Latest studies
- Not yet recruitingPHASE3
A Research Study Investigating Denecimig (Mim8) in Adults With Acquired Haemophilia A
This study is looking at a new medicine called denecimig for adults with a rare bleeding condition called acquired haemophilia A. We want to see if it's safe and helps stop or treat bleeding. Participants would be in the study for up to about 1 year and 5 months.
Haemophilia AUnited States - RecruitingPHASE2, PHASE3
Optimizing Reperfusion to Improve Outcomes and Neurologic Function
This study is looking at a new medicine called JX10 for people who have recently had a stroke. It wants to see if JX10 helps people recover better and if it's safe to use compared to a dummy medicine (placebo).
Acute Ischemic StrokeUnited States - RecruitingPHASE3
A Study to Evaluate the Long-term Safety and Efficacy of Lunsekimig in Adult Participants With Chronic Obstructive Pulmonary Disease (COPD)
This study looks at a new treatment called Lunsekimig for people with a severe lung condition called COPD. It aims to see how safe and effective it is over a long time, especially for those who have already tried it in earlier studies.
Chronic Obstructive Pulmonary DiseaseUnited States - RecruitingPHASE1, PHASE2
A Safety and Efficacy Study of a One-time Intravitreal Injection of SAR446597 in Participants With Geographic Atrophy Secondary to Age-related Macular Degeneration
This study is testing a new, one-time eye injection for people with Geographic Atrophy (GA), a severe form of age-related macular degeneration (AMD). Researchers want to see if it's safe and helps improve or maintain vision. It involves a single treatment followed by long-term check-ups.
Geographic AtrophyUnited States - RecruitingPHASE3
A Study to Evaluate the Effectiveness and Safety of Setidegrasib, Given With Either mFOLFIRINOX or NALIRIFOX Chemotherapies, in People With Pancreatic Cancer
This study is testing a new drug called setidegrasib for people in the UK with advanced pancreatic cancer. It's for those whose cancer has spread and has a specific gene change (KRAS G12D). The study wants to see if adding setidegrasib to standard chemotherapy helps people live longer and feel better.
Pancreatic CancerMetastatic Pancreatic CancerMetastatic Pancreatic AdenocarcinomaUnited States - RecruitingPHASE3
A Study Evaluating Efruxifermin in Subjects With Compensated Cirrhosis Due to NASH/MASH
This study is testing a new medicine, efruxifermin, for people with a serious liver condition called NASH/MASH cirrhosis. It's to see if the medicine helps improve liver health in those with scarring that hasn't yet caused severe problems.
NASH - Nonalcoholic SteatohepatitisMASH - Metabolic Dysfunction-Associated SteatohepatitisUnited States - Active not recruitingPHASE1
NEPC Study: An Exploratory Safety and Efficacy Study With PSMA, SSTR2 and GRPR Targeted Radioligand Therapy in Metastatic Neuroendocrine Prostate Cancer.
This study looks at new ways to treat prostate cancer that has spread. It uses special scans to find cancer cells and then delivers targeted radiation therapy to those cells, aiming to see how well it works and if it's safe.
Metastatic Neuroendocrine Prostate CancerUnited States - Active not recruiting
Characterization And Clinical Outcomes of AA Patients Treated With Ritlecitinib
This study looks at how well a new medicine called Ritlecitinib works for people with a type of hair loss called alopecia areata in everyday life. It will check patient details, how the medicine is used, and how patients feel about their treatment.
Alopecia AreataUnited States - Available
Expanded Access Program of Neladalkib (NVL-655) for Patients With Advanced ALK+ NSCLC or Other ALK+ Solid Tumors
This program offers people with advanced ALK-positive lung cancer or other ALK-positive tumours an opportunity to receive an investigational medicine called neladalkib (NVL-655). It is for those who can't join a regular trial and have run out of other good treatment options.
Non Small Cell Lung CancerALK-positive Non-small Cell Lung Cancer (NSCLC)United States - RecruitingPHASE2
A Phase IIb Study to Evaluate AZD8965 in Participants With IPF.
This study is looking into a new drug, AZD8965, for people with Idiopathic Pulmonary Fibrosis (IPF). It aims to see if different doses of this drug are safe and effective, compared to a dummy drug, for people with IPF, including those already on other treatments.
Idiopathic Pulmonary Fibrosis (IPF)United States - RecruitingPHASE1, PHASE2
A Phase I/II Trial of JR-446 in Mucopolysaccharidosis Type IIIB (MPS IIIB)
This study is looking into a new medicine called JR-446 for young children (under 6) with a rare genetic condition called Mucopolysaccharidosis Type IIIB (MPS IIIB). We want to see if the medicine is safe and helps with the condition.
