Can I take Iron supplements and Wellbutrin together?

Why this happens

Iron supplements and bupropion are processed by the body through different pathways. Iron is absorbed in the digestive tract and does not interfere with the liver enzymes that break down bupropion. Furthermore, they do not compete for the same receptors in the brain or body.

You can safely take these together. To reduce the risk of an upset stomach, you may wish to take your iron supplement with food (unless your doctor has told you otherwise) and take your Wellbutrin at its usual scheduled time. If you experience significant constipation, ensure you drink plenty of water and speak to a pharmacist.

Seizure disorders or epilepsy

Bupropion significantly increases the risk of seizures. You must not take it if you have a history of epilepsy, an eating disorder (bulimia or anorexia), or if you are undergoing sudden withdrawal from alcohol or benzodiazepines.

Accidental overdose in children

Iron supplements are a leading cause of fatal poisoning in children. You must store this medicine in a secure place out of the reach and sight of children.

Eating disorders (Anorexia or Bulimia)

There is a much higher risk of having a seizure if you take Wellbutrin and have ever been diagnosed with an eating disorder.

Alcohol

It is best to avoid or strictly limit alcohol while taking bupropion. Combining them can increase the risk of neurological side effects and, more seriously, may increase the risk of having a seizure. If you drink alcohol regularly, do not stop suddenly without talking to your doctor, as this can also trigger seizures.

It is best to avoid or strictly limit alcohol when taking iron supplements. Chronic alcohol consumption can interfere with how iron is stored and processed in the liver, potentially increasing the risk of iron toxicity or liver strain.

Tea, Coffee, and Caffeine

Caffeine and tannins found in tea and coffee significantly reduce the amount of iron your body absorbs. You should avoid drinking these for at least 2 hours before or after taking your iron supplement.

Bupropion and caffeine are both stimulants. Consuming high amounts of caffeine (coffee, tea, energy drinks) while taking this medicine can increase the risk of side effects like anxiety, tremors, rapid heartbeat, and insomnia.

Dairy products (Milk, Cheese, Yoghurt)

Calcium in dairy products prevents iron from being absorbed properly. Avoid consuming dairy for at least 2 hours before or after your dose.

Eggs and Whole Grains

Compounds in eggs (phosphoprotein) and whole grains (phytates) can interfere with iron absorption. It is best to take iron on an empty stomach, at least 1 hour before or 2 hours after meals.

Vitamin C (Orange Juice)

Taking your iron supplement with a glass of orange juice or foods rich in Vitamin C is beneficial, as it helps your body absorb the iron more effectively.

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.