Latest studies
- Active not recruitingNA
COMBINE-INTERVENE: COMBINEd Ischemia and Vulnerable Plaque Percutaneous INTERVENtion to Reduce Cardiovascular Events
This study looks at a new way to treat blocked heart arteries. It compares two methods for deciding where to place stents: one using blood flow measurements, and another adding detailed artery scans. The aim is to see if combining these methods leads to better heart health.
Multivessel Coronary Artery DiseaseIschemiaVulnerable PlaqueCoronary Artery DiseaseNetherlands - Active not recruiting
Post-Market Registry of the GORE® VIABAHN® VBX Balloon Expandable Endoprosthesis Implanted in Peripheral Vessels
This study is a registry checking how well a medical device called the GORE VIABAHN VBX Stent Graft works in patients with circulation problems in their legs and other body parts. It aims to gather information on its safety and performance after it's been used in real-world settings.
Peripheral Vascular DiseasesNetherlands - Active not recruitingPHASE3
Assessment of Efficacy and Safety of Monalizumab Plus Cetuximab Compared to Placebo Plus Cetuximab in Recurrent or Metastatic Head and Neck Cancer
This study looks at a new drug, Monalizumab, combined with Cetuximab, for people with head and neck cancer that has come back or spread. It compares this combination to Cetuximab with a dummy drug (placebo) to see if it's safe and effective.
Squamous Cell Carcinoma of the Head and NeckNetherlands - RecruitingPHASE3
ADT +/- Darolutamide in de Novo Metastatic Prostate Cancer Patients With Vulnerable Functional Ability (PEACE6-Vulnerable)
This study looks at a new drug, darolutamide, along with standard hormone therapy for men with prostate cancer that has spread. It's for those who might not be able to have other treatments because of their general health.
Prostate Cancer MetastaticNetherlands - RecruitingPHASE1, PHASE2
A Study to Evaluate the Safety and Efficacy of BEAM-302 in Adult Patients With Alpha-1 Antitrypsin Deficiency (AATD)
This study is testing a new medicine, BEAM-302, for adults with Alpha-1 Antitrypsin Deficiency (AATD). It will check if the medicine is safe, how well it works, and find the best dose to help people with lung or liver problems caused by AATD.
Alpha 1-Antitrypsin DeficiencyNetherlands - Active not recruitingPHASE2
A Study of Relatlimab Plus Nivolumab in Combination With Chemotherapy vs. Nivolumab in Combination With Chemotherapy as First Line Treatment for Participants With Stage IV or Recurrent Non-small Cell Lung Cancer (NSCLC)
This study looks at new drug combinations to treat advanced lung cancer. It compares two different drug mixes, each including chemotherapy, to see which works best and is safest for people with Stage IV or recurrent non-small cell lung cancer.
Non-small Cell Lung CancerRecurrent Non-small Cell Lung CancerMetastatic Non-small Cell Lung CancerNetherlands - Active not recruitingPHASE3
CORE-OLE: A Study of Olezarsen (ISIS 678354) Administered Subcutaneously to Participants With Severe Hypertriglyceridemia (SHTG)
This study is looking at a new medicine called Olezarsen for people with very high triglyceride levels. It's an ongoing study for those who have already started the treatment in previous trials, checking its long-term safety and how well it's tolerated.
Severe HypertriglyceridemiaNetherlands - Active not recruitingPHASE3
A Trial to Assess Efficacy and Safety of Octreotide Subcutaneous Depot in Patients With GEP-NET
This study is testing a new medicine, CAM2029, for a type of cancer called GEP-NET. It compares CAM2029 to existing treatments, octreotide LAR and lanreotide ATG, to see if it's more effective and safe for advanced GEP-NET.
Gastro-enteropancreatic Neuroendocrine TumorNetherlands - Recruiting
The RESBIOP-study: Resection Versus Biopsy in High-grade Glioma Patients (ENCRAM 2202)
This study compares two ways to treat serious brain tumours (high-grade gliomas) in older patients or those who are not very active: having surgery to remove the tumour (resection) or taking a small tissue sample (biopsy). It looks at survival, quality of life, and if patients can then have other treatments.
GlioblastomaGlioblastoma, IDH-wildtypeGlioblastoma MultiformeGlioblastoma Multiforme, AdultNetherlands - Active not recruitingPHASE3
A Study To Assess Adverse Events and Effectiveness of Upadacitinib Oral Tablets in Adult and Adolescent Participants With Vitiligo
This study looks into a new tablet medicine, upadacitinib, for adults and teenagers with a type of vitiligo. Researchers want to see how safe it is and how well it helps improve skin when compared to a dummy pill or light therapy.
