AT-rich interaction domain 1A

Normal function

The ARID1A gene provides instructions for making a protein that forms one piece (subunit) of several different SWI/SNF protein complexes. SWI/SNF complexes regulate gene activity (expression) by a process known as chromatin remodeling. Chromatin is the network of DNA and protein that packages DNA into chromosomes. The structure of chromatin can be changed (remodeled) to alter how tightly DNA is packaged. Chromatin remodeling is one way gene expression is regulated during development; when DNA is tightly packed, gene expression is lower than when DNA is loosely packed.

Through their ability to regulate gene activity, SWI/SNF complexes are involved in many processes, including repairing damaged DNA; copying (replicating) DNA; and controlling the growth, division, and maturation (differentiation) of cells. The ARID1A protein and other SWI/SNF subunits are thought to act as tumour suppressors, which keep cells from growing and dividing too rapidly or in an uncontrolled way.

The ARID1A subunit is able to attach (bind) to DNA and is thought to help target SWI/SNF complexes to the chromatin location that needs to be remodeled.

Conditions referring to this gene or chromosome

• Bladder cancer

• Coffin-Siris syndrome

• Cholangiocarcinoma

Other names

ARI1A_HUMAN

ARID domain-containing protein 1A

AT rich interactive domain 1A (SWI-like)

AT-rich interactive domain-containing protein 1A

B120

BAF250

BAF250a

BM029

brain protein 120

BRG1-associated factor 250a

C1orf4

chromatin remodeling factor p250

ELD

hELD

hOSA1

MRD14

osa homolog 1

OSA1

OSA1 nuclear protein

P270

SMARCF1

SWI-like protein

SWI/SNF complex protein p270

SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin subfamily F member 1