromes. Researchers want to find out if taking this tablet at home works better at managing the condition and improving quality of life than standard supportive hospital care.
Myelodysplastic Syndrome/Myeloproliferative Neoplasm (MDS/MPN) Overlap SyndromesScotland - Completed
To determine if critically ill patients with acute respiratory failure treated with carbocisteine, hypertonic saline, or both, experience increased hydration of airway mucus.
This study looks at whether medicines called carbocisteine and hypertonic saline help clear thick phlegm from the lungs of critically ill patients on breathing machines. By testing small mucus samples, researchers hope to see how these treatments work to help patients recover and breathe on their own sooner.
Critically ill patients with acute respiratory failure (ARF)Scotland - Recruiting
CAMELOT - Continuous rectus sheath Analgesia in eMErgency LaparOTomy
The CAMELOT study tests a new pain relief method for people having emergency tummy surgery. It looks at whether placing two tiny numbing tubes into the stomach wall during surgery helps control pain better, reduces the need for strong morphine painkillers, and helps patients recover more quickly.
Use of rectus sheath catheters (RSCs) in patients undergoing emergency bowel surgery.Scotland - RecruitingPhase I
The first-in-human trial of MDX-124 in patients with advanced cancer
This clinical trial is testing a new drug called MDX-124 for adults with advanced solid cancers. It is the first time this medicine is being given to humans. Doctors want to find out what dose is safe, how well the body copes with it, and what side effects it causes.
Locally advanced, unresectable or metastatic solid malignanciesScotland - Completed
Does nocturnal haemodialysis improve heart disease for patients on dialysis?
This study looks at whether having dialysis overnight for 6 to 8 hours is gentler on the heart than standard daytime dialysis. Standard dialysis can cause heart scarring. Researchers want to see if slower, longer overnight treatment protects the heart and improves health for people with kidney failure.
Haemodialysis, kidney failureScotland - CompletedPhase II
A clinical trial adding Sativex (a cannabis-based medicine) to standard treatment, temozolomide, to find out if it is beneficial for patients whose glioblastoma brain tumour has returned after treatment
The ARISTOCRAT trial is testing whether adding a cannabis-based mouth spray called Sativex to standard chemotherapy (temozolomide) helps people whose glioblastoma brain tumour has returned. Researchers want to see if combining these treatments slows tumour growth, helps patients live longer, and improves day-to-day quality of life.
Glioblastoma multiformeScotland - Recruiting
Cerebrospinal fluid shunting or dural venous sinus stenting to preserve vision in idiopathic intracranial hypertension (IIH Intervention)
Idiopathic intracranial hypertension (IIH) causes high pressure around the brain that can threaten your sight. This UK study compares two standard operations: inserting a small drainage tube (shunt) or a tiny mesh tube (stent). The aim is to discover which treatment best protects your vision and helps the NHS.
Idiopathic intracranial hypertensionScotland - Completed
The neoGASTRIC trial: Avoiding routine gastric residual volume measurement in neonatal critical care
Premature babies fed through a tube often have their stomach contents checked regularly to see how they digest milk. The neoGASTRIC study looks at whether stopping these routine checks helps premature babies reach full milk feeds more quickly and safely. It compares two standard care approaches already used in hospitals.
Preterm birthScotland - Recruiting
Treating people with a lung collapse (pneumothorax) without inserting a needle into the chest. Is it safe and effective?
This UK clinical trial is looking at whether a collapsed lung can heal safely on its own without needing a chest drain. Researchers want to see if simply resting and being monitored allows patients aged 16 to 50 to recover well at home, avoiding invasive hospital procedures.
Primary spontaneous pneumothoraxScotland - Completed
No routine measurement of gastric residual volume in paediatric critical care
Children in intensive care need good nutrition through a feeding tube to help them heal. Doctors usually use a syringe to check fluid in the stomach every six hours, which can pause feeding. This study looks at whether stopping these routine checks safely allows children to get more of their required food.
Oral and GastrointestinalScotland - Recruiting
Pilot study of safety and efficacy of unilateral MRI-guided focused ultrasound thalamotomy in tremor-dominant Parkinson’s disease
This Scottish study tests a non-invasive treatment for Parkinson’s tremors. Using sound waves guided by an MRI scanner, doctors create a tiny heat spot in the brain to calm shaking. The trial checks whether this single-session treatment is safe and effective for people whose tremors do not improve with medicine.
