Can I take Fibre supplements and Rybelsus together?
Drug interaction guide
Originally published 25 Jan 2026
Meets Patient’s editorial guidelines
- DownloadDownload
- Share
- Language
- Discussion
Taking fibre supplements at the same time as Rybelsus may prevent your body from absorbing the medication properly, making it less effective at controlling your blood sugar levels.
In this article:
Continue reading below
Why this happens
Rybelsus (semaglutide) is a very sensitive tablet that must be absorbed through the stomach lining. Fibre supplements can bulk up the stomach contents and bind to the medication, physically blocking it from being absorbed into your bloodstream.
What you should do
You must take Rybelsus on an empty stomach when you first wake up with a small sip of plain water (no more than 120ml). Wait at least 30 to 60 minutes before taking your fibre supplement, eating, or taking any other oral medications.
Continue reading below
Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
Patient picks for Drug interactions

Treatment and medication
Can I take Apixaban and Sertraline together?
Taking these two medicines together can increase your risk of bleeding. This includes bruising more easily, nosebleeds, or more serious internal bleeding.

Treatment and medication
Can I take Esomeprazole and Vitamin c together?
Esomeprazole may slightly reduce how much Vitamin C your body absorbs, but this is generally not a cause for concern for most people.
Continue reading below
Article history
The information on this page is written and peer reviewed by qualified clinicians.
25 Jan 2026 | Originally published

Ask, share, connect.
Browse discussions, ask questions, and share experiences across hundreds of health topics.

Feeling unwell?
Assess your symptoms online for free
Sign up to the Patient newsletter
Your weekly dose of clear, trustworthy health advice - written to help you feel informed, confident and in control.
By subscribing you accept our Privacy Policy. You can unsubscribe at any time. We never sell your data.