Can I take Amlodipine and Tramadol together?

Why this happens

Both drugs can lower blood pressure through different pathways. Amlodipine relaxes your blood vessels, while tramadol can affect the central nervous system and occasionally cause 'orthostatic hypotension' (a drop in blood pressure upon standing). Additionally, both are processed by the liver, which can sometimes lead to one drug affecting the levels of the other.

What you should do

It is generally safe to take these together, but you should be cautious. When starting tramadol or increasing your dose, get up slowly from a sitting or lying position to avoid dizziness. If you feel very dizzy, faint, or notice a very slow heartbeat, contact your doctor. It is a good idea to monitor your blood pressure at home more frequently when you first start taking both.

Important precautions

Epilepsy or history of seizures

Tramadol can increase the risk of having a seizure, especially if you have a history of epilepsy or are taking other medicines that lower the seizure threshold.

Asthma or breathing problems

Tramadol can cause dangerous breathing difficulties (respiratory depression). You must not take it if you have severe asthma or significant lung disease.

Severe heart disease (Aortic Stenosis)

You must inform your doctor if you have narrowing of the aortic heart valve, as amlodipine can cause a dangerous drop in blood pressure in patients with this condition.

Food and drink warnings

Grapefruit and grapefruit juice

Grapefruit can increase the amount of amlodipine in your body, which may cause your blood pressure to drop too low and increase the risk of side effects like headaches or swelling. While the effect is usually small, it is best to avoid large amounts of grapefruit juice while taking this medicine.

Alcohol

You must avoid drinking alcohol while taking tramadol. Alcohol increases the sedative effects of the medicine, which can lead to dangerous levels of drowsiness, breathing difficulties, and a risk of unconsciousness.

Using other medicines

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.