Latest studies
- CompletedPhase III
A randomized, open-label phase 3 study of amivantamab + FOLFIRI versus cetuximab/bevacizumab + FOLFIRI in participants with KRAS/NRAS and BRAF wildtype recurrent, unresectable or metastatic colorectal cancer who have received prior chemotherapy
This clinical trial is testing a new targeted drug, amivantamab, combined with chemotherapy for people with advanced bowel cancer. Researchers want to see if this combination works better at slowing cancer growth and helping people live longer than current standard targeted treatments after their first chemotherapy has stopped working.
Recurrent, unresectable or metastatic colorectal cancerHungary - RecruitingPHASE3
A Phase III Study to Investigate the Efficacy and Safety of the Combination of Elecoglipron and Dapagliflozin in Adults With Type 2 Diabetes Mellitus
This study looks at new ways to treat type 2 diabetes by testing two medicines, Elecoglipron and Dapagliflozin, both on their own and together. Researchers want to see how well they work and if they are safe for adults with type 2 diabetes.
Type 2 Diabetes MellitusHungary - RecruitingPHASE3
A Study to Find Out if the Study Drug Elecoglipron Helps Adults With Type 2 Diabetes Mellitus by Comparing it With Semaglutide, a Medicine Already Used to Treat Type 2 Diabetes Mellitus
This study compares a new medicine, Elecoglipron, to an existing one, Semaglutide, for adults with Type 2 Diabetes. It aims to see if the new drug is safe and effective for people whose diabetes isn't well-controlled and who have a higher risk of heart problems.
Type 2 Diabetes MellitusHungary - RecruitingPHASE3
A Clinical Study to Evaluate the Effects of Enicepatide (RO7795068) in Participants With Obesity or Overweight Without Type 2 Diabetes
This study is testing a new medicine, enicepatide, for people who are overweight or have obesity but do not have type 2 diabetes. It aims to see if the medicine helps with weight loss and if it's safe compared to a dummy medicine.
Obesity or OverweightHungary - RecruitingPHASE3
Study of Plozasiran in Adults With Severe Hypertriglyceridemia at Risk of Acute Pancreatitis
This study is testing a new medicine, plozasiran, for people with very high triglycerides who have had pancreatitis. It will check if the medicine is safe and helps reduce the risk of future pancreatitis attacks. Participants will get either the study medicine or a dummy medicine.
Severe HypertriglyceridemiaHungary - RecruitingPHASE3
A Study to Compare Elritercept to Placebo in Adults With Myelofibrosis and Anemia Who Are Taking Ruxolitinib
This study looks at a new drug, elritercept, for people with myelofibrosis and anaemia who are already taking ruxolitinib. It compares elritercept to a dummy drug (placebo) to see if it improves anaemia and other symptoms, and how safe it is.
MyelofibrosisAnemiaHungary - RecruitingPHASE3
INTREPID: A Study of Sapablursen Evaluating the Safety and Efficacy in Participants With Polycythemia Vera (PV)
This study is testing a new medicine called sapablursen for people with Polycythemia Vera (PV). It aims to see if adding sapablursen to usual treatment is safe and helps control the condition better. Participants will be involved for up to three years, comparing the new medicine to a dummy treatment.
Polycythemia VeraHungary - RecruitingPHASE3
An Open-label Study Comparing Lutetium (177Lu) Vipivotide Tetraxetan Versus Observation in PSMA Positive OMPC.
This study looks at a new treatment called AAA617 for men with early-stage prostate cancer that has spread a little (oligometastatic). It compares AAA617 to careful watching, to see if it can stop the cancer from growing and help men live better for longer.
Oligometastatic Prostate Cancer (OMPC)Hungary - RecruitingPHASE2
Belzutifan/MK-6482 for the Treatment of Advanced Pheochromocytoma/Paraganglioma (PPGL), Pancreatic Neuroendocrine Tumor (pNET), Von Hippel-Lindau (VHL) Disease-Associated Tumors, Advanced Gastrointestinal Stromal Tumor (wt GIST), or Solid Tumors With HIF-2α Related Genetic Alterations (MK-6482-015)
This study is testing a new medicine called belzutifan for certain types of advanced cancers, including rare adrenal gland, gut, and kidney cancers. We want to see how well it works and if it's safe for people aged 12 and over.
