Latest studies
- RecruitingPHASE1, PHASE2
The Pediatric Acute Leukemia (PedAL) Screening Trial - A Study to Test Bone Marrow and Blood in Children With Leukemia That Has Come Back After Treatment or Is Difficult to Treat - A Leukemia & Lymphoma Society and Children's Oncology Group Study
This study looks at blood and bone marrow from children and young people with leukaemia that's come back or is hard to treat. It helps doctors understand the leukaemia better, which could lead to improved treatments and new ways to diagnose and care for young patients.
Acute Lymphoblastic LeukemiaAcute Myeloid LeukemiaAcute Myeloid Leukemia Post Cytotoxic TherapyJuvenile Myelomonocytic LeukemiaUnited States - Active not recruitingPHASE3
CORE-OLE: A Study of Olezarsen (ISIS 678354) Administered Subcutaneously to Participants With Severe Hypertriglyceridemia (SHTG)
This study is looking at a new medicine called Olezarsen for people with very high triglyceride levels. It's an ongoing study for those who have already started the treatment in previous trials, checking its long-term safety and how well it's tolerated.
Severe HypertriglyceridemiaUnited States - Enrolling by invitation
Allied Cleft & Craniofacial Quality-Improvement and Research Network (ACCQUIREnet)
This project, ACCQUIREnet, helps doctors and nurses who care for children with cleft lip and/or palate improve their treatment. They collect information on how well different treatments work to make sure children get the best care possible.
Cleft LipCleft PalateCleft Lip and PalateUnited States - Active not recruitingPHASE3
A Trial to Assess Efficacy and Safety of Octreotide Subcutaneous Depot in Patients With GEP-NET
This study is testing a new medicine, CAM2029, for a type of cancer called GEP-NET. It compares CAM2029 to existing treatments, octreotide LAR and lanreotide ATG, to see if it's more effective and safe for advanced GEP-NET.
Gastro-enteropancreatic Neuroendocrine TumorUnited States - RecruitingPHASE2
DALY II USA/ MB-CART2019.1 for DLBCL
This study is testing a new cell therapy called zamtocabtagene autoleucel for different types of lymphoma, including Diffuse Large B-cell Lymphoma (DLBCL), when other treatments haven't worked. It looks at how well it works and if it's safe.
Refractory Diffuse Large B Cell Lymphoma (DLBCL)Relapsed Diffuse Large B Cell LymphomaHigh Grade B-cell Lymphoma (HGBCL)Primary Mediastinal B-cell Lymphoma (PMBCL)United States - Recruiting
The RESBIOP-study: Resection Versus Biopsy in High-grade Glioma Patients (ENCRAM 2202)
This study compares two ways to treat serious brain tumours (high-grade gliomas) in older patients or those who are not very active: having surgery to remove the tumour (resection) or taking a small tissue sample (biopsy). It looks at survival, quality of life, and if patients can then have other treatments.
GlioblastomaGlioblastoma, IDH-wildtypeGlioblastoma MultiformeGlioblastoma Multiforme, AdultUnited States - Active not recruitingPHASE3
A Study To Assess Adverse Events and Effectiveness of Upadacitinib Oral Tablets in Adult and Adolescent Participants With Vitiligo
This study looks into a new tablet medicine, upadacitinib, for adults and teenagers with a type of vitiligo. Researchers want to see how safe it is and how well it helps improve skin when compared to a dummy pill or light therapy.
VitiligoUnited States - RecruitingPHASE3
A Study of Tacabrutideg (BGB-16673) Compared to Investigator's Choice in Participants With Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma Previously Exposed to Both Bruton Tyrosine Kinase (BTK) and B-cell Leukemia/Lymphoma 2 Protein (BCL2) Inhibitors
This study looks at a new drug, BGB-16673, for people with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL). It compares BGB-16673 to existing treatments in patients whose cancer has come back after trying two other types of drugs.
CLLChronic Lymphocytic LeukemiaUnited States - Active not recruitingNA
ALT-FLOW II Trial of the Edwards APTURE Transcatheter Shunt System
This study looks at a new device for people with heart failure. It wants to see if the Edwards APTURE shunt system can help improve symptoms for those whose hearts pump well but still feel unwell, even with their usual medicines.
Heart FailureUnited States - Active not recruitingPHASE3
A Study to Evaluate the Efficacy and Safety of Ocrelizumab in Adults With Primary Progressive Multiple Sclerosis
This study is looking at a new treatment called Ocrelizumab for primary progressive multiple sclerosis (PPMS). It compares Ocrelizumab to a dummy drug (placebo) to see how safe and effective it is for adults, including those who have had PPMS for a while.
