Latest studies
- Completed
The Scandcleft project
The Scandcleft project compares different surgical timings and techniques for babies born with a complete cleft lip and palate on one side. By tracking children's speech, teeth, and facial growth into their teens, researchers aim to discover which surgical schedule gives children the best possible long-term results.
Complete unilateral cleft lip and palateNorway - Completed
Magnet4Europe - Improving mental health and wellbeing in the health care workplace
Hospital staff often face heavy workloads and stress. Magnet4Europe is a study testing a new way of organising hospital work to improve doctors' and nurses' mental health and wellbeing. By taking short yearly surveys, staff help researchers see if redesigning workplace culture makes hospital care safer and workplaces happier.
The impact of organizational redesign of acute care hospitals according to the Magnet© principles of organizational redesign on mental health and wellbeing of health professionalsNorway - Completed
Integrated short-term palliative rehabilitation in incurable cancer
This clinical trial investigates whether a short rehabilitation programme can help people with advanced, incurable cancer stay independent and improve their quality of life. Participants receive either standard care alone or standard care with up to three specialist rehabilitation sessions, along with answering questionnaires about their daily wellbeing over 16 weeks.
Advanced incurable solid cancer: lung, colorectal, breast, prostate, etc.Norway - RecruitingPhase II
A study to learn if ZED1227 can improve continued celiac disease symptoms despite a gluten-free diet
This study is testing a new capsule called ZED1227 for adults with coeliac disease. Researchers want to see if this medicine can protect the gut and ease lingering tummy symptoms caused by accidental gluten exposure, even in people who already follow a strict gluten-free diet.
Coeliac diseaseNorway - RecruitingPhase I/II
A trial looking at different treatments for neuroblastoma which has come back after initial therapy
The BEACON2 trial is testing new combinations of cancer medicines for children and young people whose neuroblastoma has returned or worsened after initial treatment. The goal is to find out which drug combinations are safest and work best to control the disease and improve future care.
Relapsed NeuroblastomaNorway - RecruitingPHASE2
Belzutifan/MK-6482 for the Treatment of Advanced Pheochromocytoma/Paraganglioma (PPGL), Pancreatic Neuroendocrine Tumor (pNET), Von Hippel-Lindau (VHL) Disease-Associated Tumors, Advanced Gastrointestinal Stromal Tumor (wt GIST), or Solid Tumors With HIF-2α Related Genetic Alterations (MK-6482-015)
This study is testing a new medicine called belzutifan for certain types of advanced cancers, including rare adrenal gland, gut, and kidney cancers. We want to see how well it works and if it's safe for people aged 12 and over.
Pheochromocytoma/ParagangliomaPancreatic Neuroendocrine TumorVon Hippel-Lindau DiseaseAdvanced Gastrointestinal Stromal TumorNorway - Recruiting
Optimal personalised treatment of early breast cancer using multiparameter analysis
This study looks at whether a specialised tumour test can help women with early breast cancer safely avoid chemotherapy. Researchers want to see if hormone therapy alone works just as well for some women, sparing them difficult side effects without increasing the risk of their cancer returning.
Breast cancerNorway - RecruitingPhase III
A study of JNJ-78934804 in participants with moderately to severely active Crohn's disease
This clinical trial is testing a new combination medicine, JNJ-78934804, for moderate to severe Crohn’s disease. It combines two drugs into one injection to target gut inflammation. Researchers want to see if this two-in-one approach works better than a single medicine for people whose previous treatments have stopped working.
Crohn’s diseaseNorway - Not yet recruiting
Phase 3a and 3b update of the gastric cancer module, EORTC QLQ-STO22
Researchers are updating a widely used questionnaire that measures how stomach cancer and modern treatments affect daily life and well-being. If you have stomach cancer, you can help by completing the draft survey and sharing your feedback during a single, one-off chat lasting up to an hour.
Gastric adenocarcinomaNorway - RecruitingHuman Pharmacology (Phase I)- Other
A Phase 1, Open-Label, Multicenter Study of INCB160058 in Participants With Myeloproliferative Neoplasms.
This early-stage clinical trial is testing a new experimental medicine called INCB160058 for adults with myeloproliferative neoplasms (rare blood disorders). The main aim is to find out if the drug is safe, learn how the body handles it, and see what the best dose might be for future treatment.