Parkinson's diseaseScotland - RecruitingPhase II
Assessing if stopping and starting standard of care medication for later stage melanoma can reduce the body's resistance to the treatment
This clinical trial tests a new way of taking standard medicines for advanced skin cancer (melanoma). Instead of taking pills every day, some patients take planned breaks guided by regular blood tests. Researchers want to see if pausing and restarting treatment stops cancer cells from becoming resistant, helping the medicine work longer.
Cutaneous melanomaScotland - Completed
Effectiveness of a maternity improvement programme to reduce excess bleeding and need for transfusion after childbirth: the Obstetric Bleeding Study UK (OBS UK)
Heavy bleeding is a common complication after giving birth. The OBS UK study tests a new maternity care package across 36 NHS hospitals to help staff spot and treat heavy bleeding faster. By measuring blood loss accurately and acting early, researchers hope to reduce blood transfusions and improve safety.
Obstetric bleedingScotland - CompletedNot Applicable
Engagement and acceptability of a digital programme for anxiety
Researchers are testing a new smartphone app designed to help adults manage worry and stress. The app uses short, interactive text chats, videos, and worksheets based on talking therapy. This study looks at how easy and helpful people find the six-week programme from home to improve future digital mental healthcare.
Anxiety symptoms in adultsScotland - CompletedNot Applicable
Ambulatory ECG monitor versus standard care in acute unexplained syncope (sudden loss of consciousness also known as blackout or fainting)
Fainting and sudden blackouts are common reasons people visit hospital, but finding the cause can be tricky once you feel better. This UK trial tests whether wearing a small, stick-on heart monitor for two weeks helps doctors spot hidden heart rhythm problems faster than standard NHS care alone.
Early diagnosis of patients presenting to Emergency Departments with undiagnosed syncope (blackouts).Scotland - RecruitingPhase III
Investigating the clinical and cost-effectiveness of two different drugs (amiodarone and beta blockers) to treat patients with new-onset atrial fibrillation whilst in the intensive care unit
This UK study looks at two standard NHS medicines for an irregular heartbeat that can start during a stay in intensive care. Researchers want to find out whether drugs called beta-blockers or a drug called amiodarone work best to return the heart to a normal rhythm safely.
New onset atrial fibrillation (NOAF)Scotland - CompletedPhase III
Pain relief after instrumented spinal surgery trial
Having lower back surgery can cause significant pain, which can slow down recovery. The PRAISE study compares three different ways to relieve pain after spinal surgery: standard pain tablets and drips, a targeted spinal injection, or a nerve block in the back muscles, to see which helps patients heal best.
Patients scheduled for elective, posterior lumbar-instrumented spinal surgery +/- decompression.Scotland - Recruiting
CONNECT: using electronic devices (e.g. smartphones, smartwatches) to predict relapse of psychosis
The CONNECT study explores whether everyday smartwatches and mobile phones can help spot early warning signs of a psychosis relapse. By monitoring daily activity, sleep, and brief mood check-ins over 12 months, researchers hope to help NHS teams step in earlier to keep people well.
PsychosisScotland - Recruiting
Pressurised IntraPeritoneal Aerosolised Chemotherapy (PIPAC) in the management of cancers of the bowel, ovary and stomach: a randomised controlled trial of efficacy in peritoneal metastases
This UK clinical trial is testing a new way to deliver chemotherapy called PIPAC for people whose bowel, ovarian, or stomach cancer has spread to the lining of the abdomen. It aims to see if spraying chemotherapy directly into the tummy during keyhole surgery works better than standard chemotherapy alone.
Colorectal, ovarian and stomach cancer with peritoneal metastasisScotland - RecruitingPhase IV
A shorter duration of antibiotic treatment versus a longer duration of antibiotic treatment for patients with a flare-up of their chronic lung condition requiring intravenous antibiotics
This UK trial looks at whether a 7-day course of intravenous (IV) antibiotics works just as well as the standard 14-day course for bronchiectasis flare-ups. Researchers want to see if shorter treatment helps people stay well for longer, reduces side effects, and cuts the risk of antibiotic resistance.
