Can I take Amitriptyline and Aspirin together?

Why this happens

Amitriptyline belongs to a group of medicines that can affect how your blood platelets work. Aspirin is a blood-thinner that also stops platelets from sticking together. When used together, their combined effect makes it harder for your blood to clot, increasing the risk of internal bleeding.

What you should do

Use this combination with caution. If you need to take them together, watch for signs of bleeding such as dark, tarry stools, coughing up blood, or severe stomach pain. If you notice these symptoms, contact your doctor immediately. Your doctor may suggest a different painkiller or a medicine to protect your stomach.

Important precautions

Asthma

Do not take aspirin if you have asthma, as it can trigger a severe or life-threatening asthma attack.

Pregnancy (third trimester)

Do not take aspirin if you are more than 6 months pregnant, as it can cause serious heart and kidney problems in the unborn baby and increase the risk of bleeding during delivery.

Suicidal thoughts

Amitriptyline can increase thoughts of self-harm or suicide, particularly when first starting treatment or changing doses. Seek immediate medical help if your mood changes or you feel distressed.

Food and drink warnings

Alcohol

Drinking alcohol while taking amitriptyline can make you feel very sleepy and unsteady on your feet. It is best to avoid alcohol, especially when you first start treatment or if your dose is increased.

Using other medicines

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.