Latest studies
- CompletedPhase III
HYPATIA: A prospective randomised controlled trial of hydroxychloroquine to improve pregnancy outcome in women with antiphospholipid antibodies
This trial looks at whether a tablet called hydroxychloroquine can help women with antiphospholipid antibodies have safer, healthier pregnancies. These antibodies increase the risk of blood clots and miscarriage. Women planning a pregnancy will take either the study medicine or a dummy tablet alongside their usual care until giving birth.
Women with persistent antiphospholipid antibodies who are planning pregnancyNetherlands - RecruitingPhase II/III
A trial assessing preoperative chemotherapy in patients with locally advanced but operable colon cancer
The FOxTROT trials look at whether giving bowel cancer treatments, such as chemotherapy or immunotherapy, before surgery helps shrink tumours and stops cancer returning. The study tests this approach in people of different ages, fitness levels, and tumour types to see who benefits the most.
Locally advanced but operable colon cancerNetherlands - RecruitingPhase IV
Are RNA signatures (biomarkers) in the tissue which surrounds the joints (synovial tissue) from patients with rheumatoid arthritis predictive of response to drug treatments?
This UK clinical study tests whether examining a small sample of joint tissue can help doctors pick the best medicine for rheumatoid arthritis. Adults with active arthritis will have a minor joint biopsy and receive one of two standard biologic medicines to see if tissue tests improve treatment success.
Rheumatoid arthritisNetherlands - CompletedPhase III
A study comparing talquetamab in combination with daratumumab or in combination with daratumumab and pomalidomide versus daratumumab in combination with pomalidomide and dexamethasone in participants with multiple myeloma that returns after treatment or is resistant to treatment
This study tests whether a new medicine called talquetamab, given alongside other cancer drugs, helps people with multiple myeloma that has returned or stopped responding to past treatments. Researchers want to see if these new combinations keep the cancer under control for longer than the current standard treatment.
Relapsed or refractory multiple myelomaNetherlands - RecruitingPhase I/II
A trial looking at different treatments for neuroblastoma which has come back after initial therapy
The BEACON2 trial is testing new combinations of cancer medicines for children and young people whose neuroblastoma has returned or worsened after initial treatment. The goal is to find out which drug combinations are safest and work best to control the disease and improve future care.
Relapsed NeuroblastomaNetherlands - RecruitingPhase III
A study of the anti-inflammatory medication colchicine for people with blocked arteries of the legs
Peripheral arterial disease (PAD) causes narrowed blood vessels in the legs. This clinical trial is testing whether an anti-inflammatory tablet called colchicine can help protect arteries and reduce the risk of serious complications, such as heart attacks, strokes, and leg amputations, in people living with PAD.
Peripheral artery diseaseNetherlands - CompletedPhase III
A randomized, open-label phase 3 study of amivantamab + FOLFIRI versus cetuximab/bevacizumab + FOLFIRI in participants with KRAS/NRAS and BRAF wildtype recurrent, unresectable or metastatic colorectal cancer who have received prior chemotherapy
This clinical trial is testing a new targeted drug, amivantamab, combined with chemotherapy for people with advanced bowel cancer. Researchers want to see if this combination works better at slowing cancer growth and helping people live longer than current standard targeted treatments after their first chemotherapy has stopped working.
Recurrent, unresectable or metastatic colorectal cancerNetherlands - RecruitingPhase IV
The 3TR-PARTNER-RA study: Are RNA signatures (biomarkers) in the tissue which surrounds the joints (synovial tissue) from patients with early Rheumatoid Arthritis (symptoms <12 months) predictive of response to biologic drug treatments?
This UK clinical study investigates whether testing a tiny sample of joint tissue can help doctors choose the most effective treatment for early rheumatoid arthritis. Researchers want to see if specific biological markers can predict whether a modern medicine called abatacept works well for newly diagnosed patients.
Rheumatoid arthritisNetherlands - CompletedPhase II
Testing new medicine for adults with Cystic Fibrosis who do not have access to the currently available CFTR-modulating drugs due to genetic mutations
This clinical trial tests a new three-in-one medicine for adults with cystic fibrosis who have rare genetic mutations. These patients cannot access currently approved treatments. Researchers are checking whether this daily combination of capsules can safely improve lung health after promising results in laboratory tests using patient cell samples.