VitiligoNetherlands - RecruitingPHASE3
A Study of Tacabrutideg (BGB-16673) Compared to Investigator's Choice in Participants With Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma Previously Exposed to Both Bruton Tyrosine Kinase (BTK) and B-cell Leukemia/Lymphoma 2 Protein (BCL2) Inhibitors
This study looks at a new drug, BGB-16673, for people with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL). It compares BGB-16673 to existing treatments in patients whose cancer has come back after trying two other types of drugs.
CLLChronic Lymphocytic LeukemiaNetherlands - RecruitingPHASE3
A Clinical Study of the Anti-cancer Effects of an Investigational Therapy or Chemotherapy in Patients With Recurring Uterine Cancer
This study is looking at a new treatment (BNT323) for women with advanced womb cancer that has come back. It compares BNT323 to standard chemotherapy to see if it works better at shrinking tumours and keeping the cancer from growing.
Endometrial CancerNetherlands - RecruitingNA
TUBectomy With Delayed Oophorectomy in High Risk Women to Assess the Safety of Prevention
This study looks at a new way to lower ovarian cancer risk in women with certain gene changes. Instead of removing both ovaries and fallopian tubes at once, it explores removing only the fallopian tubes first, and the ovaries later, to delay menopause and its effects. We want to see if this new approach is safe and effective.
BRCA1 Gene MutationBRCA2 Gene MutationRAD51C Gene MutationRAD51D Gene MutationNetherlands - RecruitingPHASE3
A Study to Evaluate the Efficacy and Safety of DNTH103 in Adults With Chronic Inflammatory Demyelinating Polyneuropathy (CAPTIVATE)
This study looks at a new drug, claseprubart, for Chronic Inflammatory Demyelinating Polyneuropathy (CIDP). It aims to see if the drug helps people with CIDP and if it's safe. Some participants will receive the drug, and others a dummy treatment.
Chronic Inflammatory Demyelinating PolyneuropathyNetherlands - RecruitingPHASE4
Anticoagulation for Stroke Prevention In Patients With Recent Episodes of Atrial Fibrillation Occurring Transiently With Stress
This study looks at whether blood-thinning medicines (anticoagulants) can prevent strokes and other heart-related problems in people who have had temporary episodes of an irregular heartbeat called atrial fibrillation (AF) during stressful times like surgery or serious illness.
StrokeAtrial FibrillationNetherlands - Active not recruitingPHASE3
Study of Talazoparib With Enzalutamide in Men With DDR Gene Mutated mCSPC
This study is for men with a certain type of advanced prostate cancer (mCSPC) that has spread and has specific gene changes. It compares a new drug called talazoparib, given with standard treatment enzalutamide, against enzalutamide alone, to see if it's safe and effective.
Prostate CancerNetherlands - Active not recruitingPHASE3
A Study to Compare the Efficacy and Safety of Luspatercept (ACE-536) Versus Epoetin Alfa for the Treatment of Anemia Due to IPSS-R Very Low, Low, or Intermediate Risk Myelodysplastic Syndromes (MDS) Participants Who Require Red Blood Cell Transfusions and Are ESA Naïve
This study compares a new medicine, luspatercept, with a standard one, epoetin alfa, for people with a type of blood disorder called myelodysplastic syndromes (MDS). It aims to see if luspatercept can reduce the need for blood transfusions.
Myelodysplastic SyndromesNetherlands - RecruitingPHASE3
A Study to Investigate the Efficacy and Safety of Anifrolumab Administered as Subcutaneous Injection and Added to Standard of Care Compared With Placebo Added to Standard of Care in Adult Participants With Idiopathic Inflammatory Myopathies (Polymyositis and Dermatomyositis)
This study looks at a new drug called anifrolumab for adults with muscle conditions like polymyositis or dermatomyositis. Researchers want to see if it's safe and helps improve symptoms when added to their usual treatment.
Polymyositis, DermatomyositisNetherlands - Active not recruiting
Real World Data Collection in Subjects Treated With the FARAPULSE Pulsed Field Ablation System
This study looks at how safe and effective a new treatment called FARAPULSE is for atrial fibrillation. It collects real-world information about people treated with this system in hospitals to see how well it works and if it improves their quality of life.