Mucopolysaccharidosis IIIBUnited States - RecruitingPHASE3
FIBRONEER-ACT: A Study to Test Whether Nerandomilast Helps People With Fibrosing Interstitial Lung Disease at Risk for Disease Progression
This study tests a new medicine called nerandomilast for people with certain types of lung scarring (fibrosing interstitial lung disease). It aims to see if the medicine can stop the disease from getting worse. Participants take the medicine or a dummy pill, and doctors check their lung health over about two years.
Interstitial Lung DiseasesUnited States - RecruitingPHASE3
A Master Protocol of Multiple Agents in Adults With Metabolic Dysfunction-Associated Steatotic Liver Disease (SYNERGY-Outcomes)
This study looks at new medicines, retatrutide and tirzepatide, for adults with a type of fatty liver disease called MASLD. It aims to see if these drugs can help prevent serious liver problems. Some participants will receive a dummy drug (placebo) to compare.
Metabolic Dysfunction-Associated Steatotic Liver DiseaseUnited States - RecruitingPHASE2
A Study in Adults With Geographic Atrophy
This study is testing a new medicine, STL303, for Geographic Atrophy (GA), an eye condition that can cause blurry central vision. We want to see if it's safe and effective in slowing down this vision loss for people aged 60 and over.
Geographic AtrophyUnited States - RecruitingPHASE3
ATSN-201 Gene Therapy in RS1-Associated X-linked Retinoschisis
This study is looking at a new gene therapy, ATSN-201, for a rare eye condition called X-linked Retinoschisis (XLRS). It aims to see if the treatment is safe and effective for people aged 6 and over who have XLRS caused by a specific gene problem.
X-linked RetinoschisisUnited States - RecruitingPHASE3
Efficacy, Safety, and Tolerability Study of Lunsekimig Compared With Placebo in Adult Participants With Inadequately Controlled Chronic Obstructive Pulmonary Disease (COPD) Characterized by an Eosinophilic Phenotype
This study is testing a new medicine, lunsekimig, for adults aged 40-80 with COPD that's not well-controlled. We want to see if it helps improve breathing, is safe, and has manageable side effects compared to a dummy medicine.
Chronic Obstructive Pulmonary DiseaseUnited States - RecruitingPHASE1, PHASE2
A Clinical Study to Evaluate the Safety and Efficacy of ETX101 in Infants and Children With SCN1A-Positive Dravet Syndrome
This study is looking at a new medicine called ETX101 for babies and children with Dravet Syndrome. Researchers want to see if it's safe and helps reduce seizures. It includes different age groups, from 6 months up to 17 years.
Dravet SyndromeUnited States - RecruitingPHASE3
Single-arm Study of IgPro20 in Adults With Secondary Immune Deficiencies Due to Hematologic Malignancies Treated With B-cell Targeting Chimeric Antigen Receptor T-cell and T-cell Redirecting Therapies
This study looks at a medicine called IgPro20 for adults with weakened immune systems due to cancer treatments. It checks if IgPro20 can reduce serious infections and if it's safe. This could help people after certain cell therapies.
Secondary Immune DeficiencyUnited States - Active not recruitingPHASE2
Phase 2 Safety and Efficacy Study of Tulisokibart (MK-7240/PRA023) in Subjects With Systemic Sclerosis Associated With Interstitial Lung Disease (SSc-ILD) (MK-7240-007)
This study looks at a new drug, tulisokibart, for people with a lung condition called interstitial lung disease (ILD) linked to scleroderma. We want to see if it's safe and helps improve the condition.
Diffuse Cutaneous Systemic SclerosisInterstitial Lung DiseaseUnited States - RecruitingPHASE3
Evaluating the Impact of Maridebart Cafraglutide on Cardiovascular Outcomes in Participants With Atherosclerotic Cardiovascular Disease and Overweight or Obesity
Researchers are studying a new drug called Maridebart Cafraglutide to see if it can help people with heart disease and who are overweight or obese. The goal is to find out if this drug can lower the risk of heart attacks, strokes, and other serious heart problems.
Atherosclerotic Cardiovascular DiseaseOverweightObesityUnited States - RecruitingPHASE3
A Three-Part Phase 3 Study of Sofetabart Mipitecan in Participants With Platinum-Resistant (Part A) and Platinum-Sensitive (Parts B and C) Ovarian Cancer
This study is testing a new medicine, Sofetabart Mipitecan, for certain ovarian, fallopian tube, and peritoneal cancers. It aims to see if it works better than current treatments and is safe, for people whose cancer either has or hasn't responded well to previous platinum-based treatments.
