Can I take Amlodipine and Ginseng together?

Why this happens

Ginseng has complex effects on the body. It can act as a mild diuretic (water pill) and has its own blood-pressure-lowering properties, which can add to the effect of amlodipine. However, some types of ginseng may also interfere with how the liver processes amlodipine (via the CYP3A4 enzyme), potentially changing the amount of medicine in your bloodstream.

What you should do

You should speak with your doctor or pharmacist before combining these two. If you decide to take them together, monitor your blood pressure regularly at home. Seek medical advice if you feel dizzy, faint, or notice significant changes in your blood pressure readings.

Important precautions

High blood pressure (Hypertension)

Ginseng can increase blood pressure and may counteract the effects of amlodipine, making your blood pressure harder to control.

Diabetes

Ginseng can lower blood sugar levels. If you take medication for diabetes, using ginseng may increase the risk of your blood sugar dropping too low (hypoglycaemia).

Bleeding disorders or use of blood thinners (e.g. warfarin)

Ginseng can interfere with blood clotting and may increase the risk of bleeding, especially if you are taking anticoagulant or antiplatelet medications.

Food and drink warnings

Grapefruit juice

Grapefruit juice can increase the amount of amlodipine in your blood, which may lower your blood pressure too much. While the effect is usually small, it is best to avoid drinking large amounts of grapefruit juice while taking this medicine.

Alcohol

Ginseng may speed up the way your body breaks down alcohol. This could potentially change how alcohol affects you, though the clinical significance is not fully established. Use caution if combining the two.

Caffeine

Ginseng can have a stimulant effect. Combining it with caffeine (found in coffee, tea, and energy drinks) may increase the risk of side effects like a racing heart, nervousness, or trouble sleeping.

Using other medicines

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.