Can I take Lixiana and Solifenacin together?

Why this happens

Lixiana is an anticoagulant (blood thinner) that works by blocking a specific clotting factor in the blood. Solifenacin is an antimuscarinic used to treat overactive bladder by relaxing the bladder muscles. These drugs are processed by different pathways in the body and do not interfere with how the other works.

You can take these medicines together as prescribed by your doctor. However, always watch for general side effects. If you notice unusual bruising or bleeding (linked to Lixiana) or severe constipation and dry mouth (linked to solifenacin), consult your healthcare professional.

Bleeding risk

Lixiana increases your risk of serious bleeding. Seek immediate medical help if you have a fall or head injury, or if you notice signs of internal bleeding such as black tarry stools, blood in your urine, or coughing up blood.

Surgery or dental procedures

You must tell your doctor or dentist you are taking Lixiana before any procedure, as you may need to stop taking it temporarily to prevent dangerous bleeding.

Do not take solifenacin if you have narrow-angle glaucoma, as it can increase the pressure in your eyes and worsen the condition.

Urinary retention

Do not take solifenacin if you have difficulty emptying your bladder (urinary retention), as it may make this problem worse.

Alcohol

It is best to avoid or strictly limit alcohol while taking Lixiana. Alcohol can increase the risk of bleeding in your stomach and intestines. Additionally, heavy drinking can affect how your liver functions, which may interfere with how your body processes this medication.

It is best to avoid or strictly limit alcohol while taking solifenacin. Both alcohol and solifenacin can cause drowsiness and blurred vision; combining them increases the risk of these side effects and may impair your coordination.

Caffeine (Coffee, Tea, Energy Drinks)

You should limit your intake of caffeine. Solifenacin is used to treat an overactive bladder, but caffeine is a natural diuretic and bladder irritant that can worsen symptoms like urgency and frequency, potentially making your medication less effective.

Grapefruit Juice

Grapefruit juice can increase the level of solifenacin in your blood, which may increase the risk of side effects such as dry mouth, constipation, and blurred vision. It is best to avoid drinking large amounts of grapefruit juice.

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.