Ovarian NeoplasmsFallopian Tube NeoplasmsPeritoneal NeoplasmsNeoplasm MetastasisUnited States - Active not recruitingPHASE3
Beamion LUNG-2: A Study to Test Whether Zongertinib (BI 1810631) Helps People With Advanced Non-small Cell Lung Cancer With HER2 Mutations Compared With Standard Treatment
This study looks at a new drug, zongertinib, for advanced lung cancer with a specific genetic change (HER2 mutation). It compares zongertinib to standard treatment to see if it can better slow down cancer growth and improve how long people live without their cancer getting worse.
Lung Cancer, Non-squamous, Non-small CellUnited States - Not yet recruitingPHASE1, PHASE2
DAREON®-36: A Study to Test Obrixtamig in Combination With ZL-1310 in People With Advanced Small Cell Lung Cancer or Other Neuroendocrine Cancers
This study tests new medicines, obrixtamig and ZL-1310, for advanced lung and other neuroendocrine cancers. It aims to find a safe dose and see how they work, especially when combined with another drug to help your immune system fight cancer.
Small Cell Lung CancerLarge Cell Neuroendocrine Lung CarcinomaExtrapulmonary Neuroendocrine Carcinoma of Small Cell HistologyExtrapulmonary Neuroendocrine Carcinoma of Large Cell HistologyUnited States - Active not recruitingPHASE3
A Study to Compare the Efficacy and Safety of SCENESSE and Narrow-Band Ultraviolet (NB-UVB) Light Versus NB-UVB Light Alone in Patients With Vitiligo
This study looks at a new treatment for vitiligo, a condition where patches of skin lose their colour. It compares a special implant (afamelanotide) combined with light therapy (NB-UVB) against light therapy alone, to see how well they work and if they are safe.
VitiligoUnited States - RecruitingPHASE4
A Study of Pirtobrutinib (LY3527727) in Participants With Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma
This study looks at the long-term safety of a medicine called pirtobrutinib for people with chronic lymphocytic leukaemia (CLL) or small lymphocytic lymphoma (SLL). It's for those already taking part in a previous pirtobrutinib study, to continue treatment and monitoring.
Chronic Lymphocytic LeukemiaLymphoma, Small LymphocyticUnited States - Active not recruitingPHASE3
EASi-KIDNEY™ (The Studies of Heart & Kidney Protection With BI 690517 in Combination With Empagliflozin)
This study looks at a new medicine, BI 690517, combined with empagliflozin, for adults with chronic kidney disease. It aims to see if this combination can help slow down kidney disease progression and protect the heart, for people with and without type 2 diabetes.
Kidney Disease, ChronicUnited States - Enrolling by invitationPHASE2
Long-term Follow-up of Patients Treated With Genetically Modified Autologous T Cells
This study is checking on people who have had a special treatment called AUTO CAR T cell therapy. Doctors want to see how these patients are doing for up to 15 years after their treatment. This helps them understand the long-term effects of this new therapy for blood cancers.
Patients Followed for up to 15 Years Following Their First Dose of AUTO CAR T Cell TherapyMultiple MyelomaDLBCLALL, Adult and PediatricUnited States - Active not recruitingPHASE3
A Research Study to Evaluate the Efficacy and Safety of Cenerimod in Subjects Suffering From Systemic Lupus Erythematosus
This study is testing a new medicine, cenerimod, for people with a type of lupus called Systemic Lupus Erythematosus (SLE). It aims to see if adding cenerimod to current treatments helps reduce symptoms and is safe.
Lupus Erythematosus, SystemicUnited States - RecruitingPHASE3
A Master Protocol (AMAZ): A Study of Mirikizumab (LY3074828) in Pediatric Participants With Ulcerative Colitis or Crohn's Disease (SHINE-ON)
This study looks at a medicine called Mirikizumab for children and teenagers aged 2 to 19 with Ulcerative Colitis or Crohn's Disease. It checks how well the medicine works over a long time to help manage these conditions.
Ulcerative ColitisUlcerative Colitis ChronicInflammatory Bowel DiseasesCrohn's DiseaseUnited States - RecruitingPHASE3
A Study to Test Whether Vicadrostat (BI 690517) in Combination With Empagliflozin Helps People With Heart Failure and a Weak Pumping Function of the Left Side of the Heart
This study investigates if a new drug, vicadrostat, combined with empagliflozin, can help adults with heart failure and a weakened heart pump. Participants will take study medications for up to 3.5 years, alongside their usual care.
