Can I take Metformin and Ibuprofen together?

Why this happens

Ibuprofen can reduce blood flow to the kidneys and affect how well they filter waste. Since metformin is removed from the body by the kidneys, any decrease in kidney function can cause metformin levels to build up. High levels of metformin increase the risk of lactic acidosis (a dangerous build-up of acid in the blood).

What you should do

Use with caution. If you need pain relief, paracetamol is generally a safer choice for people taking metformin. If you must take ibuprofen, keep the dose low and only use it for a short time. Stay well-hydrated and speak to your doctor if you feel unusually tired, dizzy, or have stomach pain, as these can be early signs of lactic acidosis.

Important precautions

Lactic acidosis risk (Dehydration)

If you develop severe vomiting, diarrhoea, or a high fever, stop taking metformin and contact a doctor immediately. These conditions can lead to severe dehydration, which significantly increases the risk of a rare but life-threatening build-up of acid in the blood (lactic acidosis).

Asthma

Do not take ibuprofen if you have asthma, as it can cause a life-threatening worsening of your breathing or a severe allergic reaction.

Severe kidney or liver disease

You must stop taking metformin if you become severely dehydrated or develop a serious infection, as this can lead to a dangerous build-up of acid in the blood (lactic acidosis).

Stomach ulcers or kidney problems

Avoid ibuprofen if you have a history of stomach ulcers or kidney disease, as it can cause internal bleeding or sudden kidney failure.

Pregnancy (third trimester)

Do not take ibuprofen if you are more than 6 months pregnant, as it can cause serious heart and kidney problems in the unborn baby and complications during birth.

Contrast dye scans (e.g., CT or X-ray)

You must tell your doctor you take metformin if you are having a scan involving an injection of 'contrast dye'. You will usually need to stop taking metformin 48 hours before and after the procedure to prevent kidney damage.

Food and drink warnings

Alcohol

Drinking alcohol while taking metformin can increase the risk of a rare but serious condition called lactic acidosis. It can also affect your blood sugar control and increase the risk of low blood sugar (hypoglycaemia). It is best to avoid excessive drinking and binge drinking.

It is best to avoid or strictly limit alcohol while taking ibuprofen. Combining alcohol with non-steroidal anti-inflammatory drugs (NSAIDs) like ibuprofen increases the risk of irritation to your stomach lining and can lead to stomach ulcers or bleeding.

Food (General)

It is recommended to take ibuprofen with food or a glass of milk to reduce the risk of stomach upset or irritation.

Vitamin B12 absorption

Long-term use of metformin can prevent your body from absorbing enough vitamin B12 from your food. You may need to have your B12 levels checked by your doctor or take a supplement if you develop symptoms like extreme tiredness or a sore tongue.

Using other medicines

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.