Treatment of Cystic Fibrosis (CF) in patients with CFTR mutations who are responders in the organoid assayNetherlands - RecruitingPHASE3
A Study of ZL-1310 Versus Investigator's Choice of Therapy in Participants With Relapsed Small Cell Lung Cancer (DLLEVATE)
This study, called DLLEVATE, is looking at a new treatment, ZL-1310, for people with small cell lung cancer that has come back. It compares ZL-1310 to other standard treatments to see if it's safe and works well. You might be eligible if you're over 18 and have had previous treatments.
Small-cell Lung CancerNetherlands - RecruitingPHASE3
A Clinical Study to Evaluate the Effects of Enicepatide (RO7795068) in Participants With Obesity or Overweight Without Type 2 Diabetes
This study is testing a new medicine, enicepatide, for people who are overweight or have obesity but do not have type 2 diabetes. It aims to see if the medicine helps with weight loss and if it's safe compared to a dummy medicine.
Obesity or OverweightNetherlands - Completed
Multi-centre European study of major infectious disease syndromes (MERMAIDS) – Acute respiratory infections
This study looks at acute chest and throat infections to understand why some people get much sicker than others. Researchers from the University of Oxford are collecting blood and swab samples from adults treated at GP surgeries or hospitals to help develop better, more personalised treatments for future infections.
Acute respiratory infectionsNetherlands - Completed
Vitamin D and lifestyle Intervention for gestational diabetes mellitus (GDM) prevention
This study looks at ways to prevent gestational diabetes, which is high blood sugar during pregnancy. Researchers are testing whether vitamin D supplements, healthy eating advice, regular physical activity, or combinations of these can help pregnant women with a higher body mass index stay healthy throughout their pregnancy.
Gestational diabetesNetherlands - CompletedPhase II
A Phase II study to understand the safety and effects of inhaled SNG001, the study medication, in patients who are mechanically ventilated due to a respiratory viral infection in the lungs
This study tests an inhaled medicine called SNG001 for people in intensive care with severe chest infections caused by viruses like flu or COVID-19. Researchers want to see if breathing in this natural virus-fighting protein helps patients recover faster and spend less time on a breathing machine.
Respiratory viral infectionsNetherlands - Recruiting
Quality of Pediatric Resuscitation in a Multicenter Collaborative
This study looks at how the quality of CPR given to children during a cardiac arrest affects their recovery. Researchers are observing children in hospitals to see if better CPR techniques and after-care improve survival and brain function.
Cardiac ArrestCardiopulmonary ArrestNetherlands - RecruitingPHASE2
Belzutifan/MK-6482 for the Treatment of Advanced Pheochromocytoma/Paraganglioma (PPGL), Pancreatic Neuroendocrine Tumor (pNET), Von Hippel-Lindau (VHL) Disease-Associated Tumors, Advanced Gastrointestinal Stromal Tumor (wt GIST), or Solid Tumors With HIF-2α Related Genetic Alterations (MK-6482-015)
This study is testing a new medicine called belzutifan for certain types of advanced cancers, including rare adrenal gland, gut, and kidney cancers. We want to see how well it works and if it's safe for people aged 12 and over.
Pheochromocytoma/ParagangliomaPancreatic Neuroendocrine TumorVon Hippel-Lindau DiseaseAdvanced Gastrointestinal Stromal TumorNetherlands - RecruitingPHASE3
An Open-label Study Comparing Lutetium (177Lu) Vipivotide Tetraxetan Versus Observation in PSMA Positive OMPC.
This study looks at a new treatment called AAA617 for men with early-stage prostate cancer that has spread a little (oligometastatic). It compares AAA617 to careful watching, to see if it can stop the cancer from growing and help men live better for longer.
Oligometastatic Prostate Cancer (OMPC)Netherlands - RecruitingPhase III
Phase 3, randomised, double-blind, placebo- controlled, 3-arm study to investigate the safety and efficacy of efimosfermin alfa in participants with biopsy-confirmed F2- or F3-stage metabolic dysfunction-associated steatohepatitis (MASH) (ZENITH-1)
This clinical trial is testing a new injection called efimosfermin alfa for people with metabolic dysfunction-associated steatohepatitis (MASH), an inflamed fatty liver condition. Researchers want to see if monthly injections over four years can safely reduce liver fat, ease inflammation, and improve liver scarring compared to a dummy treatment.
