Can I take Calcium and Ezetimibe together?

Why this happens

Ezetimibe works by blocking the absorption of cholesterol in the small intestine, while calcium is absorbed through different pathways. They do not interfere with each other's absorption, metabolism, or excretion.

What you should do

You can continue to take both calcium and ezetimibe as prescribed. You do not need to space them apart or change the time of day you take them.

Important precautions

Kidney stones

If you have a history of kidney stones, taking calcium supplements can increase the risk of developing new stones. Your doctor may need to monitor your calcium levels or adjust your dose.

Liver disease

Ezetimibe should not be used if you have moderate to severe liver disease, as it may worsen your condition. If you develop unexplained muscle pain or yellowing of the skin, seek medical advice immediately.

Taking other medications (e.g., antibiotics or bisphosphonates)

Calcium can stop other important medicines from being absorbed. You must space calcium doses at least 2 hours apart from other medications, particularly tetracycline antibiotics, bisphosphonates, and iron supplements.

Food and drink warnings

Caffeine (Coffee, tea, energy drinks)

Caffeine can slightly reduce the amount of calcium your body absorbs and increase the amount lost through urine. It is best to limit high caffeine intake or avoid consuming large amounts of caffeine at the same time as your calcium supplement.

High-fibre foods (e.g., whole grains, bran, beans) and Spinach/Rhubarb

Foods very high in fibre or containing oxalates (like spinach and rhubarb) can bind to calcium in the digestive tract, preventing it from being absorbed properly. Try to take your calcium supplement at a different time from these foods (at least 2 hours apart).

Alcohol

Heavy alcohol consumption can interfere with how your body absorbs calcium and processes Vitamin D. It is advisable to keep alcohol intake within recommended limits to ensure your bones get the full benefit of the supplement.

Using other medicines

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.