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Can I take Royal sun and Turkey tail together?

Drug interaction guide

Both Royal Sun (Agaricus blazei) and Turkey Tail (Trametes versicolor) are medicinal mushrooms that can stimulate the immune system. Taking them together may lead to an overactive immune response. Additionally, both may have mild blood-thinning effects and could lower blood sugar levels.

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Why this happens

These mushrooms contain beta-glucans which activate various immune cells (like natural killer cells and macrophages). Because they both work on similar pathways, their effects can add together (additive effect). They may also interfere with how blood clots and how the body processes glucose.

If you have an autoimmune condition (like lupus or rheumatoid arthritis), are taking blood-thinning medication (like warfarin), or take medicine for diabetes, speak to your doctor before combining these supplements. If you are scheduled for surgery, stop taking both at least two weeks beforehand.

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Bleeding disorders or surgery

These supplements may slow blood clotting and increase the risk of bleeding. You must stop taking these at least 2 weeks before any scheduled surgery. Use with caution if you are taking blood-thinning medications like warfarin or aspirin.

Diabetes

These supplements can lower blood sugar levels. If you are taking insulin or other diabetes medications, monitor your blood sugar closely as your dose may need adjustment to prevent hypoglycaemia (dangerously low blood sugar).

Auto-immune conditions (e.g., multiple sclerosis, lupus, rheumatoid arthritis)

These supplements can increase immune system activity, which may worsen the symptoms of autoimmune diseases. Avoid use if you have these conditions.

Alcohol

It is best to avoid or strictly limit alcohol when taking medicinal mushrooms. Both alcohol and certain compounds in these mushrooms are processed by the liver; combining them may increase the strain on your liver or alter how the supplements are metabolised.

General Food Intake

These medicinal mushrooms contain complex polysaccharides (beta-glucans). For the best absorption, it is often recommended to take them on an empty stomach, at least 30 minutes before a meal, or with a small amount of Vitamin C (such as a small glass of orange juice) which may help the body absorb the active compounds.

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Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.

Article history

The information on this page is written and peer reviewed by qualified clinicians.

  • 25 Jan 2026 | Originally published
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