BronchiectasisScotland - RecruitingPhase II
SOPRANO - Stereotactic radiotherapy alone or stereotactic radiotherapy follow by niraparib treatment for ovarian cancer with progressive disease in three or less lesions, or recurrence of 3 or less metastatic lesions that had previously achieved complete response.
This trial tests whether targeted, pinpoint radiotherapy can help control ovarian cancer that has grown in just a few small spots after drug treatment. Patients receive radiotherapy to the growing tumours, either on its own or followed by a daily targeted tablet called niraparib, to delay further cancer progression.
Oligometastatic or oligoprogressive ovarian, fallopian tube or primary peritoneal carcinomaScotland - RecruitingPhase II
EXPErimental medicine Route To Success in Amyotrophic Lateral Sclerosis (EXPERTS-ALS)
EXPERTS-ALS is a UK clinical trial testing whether existing, widely used medications can help slow down amyotrophic lateral sclerosis (ALS). Researchers check blood samples for a nerve protein called NFL to see if a drug protects nerve cells. There is no dummy pill, so every participant receives an active treatment.
Amyotrophic lateral sclerosis (ALS)Scotland - Completed
COBIx: Multi-site validation study of the COBIx reporting tool
This UK study tests a computer program called COBIx to help doctors examine bowel tissue samples (biopsies). COBIx spots healthy samples and flags serious conditions like bowel cancer. Researchers are testing 10,000 routine NHS samples to see if the tool can safely speed up diagnoses and reduce hospital backlogs.
Colon and rectal endoscopic biopsyScotland - Completed
Developing and testing a way to correctly identify people with chronic pain from their primary care records
Researchers in Scotland are testing a computer tool to identify people living with chronic pain using GP records. By comparing medical files with patient surveys and interviews, the study aims to give the NHS accurate figures, helping planners design better pain services and improve everyday care across the country.
Chronic painScotland - RecruitingPhase II
Sotagliflozin in patients with heart failure symptoms and type 1 diabetes
This UK trial looks at whether a daily tablet called sotagliflozin can help people living with both type 1 diabetes and heart failure. Researchers want to see if the medication improves everyday symptoms, boosts quality of life, and is safe to use alongside standard daily insulin routines.
Type 1 Diabetes, Heart FailureScotland - RecruitingPhase III
MiTiGate trial: Is Botox more effective than lidocaine and treatment as usual in myalgia temporomandibular disorder (TMD)?
The MiTiGate trial looks at treatments for ongoing jaw muscle pain (M-TMD). Researchers are comparing standard daily pain tablets (amitriptyline or gabapentin) with injections of either Botox or a numbing medicine called lidocaine. The aim is to find out which option provides the safest, most effective, and best-value relief.
Myalgia temporomandibular disorder (M TMD)Scotland - CompletedNot Applicable
Post-market clinical follow-up for stenfilcon A sphere and toric lenses
This study looks at how well stenfilcon A contact lenses work in everyday life. Researchers want to confirm their real-world safety and comfort in people who already wear them. If you are aged 8 to 75 and already use these soft lenses, you may be invited for a single routine check-up.
Myopia, astigmatism, hyperopiaScotland - RecruitingPhase II
A study to learn if ZED1227 can improve continued celiac disease symptoms despite a gluten-free diet
This study is testing a new capsule called ZED1227 for adults with coeliac disease. Researchers want to see if this medicine can protect the gut and ease lingering tummy symptoms caused by accidental gluten exposure, even in people who already follow a strict gluten-free diet.
Coeliac diseaseScotland - Completed
Developing a checklist to allow accurate diagnosis of vulval lichen sclerosus
This UK study tests a simple checklist to help doctors diagnose vulval lichen sclerosus more quickly and accurately. Researchers want to see if this new tool helps non-specialists spot the skin condition sooner. Women aged 18 and over attending a specialist clinic for vulval symptoms can take part during one appointment.
Vulval lichen sclerosusScotland - RecruitingPhase I/II
A trial looking at different treatments for neuroblastoma which has come back after initial therapy
The BEACON2 trial is testing new combinations of cancer medicines for children and young people whose neuroblastoma has returned or worsened after initial treatment. The goal is to find out which drug combinations are safest and work best to control the disease and improve future care.