Myeloproliferative NeoplasmsNorway - CompletedPhase III
Prevention of complications to Improve outcome in elderly patients with acute stroke - A randomised clinical trial
This clinical trial looks at whether giving common medicines right after a stroke can prevent complications like fever, sickness, and chest infections before they start. Researchers want to see if treating older adults early with paracetamol, antibiotics, or anti-sickness medicine helps them recover better and stay independent.
Acute ischaemic stroke or intracerebral haemorrhageNorway - CompletedPhase II/III
ENRICH Ibrutinib for untreated mantle cell lymphoma
The ENRICH study is testing a targeted medicine called ibrutinib for people aged 60 and older who have newly diagnosed mantle cell lymphoma. Researchers want to see if ibrutinib, taken with an antibody drug, works better and causes fewer side effects than traditional chemotherapy.
Mantle cell lymphoma (MCL)Norway - AuthorisedTherapeutic use (Phase IV)
Treatment strategies for juvenile idiopathic arthritis patients with sustained inactive disease: A phase 4, multicentre, randomised trial comparing maintenance versus tapered TNF alpha inhibitor monotherapy - the Treat-JIA trial
This study looks at young people with juvenile idiopathic arthritis whose condition is currently quiet and well controlled. Researchers want to find out whether it is safe to slowly reduce and stop their regular biologic injections, or if it is better to carry on taking them as normal.
Juvenil Idiopatic ArthritisNorway - AuthorisedTherapeutic exploratory (Phase II)
Inducing durable immunological control of HIV-1 through administration of long-acting broadly neutralizing antibodies and low-dose anti-PD-1 – a randomized, double-blinded, placebo-controlled trial (the IDUNN trial)
This study tests whether a combination of specialised immune proteins and an immune-boosting drug can control HIV without daily medication. Participants carefully pause their usual tablets under close medical monitoring to see if the new treatments can keep the virus suppressed on their own.
HIV-1 diseaseNorway - AuthorisedTherapeutic confirmatory (Phase III)
A Phase 3, Randomized, Open-Label Study of Linvoseltamab Versus Daratumumab in Participants with Smoldering Multiple Myeloma at High Risk of Developing Multiple Myeloma
This study looks at adults with high-risk smoldering multiple myeloma, an early form of blood cancer. Researchers are comparing a newer medicine called linvoseltamab against an established treatment called daratumumab. The goal is to see which medicine is better at delaying or stopping the condition from turning into active cancer.
High Risk Smoldering Multiple Myeloma (HR-SMM)Norway - AuthorisedTherapeutic exploratory (Phase II)
HOVON 168: Epcoritamab in Addition to R-Mini-CHOP Compared to R-Mini-CHOP in Elderly, Frail or Unfit Patients with Diffuse Large B-cell Lymphoma
This study looks at a new drug combination for older or frail adults with diffuse large B-cell lymphoma, a type of blood cancer. Researchers want to see if adding an antibody drug called epcoritamab to standard, gentler chemotherapy helps clear the cancer better and keeps people well for longer.
Diffuse large B-cell lymphoma (DLBCL)Norway - AuthorisedTherapeutic use (Phase IV)
ACTOR – AUC Control of Tacrolimus in Organ Recipients
This study looks at how the body absorbs a common anti-rejection medicine called Prograf (tacrolimus) after a kidney transplant. Researchers will take blood samples over 12 hours and look at gut bacteria to find safer, more accurate ways to check medicine levels for kidney transplant patients.
Kidney transplantationNorway - AuthorisedTherapeutic exploratory (Phase II)
A phase II randomised trial investigating the benefit of adjuvant immunotherapy after neoadjuvant chemoimmunotherapy for resectable NSCLC (ADIL)
This study looks at non-small cell lung cancer that can be treated with surgery. Researchers want to find out if having an immunotherapy drug called Imfinzi after surgery helps stop the cancer from returning, following initial chemo-immunotherapy before surgery. It aims to see if extra treatment improves long-term health.
