Can I take Atenolol and Rybelsus (semaglutide) together?

Why this happens

Rybelsus lowers blood sugar. While atenolol is for blood pressure, it can also lower blood sugar or make it harder for your body to recover from a 'sugar crash'. Crucially, atenolol blocks the 'fight or flight' response (adrenaline) that usually causes your heart to race when your sugar is low, meaning you might not realise you are in danger until the symptoms are severe.

What you should do

You can take these together, but you must be extra vigilant. Monitor your blood sugar levels regularly as directed by your doctor. Learn to recognise other signs of low blood sugar that atenolol doesn't hide, such as sweating, dizziness, hunger, or confusion. If you feel unwell, treat the low sugar immediately and inform your GP.

Important precautions

Asthma or COPD

Atenolol can cause severe breathing difficulties or trigger a life-threatening asthma attack by narrowing your airways. Do not take this medicine if you have a history of asthma or wheezing.

History of pancreatitis or severe stomach pain

Rybelsus can cause inflammation of the pancreas (pancreatitis). Seek immediate medical help if you experience severe, persistent stomach pain that may radiate to your back.

Diabetes

Atenolol can mask the warning signs of low blood sugar (hypoglycaemia), such as a fast heartbeat or tremors. You must monitor your blood sugar more closely as you may not feel the usual symptoms of a 'hypo'.

Food and drink warnings

Food, beverages, and other oral medicines

Rybelsus must be taken on an empty stomach with no more than half a glass (120ml) of plain water. You must wait at least 30 minutes before eating, drinking anything else, or taking other oral medicines. If you do not wait, the medicine will not be absorbed properly and will not work.

Alcohol

Alcohol can affect blood sugar levels and may increase the risk of low blood sugar (hypoglycaemia) when taking Rybelsus. For Atenolol, alcohol can enhance the blood-pressure-lowering effect, which may make you feel dizzy or lightheaded.

Using other medicines

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.