Atrial FibrillationNetherlands - RecruitingPHASE2
A Study to Learn More About the Study Medicine Called Inotuzumab Ozogamicin (InO) in Children (1 to <18 Years) With First Relapse ALL
This study looks at a new medicine, Inotuzumab Ozogamicin (InO), for children aged 1 to 17 with a type of blood cancer called Acute Lymphoblastic Leukaemia (ALL) that has come back. It compares InO to a standard treatment to see which works better and is safer.
ACUTE LYMPHOBLASTIC LEUKEMIANetherlands - RecruitingNA
FMRI-neurofeedback in Parkinson's Disease
This study explores a new way to help people with Parkinson's by training their brains to improve movement. It uses a special scan (fMRI) to give real-time feedback, hoping to offer a non-drug, non-surgical option for managing symptoms.
Parkinson DiseaseNetherlands - Active not recruitingPHASE3
Durvalumab+ Gemcitabine/Cisplatin (Neoadjuvant Treatment) and Durvalumab (Adjuvant Treatment) in Patients With MIBC
This study looks at a new way to treat muscle-invasive bladder cancer using a drug called Durvalumab alongside standard chemotherapy. It aims to see if this combination, given before and after surgery, can improve treatment outcomes and safety for patients.
Muscle Invasive Bladder CancerNetherlands - Enrolling by invitationNA
Primary Posterior Tracheopexy Prevents Tracheal Collapse
This study looks at a new surgery during a baby's first operation for a birth defect called oesophageal atresia. We want to see if adding this small procedure helps prevent their windpipe from collapsing, which can cause breathing problems.
Oesophageal Atresia With Tracheo-Oesophageal FistulaTracheomalaciaOesophageal AtresiaNetherlands - RecruitingPHASE2
Evaluation of the Safety and Efficacy of Treatment w/High Dose Melphalan Given Directly Into the Liver Followed by Treatment w/Approved Cancer Treatment or Approved Cancer Treatment Alone in Patients w/ Metastatic Colorectal Cancer w/Liver Dominant Disease
This study looks at a new way to treat bowel cancer that has spread to the liver. Half of the patients will get a special liver treatment plus standard drugs, and the other half will get standard drugs only. It aims to see if the liver treatment is safe and effective.
Refractory Metastatic Colorectal CancerNetherlands - RecruitingPHASE1
A Clinical Study of the Safety and Effectiveness of an Investigational Cell Therapy Given With and Without an Investigational RNA-based Vaccine in Patients With Organ Tumors
This study is testing a new cell therapy and a vaccine for people with advanced solid tumors. It aims to find out how safe they are and if they can help shrink tumors that have a specific marker called CLDN6.
Solid TumorNetherlands - RecruitingPHASE2, PHASE3
An International Clinical Program for the Diagnosis and Treatment of Children With Ependymoma
This study aims to improve treatment and understanding of childhood ependymoma. It involves different treatment approaches, including chemotherapy and radiotherapy, for children and young adults up to 22 years old. The goal is to find better ways to help these patients.
Childhood EpendymomaNetherlands - Active not recruitingNA
Pregnancy Outcome and Safety of Interrupting Therapy for Women With Endocrine Responsive Breast Cancer
This study aims to understand if temporarily stopping hormone therapy for early breast cancer to allow for pregnancy is safe. It will also look at fertility and emotional well-being for young women.
Early Breast CancerNetherlands - Active not recruitingPHASE2
A Study of the Efficacy and Safety of Adjuvant Autogene Cevumeran Plus Atezolizumab and mFOLFIRINOX Versus mFOLFIRINOX Alone in Participants With Resected PDAC
This study looks at new treatments for pancreatic cancer after surgery. It compares a new combination of drugs (Autogene Cevumeran, Atezolizumab, and mFOLFIRINOX) with a standard treatment (mFOLFIRINOX alone) to see which works best and is safest for patients with no remaining cancer after their operation.
Adenocarcinoma, Pancreatic DuctalNetherlands - AuthorisedTherapeutic confirmatory (Phase III)
HOVON 182 CLL: Prospective randomized phase 3 study of treatment with rituximab (6 cycles) in combination with 6 or 26 cycles of venetoclax in patients with relapsed or refractory chronic lymphocytic leukemia RED RIVER CLL study: Reduced Duration Rituximab VEnetoclax in Relapsed/refractory CLL
This study looks at a new way to treat a type of blood cancer called chronic lymphocytic leukaemia (CLL) that has come back or not responded to previous treatment. It tests if a shorter course of a drug called venetoclax, combined with rituximab, works as well as a longer course.