Pheochromocytoma/ParagangliomaPancreatic Neuroendocrine TumorVon Hippel-Lindau DiseaseAdvanced Gastrointestinal Stromal TumorHungary - Completed
Evaluation of a dermocosmetic regimen for acne-prone skin in volunteers with mild, moderate or severe skin conditions
Acne is a common skin condition that affects confidence and well-being. This study tests whether a daily skincare routine using Eucerin products helps clear mild to severe spots. Researchers want to see how well these creams work over a year in people aged 12 to 50 across the UK and worldwide.
Subjects with acne-prone skin aged 12-50 years with Investigator's Global Assessment (IGA) grades 2-4, evaluating treatment of mild to severe acne vulgaris.Hungary - RecruitingPhase III
A study of JNJ-78934804 in participants with moderately to severely active Crohn's disease
This clinical trial is testing a new combination medicine, JNJ-78934804, for moderate to severe Crohn’s disease. It combines two drugs into one injection to target gut inflammation. Researchers want to see if this two-in-one approach works better than a single medicine for people whose previous treatments have stopped working.
Crohn’s diseaseHungary - RecruitingTherapeutic confirmatory (Phase III)
A Long-Term Extension Study to Evaluate the Safety of Filgotinib in Subjects with Ulcerative Colitis
This study looks at the long-term safety of a tablet called filgotinib (Jyseleca) for adults with ulcerative colitis. Doctors want to see how well it works over time and check for any side effects by monitoring patients' health, routine blood tests, and everyday bowel symptoms.
Ulcerative Colitis (UC)Hungary - RecruitingTherapeutic confirmatory (Phase III)
KontRASt-02: A randomized, controlled, open label, phase III study evaluating the efficacy and safety of JDQ443 versus docetaxel in previously treated subjects with locally advanced or metastatic KRAS G12C mutant non-small cell lung cancer.
This clinical trial compares a new targeted drug called JDQ443 with standard chemotherapy (docetaxel). It is for adults with advanced non-small cell lung cancer that carries a specific genetic change called KRAS G12C. Researchers want to find out which treatment keeps cancer from growing for longer.
Advanced non-small cell lung cancer harboring the KRAS G12C mutationHungary - CompletedPhase III
Prevention of complications to Improve outcome in elderly patients with acute stroke - A randomised clinical trial
This clinical trial looks at whether giving common medicines right after a stroke can prevent complications like fever, sickness, and chest infections before they start. Researchers want to see if treating older adults early with paracetamol, antibiotics, or anti-sickness medicine helps them recover better and stay independent.
Acute ischaemic stroke or intracerebral haemorrhageHungary - AuthorisedTherapeutic confirmatory (Phase III)
A Phase III, Multicentre, Randomised, Open-label Study to Compare the Efficacy and Safety of AZD0486 plus Rituximab versus Chemotherapy plus Rituximab in Previously Untreated Participants with Follicular Lymphoma (SOUNDTRACK-F1)
This phase 3 trial is testing a new targeted medicine called surovatamig (AZD0486) combined with rituximab for people newly diagnosed with follicular lymphoma. Researchers want to see if this new combination works better and is safer than standard chemotherapy combined with rituximab.
Follicular LymphomaHungary - AuthorisedTherapeutic exploratory (Phase II)
A Phase 2, randomized, double-blind, placebo-controlled trial to evaluate the efficacy, safety, and tolerability of CRD-4730 in patients with heart failure with reduced ejection fraction (HFREF) (CALIBRATE-HF)
This study is testing a new tablet called CRD-4730 for adults with heart failure. Researchers want to see if the medicine can help the heart pump blood better, ease everyday symptoms, and improve quality of life. Participants will take either the study drug or a dummy pill for 24 weeks.
heart failureHungary - AuthorisedTherapeutic confirmatory (Phase III)
A Phase 3, randomized, double-blind, placebo-controlled study to evaluate the efficacy and safety of rozanolixizumab in adult participants with ocular myasthenia gravis
This clinical trial is testing a medicine called rozanolixizumab (Rystiggo) for adults with ocular myasthenia gravis. This condition causes eye muscle weakness, leading to droopy eyelids and double vision. Researchers want to see if this injection reduces eye symptoms and improves daily life compared to a dummy treatment (placebo).