Multiple Sclerosis, Primary ProgressiveUnited States - RecruitingPHASE3
A Study of Orforglipron (LY3502970) in Adolescent Participants With Obesity, or Overweight With Related Comorbidities
This study is looking at a new once-a-day tablet, orforglipron, for teenagers (12-17 years old) with obesity or who are overweight with other health issues. It will check if the medicine helps with weight and if it's safe to use.
ObesityOverweightUnited States - RecruitingPHASE3
A Clinical Study of the Anti-cancer Effects of an Investigational Therapy or Chemotherapy in Patients With Recurring Uterine Cancer
This study is looking at a new treatment (BNT323) for women with advanced womb cancer that has come back. It compares BNT323 to standard chemotherapy to see if it works better at shrinking tumours and keeping the cancer from growing.
Endometrial CancerUnited States - Active not recruiting
Delirium in Children Undergoing Stem Cell Transplantation
This study looks at a temporary change in thinking called delirium in children having stem cell transplants. We want to find out how often it happens, why it happens, and how it affects children, aiming to reduce it. It's for children aged up to 21 undergoing this treatment.
Stem Cell Transplant ComplicationsDeliriumUnited States - Active not recruiting
Nerve Transfer After Spinal Cord Injury- Multi-center
This study looks at a new surgery called 'nerve transfer' for people with spinal cord injuries affecting their hands. It aims to see if this surgery can improve hand movement and quality of life for those with complete paralysis after their injury.
TetraplegiaSpinal Cord InjuriesQuadriplegia FlaccidUnited States - RecruitingNA
TUBectomy With Delayed Oophorectomy in High Risk Women to Assess the Safety of Prevention
This study looks at a new way to lower ovarian cancer risk in women with certain gene changes. Instead of removing both ovaries and fallopian tubes at once, it explores removing only the fallopian tubes first, and the ovaries later, to delay menopause and its effects. We want to see if this new approach is safe and effective.
BRCA1 Gene MutationBRCA2 Gene MutationRAD51C Gene MutationRAD51D Gene MutationUnited States - RecruitingPHASE3
A Study to Evaluate the Efficacy and Safety of DNTH103 in Adults With Chronic Inflammatory Demyelinating Polyneuropathy (CAPTIVATE)
This study looks at a new drug, claseprubart, for Chronic Inflammatory Demyelinating Polyneuropathy (CIDP). It aims to see if the drug helps people with CIDP and if it's safe. Some participants will receive the drug, and others a dummy treatment.
Chronic Inflammatory Demyelinating PolyneuropathyUnited States - RecruitingPHASE3
Efficacy, Safety, and Tolerability Study of Lunsekimig Compared With Placebo in Adult Participants With Inadequately Controlled Chronic Obstructive Pulmonary Disease (COPD) Characterized by an Eosinophilic Phenotype
This study is testing a new medicine, lunsekimig, for adults aged 40-80 with COPD that's not well-controlled. We want to see if it helps improve breathing, is safe, and has manageable side effects compared to a dummy medicine.
Chronic Obstructive Pulmonary DiseaseUnited States - RecruitingPHASE4
Anticoagulation for Stroke Prevention In Patients With Recent Episodes of Atrial Fibrillation Occurring Transiently With Stress
This study looks at whether blood-thinning medicines (anticoagulants) can prevent strokes and other heart-related problems in people who have had temporary episodes of an irregular heartbeat called atrial fibrillation (AF) during stressful times like surgery or serious illness.
StrokeAtrial FibrillationUnited States - RecruitingPHASE1, PHASE2
A Study of YL201 in Patients With Advanced Solid Tumors
This study is testing a new medicine, YL201, for people with advanced cancers that haven't responded to other treatments. It will check if YL201 is safe and how well it works, sometimes given alongside another medicine called atezolizumab. It's an early-stage study happening in China and the US.
Advanced Solid TumorUnited States - RecruitingPHASE2, PHASE3
A Study of Zilovertamab Vedotin (MK-2140) in Combination With Standard of Care in Participants With Relapsed or Refractory Diffuse Large B-Cell Lymphoma (rrDLBCL) (MK-2140-003)
This study is testing a new medicine, zilovertamab vedotin (ZV), combined with standard treatments for a type of lymphoma called diffuse large B-cell lymphoma (DLBCL). It's for people whose lymphoma has come back or hasn't responded to previous treatments.
