Can I take Lactulose and Ropinirole together?

Why this happens

Lactulose is a laxative that stays in the bowel and is not absorbed into the bloodstream. Ropinirole is absorbed into the blood to treat Parkinson's disease or Restless Legs Syndrome. Because they work in different parts of the body and are processed through different pathways, they do not interfere with each other.

You can continue taking both medicines as prescribed. However, if you experience severe diarrhoea from the lactulose, this could theoretically affect how other medicines are absorbed. If you have persistent diarrhoea, speak to your doctor or pharmacist.

Sudden onset of sleep and extreme drowsiness

Ropinirole can cause you to fall asleep suddenly without any warning or feeling tired beforehand. You must not drive or operate machinery if you experience this, and you should inform your doctor immediately.

Impulse control disorders

Ropinirole can cause changes in behaviour that lead to strong impulses, such as an unusual urge to gamble, increased sexual drive, or uncontrollable binge eating and spending. Inform your doctor or family if you notice these behaviours.

Low blood pressure (Hypotension)

Ropinirole can cause your blood pressure to drop, especially when standing up quickly, which may lead to dizziness or fainting. Move slowly when changing positions.

Galactosaemia

You must not take lactulose if you have galactosaemia, a rare genetic disorder where your body cannot process galactose.

Diabetes

If you are taking high doses of lactulose for liver disease (portal systemic encephalopathy), the sugar content may affect your blood glucose levels.

Alcohol

It is best to avoid or strictly limit alcohol while taking ropinirole. Combining alcohol with this medicine can significantly increase drowsiness and the risk of 'sleep attacks' (suddenly falling asleep during daily activities). It may also worsen side effects like dizziness or lightheadedness when standing up.

It is best to avoid or strictly limit alcohol when taking lactulose. Alcohol can cause dehydration, which may worsen the constipation you are trying to treat. Additionally, if you are taking lactulose for liver disease (hepatic encephalopathy), alcohol must be avoided entirely as it can significantly worsen your condition.

Water and Fluids

It is essential to drink plenty of fluids (such as water) while taking lactulose. This medicine works by drawing water into the bowel to soften stools; if you do not drink enough, the medicine may not work effectively and you may become dehydrated.

Caffeine (Coffee, Tea, Energy Drinks)

Caffeine can increase the levels of ropinirole in your blood, which may increase the risk of side effects. If you significantly change your caffeine intake (e.g., stopping coffee or starting to drink much more), you should inform your doctor as your dose may need adjusting.

High-protein meals

Taking ropinirole with a very high-protein meal may slightly delay the time it takes for the medicine to be absorbed, though it can be taken with or without food. If the medicine causes nausea, taking it with a light snack may help.

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.