Ocular Myasthenia GravisHungary - AuthorisedTherapeutic confirmatory (Phase III)
A Phase 3, open-label extension study to evaluate the long-term safety and efficacy of rozanolixizumab in adult participants with ocular myasthenia gravis
This clinical trial tests a medicine called rozanolixizumab (Rystiggo) for adults with ocular myasthenia gravis. This condition causes eye muscle weakness, leading to drooping eyelids and double vision. Researchers want to find out how safe and effective this medicine is when used over a longer period.
Ocular Myasthenia GravisHungary - AuthorisedTherapeutic exploratory (Phase II)
Randomized, Multicenter, Vehicle-Controlled, Double-Masked Study to Evaluate the Efficacy and Safety of Intranasal Cenegermin (Recombinant Human Nerve Growth Factor [rhNGF]) in Adult Participants with Non-Arteritic Anterior Ischemic Optic Neuropathy (NAION)
This clinical trial is testing a new nasal spray called cenegermin for adults with NAION, an eye condition causing sudden sight loss. Researchers want to see if this treatment helps repair damaged nerve cells and improves vision on an eye chart over a period of 24 weeks.
Non-Arteritic Anterior Ischemic Optic Neuropathy (NAION)Hungary - AuthorisedHuman Pharmacology (Phase I)- Other
A trial to learn how safe anifrolumab is, how it moves throughout the body over time, and how it affects the body of adults with systemic lupus erythematosus
This clinical study looks at a medicine called anifrolumab in adults with systemic lupus erythematosus (lupus). Researchers want to see how safe the drug is, how it moves through the bloodstream, and how it affects the body. The goal is to improve future treatment options for people with lupus.
Systemic Lupus ErythematosusHungary - AuthorisedTherapeutic exploratory (Phase II)
A Phase 2, Randomized, Double-Blinded, Placebo-Controlled, Multicenter Study to Evaluate the Efficacy and Safety of Efgartigimod PH20 Subcutaneous Administered by Prefilled Syringe in Adult Participants with Sjogren’s Disease-Associated Sensorimotor or Sensory Polyneuropathy
This study tests a medicine called Vyvgart in adults with Sjögren's disease who have nerve damage in their hands, legs, or feet. Researchers want to see if regular injections under the skin can ease nerve symptoms, reduce fatigue, and be used safely compared with a dummy treatment.
Sjogren’s Disease-Associated Sensorimotor Polyneuropathy (SMPN) or Sensory Polyneuropathy (SPN)Hungary - AuthorisedTherapeutic confirmatory (Phase III)
A Phase 3 Randomized, Open-Label Study of Atebimetinib in Combination with the Modified Gemcitabine and nab-Paclitaxel Regimen Versus the Standard Gemcitabine and nab-Paclitaxel Regimen for the Treatment of Patients with Metastatic Pancreatic Ductal Adenocarcinoma Cancer (MAPKeeper 301)
This clinical trial is testing a new targeted medicine called atebimetinib for advanced pancreatic cancer. Doctors want to see if adding this drug to standard chemotherapy helps people live longer and improves their quality of life compared to standard chemotherapy alone.
Metastatic Pancreatic Ductal AdenocarcinomaHungary - AuthorisedTherapeutic exploratory (Phase II)
Randomized, double-blind, placebo-controlled, parallel-group, multicenter study to evaluate the safety and efficacy of 2 dose levels of the oral ghrelin receptor agonist AC01 over 12 weeks in patients with chronic advanced heart failure with reduced ejection fraction (HFrEF)
This study tests a new daily tablet called AC01 for people with long-term heart failure. Researchers want to see if this medicine can help the heart pump blood more effectively. Participants take either the real medicine or a dummy tablet for 12 weeks while doctors monitor their heart health.
chronic advanced heart failure with reduced ejection fraction (HFrEF)Hungary - AuthorisedTherapeutic exploratory (Phase II)
A Randomized, Double-Blind, Placebo-controlled, Parallel Arm, 52-week Study to Assess Efficacy, Safety, Tolerability, and Pharmacokinetics of Two Doses of EXPD-101 in Participants with COPD
This 52-week clinical study is testing an experimental medicine called EXPD-101 for adults living with COPD. Researchers want to find out if taking this treatment can safely reduce chest flare-ups, ease breathing symptoms, and help people stay out of hospital compared with a dummy treatment (placebo).
