Can I take Hydroxychloroquine and Naproxen together?
Drug interaction guide
Originally published 25 Jan 2026
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Taking hydroxychloroquine and naproxen together may increase the risk of stomach irritation, ulcers, or bleeding. There is also a small potential for increased strain on the kidneys.
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Why this happens
Both medications can affect the lining of the stomach and the way the kidneys filter blood. While hydroxychloroquine is not a typical 'NSAID' like naproxen, combining them can sometimes increase the likelihood of gastrointestinal side effects or affect kidney function, especially during long-term use.
What you should do
You can usually take these together, but you should be cautious. Always take these medicines with food to protect your stomach. Contact your doctor immediately if you notice signs of stomach bleeding, such as very dark/tarry stools or coffee-ground-like vomit. Your doctor may want to monitor your kidney function with occasional blood tests if you take these long-term.
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Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
25 Jan 2026 | Originally published

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