Medical condition: Metabolic Dysfunction-Associated Steatohepatitis (MASH) Medical condition in lay language: Metabolic Fatty Liver Inflamation Therapeutic areas: Diseases [C] - Nutritional and Metabolic Diseases [C18]Netherlands - Completed
Evaluation of a dermocosmetic regimen for acne-prone skin in volunteers with mild, moderate or severe skin conditions
Acne is a common skin condition that affects confidence and well-being. This study tests whether a daily skincare routine using Eucerin products helps clear mild to severe spots. Researchers want to see how well these creams work over a year in people aged 12 to 50 across the UK and worldwide.
Subjects with acne-prone skin aged 12-50 years with Investigator's Global Assessment (IGA) grades 2-4, evaluating treatment of mild to severe acne vulgaris.Netherlands - RecruitingPhase III
A study of JNJ-78934804 in participants with moderately to severely active Crohn's disease
This clinical trial is testing a new combination medicine, JNJ-78934804, for moderate to severe Crohn’s disease. It combines two drugs into one injection to target gut inflammation. Researchers want to see if this two-in-one approach works better than a single medicine for people whose previous treatments have stopped working.
Crohn’s diseaseNetherlands - RecruitingHuman Pharmacology (Phase I)- First administration to humans
A PHASE 1 TRIAL TO EVALUATE THE SAFETY, TOLERABILITY, PK, AND PD of AX-0810 IN HEALTHY PARTICIPANTS
This early-stage clinical trial tests a new medicine called AX-0810 in healthy adult volunteers. Researchers want to see if the drug is safe, well-tolerated, and how the human body processes it. The goal is to develop future treatments for people living with serious liver conditions.
Cholestatic liver diseaseNetherlands - RecruitingPhase I
Deferred registration - ICON Clinical (UK) Limited/Newcastle Upon Tyne Hospitals NHS Foundation Trust Code: BP45361
This is an early-stage Phase 1 clinical trial taking place in the UK with Newcastle Upon Tyne Hospitals NHS Foundation Trust. Full details about the study are temporarily withheld under official UK research rules. The study plans to include men and women aged between 40 and 75 years.
The Health Research Authority has approved a deferral. Full details will be added to the trial record on or before the deferral expiry date.Netherlands - RecruitingHuman Pharmacology (Phase I)- Other
A Phase I, open-label, non-randomized study to assess the absorption, distribution, metabolism and excretion (ADME) and pharmacokinetics of LTP001 following a single oral dose of [14C]LTP001 in healthy male participants
This early-stage study looks at how a new medicine, called LTP001, moves through the human body. Healthy adult men will take a single dose containing a safe, tiny tracking marker. Researchers will collect blood and urine samples to see how the body absorbs, breaks down, and removes the drug.
Healthy volunteersNetherlands - RecruitingTherapeutic exploratory (Phase II)
A Phase 2 Study to Investigate the Safety and Efficacy of Petosemtamab in Adults with Non-Small Cell Lung Cancer in Combination with Pembrolizumab.
This clinical trial is testing a new drug called petosemtamab combined with an established immunotherapy called pembrolizumab (Keytruda). It aims to find out if this combination is safe and effective at shrinking tumours in adults diagnosed with non-small cell lung cancer.
Non Small Cell Lung CancerNetherlands - CompletedPhase III
Prevention of complications to Improve outcome in elderly patients with acute stroke - A randomised clinical trial
This clinical trial looks at whether giving common medicines right after a stroke can prevent complications like fever, sickness, and chest infections before they start. Researchers want to see if treating older adults early with paracetamol, antibiotics, or anti-sickness medicine helps them recover better and stay independent.
Acute ischaemic stroke or intracerebral haemorrhageNetherlands - AuthorisedTherapeutic exploratory (Phase II)
RADICAL-IO: thRee cycles of immunotherApy without raDical therapy In mediCALly InOperable stage I non-small cell lung cancer
This study is looking at a treatment for people with early-stage (Stage I) non-small cell lung cancer who cannot have surgery. Researchers want to see if three doses of an immunotherapy drug called cemiplimab can safely keep the cancer under control without needing major operations or intensive radiotherapy.