Chronic Obstructive Pulmonary Disease (COPD) exacerbationsHungary - AuthorisedTherapeutic confirmatory (Phase III)
A Phase 3, Randomized, DoubleBlind, Placebo-controlled, Multicenter, Parallel-group Study to Evaluate the Efficacy and Safety of Once Daily Treprostinil Palmitil Inhalation Powder in Participants with Pulmonary Arterial Hypertension (PALM-PAH)
This study is testing a new once-daily dry powder inhaler called treprostinil palmitil for pulmonary arterial hypertension (high blood pressure in the lungs). Doctors want to see if inhaling this medicine once a day helps people walk further and improves their daily symptoms compared with a dummy medicine (placebo).
Pulmonary Arterial HypertensionHungary - AuthorisedTherapeutic confirmatory (Phase III)
A Multicenter, Randomized, Double-Blind, Placebo-Controlled, Phase 3 Study to Evaluate the Efficacy and Safety of Telitacicept in Adult Participants with Active Primary Sjögren’s Disease
This study tests a new injection called telitacicept for adults with active primary Sjögren's disease. Researchers want to see if this medicine works better and is safer than a dummy treatment (placebo) at lowering general disease activity, easing dryness, and improving daily symptoms over 48 weeks.
Active Primary Sjögren’s DiseaseHungary - AuthorisedTherapeutic use (Phase IV)
Evaluation of Thrombin Generation and Thrombosis Risk in Women on Hormonal Contraceptives with a Focus on Modifiable Risk Factors
This study looks at how different hormonal contraceptive pills affect blood clotting. Researchers will compare blood samples from women using various types of birth control pills with women who do not use them. The goal is to see how different hormones and lifestyle habits influence the risk of blood clots.
Venous Thromboembolism Risk associated with Hormonal ContraceptivesHungary - RecruitingTherapeutic confirmatory (Phase III)
Double-Blind, Placebo-Controlled, Phase 3 Study to Evaluate the Efficacy and Safety of Plozasiran in Adults with Hypertriglyceridemia (MUIR-3 Study)
This study tests a new injection called plozasiran in adults with high levels of blood fats, known as triglycerides. Researchers want to see if plozasiran can safely lower these fats over one year compared to a dummy jab (placebo). This could help reduce risks to the heart and pancreas.
HypertriglyceridemiaHungary - RecruitingTherapeutic confirmatory (Phase III)
A Phase 3, 52-Week, Multicenter, Randomized, Placebo-controlled, Double-blind Study to Assess the Efficacy, Safety, and Tolerability of Rocatinlimab in Adult Subjects With Prurigo Nodularis Who are Inadequately Controlled on Topical Therapies or Not Eligible for Topical Therapies
This study tests whether a new medicine called rocatinlimab helps adults with prurigo nodularis. This skin condition causes intensely itchy, firm lumps to form on the skin. The trial checks if the treatment can reduce severe itching and heal skin bumps when prescription creams have not provided enough relief.
Prurigo NodularisHungary - RecruitingTherapeutic confirmatory (Phase III)
A Randomized, Double-Blind, Dose Finding and Comparison Study of the Safety and Efficacy of High Doses of Eteplirsen, Preceded by an Open-Label Dose Escalation, in Patients with Duchenne Muscular Dystrophy With Deletion Mutations Amenable to Exon 51 Skipping
This clinical trial is testing whether higher doses of a medicine called eteplirsen are safe and helpful for boys with Duchenne muscular dystrophy. It is for males with a specific genetic change that can be treated by skipping exon 51, aiming to protect muscle strength over nearly three years.