DLBCLDiffuse Large B-Cell LymphomaUnited States - RecruitingPHASE3
A Study of Sepiapterin in Participants With Phenylketonuria (PKU)
This study is looking at a new medicine called sepiapterin for children with Phenylketonuria (PKU). It aims to see if starting this medicine early can help protect their brain development over a long time.
PhenylketonuriaUnited States - Active not recruitingPHASE3
Study of Talazoparib With Enzalutamide in Men With DDR Gene Mutated mCSPC
This study is for men with a certain type of advanced prostate cancer (mCSPC) that has spread and has specific gene changes. It compares a new drug called talazoparib, given with standard treatment enzalutamide, against enzalutamide alone, to see if it's safe and effective.
Prostate CancerUnited States - Active not recruitingPHASE3
A Study to Compare the Efficacy and Safety of Luspatercept (ACE-536) Versus Epoetin Alfa for the Treatment of Anemia Due to IPSS-R Very Low, Low, or Intermediate Risk Myelodysplastic Syndromes (MDS) Participants Who Require Red Blood Cell Transfusions and Are ESA Naïve
This study compares a new medicine, luspatercept, with a standard one, epoetin alfa, for people with a type of blood disorder called myelodysplastic syndromes (MDS). It aims to see if luspatercept can reduce the need for blood transfusions.
Myelodysplastic SyndromesUnited States - RecruitingPHASE2, PHASE3
FORTIFI-HN01: A Study of Ficerafusp Alfa (BCA101) or Placebo in Combination With Pembrolizumab in First-Line PD-L1-pos, R or M HNSCC
This study looks at a new drug, ficerafusp alfa, combined with pembrolizumab (Keytruda®) for people with advanced head and neck cancer. It compares this combination against pembrolizumab alone to see if it works better and is safe.
Metastatic Head and Neck Squamous Cell CarcinomaRecurrent Head and Neck Squamous Cell CarcinomaUnited States - RecruitingPHASE3
A Study to Investigate the Efficacy and Safety of Anifrolumab Administered as Subcutaneous Injection and Added to Standard of Care Compared With Placebo Added to Standard of Care in Adult Participants With Idiopathic Inflammatory Myopathies (Polymyositis and Dermatomyositis)
This study looks at a new drug called anifrolumab for adults with muscle conditions like polymyositis or dermatomyositis. Researchers want to see if it's safe and helps improve symptoms when added to their usual treatment.
Polymyositis, DermatomyositisUnited States - Active not recruitingPHASE3
A Study of Remternetug (LY3372993) in Early Alzheimer's Disease (TRAILRUNNER-ALZ 3)
This study, called TRAILRUNNER-ALZ 3, is looking at a new medicine called Remternetug for people in the early stages of Alzheimer's disease. Researchers want to see if it can slow down memory, thinking, or daily living problems compared to a dummy drug (placebo).
Alzheimer's DiseaseUnited States - RecruitingPHASE1
A Study to Evaluate the Safety, Tolerability, Pharmacokinetics (PK) and Preliminary Clinical Activity of RO7673396 in Participants With Advanced Solid Tumors Harboring Rat Sarcoma Viral Oncogene Homolog (RAS) Mutation(s)
This study is looking at a new drug, RO7673396, for advanced cancers with a specific gene change (RAS mutation). We want to check if it's safe and how the body handles it. We'll also see if it helps shrink tumors.
NeoplasmsUnited States - Recruiting
The GBA Multimodal Study in Parkinson's Disease
This study looks at how a specific gene change (GBA mutation) might be linked to Parkinson's disease. Researchers are using special brain scans and typing tests to understand changes in the brain and whether early signs of the disease can be found.
Parkinson DiseaseGBA Gene MutationGaucher DiseaseUnited States - Active not recruitingNA
ASCEND CSP IDE Study
This study is testing a new type of heart device lead for people with heart failure. It looks at how safe and effective the "CSP ICD Lead" is when used with special heart devices to help control irregular heartbeats and improve heart function.
Heart FailureVentricular ArrythmiaUnited States - Active not recruitingPHASE3
Phase 3 Study of Daraxonrasib (RMC-6236) in Patients With Previously Treated Metastatic Pancreatic Ductal Adenocarcinoma (PDAC)
This study is looking for a new treatment for pancreatic cancer that has spread. It compares a new medicine called RMC-6236 with standard chemotherapy for people whose cancer has already been treated once before. The aim is to see if the new medicine is safer and works better.
