Latest studies
- AuthorisedTherapeutic confirmatory (Phase III)
Reduced anticoagulation targets in extracorporeal life support
This study looks at using lower doses of blood-thinning medicines like Heparin and Nadroparin for people on a life support machine called ECMO. It aims to see if this can reduce serious bleeding or blood clots and improve patient survival rates.
Netherlands - Ongoing, recruitingHuman Pharmacology (Phase I)- Other
A Phase 1b, Open-Label, Multiple Ascending Dose, Multicenter Study of VRG50635 in Participants With Sporadic and Familial Amyotrophic Lateral Sclerosis Followed by Long-Term Treatment
This study is testing a new medicine called VRG50635 for people with Amyotrophic Lateral Sclerosis (ALS). It's an early-stage study to see how the medicine works, how much to give, and if it's safe. Both common and inherited forms of ALS are included.
Amyotrophic Lateral SclerosisNetherlands - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A Phase 3, Open-label Study Evaluating the Pharmacokinetics, Safety, and Tolerability of Elexacaftor/Tezacaftor/Ivacaftor in Cystic Fibrosis Subjects 12 to Less Than 24 Months of Age
This study is testing a new combination medicine for babies and toddlers aged 12 to 24 months with Cystic Fibrosis. Researchers want to ensure the medicine is safe and well-tolerated, and how it moves through the body.
Cystic FibrosisNetherlands - Ongoing, recruitingTherapeutic confirmatory (Phase III)
Influencing Progression of Airway Disease in Primary Antibody Deficiency
This study looks at people with primary antibody deficiency to see if a higher dose of immunoglobulin (Ig) replacement therapy can slow down lung problems. We'll compare lung changes over two years using scans and other health measures. This could help improve treatment for these conditions.
Primary antibody deficiency:Netherlands - Ongoing, recruitingPhase II and Phase III (Integrated)
A Phase 2/3, Randomized, Double-Blinded, Placebo-Controlled, Parallel-Group Study to Investigate the Efficacy and Safety of Efgartigimod PH20 SC in Adult Participants With Bullous Pemphigoid
This study is looking into a new medicine, efgartigimod, for people with bullous pemphigoid (BP). It compares efgartigimod to a dummy drug (placebo) to see if it can help patients achieve clear skin without needing steroid tablets for a long time.
Bullous Pemphigoid (BP)Netherlands - Ongoing, recruitingHuman Pharmacology (Phase I)- Other
A SINGLE-CENTER, RANDOMIZED, PLACEBO-CONTROLLED STUDY TO ASSESS SAFETY, TOLERABILITY, AND PHARMACOKINETICS OF REPEAT DOSES OF ARM210 IN HEALTHY SUBJECTS.
This study is testing a new medicine, ARM210, for heart rhythm problems. It's the first time it will be given multiple times to healthy volunteers to check it's safe, how well people tolerate it, and how the body handles the medicine.
Cardiac arrhythmiasNetherlands - Ongoing, recruitingTherapeutic exploratory (Phase II)
A Phase II, single arm, multicenter open label trial to determine the efficacy and safety of tisagenlecleucel (CTL019) in adult patients with refractory or relapsed follicular lymphoma
This study is for adults in the UK with a type of cancer called follicular lymphoma that has come back or not responded to previous treatments. It investigates a new cell therapy called tisagenlecleucel to see how well it works and if it's safe.
Adult patients with refractory or relapsed follicular lymphomaNetherlands - Active not recruitingPHASE3
A Study of Tucatinib vs. Placebo in Combination With Ado-trastuzumab Emtansine (T-DM1) for Patients With Advanced or Metastatic HER2+ Breast Cancer
This study looks at a new drug, tucatinib, combined with T-DM1 to treat advanced HER2-positive breast cancer. It aims to see if this combination works better than T-DM1 alone for cancer that has spread or can't be removed by surgery.
HER2-positive Breast CancerNetherlands - Ongoing, recruitingPhase I and Phase II (Integrated)- Other
A Phase 1/2, Umbrella Study of the Efficacy and Safety of Pembrolizumab plus Enfortumab vedotin +/- Investigational Agents in First-Line metastatic urothelial carcinoma
This study is looking at new treatments for advanced bladder cancer that has spread. It combines pembrolizumab and enfortumab vedotin, sometimes with other new medicines, to see if they are safe and work well as a first treatment.