Heart FailureUnited States - Enrolling by invitationPHASE2
Long-term Safety and Efficacy Evaluation of Lunsekimig (SAR443765) in Adult Participants With Asthma
This study is looking at the long-term safety and effectiveness of a new medicine called Lunsekimig for adults with asthma. It's for people who have already taken part in a previous study with this medicine and want to continue their treatment.
AsthmaUnited States - RecruitingPHASE3
A Study of Baricitinib (LY3009104) for the Delay of Stage 3 Type 1 Diabetes in At-Risk Children and Adults
This study is looking into whether a medicine called baricitinib can delay Type 1 Diabetes in children and adults who are at a high risk of developing it. It's a key step in preventing the condition.
Diabetes Mellitus, Type 1United States - RecruitingPHASE2
Belzutifan/MK-6482 for the Treatment of Advanced Pheochromocytoma/Paraganglioma (PPGL), Pancreatic Neuroendocrine Tumor (pNET), Von Hippel-Lindau (VHL) Disease-Associated Tumors, Advanced Gastrointestinal Stromal Tumor (wt GIST), or Solid Tumors With HIF-2α Related Genetic Alterations (MK-6482-015)
This study is testing a new medicine called belzutifan for certain types of advanced cancers, including rare adrenal gland, gut, and kidney cancers. We want to see how well it works and if it's safe for people aged 12 and over.
Pheochromocytoma/ParagangliomaPancreatic Neuroendocrine TumorVon Hippel-Lindau DiseaseAdvanced Gastrointestinal Stromal TumorUnited States - Recruiting
Computerized Registry of Patients With Venous Thromboembolism (RIETE)
The RIETE study is building a large database of information from patients with blood clots (venous thromboembolism). It helps doctors better understand and treat patients, especially those with other health problems, to improve care and understand what medicine works best for different groups.
Venous ThromboembolismUnited States - Active not recruitingPHASE1, PHASE2
Study of Sonrotoclax (BGB-11417) Monotherapy in Participants With Relapsed or Refractory Mantle Cell Lymphoma
This study is testing a new drug, BGB-11417, for people with mantle cell lymphoma that has come back or not responded to previous treatments. It aims to find the safest dose and see how well it works.
Mantle Cell LymphomaRefractory Mantle Cell Lymphoma (MCL)Relapsed Mantle Cell LymphomaUnited States - Active not recruitingPHASE3
A Study of Tirzepatide (LY3298176) on the Reduction on Morbidity and Mortality in Adults With Obesity
This study is looking at how a medication called Tirzepatide might help people living with obesity. Researchers want to see if it can reduce serious health problems and improve overall health in adults.
ObesityOverweightUnited States - Enrolling by invitationPHASE3
A Study to Learn More About the Long-Term Safety of Litifilimab (BIIB059) Injections and it's Effects on Symptoms in Adults With Systemic Lupus Erythematosus (SLE)
This study looks at the long-term safety and effects of a new drug, litifilimab, for adults with lupus. It's for people who were in earlier studies of the drug and aims to see if it helps manage symptoms and is safe over a longer period.
Systemic Lupus Erythematosus (SLE)United States - RecruitingPHASE2
A Study to Evaluate the Adverse Events, and Efficacy of Intravenous (IV) of Telisotuzumab Adizutecan in Combination With IV Oxaliplatin, Fluorouracil, Folinic Acid/Leucovorin, Bevacizumab, Panitumumab in Adult Participants With Metastatic Colorectal Cancer
This study is testing a new combination of medicines for advanced bowel cancer. It aims to see how safe and effective a new drug, telisotuzumab adizutecan, is when given with standard treatments. The study will look at side effects and whether the cancer activity changes.
Metastatic Colorectal CancerUnited States - RecruitingPHASE3
A Study to Assess Efficacy and Safety of Empasiprubart Versus IVIg in Adults With CIDP
This study compares a new medicine, empasiprubart, with standard IVIg treatment for adults with CIDP. It looks at how well they work and if they are safe. Participants will receive one of these treatments, or a dummy treatment, for several months.
Chronic Inflammatory Demyelinating PolyneuropathyCIDPCIDP - Chronic Inflammatory Demyelinating PolyneuropathyUnited States - RecruitingPHASE2, PHASE3
Study of Izalontamab Brengitecan (BMS-986507) Versus Platinum-Pemetrexed for EGFR-mutated Non-small Cell Lung Cancer After Failure of EGFR TKI Therapy (IZABRIGHT-Lung01)
This study is for people with a type of lung cancer that has a specific gene change (EGFR mutation) and has not responded to previous treatment. It compares a new medicine called Iza-bren with standard chemotherapy (carboplatin or cisplatin plus pemetrexed) to see which works better.