Pancreatic CancerPDACPDAC - Pancreatic Ductal AdenocarcinomaUnited States - Recruiting
Long-term Safety of Nipple Sparing Mastectomy in Women With High Penetrance Breast Cancer Susceptibility Genes in Breast Cancer
This study looks at the long-term safety of a specific breast surgery called nipple-sparing mastectomy. It's for women with genes that increase their risk of breast cancer who want to reduce that risk while keeping their nipple and areola.
Breast Cancer SurgeryUnited States - Active not recruitingPHASE3
Durvalumab+ Gemcitabine/Cisplatin (Neoadjuvant Treatment) and Durvalumab (Adjuvant Treatment) in Patients With MIBC
This study looks at a new way to treat muscle-invasive bladder cancer using a drug called Durvalumab alongside standard chemotherapy. It aims to see if this combination, given before and after surgery, can improve treatment outcomes and safety for patients.
Muscle Invasive Bladder CancerUnited States - RecruitingPHASE1
A Study of CLN-978, a Subcutaneously Administered CD19-directed T Cell Engager, in Subjects With Sjogren's Disease
This study is looking at a new medicine called CLN-978 for people with Sjögren's disease. It's an early-stage study to see how safe it is and how well it works. The medicine is given as an injection under the skin.
SjögrenSjogren DiseaseSjogren's SyndromeUnited States - Recruiting
Observational Study to Assess Adverse Events When Adult Female Participants Are Treated With Ubrelvy (Ubrogepant) or Qulipta (Atogepant) During Pregnancy
This study looks at the effects of migraine medications Ubrelvy or Qulipta when taken during pregnancy. Researchers will compare health outcomes for pregnant women, their babies, and children up to one year old, who took these medicines versus those who didn't.
MigraineUnited States - RecruitingPHASE3
A Study to Evaluate the Efficacy and Safety of KarXT + KarX-EC for Cognitive Impairment in Alzheimer's Disease
This study is looking at a new medicine called KarXT + KarX-EC to see if it can help improve memory and thinking skills in people with Alzheimer's disease. It also checks if the medicine is safe to use. Some people will get the active medicine, others a dummy pill.
Alzheimer's DiseaseUnited States - RecruitingPHASE1
A Study to Assess the Adverse Events, Change in Disease Activity, and How Intravenously Infused ABBV-319 Moves Through the Bodies of Adult Participants With Relapsed or Refractory (R/R) Diffuse Large B-cell Lymphoma (DLBCL), Follicular Lymphoma (FL), or Chronic Lymphocytic Leukemia (CLL)
This study is testing a new drug, ABBV-319, for people with certain types of blood cancer like lymphoma or leukemia that have come back or are not responding to current treatments. Researchers want to see if it's safe, how it moves through the body, and if it helps fight the cancer.
Diffuse Large B-Cell LymphomaChronic Lymphocytic LeukemiaFollicular LymphomaUnited States - RecruitingPHASE3
Phase 3 Extension Study to Evaluate Long-term Safety of Ianalumab in Participants With Systemic Lupus Erythematosus (SIRIUS-SLE Extension).
This study looks at the long-term safety of a new medicine, ianalumab, for people with lupus. It's for those who have already been in an earlier ianalumab study and continues to check how safe and well the medicine is tolerated over time.
Systemic Lupus ErythematosusUnited States - RecruitingPHASE2
Evaluation of the Safety and Efficacy of Treatment w/High Dose Melphalan Given Directly Into the Liver Followed by Treatment w/Approved Cancer Treatment or Approved Cancer Treatment Alone in Patients w/ Metastatic Colorectal Cancer w/Liver Dominant Disease
This study looks at a new way to treat bowel cancer that has spread to the liver. Half of the patients will get a special liver treatment plus standard drugs, and the other half will get standard drugs only. It aims to see if the liver treatment is safe and effective.
Refractory Metastatic Colorectal CancerUnited States - Active not recruitingNA
Pregnancy Outcome and Safety of Interrupting Therapy for Women With Endocrine Responsive Breast Cancer
This study aims to understand if temporarily stopping hormone therapy for early breast cancer to allow for pregnancy is safe. It will also look at fertility and emotional well-being for young women.
Early Breast CancerUnited States - Active not recruitingPHASE2
A Study of the Efficacy and Safety of Adjuvant Autogene Cevumeran Plus Atezolizumab and mFOLFIRINOX Versus mFOLFIRINOX Alone in Participants With Resected PDAC
This study looks at new treatments for pancreatic cancer after surgery. It compares a new combination of drugs (Autogene Cevumeran, Atezolizumab, and mFOLFIRINOX) with a standard treatment (mFOLFIRINOX alone) to see which works best and is safest for patients with no remaining cancer after their operation.
