WASP actin nucleation promoting factor
Last updated 8 May 2023
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The WAS gene provides instructions for making a protein called WASP. This protein is found in all blood cells. WASP is involved in relaying signals from the surface of blood cells to the actin cytoskeleton, which is a network of fibers that make up the cell's structural framework. WASP signaling triggers the cell to move and attach to other cells and tissues (adhesion). In white blood cells, which protect the body from infection, this signaling allows the actin cytoskeleton to establish the interaction between cells and the foreign invaders that they target (immune synapse).
Normal function
The WAS gene provides instructions for making a protein called WASP. This protein is found in all blood cells. WASP is involved in relaying signals from the surface of blood cells to the actin cytoskeleton, which is a network of fibers that make up the cell's structural framework. WASP signaling triggers the cell to move and attach to other cells and tissues (adhesion). In white blood cells, which protect the body from infection, this signaling allows the actin cytoskeleton to establish the interaction between cells and the foreign invaders that they target (immune synapse).
Conditions referring to this gene or chromosome
Other names
IMD2
WASP
WASP_HUMAN
WASPA
Related patient information and medicines
Patient information leaflet
Allergies
See the separate leaflet called Anaphylaxis for more details. Common allergens Things that people are commonly allergic to include: Tree and grass pollens. House dust mite. Animals, especially domestic pets such as cats and dogs. Insect venom such as that contained in wasp and bee stings. Medicines - for example, the antibiotic penicillin. Foods,.
Patient information leaflet
Anaphylaxis
The main treatment is an injection of adrenaline (epinephrine). Some people who have had a severe allergic reaction or anaphylactic reaction in the past carry an adrenaline (epinephrine) pen. This can be self-injected or injected by a bystander, in the event of anaphylaxis. What is anaphylaxis. Anaphylaxis (pronounced anna-fill-axis ) is an.
Patient information leaflet
Embarrassing problems
They may also rarely be passed on to a baby when a woman gives birth. Treatment options include chemicals or physical treatments such as freezing to destroy the warts. If you have anogenital warts, you will usually be advised to have tests to check for other sexually transmitted infections. See the separate leaflet called Anogenital Warts for more.
Patient information leaflet
Medicines to keep at home
Minor illness and mild aches or pains are common. It is useful to keep a few medicines at home in case you need something when you can't get to a pharmacy, or they are closed. Antihistamines These ease the symptoms of hay fever and other allergies - for example, hives (urticaria) , itch , sneezing, watering eyes, and a runny nose. They can also be.
Patient information leaflet
Insect bites and stings
However, in rare cases can lea... Treatment focuses on symptom relief and urgent medical attention if symptoms worsen. Insect stings How to treat an insect sting Most insect stings (of which the most common are bee and wasp stings) result in a mild local skin reaction. If you develop a mild local skin reaction: A cold compress will ease any pain.
Patient information leaflet
Can I take Lion's mane and Reishi together?
Taking Lion's Mane and Reishi together is generally considered safe for most people. However, both mushrooms have mild blood-thinning properties and can lower blood sugar levels. When taken together, these effects might be slightly stronger, though they are unlikely to cause problems for healthy individuals. Why this happens Both supplements.
Further reading and references
- WASP actin nucleation promoting factor; MedlinePlus, National Library of Medicine.
- Ancliff PJ, Blundell MP, Cory GO, Calle Y, Worth A, Kempski H, Burns S, Jones GE, Sinclair J, Kinnon C, Hann IM, Gale RE, Linch DC, Thrasher AJ. Two novel activating mutations in the Wiskott-Aldrich syndrome protein result in congenital neutropenia. Blood. 2006 Oct 1;108(7):2182-9. doi: 10.1182/blood-2006-01-010249. Epub 2006 Jun 27.
- Bhattacharya K, Swaminathan K, Peche VS, Clemen CS, Knyphausen P, Lammers M, Noegel AA, Rastetter RH. Novel Coronin7 interactions with Cdc42 and N-WASP regulate actin organization and Golgi morphology. Sci Rep. 2016 May 4;6:25411. doi: 10.1038/srep25411.
- Blundell MP, Worth A, Bouma G, Thrasher AJ. The Wiskott-Aldrich syndrome: The actin cytoskeleton and immune cell function. Dis Markers. 2010;29(3-4):157-75. doi: 10.3233/DMA-2010-0735.
- Imai K, Morio T, Zhu Y, Jin Y, Itoh S, Kajiwara M, Yata J, Mizutani S, Ochs HD, Nonoyama S. Clinical course of patients with WASP gene mutations. Blood. 2004 Jan 15;103(2):456-64. doi: 10.1182/blood-2003-05-1480. Epub 2003 Sep 11.
- Looi CY, Sasahara Y, Watanabe Y, Satoh M, Hakozaki I, Uchiyama M, Wong WF, Du W, Uchiyama T, Kumaki S, Tsuchiya S, Kure S. The open conformation of WASP regulates its nuclear localization and gene transcription in myeloid cells. Int Immunol. 2014 Jun;26(6):341-52. doi: 10.1093/intimm/dxt072. Epub 2014 Jan 8.
- Ochs HD, Notarangelo LD. Structure and function of the Wiskott-Aldrich syndrome protein. Curr Opin Hematol. 2005 Jul;12(4):284-91. doi: 10.1097/01.moh.0000168520.98990.19.
- Ochs HD. Mutations of the Wiskott-Aldrich Syndrome Protein affect protein expression and dictate the clinical phenotypes. Immunol Res. 2009;44(1-3):84-8. doi: 10.1007/s12026-008-8084-3.
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