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Can I take Levothyroxine and Vitamin d together?

Drug interaction guide

There is no direct harmful interaction between levothyroxine and vitamin D. In fact, many people take them together because vitamin D deficiency is common in people with thyroid conditions. However, if your vitamin D supplement also contains calcium, it can significantly interfere with how your body absorbs your thyroid medication.

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Why this happens

Vitamin D itself does not change how levothyroxine works. However, many vitamin D supplements are combined with calcium. Calcium binds to levothyroxine in the digestive tract, preventing the medicine from entering your bloodstream. Additionally, correcting a severe vitamin D deficiency can sometimes slightly alter how your body uses thyroid hormones, though this is usually beneficial.

What you should do

You can safely take both, but timing is important. If your vitamin D supplement contains calcium, you must wait at least 4 hours after taking your levothyroxine before taking the supplement. It is best to take levothyroxine on an empty stomach, 30 to 60 minutes before breakfast. Always inform your doctor if you start a new supplement, as they may want to check your thyroid levels (TSH) after a few weeks to ensure your dose is still correct.

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Using other medicines

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.

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Article history

The information on this page is written and peer reviewed by qualified clinicians.

  • 25 Jan 2026 | Originally published
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