Can I take Lisinopril and Ibuprofen together?

Why this happens

Lisinopril works by relaxing blood vessels and helping the kidneys remove salt and water. Ibuprofen (an NSAID) blocks certain chemicals called prostaglandins. These chemicals are needed to keep the blood vessels in the kidneys open. When ibuprofen blocks them, it reduces blood flow to the kidneys and causes the body to retain salt and water, which opposes the blood-pressure-lowering effect of lisinopril.

You should avoid taking ibuprofen regularly while on lisinopril. If you need pain relief, paracetamol is generally a safer choice. If you must take ibuprofen, use the lowest dose for the shortest time possible. Contact your doctor immediately if you notice decreased urination, swelling in your ankles or feet, or unusual tiredness. Your doctor may want to monitor your kidney function and blood pressure more closely.

Stomach ulcers or bleeding

Avoid ibuprofen if you have ever had a stomach ulcer, perforation, or bleeding, as it can cause serious damage to the stomach lining.

Pregnancy

Lisinopril must not be taken during pregnancy as it can cause serious damage to the developing baby, particularly affecting their kidneys.

Pregnancy (third trimester)

Do not take ibuprofen if you are more than 6 months pregnant, as it can cause serious heart and kidney problems in the unborn baby and complications during birth.

Asthma

Do not take ibuprofen if you have asthma that is worsened by aspirin or other non-steroidal anti-inflammatory drugs (NSAIDs), as it can trigger a severe or life-threatening asthma attack.

Kidney function

Taking lisinopril and ibuprofen together significantly increases the risk of sudden kidney failure. This risk is even higher if you are also taking a diuretic (water tablet). Avoid using ibuprofen while on lisinopril unless specifically directed by your doctor.

Angioedema (Severe Swelling) - lisinopril

Seek emergency medical help immediately if you experience swelling of the face, lips, tongue, or throat, or difficulty breathing. This is a rare but life-threatening allergic reaction called angioedema.

Potassium-rich foods and salt substitutes

Lisinopril can increase the levels of potassium in your blood. Avoid using salt substitutes containing potassium (such as Lo-Salt) and speak to your doctor before significantly increasing your intake of high-potassium foods like bananas, spinach, or pulses. High potassium levels can cause heart palpitations.

Alcohol

It is best to avoid or strictly limit alcohol while taking these medicines. For ibuprofen, alcohol increases the risk of stomach irritation and bleeding. For lisinopril, alcohol can enhance the blood-pressure-lowering effect, which may make you feel dizzy, lightheaded, or faint.

Food (General)

While not an interaction that changes how the drug works, you should always take ibuprofen with food or a glass of milk. This helps to protect your stomach lining and reduce the risk of indigestion or stomach ache.

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.