Advanced Urothelial CarcinomaNetherlands - Ongoing, recruitingTherapeutic exploratory (Phase II)
A Multicenter, Open-label, Phase 2 Basket Study of MK‑7684A, a Co formation of Vibostolimab (MK‑7684) With Pembrolizumab (MK‑3475), With or Without Other Anticancer Therapies in Participants With Selected Solid Tumors (KEYVIBE 005)
This study, called KEYVIBE 005, is testing a new combination of medicines (MK-7684A, which includes vibostolimab and pembrolizumab) for people with advanced solid tumours. Researchers want to see how well this new treatment shrinks tumours and stops them from growing, either alone or with other cancer therapies.
Advanced solid tumorsNetherlands - Ongoing, recruitingPhase I and Phase II (Integrated)- Other
A Long-Term Follow-up Study to Evaluate the Safety and Efficacy of Adeno-Associated Virus (AAV) Serotype 8 (AAV8)-Mediated Gene Transfer of Glucose-6-Phosphatase (G6Pase) in Adults with Glycogen Storage Disease Type Ia (GSDIa)
This study looks at a new gene treatment called Pariglasgene brecaparvovec for adults with a rare liver condition called Glycogen Storage Disease Type Ia (GSDIa). It aims to see how safe it is and if it helps control blood sugar levels long-term.
Glycogen storage disease type IaNetherlands - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A randomised double-blind placebo-controlled clinical trial investigating the effect and safety of oral semaglutide in subjects with early Alzheimer´s disease (EVOKE)
This study is testing a new medicine called semaglutide for people with early Alzheimer's disease. Researchers want to see if it can help improve memory and thinking, and how safe it is to use.
Mild cognitive impairment (MCI) or mild dementia, both of the Alzheimer’s typeNetherlands - Ongoing, recruitingHuman Pharmacology (Phase I)- Other
A Phase 1, open label, randomized, 2-sequence, 2-period, crossover, single center study to evaluate the pharmacokinetics of follitropin alfa from 2 manufacturing processes, administered as a single subcutaneous 450 IU dose to pituitary-suppressed healthy premenopausal female participants.
This study is looking at how a fertility medicine (follitropin alfa) is handled by the body. It compares two versions of the medicine in healthy women to understand how they work. This information helps us learn more about potential treatments for infertility.
InfertilityNetherlands - RecruitingPhase II
Radiotherapy (miBG) in neuroblastoma combined with chemotherapy (talazoparib)
This study for children and young people with high-risk neuroblastoma tests a new combination of treatments: a targeted radiation therapy (131I-mIBG) and a chemotherapy drug (talazoparib). The goal is to see if this combination works better, especially for patients with certain gene changes.
Relapsed and refractory high-risk neuroblastomaNetherlands - RecruitingPhase III
Phase III study of daraxonrasib (RMC-6236) in previously treated NSCLC patients with RAS mutations
This study compares a new medicine, daraxonrasib, with a standard treatment, docetaxel, for lung cancer patients whose cancer has a specific change (RAS mutation) and has been treated before. It aims to see which medicine works better.
RAS mutant non-small cell lung cancerNetherlands - Ongoing, recruitingHuman Pharmacology (Phase I)- First administration to humans
A randomized double-blind placebo-controlled phase 1 study on the safety, tolerability and pharmacokinetics/-dynamics of escalating single intravenous doses of AK1967 (Procizumab) in healthy male volunteers
This study is testing a new medicine called AK1967 (Procizumab) in healthy men. It aims to see if the medicine is safe, how well the body handles it, and what it does in the body. This is a very early study, giving small doses for the first time in people.
Circulatory shockNetherlands - Active not recruitingPHASE3
Study of Subcutaneous Epcoritamab in Combination With Intravenous Rituximab and Oral Lenalidomide (R2) to Assess Adverse Events and Change in Disease Activity in Adult Participants With Follicular Lymphoma
This study looks at a new drug, epcoritamab, combined with standard medicines (R2) for adults with follicular lymphoma that has come back or not responded to previous treatments. It aims to see how safe and effective this new combination is.