Non Small Cell Lung Cancer (NSCLC)Norway - AuthorisedTherapeutic use (Phase IV)
Influence of Antimicrobial Drugs on Mycophenolic acid and Tacrolimus Pharmacokinetics and the Gut Microbiome in Kidney Transplant Recipients (AXIS)
This study looks at how antibiotics and other infection-fighting medicines affect anti-rejection drugs in kidney transplant patients. Researchers want to see if these medicines change drug levels in the blood or alter the friendly bacteria in the gut, helping doctors prescribe safer doses in the future.
Kidney transplantationNorway - AuthorisedTherapeutic confirmatory (Phase III)
A randomized, open-label, multicenter, Phase 3 study to investigate mocertatug rezetecan compared with chemotherapy in participants with endometrial cancer after platinum-based chemotherapy and immunotherapy
This Phase 3 clinical trial tests a new drug called mocertatug rezetecan for womb (endometrial) cancer. Researchers want to see if it works better and is safer than standard chemotherapy for people whose cancer has returned or worsened after earlier treatments like platinum chemotherapy and immunotherapy.
Neoplasms, EndometrialNorway - AuthorisedTherapeutic exploratory (Phase II)
Endocrinological Support Therapy After Military Operations
This study looks at how healthy male soldiers recover their physical strength, stamina, and mental sharpness after intense military exercises. Researchers are testing whether a hormone treatment called Nebido (testosterone) speeds up recovery compared to a simple salt water dummy injection, helping people bounce back faster after extreme physical exhaustion.
The participants do not have any medical conditionNorway - AuthorisedTherapeutic exploratory (Phase II)
A single-arm pilot study to investigate tumor absorbed dose dynamics and feasibility of pre-treatment dosimetry with [177Lu]-PSMA-I&T in male participants aged ≥ 18 years with metastatic castration-resistant prostate cancer
This study looks at a targeted radiation therapy called 177Lu-PSMA-I&T for men with advanced prostate cancer. Researchers want to measure how much radiation reaches the tumours before and after treatment. This helps doctors learn if tailoring radiation doses can make the treatment safer and more effective.
Metastatic castration-resistant prostate cancerNorway - RecruitingTherapeutic confirmatory (Phase III)
A multi-center, open-label, uncontrolled, single-arm, extension study to determine the long-term safety and tolerability of oral lucerastat in adult subjects with Fabry disease.
This study looks at a daily oral medicine called lucerastat for adults with Fabry disease. Researchers want to find out how safe the medicine is and how well people tolerate it over a longer time. Everyone who takes part receives the active medicine, with no dummy pills used.
Fabry diseaseNorway - AuthorisedTherapeutic exploratory (Phase II)
Neo-adjuvant versus Adjuvant chemotherapy in Upper Tract Urothelial Carcinoma: A feasibility phase II randomized clinical trial (“URANUS”)
This study looks at cancer in the upper urinary tract. Doctors want to see whether it is better for patients to have chemotherapy before surgery or after surgery. The aim is to find out which timing allows more people to complete their full three courses of treatment safely.
Upper Tract Urothelial Carcinoma. Upper urinary tract transitional cell carcinomaNorway - RecruitingTherapeutic confirmatory (Phase III)
A Randomized, Double-Blind, Dose Finding and Comparison Study of the Safety and Efficacy of High Doses of Eteplirsen, Preceded by an Open-Label Dose Escalation, in Patients with Duchenne Muscular Dystrophy With Deletion Mutations Amenable to Exon 51 Skipping
This clinical trial is testing whether higher doses of a medicine called eteplirsen are safe and helpful for boys with Duchenne muscular dystrophy. It is for males with a specific genetic change that can be treated by skipping exon 51, aiming to protect muscle strength over nearly three years.
Duchenne Muscular DystrophyNorway - RecruitingTherapeutic exploratory (Phase II)
A randomized, double-blind parallel group study to investigate propofol injection pain compared with placebo in healthy adult male and female participants. (PropPain)
Propofol is a common anaesthetic that helps people sleep during surgery, but it can cause stinging when injected. This study tests how much discomfort a propofol injection causes compared to a harmless saltwater injection in healthy adults. Researchers hope the findings will help make future injections more comfortable.
