Can I take Esomeprazole and Vitamin c together?
Drug interaction guide
Originally published 25 Jan 2026
Meets Patient’s editorial guidelines
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Esomeprazole may slightly reduce how much Vitamin C your body absorbs, but this is generally not a cause for concern for most people.
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Why this happens
Vitamin C (ascorbic acid) needs an acidic environment in the stomach to be absorbed most effectively. Esomeprazole works by reducing stomach acid, which can make it slightly harder for the body to take in the vitamin.
What you should do
You can continue taking both together. If you are concerned about your Vitamin C levels, you can take your Vitamin C supplement at a different time of day than your esomeprazole, or simply ensure you have a diet rich in fruits and vegetables.
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Important precautions
Severe kidney or liver problems
Your doctor may need to prescribe a lower dose, as these organs are responsible for processing and clearing the medicine from your body.
Magnesium deficiency
Taking this medicine for more than three months can cause your blood magnesium levels to drop significantly, leading to fatigue, muscle spasms, or dizziness.
Food and drink warnings
Alcohol
While alcohol does not directly interact with esomeprazole, it can increase stomach acid production and irritate the stomach lining, which may worsen the symptoms you are taking esomeprazole to treat.
Caffeine (Coffee, Tea, Energy drinks)
Caffeine can trigger or worsen acid reflux and heartburn symptoms. If you are taking esomeprazole for these conditions, you may find that reducing caffeine intake helps the medicine work more effectively.
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Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
25 Jan 2026 | Originally published
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