Can I take Colecalciferol and Esomeprazole together?
Drug interaction guide
Originally published 25 Jan 2026
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There is no evidence of a harmful interaction between colecalciferol (Vitamin D3) and esomeprazole. In fact, taking them together may be beneficial for your bone health.
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Why this happens
Esomeprazole is a proton pump inhibitor (PPI) that reduces stomach acid. Long-term use of PPIs can sometimes interfere with the absorption of certain minerals like calcium. Colecalciferol helps your body absorb calcium more effectively, which can help counteract the potential bone-thinning effects associated with long-term esomeprazole use.
What you should do
You can safely take these two medications together. You do not need to space them apart or change the time of day you take them. If you are taking esomeprazole for a long period, it is actually quite common for doctors to recommend a Vitamin D supplement like colecalciferol to protect your bones.
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Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
25 Jan 2026 | Originally published

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