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Can I take Morphine and Solifenacin together?

Drug interaction guide

Taking morphine and solifenacin together can significantly increase the risk of severe constipation and difficulty passing urine (urinary retention). It may also lead to an increased risk of confusion, dry mouth, blurred vision, and extreme sleepiness.

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Why this happens

Both drugs have 'anticholinergic' effects, meaning they slow down the movement of the gut and the bladder. When used together, these effects add up, making it much harder for your body to move waste through your system or empty your bladder.

What you should do

Use this combination with caution. Ensure you drink plenty of water and eat a high-fibre diet to prevent constipation. If you find it difficult to urinate, or if you experience severe stomach pain or confusion, contact your doctor immediately. Your doctor may need to adjust your doses.

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Using other medicines

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.

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Article history

The information on this page is written and peer reviewed by qualified clinicians.

  • 25 Jan 2026 | Originally published
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