Relapsed or refractory small lymphocytic lymphoma, Relapsed or refractory chronic lymphocytic leukemiaNetherlands - AuthorisedTherapeutic exploratory (Phase II)
J5D-MC-FPAC: A Phase 2a, Randomized, Multicenter, Double-Blind, Placebo-Controlled Proof of Concept Study to Investigate Efficacy and Safety of LY4005130 in Adult Participants With Severe Alopecia Areata
This study is testing a new medicine, LY4005130, for adults with severe alopecia areata. It's a key step to see if the medicine can help hair grow back and if it's safe. Some people will get the medicine, others a dummy treatment, to compare results.
Alopecia AreataNetherlands - RecruitingPHASE3
A Phase 3 Study of Ersodetug in Patients With Tumor Hyperinsulinism
This study is testing a new drug, Ersodetug, for adults with a rare condition called Tumour Hyperinsulinism (Tumour HI). It aims to see if the drug can help control very low blood sugar levels caused by certain tumours, when current treatments aren't enough.
Tumor Hyperinsulinism (Tumor HI)Netherlands - Recruiting
Quality of Pediatric Resuscitation in a Multicenter Collaborative
This study looks at how the quality of CPR given to children during a cardiac arrest affects their recovery. Researchers are observing children in hospitals to see if better CPR techniques and after-care improve survival and brain function.
Cardiac ArrestCardiopulmonary ArrestNetherlands - Enrolling by invitationPHASE2, PHASE3
HELIOS: Open-Label, Long-Term Extension Study to Investigate the Safety, Tolerability, and Efficacy of DISC-1459 (Bitopertin) in Participants With EPP or XLP
This study looks at a new medicine called DISC-1459 (Bitopertin) for people with Erythropoietic Protoporphyria (EPP). It's an ongoing study to see if the medicine is safe, well-tolerated, and effective over a long time for those who have already tried it in earlier studies.
Erythropoietic ProtoporphyriaNetherlands - Active not recruitingPHASE2
A Study to Evaluate Efficacy and Safety of an Investigational Drug Named Volixibat in Patients With Itching Caused by Primary Sclerosing Cholangitis (PSC)
This study is testing a new medicine, volixibat, for people with Primary Sclerosing Cholangitis (PSC) who experience bothersome itching. It aims to see if the medicine can reduce itching and affect how PSC progresses.
Primary Sclerosing CholangitisNetherlands - Active not recruitingPHASE1
Anvumetostat Alone or in Combination With Other Therapies in Subjects With Advanced Thoracic Tumors With Homozygous MTAP-deletion (Master Protocol) (MTAPESTRY 104).
This study, called MTAPESTRY 104, is testing a new drug called Anvumetostat, alone or with other treatments, for advanced lung cancers that have a specific genetic change (MTAP-deletion). It aims to find the safest and most effective dose.
Thoracic TumorsNon-small Cell Lung CancerNetherlands - Active not recruitingPHASE1
DAREON™-7: A Study to Test How Well Different Doses of BI 764532 in Addition to Chemotherapy Are Tolerated by People With Advanced Neuroendocrine Cancers
This study looks at a new medicine, BI 764532, combined with chemotherapy for advanced neuroendocrine cancers. It aims to find safe doses and see if it helps patients whose cancers have a specific marker called DLL3.
Neuroendocrine NeoplasmsNetherlands - Active not recruitingPHASE1, PHASE2
Sub-study of Belantamab Mafodotin (GSK2857916) in Combination With Nirogacestat in Participants With RRMM
This study is looking at a new combination of two drugs, Belantamab Mafodotin and Nirogacestat, for people with multiple myeloma that has come back or not responded to previous treatments. The main goal is to find a safe dose and see how well it works.
Multiple MyelomaNetherlands - Recruiting
The Effect of Subclinical Leaflet Thrombosis and Prosthesis Type on Transcatheter Aortic Valve Degeneration (POPular PET TAVI)
This study looks at how different types of replacement heart valves wear out over time. We're also checking if tiny blood clots on these valves, which you wouldn't feel, affect how quickly they start to show signs of damage after 5 years.
Aortic Valve StenosisNetherlands - AuthorisedTherapeutic use (Phase IV)
BIOlogical treatment GRAdual Interval Longing in severe Asthma (BIO-GRAIL)
This study looks at how new biological medicines help people with severe asthma. Researchers want to see if these treatments can keep asthma under control for about a year, even when the time between doses is made longer. It aims to improve asthma management and reduce flare-ups.