Follicular Lymphoma (FL)Netherlands - Ongoing, recruitingTherapeutic confirmatory (Phase III)
Sodium zirconium cyclosilicate to allow liberal fruit and vegetable intake for patients with CKD stage 3b and 4 (LIBERAL study)
This study looks at a medicine called Lokelma for people with kidney disease (stages 3b-4). It aims to see if Lokelma can help them eat more fruits and vegetables, which are high in potassium, without their potassium levels becoming too high. It compares different doses of Lokelma.
Patients with chronic kidney disease stage 3b to 4Netherlands - Recruiting
Helping young people to adapt their internet use and promote mental well-being in a rapidly changing world
This study helps young people aged 12-16 learn healthier ways to use the internet and improve their mental well-being. It uses fun phone apps to teach skills for managing emotions and controlling internet habits, aiming to reduce potential harm from too much screen time.
Problematic usage of the internet in adolescentsNetherlands - Ongoing, recruitingHuman Pharmacology (Phase I)- Other
A study to investigate the safety, tolerability, and pharmacokinetics of Ent001 in patients with moderately to severely active ulcerative colitis
This study is looking at a new medicine called Ent001 for people in the UK with a bowel condition called ulcerative colitis. It wants to find out if the medicine is safe, how the body handles it, and if people can tolerate it well, especially if their colitis is quite active.
Inflammatory bowel disease (moderate to severe active ulcerative colitis)Netherlands - Ongoing, recruitingTherapeutic confirmatory (Phase III)
An Open-label Extension Trial to Evaluate the Long-term Safety of KVD900, an Oral Plasma Kallikrein Inhibitor, for On-demand Treatment of Angioedema Attacks in Adolescent and Adult Patients with Hereditary Angioedema Type I or II A Pharmacokinetic Subtrial in Adolescent Patients with Hereditary Angioedema Type I or II Participating in the KVD900-302 Trial
This study looks at how safe a medicine called KVD900 is when used long-term for swelling attacks in people with Hereditary Angioedema (HAE) Type 1 or 2. It also checks how the body handles the medicine in teenagers.
Hereditary Angioedema Type I or IINetherlands - Ongoing, recruitingTherapeutic exploratory (Phase II)
A participant - and investigator-blinded, randomized, placebo-controlled, multicenter, platform study to investigate efficacy, safety, and tolerability of various single treatments in patients with idiopathic pulmonary fibrosis
This study is looking into new treatments for Idiopathic Pulmonary Fibrosis (IPF). It compares a new medicine, LTP001, with a dummy pill (placebo) to see if it can slow down the lung disease and improve how people feel, checking for safety and side effects along the way.
Idiopathic pulmonary fibrosisNetherlands - Ongoing, recruitingTherapeutic confirmatory (Phase III)
IMPAHCT-FUL: A Long-Term Extension, Multi-Center Safety Study of AV-101 in Subjects With Pulmonary Arterial Hypertension (PAH) Who Have Completed Study AV-101-002
This study looks at the long-term safety of a new medicine, AV-101, for people with pulmonary arterial hypertension (PAH). It's for those who have already tried AV-101 in a previous study and aims to learn more about how well it's tolerated over time.
Pulmonary Arterial Hypertension (PAH)Netherlands - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A Phase 3, Single-arm, Open-label Extension of the Vericiguat VALOR Study in Pediatric Participants with Heart Failure due to Systemic Left Ventricular Systolic Dysfunction (VALOR EXT)
This study looks at a medicine called Vericiguat for children with a type of heart failure. It checks how safe the medicine is and if it causes any unwanted effects. This is a follow-up study for those already taking part.
Heart Failure due to Systemic Left Ventricular Systolic DysfunctionNetherlands - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A Randomized, Multicenter, Double Blind, Phase III Study of Adjuvant Nivolumab or Placebo in Subjects with Resected Esophageal, or Gastroesophageal Junction Cancer
This study looks at whether a drug called Nivolumab can help prevent cancer from coming back in people who have had surgery for oesophageal or stomach cancer. It compares Nivolumab to a dummy drug to see if it improves the time patients live without their cancer returning.