Adenocarcinoma, Pancreatic DuctalUnited States - Enrolling by invitation
Natural History Study of SCID Disorders
This study looks at how children with a rare immune problem called SCID respond to different treatments. Doctors are collecting information to understand which treatments work best and help these children live healthier lives. It's about naturally observing treatment journeys, not testing new drugs.
Severe Combined Immunodeficiency (SCID)Leaky SCIDOmenn SyndromeReticular DysgenesisUnited States - RecruitingPHASE1, PHASE2
Study of Allo-QuadCAR01-T, an Allogeneic CAR-T Targeting CD19/CD20, in Patients With Relapsed or Refractory B-Cell Malignancies
This study tests a new 'off-the-shelf' CAR-T cell therapy, Allo-QuadCAR01-T, for hard-to-treat B-cell cancers like lymphoma. It uses donor cells that target two cancer markers, aiming to be faster and potentially more effective than current treatments. Researchers will check its safety and how well it works.
Lymphoma Diffuse Large B-cellLeukemia and LymphomaLeukemia RelapseLymphoma Receiving CAR-T TherapyUnited States - RecruitingPHASE3
CAPRI: A Phase 3 Randomized, Double-Masked Study Comparing the Efficacy of EYP-1901 Against Aflibercept in DME
This study is testing a new eye treatment, EYP-1901, against an existing one, Aflibercept, for people with diabetic macular edema (DME). It aims to see if the new treatment works just as well to improve or keep vision stable.
Diabetic Macular EdemaDMEDiabetic Macular Edema (DME)United States - RecruitingPHASE3
To Evaluate Efficacy of Belinostat or Pralatrexate in Combination Against CHOP Alone in PTCL
This study looks at new drug combinations (Bel-CHOP or Fol-COP) for a type of blood cancer called Peripheral T-Cell Lymphoma, which hasn't been treated before. It aims to see if these new combinations work better than the standard treatment (CHOP) and are safe.
Peripheral T Cell LymphomaUnited States - Active not recruitingPHASE1, PHASE2
A Phase 1b/2 Study of T-DXd Combinations in HER2-positive Metastatic Breast Cancer
This study is looking at new combinations of medicines for HER2-positive breast cancer that has spread. It aims to see how safe and effective these combinations are in patients whose advanced breast cancer has come back or spread.
Metastatic Breast CancerUnited States - Active not recruitingPHASE1
A Study of Safety and Efficacy of KFA115 Alone and in Combo With Pembrolizumab in Patients With Select Advanced Cancers
This study looks at a new drug, KFA115, on its own and with another drug, pembrolizumab, for various advanced cancers. It aims to find a safe and effective dose, helping doctors understand how these treatments work.
Carcinoma, Non-Small-Cell LungCutaneous MelanomaCarcinoma, Renal CellCarcinoma, Ovarian EpithelialUnited States - Recruiting
Drug-Eluting Registry: Real-World Treatment of Lesions in the Peripheral Vasculature
This study looks at how well Boston Scientific's special drug-coated devices work in treating blood vessel problems in people's arms and legs. It helps doctors understand their real-world use for conditions like Peripheral Vascular Disease.
Peripheral Vascular DiseasesUnited States - RecruitingPHASE3
A Phase 3 Study of Ersodetug in Patients With Tumor Hyperinsulinism
This study is testing a new drug, Ersodetug, for adults with a rare condition called Tumour Hyperinsulinism (Tumour HI). It aims to see if the drug can help control very low blood sugar levels caused by certain tumours, when current treatments aren't enough.
Tumor Hyperinsulinism (Tumor HI)United States - Active not recruitingNA
Adjuvant Chemotherapy in Patients With Intermediate or High Risk Stage I or Stage IIA Non-squamous Non-Small Cell Lung Cancer: AIM-HIGH (Adjuvant Intervention in Molecular High Risk Patients)
This study looks into whether extra chemotherapy after surgery helps people with early-stage non-small cell lung cancer that is considered high risk. It uses a special gene test to identify these patients and compares two ways of looking after them.
Non-Small Cell Lung CancerUnited States - Recruiting
Quality of Pediatric Resuscitation in a Multicenter Collaborative
This study looks at how the quality of CPR given to children during a cardiac arrest affects their recovery. Researchers are observing children in hospitals to see if better CPR techniques and after-care improve survival and brain function.
Cardiac ArrestCardiopulmonary ArrestUnited States