Severe AsthmaNetherlands - RecruitingPHASE2
Surgery for Recurrent Glioblastoma
This study looks at whether a second surgery for recurrent glioblastoma brain cancer, followed by treatment, is better than just having treatment alone. It aims to see if surgery helps people live longer, feel better, and have a good quality of life.
GlioblastomaNetherlands - RecruitingPHASE2, PHASE3
A Study of TAK-861 for the Treatment of Selected Central Hypersomnia Conditions
This study is testing a new medicine, TAK-861, for people with narcolepsy type 1. It checks how safe the medicine is and if it helps reduce sleepiness and sudden muscle weakness. Participants have already taken TAK-861 in previous studies.
Narcolepsy Type 1Netherlands - AuthorisedTherapeutic confirmatory (Phase III)
A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of ALKS 2680 in Adults With Narcolepsy Type 2
This study is testing a new medicine, ALKS 2680, for adults with Narcolepsy Type 2. We want to see if it helps reduce sleepiness and improve daily life compared to a dummy pill. It's a key step to confirm if the medicine works and is safe.
Narcolepsy Type 2Netherlands - Active not recruitingPHASE3
A Study of Belrestotug Plus Dostarlimab Compared With Placebo Plus Pembrolizumab in Previously Untreated Participants With Programmed Death Ligand 1 (PD-L1) High Non-small-cell Lung Cancer (NSCLC)
This study is looking at a new combination of medicines, belrestotug and dostarlimab, for people with a certain type of lung cancer that hasn't been treated before. It compares this combination to a standard treatment (pembrolizumab) and a dummy drug (placebo).
Lung Cancer, Non-Small CellNetherlands - Active not recruitingPHASE3
Study of Cabozantinib in Combination With Atezolizumab Versus Sorafenib in Participants With Advanced Hepatocellular Carcinoma (HCC) Who Have Not Received Previous Systemic Anticancer Therapy
This study looks at new drug combinations for advanced liver cancer that hasn't been treated before. It compares cabozantinib with atezolizumab against a standard treatment, sorafenib, to see which works better and is safer.
Hepatocellular CarcinomaNetherlands - Active not recruitingPHASE1, PHASE2
Pharmacokinetics, Safety and Efficacy of the Selumetinib Granule Formulation in Children Aged ≥1 to <7 Years With NF1-related Symptomatic, Inoperable PN
This study is testing a new liquid form of the medicine selumetinib for children aged 1 to 6 with a type of tumour linked to Neurofibromatosis Type 1 (NF1). It aims to find the right dose and check if it's safe and helps shrink the tumours.
Neurofibromatosis Type 1Netherlands - Recruiting
INflammation and Small Vessel Disease Study
This study looks at whether inflammation in the body affects brain damage and memory in people with a condition called cerebral small vessel disease. It aims to understand if changes in inflammation can predict future problems.
Cerebral Small Vessel DiseasesInflammationStrokeNetherlands - Recruiting
Annuloplasty Rings and Band Post-Market Clinical Follow-Up Study
This study looks at how well special rings and bands work to fix leaky heart valves (mitral and tricuspid regurgitation). It follows people who've had surgery with these Abbott devices for five years to make sure they're safe and effective.
Mitral RegurgitationTricuspid RegurgitationValvular Heart DiseaseNetherlands - RecruitingPHASE1, PHASE2
FaR-RMS: An Overarching Study for Children and Adults With Frontline and Relapsed RhabdoMyoSarcoma
This study, FaR-RMS, is for children and adults with a type of cancer called rhabdomyosarcoma. It's looking for better ways to treat both newly diagnosed and returning cancer, using different combinations of medicines and radiotherapy.
RhabdomyosarcomaNetherlands - Enrolling by invitationPHASE3
Global Open-Label Extension Study of Del-desiran for the Treatment of DM1
This study is an extension of previous research looking at a new medicine called del-desiran for Myotonic Dystrophy Type 1 (DM1). It aims to check its long-term safety and how well it works over several years.
Myotonic Dystrophy Type 1DM1Myotonic DystrophyMyotoniaNetherlands - Active not recruitingPHASE1, PHASE2
A Safety, Tolerability, and Efficacy Study of VX-264 in Participants With Type 1 Diabetes
This study is looking at a new medicine called VX-264 for people with Type 1 Diabetes. We want to see if it's safe, how well people tolerate it, and if it helps manage the condition. It's for adults aged 18-65.
Type 1 DiabetesNetherlands