Can I take Co-codamol and Stexerol D3 together?

Why this happens

Co-codamol is a combination of paracetamol and codeine used for pain relief. Stexerol D3 is a high-strength vitamin D3 (cholecalciferol) supplement. These medicines are processed by different pathways in the body and do not interfere with how the other works.

You can take these medicines together as prescribed. Always follow the dosage instructions on the packet or as advised by your doctor. If you experience any unusual side effects, such as severe constipation (which can be caused by the codeine in co-codamol), speak to your pharmacist or GP.

Paracetamol overdose

Co-codamol contains paracetamol. Do not take it with any other paracetamol-containing products (such as cold and flu remedies), as this can lead to fatal liver damage.

Opioid addiction and withdrawal

Co-codamol contains codeine, which can cause addiction if used for more than 3 days. Stopping suddenly after long-term use can cause withdrawal symptoms.

Breathing difficulties

Do not take co-codamol if you have severe asthma or breathing problems, as the codeine can dangerously slow your breathing.

High calcium levels (Hypercalcaemia)

Do not take Stexerol D3 if you have high levels of calcium in your blood or urine, or if you have severe kidney stones.

Alcohol

You must avoid drinking alcohol while taking co-codamol. Combining alcohol with codeine increases the risk of serious side effects, such as extreme sleepiness, breathing difficulties, and loss of consciousness. Additionally, both alcohol and paracetamol can affect the liver; combining them regularly increases the risk of liver damage.

It is best to avoid or strictly limit alcohol while taking Stexerol D3. Long-term heavy alcohol use can interfere with how your body processes Vitamin D and may weaken your bones.

Grapefruit juice

Grapefruit juice can interfere with how your body processes codeine, potentially making the medicine less effective or increasing the risk of side effects. It is best to avoid grapefruit juice while taking this medicine.

Caffeine

Some versions of co-codamol already contain caffeine. If you consume extra caffeine from coffee, tea, or energy drinks, it may make you feel shaky, anxious, or cause a racing heart.

High-fat meals

Stexerol D3 is a fat-soluble vitamin. It is best absorbed by your body when taken with a meal that contains some fat (such as dairy, eggs, or avocado).

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.