Can I take Amitriptyline and Aspirin together?
Drug interaction guide
Originally published 25 Jan 2026
Meets Patient’s editorial guidelines
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Taking amitriptyline and aspirin together can increase your risk of bleeding, particularly in the stomach or gut. You may also find that you bruise more easily.
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Why this happens
Amitriptyline belongs to a group of medicines that can affect how your blood platelets work. Aspirin is a blood-thinner that also stops platelets from sticking together. When used together, their combined effect makes it harder for your blood to clot, increasing the risk of internal bleeding.
What you should do
Back to contentsUse this combination with caution. If you need to take them together, watch for signs of bleeding such as dark, tarry stools, coughing up blood, or severe stomach pain. If you notice these symptoms, contact your doctor immediately. Your doctor may suggest a different painkiller or a medicine to protect your stomach.
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Important precautions
Back to contentsAsthma
Do not take aspirin if you have asthma, as it can trigger a severe or life-threatening asthma attack.
Pregnancy (third trimester)
Do not take aspirin if you are more than 6 months pregnant, as it can cause serious heart and kidney problems in the unborn baby and increase the risk of bleeding during delivery.
Suicidal thoughts
Amitriptyline can increase thoughts of self-harm or suicide, particularly when first starting treatment or changing doses. Seek immediate medical help if your mood changes or you feel distressed.
Food and drink warnings
Back to contentsAlcohol
Drinking alcohol while taking amitriptyline can make you feel very sleepy and unsteady on your feet. It is best to avoid alcohol, especially when you first start treatment or if your dose is increased.
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Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Taking these two medicines together can cause your blood pressure to drop lower than intended. This might make you feel dizzy, lightheaded, or faint, especially when standing up quickly. There is also a small risk that tramadol could slightly interfere with how amlodipine is processed in your body, though the main concern is the combined effect on your blood pressure and heart rate.
Article history
The information on this page is written and peer reviewed by qualified clinicians.
25 Jan 2026 | Originally published
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