Subjects with resected adenocarcinoma or squamous cell carcinoma esophageal or gastroesophageal junction cancerNetherlands - Ongoing, recruitingHuman Pharmacology (Phase I)- Other
Study to evaluate the addition of an experimental drug, CC-90010, to the usual treatment of brain cancer after surgery
This study is testing a new experimental drug, CC-90010, alongside standard treatments for a type of brain cancer called glioblastoma. It's for adults whose brain tumour has been recently diagnosed and surgically removed, either fully or in part, to see if the new drug can help.
Subjects with newly diagnosed WHO Grade IV glioblastoma (ndGBM) who have undergone complete or partial tumor resectionNetherlands - Active not recruitingPHASE3
Enfortumab Vedotin and Pembrolizumab vs. Chemotherapy Alone in Untreated Locally Advanced or Metastatic Urothelial Cancer
This study is looking at how well two new drugs, enfortumab vedotin and pembrolizumab, work together to treat advanced bladder cancer that has spread. It compares them to standard chemotherapy treatments to see if they are a better option.
Urothelial CancerNetherlands - Ongoing, recruitingTherapeutic confirmatory (Phase III)
H8H-MC-LAHV: Pediatric Options for Migraine Relief: A Randomized, Double-Blind, Placebo-Controlled Study of Lasmiditan for Acute Treatment of Migraine: PIONEER-PEDS1
This study called PIONEER-PEDS1 is looking at a new medicine called lasmiditan to help children and teenagers with migraine headaches. It compares different doses of lasmiditan with a dummy pill (placebo) to see how well it works to stop pain. This is a big final stage study.
MigraineNetherlands - Ongoing, recruitingHuman Pharmacology (Phase I)- Other
A single-dose, open-label study of TX000045 in patients with CpcPH or IpcPH and HFpEF.
This study is looking at a new medicine called TX000045 for people with certain types of high blood pressure in the lungs, especially if they also have heart failure. It's an early-stage study to see how the medicine works in the body.
Combined postcapillary and precapillary pulmonary hypertension / Isolated postcapillary pulmonary hypertensionNetherlands - Ongoing, recruitingPhase III and phase IV (Integrated)
Efficacy of Diltiazem to improve coronary microvascular dysfunction: a randomized clinical trial
This study called 'Diltiazem for Angina' is testing if a medicine called diltiazem can help people with angina by improving how their tiny heart blood vessels work. They want to see if it fixes at least one problem with these vessels without causing new ones.
AnginaNetherlands - RecruitingPHASE3
An Open Label Extension (OLE) Study (Following Completion of CTQJ230A12301) to Evaluate Long-term Safety and Tolerability of Pelacarsen (TQJ230)
This study offers ongoing treatment with pelacarsen for people who have finished a previous trial for heart disease. It aims to check the long-term safety of the medicine, which helps lower a type of cholesterol called Lp(a).
Cardiovascular Disease and Lipoprotein(a)Netherlands - Ongoing, recruitingTherapeutic confirmatory (Phase III)
CA209-8HW A Phase 3 Randomized Clinical Trial of Nivolumab alone, Nivolumab in Combination with Ipilimumab, or Investigator’s Choice Chemotherapy in Participants with Microsatellite Instability High (MSI-H) or Mismatch Repair Deficient (dMMR) Metastatic Colorectal Cancer
This study looks at new drug combinations for advanced bowel cancer that has specific genetic changes (MSI-H or dMMR). It compares them to standard chemotherapy to see which is better at stopping the cancer from growing.
Microsatellite Instability High (MSI-H) or Mismatch Repair DeficientMetastatic Colorectal Cancer (dMMR)Netherlands - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A Double-blind, Randomized, Placebo-controlled, Multicenter Study to Evaluate the Impact of Evolocumab on Major Cardiovascular Events in Patients at High Cardiovascular Risk Without Prior Myocardial Infarction or Stroke
This study looks at a new medicine called Evolocumab to see if it can lower the chance of serious heart problems like heart attacks or strokes in people at high risk who haven't had them before. It compares Evolocumab to a dummy medicine.
Adults at high risk of cardiovascular events without prior MI or stroke.Netherlands - Ongoing, recruitingHuman Pharmacology (Phase I)- First administration to humans
A phase I dose finding study of oral TNO155 in adult patients with advanced solid tumors
This study is looking into a new medication called TNO155 for adults who have advanced solid cancers that have spread. It’s a very early-stage study to find the best dose and check its safety. We want to see how the body handles this new medicine.