Stage I non-small cell lung cancerNetherlands - AuthorisedTherapeutic use (Phase IV)
Sample Collection Study to Monitor the Risk of Malignancy Due to Insertional Oncogenesis in Early Onset Patients with Metachromatic Leukodystrophy Treated with OTL-200 in the Clinical Development Program
This study monitors the long-term safety of a gene therapy called Libmeldy in adults treated for metachromatic leukodystrophy (MLD). Doctors collect blood and tissue samples to check for very rare risks, such as abnormal cell growth or cancer, helping to ensure the treatment remains safe over time.
Metachromatic leukodystrophyNetherlands - Completed
Implementing the concepts of mindfulness and community engagement to self-manage chronic diseases in four European cities
This study looks at a new community programme called SEFAC. It aims to help adults with long-term health issues, such as type 2 diabetes or heart disease. By combining mindfulness workshops, local community support, and a mobile app, it helps people build confidence and manage their health better day to day.
Citizens at risk of or has coronary heart disease and/or type 2 diabetes mellitusNetherlands - RecruitingHuman Pharmacology (Phase I)- Other
A study in healthy men to test how BI 1815368 is processed in the body
This clinical trial is testing a new medicine called BI 1815368 in healthy men aged 18 and older. Researchers want to see how the human body absorbs, breaks down, and removes the drug. It is an early safety study to help scientists develop future treatments.
Healthy volunteers trialNetherlands - AuthorisedTherapeutic confirmatory (Phase III)
AugmENtation witH cAnnabidiol iN first episode psyChosis: a doublE blind randomised controlled trial (STEP-ENHANCE Trial)
This clinical trial looks at whether cannabidiol (CBD) can help people experiencing psychosis for the first time. Participants take either CBD liquid or a harmless dummy medicine alongside their standard care for six weeks. Researchers want to see if adding CBD helps reduce symptoms and improves overall recovery.
First Episode Psychosis (FEP)Netherlands - AuthorisedHuman Pharmacology (Phase I)- Other
Network pharmacology-based personalized drug repurposing in thyroid carcinoma: a pilot feasibility trial
This early-stage clinical trial looks at a new way to treat advanced thyroid cancer. Researchers are testing whether existing medicines—originally developed for other health conditions—can be matched to a person's individual cancer cells. The goal is to see if this personalised approach is practical, safe, and helpful for patients.
Advanced thyroid cancerNetherlands - AuthorisedTherapeutic exploratory (Phase II)
A Phase 2 Randomized, Double-blind, Placebo-Controlled Study to Assess the Safety and Efficacy of MTX-474 in the Treatment of Participants with Diffuse Cutaneous Systemic Sclerosis (dcSSc)
This study tests a new medicine called MTX-474 for adults with diffuse cutaneous systemic sclerosis. This rare condition causes skin thickening and hardening across the body. Researchers want to see if MTX-474 is safe and if it helps soften the skin over 24 weeks compared to a dummy treatment.
Diffuse Cutaneous Systemic Sclerosis (dcSSc)Netherlands - AuthorisedTherapeutic exploratory (Phase II)
Giving Upfront Anti-p40 to Reduce toxicity from Dual Immune Checkpoint Inhibition in MESOthelioma
This clinical trial is testing whether a medicine called Stelara can reduce severe side effects in people receiving two immunotherapy drugs for pleural mesothelioma. Pleural mesothelioma is cancer of the chest lining. Researchers want to see if adding Stelara makes treatment safer without stopping the cancer therapy from working.
Pleural mesotheliomaNetherlands - AuthorisedTherapeutic exploratory (Phase II)
SUNCET: Low sodium oxybate Use for Nocturnal Cluster headache: safety, Efficacy and Tolerability of XYWAV - a Phase 2 Randomized, Double-Blind, Placebo-Controlled, bi-center Study
This study looks at whether a liquid medicine called low sodium oxybate can reduce severe nighttime cluster headaches. Researchers are comparing the medicine against a dummy treatment (placebo) over four weeks to see if it helps adults have fewer painful attacks while sleeping.
Cluster headacheNetherlands - AuthorisedPhase III and phase IV (Integrated)
4TAZPower: A Phase 3b/4, Randomized, Double-Blind, Parallel-Group, Placebo-Controlled, Trial to Evaluate the Efficacy and Safety of Daily Subcutaneous Injections of Elamipretide in Patients with Genetically Confirmed Barth Syndrome
This study tests whether a medicine called elamipretide can help men with Barth syndrome. Researchers want to see if daily injections under the skin can improve physical strength, walking ability, and day-to-day energy over 72 weeks, compared to an inactive dummy injection known as a placebo.