PainNorway - RecruitingTherapeutic confirmatory (Phase III)
BRISOTE: A Multicentre, Randomised, Double-blind, Parallel Group, Active-Controlled, Phase 3b Study to Evaluate the Efficacy and Safety of Benralizumab 30 mg SC in Eosinophilic Asthma Patients Uncontrolled on Medium-Dose Inhaled Corticosteroid Plus Long-acting β2 Agonist
This clinical trial is testing whether an injection called benralizumab can help adults with severe eosinophilic asthma. Researchers want to see if adding this medicine to standard daily inhalers reduces asthma attacks and improves everyday breathing over 48 weeks compared to standard inhaler treatments alone.
Eosinophilic AsthmaNorway - Active not recruitingPHASE3
Study to Assess the Safety and Efficacy of Viltolarsen in Ambulant Boys With DMD (RACER53-X)
This study is testing a medicine called viltolarsen for boys with Duchenne muscular dystrophy who can still walk. It is an extension study for children who already completed an earlier trial. Every participant receives the medicine through a weekly drip for nearly two years to check its safety and long-term effects.
Duchenne Muscular DystrophyNorway - RecruitingTherapeutic use (Phase IV)
Zoledronate Early to Hip Fractures Patients – safe and effective? A Randomized controlled double-blinded treatment strategy trial on Zoledronate in hip fracture patients: The ZEBRA trial
The ZEBRA trial is testing whether giving a bone-strengthening medicine called zoledronate soon after a hip fracture is safe and effective. Researchers want to see if early treatment helps bones heal better, improves walking and recovery, and stops future fractures, without causing unwanted side effects during your hospital stay.
Hip fractureNorway - RecruitingTherapeutic confirmatory (Phase III)
A Phase 3, Multicenter, Open-Label Extension Study of Zilucoplan in Subjects with Generalized Myasthenia Gravis
This study tests a medicine called zilucoplan (Zilbrysq) for adults with generalised myasthenia gravis. This condition causes severe muscle weakness. In this study, all patients receive the real medicine via an injection. Doctors want to see how safe the treatment is and how well it helps with daily activities over time.
Generalized Myasthenia GravisNorway - RecruitingTherapeutic exploratory (Phase II)
Efficacy and safety of co-administered cagrilintide and semaglutide (CagriSema) once weekly versus placebo in participants with type 2 diabetes and painful diabetic peripheral neuropathy
This clinical trial is testing a new once-weekly injection called CagriSema for adults with type 2 diabetes who experience nerve pain. Researchers want to find out if combining two medicines (cagrilintide and semaglutide) can safely ease nerve pain while improving blood sugar control and overall health.
Type 2 diabetes and painful diabetic peripheral neuropathyNorway - RecruitingTherapeutic confirmatory (Phase III)
A Phase 3, Multicenter, Open-Label, Long-Term Trial to Evaluate the Safety and Efficacy of Efgartigimod (ARGX-113) PH20 Subcutaneous in Adult Patients With Primary Immune Thrombocytopenia
This study looks at a medicine called efgartigimod for adults with primary immune thrombocytopenia (ITP). ITP causes low blood platelets, leading to easy bruising and bleeding. Researchers want to see if an injection under the skin is safe and helps keep platelet counts at a healthy level over time.
Primary Immune ThrombocytopeniaNorway - RecruitingTherapeutic exploratory (Phase II)
Extended Criteria Treatment for Liver Metastases With Heavy Tumour Burden
This clinical trial looks at a specialised treatment for adults whose bowel cancer has spread extensively to the liver. Doctors are testing whether giving specific medications directly to the liver helps control cancer growth, improves quality of life, and helps patients live longer.
Colorectal Liver MetastasesNorway - AuthorisedTherapeutic exploratory (Phase II)
A single arm single center exploratory observational phase II study, aimed to detect long term changes in volume of port-wine macrocheilia and color of port-wine stain in patients undergoing surgery and laser therapy during sirolimus treatment. Quality of life and efficacy and safety of sirolimus will be assessed.
This study looks at whether a medicine called sirolimus helps reduce lip swelling and fade the colour of port-wine birthmarks. Adults having surgery and laser therapy will take sirolimus. Doctors will measure lip size, check skin colour, and assess how treatment improves everyday wellbeing over five years.
Vascular malfomationNorway - AuthorisedTherapeutic use (Phase IV)
Effects of Menopausal Hormone Therapy on QTc in Genetically Confirmed Long QT Syndrome: A Prospective Randomized Sequential Crossover Study with Long-Term Observational Follow-Up (LQTS-HER)
This study looks at whether hormone replacement therapy (HRT) is safe for women with Long QT syndrome. Researchers want to see how different HRT medicines affect heart rhythm and electrical recharge times. The goal is to help women safely manage menopause symptoms without increasing their risk of heart rhythm problems.
