Can I take Cordyceps and Turkey tail together?
Drug interaction guide
Originally published 25 Jan 2026
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There are no known negative interactions between cordyceps and turkey tail mushrooms. In fact, they are often taken together in 'mushroom blends' because they work in similar ways to support the immune system. However, because both can stimulate the immune system, there is a theoretical risk for people with certain health conditions.
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Why this happens
Both cordyceps and turkey tail contain compounds called polysaccharides (specifically beta-glucans) that interact with immune cells. Taking them together may have an additive effect on immune activity. There is no evidence that they interfere with how the body absorbs or breaks down one another.
What you should do
Back to contentsIt is generally safe to take these together. However, you should consult a doctor before use if you have an autoimmune disease (like lupus or rheumatoid arthritis) or if you are taking immunosuppressant medications, as these supplements might make those conditions worse or interfere with your medicine. Stop taking both at least two weeks before any scheduled surgery as they may affect blood clotting.
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Important precautions
Back to contentsAuto-immune conditions (e.g., multiple sclerosis, lupus, rheumatoid arthritis)
These supplements can increase immune system activity, which may worsen the symptoms of autoimmune diseases. Avoid use if you have these conditions.
Bleeding disorders or upcoming surgery
Cordyceps may slow blood clotting. You must stop taking it at least two weeks before any scheduled surgery to prevent excessive bleeding.
Diabetes
Cordyceps can lower blood sugar levels. If you take insulin or oral diabetes medicines, monitor your blood sugar closely as your dose may need adjustment to avoid
Food and drink warnings
Back to contentsAlcohol
It is best to avoid or strictly limit alcohol when taking Cordyceps. Cordyceps may have a mild blood-thinning effect; combining it with alcohol can increase the risk of bruising or bleeding and may place additional strain on the liver.
It is best to avoid or strictly limit alcohol when taking Turkey Tail supplements. Combining alcohol with herbal supplements can increase the strain on your liver and may worsen potential side effects like nausea or digestive upset.
Caffeine (Coffee, Tea, Energy Drinks)
Cordyceps may have mild stimulant properties. Consuming caffeine alongside this supplement may increase feelings of jitteriness, rapid heartbeat, or difficulty sleeping.
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Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
25 Jan 2026 | Originally published

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