Duchenne Muscular DystrophyHungary - AuthorisedTherapeutic confirmatory (Phase III)
A Phase 3, Multicenter, Open Label, Basket, Long-term Extension Study of Icotrokinra in Pediatric Clinical Study Participants
This study looks at a new medicine called icotrokinra for children and young people with immune system conditions. It is an extension study, meaning it offers ongoing treatment to young patients who finished an earlier trial, helping doctors learn about the medicine's long-term safety, effects, and benefits.
Immune System DisordersHungary - RecruitingTherapeutic confirmatory (Phase III)
A Prospective, Multicenter, Long-Term Study to Assess the Safety and Efficacy of Nemolizumab (CD14152) in Subjects with Prurigo Nodularis
This study looks at a medicine called nemolizumab for adults with prurigo nodularis. Prurigo nodularis is a skin condition that causes hard, very itchy lumps. Doctors want to see if nemolizumab is safe and effective at calming severe itch and clearing skin nodules over a longer period.
Prurigo NodularisHungary - RecruitingTherapeutic confirmatory (Phase III)
Double-Blind, Placebo-Controlled, Phase 3 Study to Evaluate the Efficacy and Safety of Plozasiran in Adults with Severe Hypertriglyceridemia (SHASTA-4 Study)
This Phase 3 clinical study tests a new injection called plozasiran for adults with very high blood fats, known as triglycerides. Researchers want to see if plozasiran can safely lower these fat levels over 12 months compared to a dummy jab, reducing the risk of painful pancreas inflammation.
Severe hypertriglyceridemia (SHTG)Hungary - RecruitingTherapeutic confirmatory (Phase III)
A Phase 3, 52-Week, Randomized, Double-Blind, Placebo-Controlled, Parallel-Arm Efficacy and Safety Study with Open-Label Extension of BLU-5937 in Adult Participants with Refractory Chronic Cough, Including Unexplained Chronic Cough (CALM-1)
This clinical trial is testing a new daily tablet called BLU-5937 for adults with a long-term cough that has not responded to treatment or has no clear cause. Researchers want to see if the medicine can safely reduce how often people cough over a 24-hour period.
Refractory Chronic Cough, Including Unexplained Chronic CoughHungary - RecruitingPHASE3
A Study of the Long-term Safety and Efficacy of Danicamtiv in Adults With Symptomatic Genetic and Familial Dilated Cardiomyopathy
This study is looking at a new medicine called Danicamtiv for people with a heart condition called genetic or familial Dilated Cardiomyopathy (DCM). It wants to see how well the medicine works over a long time, if it's safe, and if people can take it easily. There are currently no specific medicines for this type of DCM.
Symptomatic Genetic Dilated Cardiomyopathy (DCM)Hungary - RecruitingPhase II and Phase III (Integrated)
A Phase 2/3, Randomized, Double-Blinded, Placebo-Controlled, Parallel-Group, 2-Arm, Multicenter, Operationally Seamless Study to Evaluate the Efficacy, Safety, Tolerability, Pharmacodynamics, Pharmacokinetics, and Immunogenicity of Efgartigimod PH20 SC in Participants Aged 18 Years and Older With Active Idiopathic Inflammatory Myopathy
This clinical trial is testing a new injection called efgartigimod for adults with inflammatory muscle disease (myositis). Researchers want to see if the medicine can safely reduce muscle inflammation, improve strength, and help people lower their daily steroid dose compared to a dummy treatment over 52 weeks.
Active Idiopathic Inflammatory Myopathy (IIM)Hungary - RecruitingTherapeutic confirmatory (Phase III)
Efficacy and safety of co-administered cagrilintide and semaglutide (CagriSema) 1.0 mg/1.0 mg s.c. once weekly versus tirzepatide 5 mg s.c. once weekly in participants with type 2 diabetes inadequately controlled on metformin, SGLT2 inhibitor or both
This study compares two weekly injectable medicines for type 2 diabetes: a new combined treatment called CagriSema and an existing medicine called Mounjaro (tirzepatide). Researchers want to see which treatment is better at lowering average blood sugar levels and helping people manage their body weight over 60 weeks.