Long QT syndromeNorway - AuthorisedTherapeutic use (Phase IV)
Reduced-dose versus full-dose systemic thrombolysis for high-risk pulmonary embolism: a multicentre, randomised, open-label, blinded-endpoint trial
This hospital study compares a reduced dose of a clot-busting drug against the standard full dose for severe blood clots in the lungs. Researchers want to see if the lower dose clears the clot just as well, while lowering the risk of dangerous bleeding complications for patients.
Pulmonary embolismNorway - AuthorisedTherapeutic use (Phase IV)
REconsidering Long-TErm ASpirin in the Elderly in Secondary Prevention of Coronary Artery Disease (RELEASE) Norway: A Randomised, Registry-based Trial
This trial looks at whether older people with long-term heart disease should keep taking daily low-dose aspirin. Researchers want to find out if stopping aspirin is safe, and whether doing so lowers the chance of dangerous bleeding without raising the risk of heart attacks or strokes.
Chronic coronary syndromeNorway - AuthorisedTherapeutic confirmatory (Phase III)
A Phase III, Open-label, Multicentre, Randomised Study Comparing Consolidation Treatment with AZD0120, an Autologous Dual Targeting Chimeric Antigen Receptor T-cell (CAR-T) Therapy Directed Against BCMA and CD19, versus Autologous Stem Cell Transplant (ASCT) in Participants with Newly Diagnosed Multiple Myeloma who are Transplant Eligible (TE NDMM) (DURGA-6)
This study compares a new cell therapy called CAR-T with the standard stem cell transplant for people newly diagnosed with multiple myeloma. Researchers want to see if using a person's own modified immune cells keeps the cancer away longer than standard treatment and helps clear out cancer cells completely.
Newly Diagnosed Multiple MyelomaNorway - AuthorisedTherapeutic confirmatory (Phase III)
A Phase 3, Randomized, Open-Label Study of Zoldonrasib (RMC-9805) Plus Daraxonrasib (RMC-6236) Versus Gemcitabine and Nab-Paclitaxel as First-Line Treatment in Patients with Metastatic KRAS G12D-Mutated Pancreatic Adenocarcinoma (RASolute 309)
This study is testing two new targeted drugs, zoldonrasib and daraxonrasib, for people with advanced pancreatic cancer that has a specific gene change called KRAS G12D. Researchers want to see if this combination works better and is kinder than standard chemotherapy at slowing the cancer down and helping people live longer.
Pancreatic AdenocarcinomaNorway - RecruitingTherapeutic confirmatory (Phase III)
APOLLO: A Randomized, Double-Blind, Placebo-Controlled Study of Bitopertin to Evaluate the Efficacy, Safety, and Tolerability in Participants with Erythropoietic Protoporphyria (EPP) or X-Linked Protoporphyria (XLP)
The APOLLO study is testing a new daily tablet called bitopertin for adults with EPP or XLP. These rare conditions cause severe skin pain in sunlight. Researchers want to see if bitopertin can reduce this pain and allow people to spend more time outdoors safely over six months.
X-Linked Protoporphyria (XLP), Erythropoietic Protoporphyria (EPP)Norway - AuthorisedTherapeutic exploratory (Phase II)
Pain Relief at Screening for Retinopathy of Prematurity - The PROPER study
The PROPER study is looking at better ways to relieve pain and discomfort in premature babies during routine eye checks for retinopathy of prematurity (ROP). Researchers are testing whether a calming medicine, given alongside standard numbing eye drops, makes these essential eye examinations gentler and less stressful for tiny babies.
Retinopathy of prematurityNorway - AuthorisedTherapeutic confirmatory (Phase III)
An Open-Label Extension Study to Evaluate the Long-Term Safety and Efficacy of BBP-418 (Ribitol) in Participants with Limb-Girdle Muscular Dystrophy 2I/R9 (LGMD2I/R9)
This study looks at a medicine called Ribitol (BBP-418) for adults with limb-girdle muscular dystrophy type 2I. Researchers want to see if taking Ribitol long-term is safe and helps people keep their muscle strength, walking ability, and lung function over time.