Barth SyndromeNetherlands - AuthorisedHuman Pharmacology (Phase I)- First administration to humans
A dose escalation and expansion study of XB010 as a single agent and combination therapy in subjects with locally advanced or metastatic solid tumors
This early-stage clinical trial is testing a new drug called XB010 in adults with advanced solid tumours. Researchers want to find out if the treatment is safe, discover the best dose, and see how well it works either on its own or alongside other cancer medicines.
Locally Advanced or Metastatic Solid TumorsNetherlands - AuthorisedTherapeutic exploratory (Phase II)
A Phase 2, randomized, double-blind, placebo-controlled trial to evaluate the efficacy, safety, and tolerability of CRD-4730 in patients with heart failure with reduced ejection fraction (HFREF) (CALIBRATE-HF)
This study is testing a new tablet called CRD-4730 for adults with heart failure. Researchers want to see if the medicine can help the heart pump blood better, ease everyday symptoms, and improve quality of life. Participants will take either the study drug or a dummy pill for 24 weeks.
heart failureNetherlands - AuthorisedHuman Pharmacology (Phase I)- Other
A Phase I Study using Oncolytic AdenoVirus Immunotherapy with Repeat Administrations in Recurrent GliOblastoma (VIRAGO)
The VIRAGO study is an early-stage clinical trial for adults whose glioblastoma (a type of brain tumour) has returned. It tests a specially altered virus designed to attack tumour cells and alert the immune system. The main goal is to check whether repeated doses of this treatment are safe.
Recurrent GlioblastomaNetherlands - AuthorisedTherapeutic exploratory (Phase II)
MDMA-assisted therapy for adolescents with treatment-resistant PTSD
This study is testing whether a medicine called MDMA, combined with talking therapy, can help teenagers with severe post-traumatic stress disorder (PTSD). It is for young people whose PTSD has not improved with standard care. Researchers want to see if the treatment is safe, practical, and helpful.
Post-traumatic stress disorderNetherlands - AuthorisedPhase I and Phase II (Integrated)- Other
A Phase 1/2, Open-Label, Multicenter, Multi-cohort Study of S241656 as Monotherapy or in Combination with other Antileukemic Agents in participants with Selected Myeloid Malignancies
This clinical trial is testing a new tablet called S241656 for adults with certain blood and bone marrow cancers, including acute myeloid leukaemia. Doctors want to find out what dose is safe, how the body handles the medicine, and whether it can help control or shrink the cancer.
Patients with Acute Myeloid Leukemia (AML), Myelodysplastic Syndrome /Acute Myeloid Leukemia (MDS/AML) or Chronic Myelomonocytic Leukemia (CMML)Netherlands - AuthorisedTherapeutic exploratory (Phase II)
HOVON 168: Epcoritamab in Addition to R-Mini-CHOP Compared to R-Mini-CHOP in Elderly, Frail or Unfit Patients with Diffuse Large B-cell Lymphoma
This study looks at a new drug combination for older or frail adults with diffuse large B-cell lymphoma, a type of blood cancer. Researchers want to see if adding an antibody drug called epcoritamab to standard, gentler chemotherapy helps clear the cancer better and keeps people well for longer.
Diffuse large B-cell lymphoma (DLBCL)Netherlands - AuthorisedTherapeutic exploratory (Phase II)
In-vivo fluorescence molecular bronchoscopy of durvalumab-680LT in patients with unresectable stage III NSCLC after chemoradiation - PulmoPrint
This study tests a new imaging technique for people with stage 3 non-small cell lung cancer. Doctors give a glowing version of the immunotherapy drug durvalumab before a camera check of the lungs. The goal is to see if tumours light up clearly to help improve future treatment.
Unresectable stage III non-small cell lung cancerNetherlands - AuthorisedTherapeutic use (Phase IV)
Optimization of Dupilumab Maintenance Dosing in Eosinophilic Esophagitis: A Phase IV, Randomized, Controlled, Single-Blind, Non-Inferiority Study
This clinical trial looks at whether adults with eosinophilic oesophagitis (an allergic inflammation of the food pipe) can stay healthy on a lower or less frequent maintenance dose of dupilumab. The study aims to find out if reducing the dose keeps symptoms away safely over one year.