Type 2 DiabetesHungary - RecruitingTherapeutic exploratory (Phase II)
A Phase 2, multinational, multicenter, randomized, double blind, placebo controlled, dose-ranging study to evaluate the efficacy and safety of SAR441566 in adults with moderate to severe Crohn’s disease.
This clinical study tests a new medicine called balinatunfib (SAR441566) for adults with moderate to severe Crohn's disease. Researchers want to see if different doses help heal the bowel lining and reduce symptoms compared to a dummy treatment (placebo), while checking for any unwanted side effects.
Crohn's diseaseHungary - RecruitingTherapeutic confirmatory (Phase III)
A Phase 3, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Efficacy and Safety of Orally Administered Deucrictibant Extended-release Tablet for Prophylaxis Against Angioedema Attacks in Adolescents and Adults with Hereditary Angioedema
This clinical trial is testing a new daily tablet called deucrictibant for adults with hereditary angioedema (HAE). Researchers want to find out if taking this tablet can safely prevent painful swelling attacks. Participants will take either the study tablet or an inactive dummy pill for 24 weeks.
Hereditary AngioedemaHungary - RecruitingTherapeutic confirmatory (Phase III)
A Phase 3 Randomized, Double-Blinded, Placebo-Controlled Multicenter Trial with Open-Label Extension to Evaluate the Efficacy, Safety, and Tolerability of Efgartigimod PH20 Subcutaneous Administered by Prefilled Syringe in Adult Patients with Primary Sjögren’s Disease
This study tests whether a medicine called efgartigimod can help adults with primary Sjögren’s disease. Researchers want to see if regular injections under the skin can ease symptoms like joint pain, dry eyes, and dry mouth, and lower overall body inflammation compared with a dummy treatment (placebo).
Primary Sjögren’s DiseaseHungary - RecruitingPhase II and Phase III (Integrated)
C4671026-A PHASE 2/3, INTERVENTIONAL SAFETY, PHARMACOKINETICS, AND EFFICACY, OPEN-LABEL, MULTI-CENTER, SINGLE-ARM STUDY TO INVESTIGATE ORALLY ADMINISTERED PF-07321332 (NIRMATRELVIR)/RITONAVIR IN NONHOSPITALIZED SYMPTOMATIC PEDIATRIC PARTICIPANTS WITH COVID-19 WHO ARE AT RISK OF PROGRESSION TO SEVERE DISEASE
This study looks at an antiviral medicine (nirmatrelvir and ritonavir) for children and young people with COVID-19. Researchers want to find out how safe the medicine is, how the body handles it, and whether it stops mild COVID-19 from turning into severe illness in vulnerable young patients.
SARS-CoV-2 InfectionHungary - RecruitingTherapeutic exploratory (Phase II)
C1131003 - AN INTERVENTIONAL PHASE 2, OPEN-LABEL, MULTI-CENTER STUDY TO EVALUATE SAFETY AND EFFICACY OF PF-06835375 IN ADULT PARTICIPANTS WITH MODERATE TO SEVERE PRIMARY IMMUNE THROMBOCYTOPENIA
This clinical trial is looking at a new injection called PF-06835375 for adults with primary immune thrombocytopenia (ITP). ITP is a condition where the body attacks its own platelets, causing low platelet counts. The study tests whether the new medicine is safe and helps raise platelet levels.
Primary immune thrombocytopeniaHungary - AuthorisedTherapeutic confirmatory (Phase III)
A Master Protocol for a Phase 3, Randomized, Multicenter, Double-blind Study to Assess Stroke and Systemic Embolism Prevention with REGN7508 and REGN9933, Monoclonal Antibodies Against Factor XI, versus Placebo in Participants with Atrial Fibrillation for Whom Oral Anticoagulation is Unsuitable (ROXI-INCLINE)
This clinical study tests two new medicines, REGN7508 and REGN9933, for adults with atrial fibrillation (an irregular heartbeat). It aims to find out if these treatments can safely stop blood clots and strokes in people who cannot take standard blood-thinning tablets due to a high risk of bleeding.