Limb Girdle Muscular Dystrophy (LGMD) Type 2INorway - AuthorisedTherapeutic exploratory (Phase II)
High-dose Insulin Euglycemic Therapy in Non-Toxic Acute Cardiogenic Shock.
This study looks at a new way to help people in hospital with cardiogenic shock, where the heart suddenly struggles to pump blood. Doctors are testing whether giving high doses of insulin, alongside sugar and potassium to keep blood levels steady, helps the heart pump better and protects vital organs.
Non-toxic acute cardiogenic shockNorway - AuthorisedTherapeutic exploratory (Phase II)
A Randomized, Delayed-Treatment Controlled, Phase 2 Pilot Study of Manualized MDMA-Assisted Therapy for Young Adults with Chronic Treatment-Resistant Major Depressive Disorder
This study tests whether midomafetamine (MDMA) combined with guided talking therapy can help adults with long-term depression that has not improved with standard treatments. Researchers want to see if this treatment is safe, practical to deliver, and effective at easing depression symptoms and improving daily functioning.
Major Depressive DisorderNorway - AuthorisedTherapeutic exploratory (Phase II)
Individualized Intrathecal Chemotherapy Based on Measurement of Brain Fluid Clearance in Pediatric Patients
This study looks at how fluid drains from around the brain and spine in children with leukaemia or lymphoma. Researchers use a safe medical dye to track fluid clearance. The findings could help doctors tailor future chemotherapy doses to each child's body, improving safety and effectiveness.
Acute lymphoblastic leukemia and lymphomaNorway - RecruitingTherapeutic confirmatory (Phase III)
A randomized double-blind, placebo-controlled, multicenter trial assessing the impact of lipoprotein (a) lowering with pelacarsen (TQJ230) on major cardiovascular events in patients with established cardiovascular disease
This study tests a new injection called pelacarsen for adults with heart disease. Researchers want to see if lowering a specific blood fat, called lipoprotein(a), helps prevent serious heart problems like heart attacks and strokes. Half the participants will receive the medicine and half will receive a dummy injection.
Cardiovascular DiseaseNorway - RecruitingTherapeutic exploratory (Phase II)
A follow-up project on the GADinLADA trial to test for the continued impact of HLA-DR3DQ2 on diabetes status and immune parameters 3 years after treatment with intranodal GAD-alum.
This follow-up study looks at adults with Latent Autoimmune Diabetes in Adults (LADA) who previously received an experimental treatment called Diamyd. Researchers want to see if the treatment is still helping their bodies make insulin three years later, particularly in people with a specific genetic background.
Latent Autoimmune Diabetes in Adults (LADA)Norway - AuthorisedTherapeutic confirmatory (Phase III)
Durvalumab after concurrent platinum/etoposide chemotherapy and high-dose twice-daily thoracic radiotherapy in limited stage small cell lung cancer – an open label, randomized phase III trial (DAHRTS)
This phase 3 trial looks at whether an immunotherapy drug called durvalumab helps people with limited-stage small cell lung cancer live longer. It tests if giving durvalumab through a drip after standard chemotherapy and radiotherapy helps keep the cancer from returning.
Small-cell lung cancer, limited stageNorway - AuthorisedTherapeutic confirmatory (Phase III)
A Phase 3, Randomized, Double-Blinded Study to Evaluate the Safety and Efficacy of Salanersen (BIIB115) After Onasemnogene Abeparvovec Treatment in Infants with Genetically Diagnosed Spinal Muscular Atrophy
This study tests a medicine called salanersen for babies with spinal muscular atrophy (SMA) who have already received gene therapy. Doctors want to see if salanersen is safe and whether it can give extra support to help infants build muscle strength, sit, crawl, and walk.
Spinal Muscular AtrophyNorway - RecruitingHuman Pharmacology (Phase I)- Other
An exploratory study to investigate the effect of FE 999302 when given together with follitropin delta during controlled ovarian stimulation
This study looks at a new medicine, FE 999302, given with a common fertility drug, follitropin delta. It's for women having IVF or similar treatments to help them get pregnant. We want to see how these medicines work together.
Infertility in women undergoing assisted reproductive technologies (ART)Norway