Non-Small Cell Lung CancerUnited States - RecruitingPHASE3
Roll-over Study for Participants Who Have Completed a Previous Clinical Study With Benralizumab (Fasenra) and Benefit From Continued Treatment
This study is for people who have already taken part in a trial for the medicine Benralizumab (Fasenra) for asthma, EGPA, or HES. If the medicine helped them, this study offers a way to continue receiving it while doctors monitor their health and the medicine's long-term effects.
AsthmaEosinophilic Granulomatosis With Polyangiitis (EGPA)Hypereosinophilic Syndrome (HES)United States - RecruitingPHASE3
Study of Plozasiran in Adults With Severe Hypertriglyceridemia at Risk of Acute Pancreatitis
This study is testing a new medicine, plozasiran, for people with very high triglycerides who have had pancreatitis. It will check if the medicine is safe and helps reduce the risk of future pancreatitis attacks. Participants will get either the study medicine or a dummy medicine.
Severe HypertriglyceridemiaUnited States - RecruitingPHASE3
EPIC-Peds: A Study to Learn About the Study Medicine Called PF-07321332 (Nirmatrelvir)/Ritonavir in Patients Under 18 Years of Age With COVID-19 That Are Not Hospitalized But Are at Risk for Severe Disease
This study is looking at a medicine called nirmatrelvir/ritonavir for children and young people under 18 with COVID-19. It aims to see how safe and effective it is for those who aren't in hospital but are at higher risk of getting seriously ill.
COVID-19United States - RecruitingPHASE3
A Clinical Study of Calderasib (MK-1084) With Targeted Therapy and Chemotherapy in People With Colorectal Cancer (MK-1084-012/KANDLELIT-012)
This study looks at a new drug, calderasib, for advanced bowel cancer with a specific genetic change (KRAS G12C). Researchers want to see if adding calderasib to standard treatments helps people live longer without their cancer growing.
Colon AdenocarcinomaRectal AdenocarcinomaUnited States - RecruitingPHASE3
A Study to Test Whether Vicadrostat in Combination With Empagliflozin Helps People With Heart Failure
This study looks into a new treatment for adults with heart failure. It combines two medicines, vicadrostat and empagliflozin, to see if they can improve heart health in people with a specific type of heart failure. Participants take tablets daily and are closely monitored.
Heart FailureUnited States - RecruitingPHASE3
Efficacy and Safety of Orforglipron in Participants With Peripheral Artery Disease
This study is testing a new medicine, Orforglipron, for people with a common blood vessel problem called Peripheral Arterial Disease (PAD) that causes leg pain when walking. It aims to see if the medicine is safe and helps improve symptoms.
Peripheral Arterial DiseaseUnited States - RecruitingPHASE2, PHASE3
Combined Dose-Finding and CV Outcomes Study With CSL300 (Clazakizumab) in Adult Subjects With ESKD Undergoing Dialysis (POSIBIL6ESKD)
This study is testing a new medicine, CSL300, for adults with advanced kidney disease on dialysis. It aims to see if CSL300 can improve heart health and is safe, especially for those with existing heart conditions or diabetes.
End Stage Kidney DiseaseUnited States - Active not recruitingPHASE3
A Study to Evaluate the Efficacy and Safety of Obinutuzumab in Participants With ISN/RPS 2003 Class III or IV Lupus Nephritis
This study is looking at a new medicine called obinutuzumab for people with a serious kidney problem called lupus nephritis. Researchers want to see if it's safe and helps better than a dummy medicine when added to usual treatments, like steroids.
Lupus NephritisUnited States - Enrolling by invitationPHASE3
Long-term Safety and Efficacy Study of Riliprubart in Participants With CIDP
This study looks at the long-term safety and effectiveness of a treatment called riliprubart for adults with a nerve condition called CIDP. It's for people who have already been in other riliprubart studies and want to continue treatment.
Polyneuropathy, Inflammatory Demyelinating, ChronicUnited States - RecruitingPHASE2
A Study to Assess the Efficacy and Safety of Efgartigimod PH20 SC in Adults With Systemic Sclerosis
This study is testing a new medicine, efgartigimod, for adults with systemic sclerosis. It aims to see if the medicine helps improve symptoms and if it's safe, compared to a dummy medicine. We're looking for people to join for about 15 months.
Systemic Sclerosis (SSc)United States