Atrial Fibrillation (AF)Hungary - RecruitingTherapeutic confirmatory (Phase III)
A Double-Blind, Randomized, Placebo-Controlled Study to Evaluate the Efficacy and Safety of Odevixibat (A4250) in Children with Biliary Atresia Who Have Undergone a Kasai Hepatoportoenterostomy (BOLD)
This clinical study is testing a medicine called odevixibat in children with biliary atresia who have had a Kasai operation. Researchers want to see if taking this daily medicine can protect the liver, improve bile flow, and delay or prevent the need for a liver transplant over two years.
Biliary AtresiaHungary - RecruitingTherapeutic exploratory (Phase II)
A Double Blind, Randomized, Placebo-Controlled Study to Evaluate the Efficacy and Safety of PRA023 in Subjects with Systemic Sclerosis Associated with Interstitial Lung Disease (SSc-ILD)
This study tests an experimental drug called tulisokibart for people with scleroderma that has caused lung scarring. Scleroderma can make breathing difficult. Researchers want to see if this medicine, given by a drip, safely slows down lung damage and improves breathing over 50 weeks compared to a dummy treatment.
Systemic sclerosis associated with interstitial lung diseaseHungary - RecruitingTherapeutic confirmatory (Phase III)
A randomised, double-blind, double-dummy, multicentre, phase III, non inferiority trial of an oral mesalazine formulation in patients with active mild to moderate ulcerative colitis for the induction of remission.
This study tests a new tablet version of mesalazine for people with mild to moderate ulcerative colitis. Researchers want to see if it is just as safe and effective as an established treatment at calming gut inflammation and helping symptoms settle down after eight weeks of daily treatment.
Ulcerative colitisHungary - RecruitingTherapeutic exploratory (Phase II)
An adaptive, randomized, double-blind, dose exploration, parallel group, placebo controlled, multicenter phase 2 trial to evaluate the efficacy, safety and tolerability of LNP023 in combination with standard-of-care with and without oral corticosteroids in adult patients with active lupus nephritis Class III-IV, +/- V
This study looks at a new drug called iptacopan (LNP023) for adults with lupus nephritis, a kidney problem caused by lupus. Researchers want to see if adding it to usual care helps heal the kidneys, cuts down lupus flare-ups, and lowers the need for strong steroid medications.
Lupus Nephritis Class III-IV, +/- VHungary - RecruitingTherapeutic exploratory (Phase II)
A Phase 2, Randomized, Double-blind, Placebo-controlled, Dose Ranging Study to Assess the Efficacy and Safety of Rocatinlimab in Adult Subjects With Moderate-to-severe Asthma
This study is testing a new medicine called rocatinlimab for adults with moderate-to-severe asthma. Researchers want to find the best dose and see if it cuts down asthma attacks that need steroid tablets or hospital care, while checking how safe and effective it is compared with a dummy medicine.
Moderate-to-severe AsthmaHungary - RecruitingTherapeutic confirmatory (Phase III)
Double-Blind, Placebo-Controlled, Phase 3 Study to Evaluate the Efficacy and Safety of Plozasiran in Adults with Severe Hypertriglyceridemia (SHASTA-3 Study)
This study tests a new injection called plozasiran for adults with very high blood fat levels, known as severe hypertriglyceridemia. Researchers want to see if the medicine can safely lower blood fats over one year compared to a dummy jab, reducing the risk of serious problems like pancreas inflammation.
Severe hypertriglyceridemia (SHTG)Hungary - RecruitingTherapeutic confirmatory (Phase III)
The ENERGY 2 Study: An Open-Label Phase 3 Study to Evaluate the Efficacy and Safety of INZ-701 in Infants with Ectonucleotide Pyrophosphatase/Phosphodiesterase 1 (ENPP1) Deficiency
The ENERGY 2 study is testing a new medicine called INZ-701 for babies with ENPP1 deficiency. This rare condition can cause harmful calcium build-up in blood vessels and heart problems. Researchers want to see if INZ-701 is safe, protects the heart, and helps babies grow well over one year.
Ectonucleotide Pyrophosphatase/Phosphodiesterase 1 (ENPP1) DeficiencyHungary