Can I take Amitriptyline and Colecalciferol together?

Why this happens

Amitriptyline is a tricyclic antidepressant that works on brain chemicals, while colecalciferol is a vitamin supplement used to maintain bone health and calcium levels. They are processed by different pathways in the body and do not interfere with how the other works.

What you should do

You can continue to take both medications as prescribed by your doctor. No special precautions or timing adjustments are necessary for this combination.

Important precautions

Suicidal thoughts and behaviour

Amitriptyline can increase thoughts of self-harm or suicide, particularly when first starting treatment or changing the dose. Patients and carers must monitor for any sudden changes in mood or behaviour.

Glaucoma (specifically acute angle-closure)

Amitriptyline can trigger a sudden, painful increase in eye pressure. If you have a history of glaucoma, you must discuss this with your doctor before starting treatment.

Hypercalcaemia (high blood calcium)

Do not take colecalciferol if you have high levels of calcium in your blood or urine, or severe kidney stones, as it can lead to serious kidney damage or heart rhythm issues.

Food and drink warnings

Alcohol

Drinking alcohol while taking amitriptyline can make you feel very sleepy and unsteady on your feet. It is best to avoid alcohol, especially when you first start treatment or if your dose is increased.

Caffeine (Coffee, Tea, Energy Drinks)

Amitriptyline can sometimes cause a fast or irregular heartbeat. High amounts of caffeine can worsen these side effects or interfere with the medicine's calming effect. Try to limit your intake of caffeine-rich drinks.

Using other medicines

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.