Eosinophilic EsophagitisNetherlands - AuthorisedTherapeutic exploratory (Phase II)
A phase 2, multicenter, randomized, double-blind, placebo-controlled study to assess the safety and efficacy of VQ-101 in participants with Parkinson’s disease carrying a heterozygous mutation of GBA1
This study tests a new medicine called VQ-101 for people with Parkinson’s disease linked to an altered gene called GBA1. Researchers want to see if this daily tablet slows down Parkinson’s symptoms and checks how safe it is compared with a dummy pill over 78 weeks.
GBA1-associated Parkinson’s diseaseNetherlands - AuthorisedTherapeutic exploratory (Phase II)
Randomized, Multicenter, Vehicle-Controlled, Double-Masked Study to Evaluate the Efficacy and Safety of Intranasal Cenegermin (Recombinant Human Nerve Growth Factor [rhNGF]) in Adult Participants with Non-Arteritic Anterior Ischemic Optic Neuropathy (NAION)
This clinical trial is testing a new nasal spray called cenegermin for adults with NAION, an eye condition causing sudden sight loss. Researchers want to see if this treatment helps repair damaged nerve cells and improves vision on an eye chart over a period of 24 weeks.
Non-Arteritic Anterior Ischemic Optic Neuropathy (NAION)Netherlands - AuthorisedTherapeutic exploratory (Phase II)
Attenuating Calciprotein particles Transformation and Inhibiting Vascular calcification Evolution by Sodium ThioSulphate trial
This study looks at a medicine called sodium thiosulphate for people having kidney dialysis. Researchers want to see if it can stop calcium from hardening inside blood vessels. Hardened arteries can cause heart problems, so finding a way to protect them could help people on dialysis stay healthier.
Vascular CalcificationNetherlands - AuthorisedTherapeutic confirmatory (Phase III)
A Long-Term Follow-Up Study of Subjects Completing the AU-011-301 (CoMpass) Trial of Bel-sar for Early Choroidal Melanoma (Indeterminate Lesions/Small Choroidal Melanomas)
This study is checking the long-term health of people who took part in an earlier trial for choroidal melanoma, a rare eye cancer. Researchers want to see how well a treatment called bel-sar protects vision and stops the tumour from growing or returning over several years.
Choroidal MelanomaNetherlands - AuthorisedTherapeutic exploratory (Phase II)
Randomized, double-blind, placebo-controlled, parallel-group, multicenter study to evaluate the safety and efficacy of 2 dose levels of the oral ghrelin receptor agonist AC01 over 12 weeks in patients with chronic advanced heart failure with reduced ejection fraction (HFrEF)
This study tests a new daily tablet called AC01 for people with long-term heart failure. Researchers want to see if this medicine can help the heart pump blood more effectively. Participants take either the real medicine or a dummy tablet for 12 weeks while doctors monitor their heart health.
chronic advanced heart failure with reduced ejection fraction (HFrEF)Netherlands - AuthorisedTherapeutic exploratory (Phase II)
A Phase 2b, randomized, placebo-controlled, observer-blind study in adults 60 years and older to evaluate the efficacy, safety, and immunogenicity of a bivalent protein vaccine candidate against Respiratory Syncytial Virus (RSV) and Human Metapneumovirus (HMPV)
This clinical trial is testing a new combination vaccine designed to protect older adults against two common chest viruses: RSV and HMPV. Researchers want to find out how well the vaccine prevents lung infections, how safe it is, and whether it helps the immune system build strong protective defences.
Infections and infestationsNetherlands - AuthorisedTherapeutic exploratory (Phase II)
A Multicenter, Open-Label, Phase II Study to Evaluate the Pharmacokinetics, Pharmacodynamics, and Safety of Subcutaneous Anifrolumab in Pediatric Participants 5 to < 18 Years of Age with Systemic Lupus Erythematosus.
This study looks at a medicine called anifrolumab (Saphnelo) in children and young people aged 5 to 17 with lupus. Researchers want to find out how the body handles the medicine given as an injection under the skin, and to check that it is safe for younger patients.
Systemic Lupus ErythematosusNetherlands