Advanced solid tumorsNetherlands - Ongoing, recruitingPhase I and Phase II (Integrated)- Other
A Phase 1b/2 Open-Label Trial of Tisotumab Vedotin (HuMax®-TF-ADC) Monotherapy and in Combination with Other Agents in Subjects with Recurrent or Stage IVB Cervical Cancer
This study is testing a new medicine called tisotumab vedotin for advanced cervical cancer that has come back or spread. It looks at how safe the medicine is by itself and when given with other common cancer drugs, and how well it works to shrink tumours.
Recurrent or stage IVB cervical cancerNetherlands - Ongoing, recruitingHuman Pharmacology (Phase I)- First administration to humans
Safety, pharmacokinetics, and preliminary efficacy of BYON4413 in acute myeloid leukemia and myelodysplastic neoplasms.
This study is testing a new medicine called BYON4413 for people in the UK with acute myeloid leukaemia (AML) or myelodysplastic syndromes (MDS) that haven't responded to previous treatments. It's an early-stage study looking at safety and how the medicine works in the body.
Patients with relapsed/refractory acute myeloid leukemia or myelodysplastic neoplasmsNetherlands - Ongoing, recruitingTherapeutic use (Phase IV)
Optimization of Albuminuria-Lowering Therapies for Individual Patients with Type 2 Diabetes Using Empagliflozin and Finerenone in a Pilot Remote Clinical Trial
This study looks at how well different diabetes medicines work together to protect kidneys in people with type 2 diabetes. It also checks how easy it is for people to take part in a study from home using digital tools, like giving urine samples and checking blood pressure.
Albuminuria, Type 2 diabetesNetherlands - Active not recruitingPHASE3
Open-label, Long-term Safety Study of Secukinumab in Polymyalgia Rheumatica (PMR)
This study is looking at the long-term safety of a treatment called secukinumab for people with Polymyalgia Rheumatica (PMR). It's for those who have already been in a previous study for secukinumab and had their PMR symptoms come back after stopping treatment.
Polymyalgia RheumaticaNetherlands - RecruitingPhase III
Study evaluating the efficacy of icotrokinra in ulcerative colitis
This study is testing a new medicine, icotrokinra, for ulcerative colitis (UC) in adults and teenagers. It aims to see if icotrokinra can help reduce UC symptoms and keep the disease under control by targeting inflammation.
Ulcerative colitisNetherlands - Ongoing, recruitingHuman Pharmacology (Phase I)- Other
A Randomized, Double-Blind (Sponsor-Unblinded), Placebo-Controlled, Single And Multiple Ascending Dose Study To Evaluate Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Bioavailability and Food Effect (Open-Label) of Sage-319 in Healthy Adult Participants.
This study is looking at a new medicine called Sage-319 in healthy adults. It aims to check if the medicine is safe, how the body handles it, and if it works as expected. We'll also see how food affects it. This is an early stage of testing.
Disorders characterized by a deficit in GABAergic signaling and cerebellar circuitry.Netherlands - Active not recruitingPHASE3
Endocrine Therapy With or Without Abemaciclib (LY2835219) Following Surgery in Participants With Breast Cancer
This study looks at a drug called abemaciclib, given with standard hormone therapy after surgery for a type of breast cancer. We want to see if it's safe and helps stop the cancer coming back in people with certain high-risk breast cancers.
Breast CancerNetherlands - Active not recruitingPHASE3
Datopotamab Deruxtecan (Dato-DXd) and Pembrolizumab With or Without Platinum Chemotherapy in 1L Non-Small Cell Lung Cancer (TROPION-Lung07)
This study looks at new drug combinations for advanced lung cancer. It compares a new drug (Datopotamab Deruxtecan) with an existing treatment (Pembrolizumab) and chemotherapy, to see if the new combinations are safer and work better.