Relapsed NeuroblastomaScotland - Recruiting
Randomised evaluation of rehabilitation after acute proximal humerus (shoulder) fracture: the REACH study
The REACH study looks at the best way to help adults recover from a broken shoulder that does not need surgery. It compares doing exercises at home using a guidebook and videos against attending regular hospital physiotherapy appointments, to see if home recovery works just as well.
Proximal humerus fractureScotland - Completed
Quality of life after radiotherapy treatment for patients with non-small cell lung cancer
The QUARTZ LUNG trial is looking at whether gentle, low-dose radiotherapy to the chest helps people with advanced (stage 4) non-small cell lung cancer feel better. Researchers want to see if this treatment improves day-to-day quality of life and eases chest symptoms compared to standard supportive care alone.
Stage IV non-small cell lung cancerScotland - Recruiting
Personalised exercise rehabilitation for people with multiple long-term conditions: Main Trial
This UK study tests whether a personalised exercise programme, called PERFORM, helps people living with two or more long-term health conditions. Researchers want to see if tailored exercise improves fitness, quality of life, and day-to-day well-being compared to standard NHS care.
Multiple long-term conditionsScotland - Recruiting
Operative or non-surgical treatment of Perthes’ disease
Perthes’ disease affects the hip joint in children, causing the top of the thigh bone to soften and flatten. This UK study compares two usual NHS treatments: physiotherapy and guided exercises without surgery, versus an operation to realign the hip bone. The aim is to see which approach works best.
Perthes’ diseaseScotland - RecruitingPhase II
AIR-NET- Testing anti-inflammatories for the treatment of bronchiectasis
The AIR-NET study tests whether three existing medicines can calm lung inflammation in adults with bronchiectasis. Researchers want to find out if repurposing these safe, well-known drugs can help ease daily symptoms, reduce chest damage, and offer better treatment options alongside usual care for people living with this lung condition.
BronchiectasisScotland - Recruiting
Lifestyle in Perimenopause: Exploring a Community Intervention
This Edinburgh-based study explores whether a friendly community group can help people manage perimenopause and menopause symptoms. By taking part in weekly walks, educational talks, and creative group discussions, researchers hope to learn if peer support and lifestyle changes can help protect bone health and lower stress.
People who are having difficulty managing symptoms of perimenopause and menopause.Scotland - RecruitingNot Applicable
Diabetic foot ulcer infection prevention study
Diabetic foot ulcers can easily become infected, leading to serious medical complications. This UK study looks at whether a special wound dressing called Cutimed Sorbact can help stop infections before they start. Researchers are comparing this dressing alongside routine NHS wound care against standard care alone over 12 weeks.
Non-infected superficial diabetes-related foot ulcersScotland - Recruiting
A feasibility study of a combined mental health and neurodevelopmental assessment for young people in crisis services
This study tests a new approach for young people aged 12 to 17 in mental health crisis. It combines urgent mental health support with a quick assessment for conditions like autism and ADHD. The goal is to see if this combined check helps teens get the right support much faster.
Neurodivergence. Mental health, suicidality, self harmScotland - RecruitingPhase II
NOVEL: A Clinical Trial of the Oxygen-carrying Substance NanO2 to Protect the Brain after Stroke
This UK clinical trial tests a new medicine called NanO2 for people who have had a severe stroke caused by a blood clot. NanO2 carries extra oxygen to brain tissue to keep it alive while doctors work to open the blocked blood vessel and restore normal blood flow.
Large vessel occlusion strokeScotland - Recruiting
Co-development of a web-app for young people with attention deficit hyperactivity disorder
Researchers in the UK are developing a new web app to support young people aged 16 to 30 who have ADHD or are waiting for an assessment. By testing the app in friendly workshops, participants help design useful tools and trusted information to improve everyday life and future NHS care.
Attention deficit hyperactivity disorder (ADHD)Scotland - RecruitingPhase I
Deferred registration: Phase I Trial: MAC code 'MAC215'
MAC215 is an early-stage (Phase 1) clinical study for adults aged 50 to 85. The UK Health Research Authority has agreed that specific study details can remain private for now. Full information about the treatment and health condition will be published after the study has ended.
The Health Research Authority has approved a deferral. Full details will be added to the trial record on or before the deferral expiry date.Scotland