Can I take Amitriptyline and Ropinirole together?

Why this happens

Both medications affect chemicals in the brain and have 'sedating' effects that add together. Amitriptyline can also interfere with how the liver processes ropinirole, potentially leading to higher levels of the drug in your system. Additionally, both drugs can lower blood pressure, increasing the risk of falls.

What you should do

Speak to your doctor before taking these together. If your doctor prescribes both, be very careful when performing tasks that require alertness, such as driving. Move slowly when standing up from a sitting or lying position. Seek medical help immediately if you experience high fever, muscle stiffness, or agitation.

Important precautions

Suicidal thoughts and mood changes

Amitriptyline can increase the risk of suicidal thoughts or self-harm, particularly when first starting treatment or changing doses. Seek immediate medical help if your mood changes or you feel depressed.

Impulse control disorders

Ropinirole can cause unusual urges, such as excessive gambling, binge eating, or increased sexual desire. If you or your family notice these behaviours, contact your doctor immediately.

Sudden onset of sleep - ropinirole

You may suddenly fall asleep without warning or feeling tired beforehand. Do not drive or operate machinery if you experience this, and inform your doctor.

Heart rhythm disorders

Amitriptyline can affect your heart rhythm. It must be used with extreme caution if you have a history of heart disease or a recent heart attack.

Food and drink warnings

Alcohol

Drinking alcohol while taking these medicines can make you feel very sleepy and unsteady on your feet. It can also increase the risk of side effects like dizziness and blurred vision. It is best to avoid alcohol, especially when you first start treatment or if your dose is increased.

Caffeine (coffee, tea, energy drinks)

Ropinirole can increase the levels of caffeine in your blood, which may lead to feeling jittery, anxious, or having a racing heart. Conversely, if you suddenly stop or significantly reduce your caffeine intake, it could change how ropinirole works in your body. Try to keep your caffeine intake consistent.

Using other medicines

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.