Can I take Lercanidipine and Sertraline together?
Drug interaction guide
Originally published 25 Jan 2026
Meets Patient’s editorial guidelines
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Taking lercanidipine and sertraline together may cause your blood pressure to drop lower than intended. This can make you feel dizzy, lightheaded, or faint, especially when standing up quickly. There is also a small possibility that sertraline could slightly increase the levels of lercanidipine in your blood.
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Why this happens
Both drugs can lower blood pressure (lercanidipine is a blood pressure medication, and sertraline can sometimes cause low blood pressure as a side effect). Additionally, both drugs are processed by the same enzyme in the liver (CYP3A4), which means they may compete for processing, potentially leading to higher levels of lercanidipine in the body.
What you should do
You can usually take these medicines together, but you should monitor your blood pressure regularly. Be careful when rising from a sitting or lying position. If you feel very dizzy, experience a racing heartbeat, or have persistent headaches, speak to your doctor, as they may need to adjust your lercanidipine dose.
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Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
25 Jan 2026 | Originally published

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