Metastatic Non Small Cell Lung CancerNetherlands - Ongoing, recruitingTherapeutic exploratory (Phase II)
A Phase 2, Open-Label, Multi-Center, Randomized Study of TAR-200 in Combination with Cetrelimab and Cetrelimab Alone in Participants with Muscle-Invasive Urothelial Carcinoma of the Bladder who are Scheduled for Radical Cystectomy and are Ineligible for or Refusing Platinum-Based Neoadjuvant Chemotherapy
This study is testing new treatments for bladder cancer that has grown into the muscle. It looks at a new drug delivery system, TAR-200, with or without another drug called cetrelimab, before surgery. The aim is to see how well these treatments shrink the cancer or make it disappear.
Muscle-Invasive Urothelial Carcinoma of the BladderNetherlands - Ongoing, recruitingTherapeutic exploratory (Phase II)
A Phase 2, Two-Part, Multiple-Ascending-Dose Study of SRP-5051 for Dose Determination, then Dose Expansion, in Patients with Duchenne Muscular Dystrophy Amenable to Exon 51-Skipping Treatment
This study is testing a new medicine called VESLETEPLIRSEN for Duchenne muscular dystrophy in males over 18. It aims to find the best dose and check how safe it is, while also measuring its effect on a muscle protein called dystrophin.
Duchenne Muscular DystrophyNetherlands - Ongoing, recruitingTherapeutic exploratory (Phase II)
A Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel Design, Prospective, 52-Week, Phase 2 Clinical Study to Evaluate the Safety and Efficacy of GV1001 Administered Subcutaneously for the Treatment of Mild to Moderate Alzheimer's Disease
This study is testing a new medicine, GV1001, for people with mild to moderate Alzheimer's disease. We want to see if it's safe and if it can help improve memory and thinking over 52 weeks. Half the participants will receive the medicine, and half will receive a dummy injection.
Alzheimer's DiseaseNetherlands - Active not recruitingPHASE2
Selinexor (KPT-330) in Patients With Relapsed/Refractory Diffuse Large B-Cell Lymphoma (DLBCL)
This study is testing a new medicine, Selinexor, for people in the UK with a type of cancer called Diffuse Large B-cell Lymphoma (DLBCL) that has come back or not responded to previous treatments. It aims to see if Selinexor can help when other options haven't worked.
Diffuse Large B-cell LymphomaNetherlands - Ongoing, recruitingHuman Pharmacology (Phase I)- Other
A Randomized, double-blind, placebo-controlled, three-way cross-over study to assess the pharmacodynamic effects of an authorised and a new compound on nerve excitability threshold tracking in healthy male subjects.
This study is looking at how a new medicine, compared to an existing one and a dummy pill, affects nerve signals in healthy men. It aims to see if the new medicine could help with nerve pain in the future by understanding how it works in the body.
neuropathic painNetherlands - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A Multicenter, Randomized, Double-blind, Placebo-controlled Phase 3 Study of the Bruton’s Tyrosine Kinase (BTK) Inhibitor, Ibrutinib, in Combination with Rituximab versus Placebo in Combination with Rituximab in Treatment Naïve Subjects with Follicular Lymphoma
This study is looking at a new way to treat follicular lymphoma, a type of cancer. It compares a drug called Ibrutinib with a standard treatment, Rituximab. The aim is to see if adding Ibrutinib helps people live longer without their cancer getting worse.
Follicular LymphomaNetherlands - Ongoing, recruitingPhase III and phase IV (Integrated)
The bilateral sentinel node detection rate of fluorescent indocyanine green compared to 99mTc and blue dye in the sentinel node procedure in stage I-IIA cervical cancer
This study compares different ways to find 'sentinel lymph nodes' in women with early cervical cancer. These nodes are the first ones cancer might spread to. We're looking at a new dye called indocyanine green against older methods to see which is best at finding these important nodes on both sides of the body.
cervical cancer stage I-IIANetherlands - Ongoing, recruitingTherapeutic exploratory (Phase II)
A Phase 2, Randomized, Double-Blind, Placebo-Controlled, Dose Finding Study to Assess the Safety and Effectiveness of Tovinontrine in Patients With Chronic Heart Failure With Reduced Ejection Fraction
This study is testing a new medicine, Tovinontrine, for people with a type of heart failure where the heart struggles to pump blood effectively. It aims to see if different doses are safe and if the medicine helps improve heart health over 12 weeks.
Heart failure (HF) with reduced ejection fraction (HFrEF)Netherlands