Latest studies
- RecruitingPHASE1, PHASE2
Study of AZD4956 as Monotherapy and in Combination With Anti-Cancer Agents in Participants With Advanced/Metastatic Homologous Recombination Deficient Solid Tumours
This study is testing a new medicine, AZD4956, alone or with another medicine, Saruparib, for people with advanced solid tumours. It aims to see if they are safe and how well they work, especially for tumours with certain genetic changes.
Solid TumoursSpain - Recruiting
Evaluation of the Epilepsy-related Quality of Life, Seizure-related Accidents and Validation of the Mjn-SERAS Solution in the Normalised Patient Environment with Real-World Data
This study is testing a medical device called mjn-SERAS, designed to detect epileptic seizures early and give a warning. It's for people aged 12-65 in the UK, Spain, and Germany who have epilepsy that hasn't responded well to medication. The aim is to see if using the device improves their daily life.
Quality of LifeEpilepsy (treatment Refractory)Spain - Active not recruitingPHASE2
ADP-A2M4CD8 Monotherapy and in Combination With Nivolumab in HLA-A2+ Subjects With MAGE-A4 Positive Ovarian Cancer (SURPASS-3)
This study is for women aged 18-75 with a certain type of ovarian cancer. It tests a new treatment, ADP-A2M4CD8, alone or with nivolumab, to see how well it works and if it's safe.
Ovarian CancerSpain - Active not recruitingPHASE1, PHASE2
A Study of E7386 in Combination With Other Anticancer Drug(s) in Participants With Solid Tumor
This study is testing a new drug, E7386, alongside other cancer medicines. It aims to find the safest and most effective dose for people with various solid tumours, especially endometrial cancer, and to understand how these combinations work.
Endometrial NeoplasmsNeoplasmsCarcinoma, HepatocellularLiver NeoplasmsSpain - Active not recruitingPHASE3
A Study to Investigate Long-term Safety and Tolerability of Itepekimab in Participants With COPD
This study looks at the long-term safety of a new medicine, itepekimab, for people with severe lung disease (COPD). It will also check if the medicine continues to help over time. Participants will have already been part of a previous study on this medicine.
Chronic Obstructive Pulmonary DiseaseSpain - RecruitingPHASE1, PHASE2
A Study of Repotrectinib (TPX-0005) in Patients With Advanced Solid Tumors Harboring ALK, ROS1, or NTRK1-3 Rearrangements
This study is looking at a new drug called repotrectinib for advanced cancers that have specific gene changes (ALK, ROS1, or NTRK). It aims to find the best dose and see how well it works in shrinking tumours and how safe it is.
Locally Advanced Solid TumorsMetastatic Solid TumorsSpain - Recruiting
Clinical Course Of Disease In Participants With FA-CM
This study looks at how a heart condition linked to Friedreich Ataxia (FA-CM) changes over time. It aims to understand how the heart gets worse and could lead to new gene therapy treatments in the future for people with FA-CM.
Friedreich AtaxiaCardiomyopathySpain - Active not recruitingPHASE3
A Study of Abemaciclib (LY2835219) in Participants With Previously Treated KRAS Mutated Lung Cancer
This study looks at a medicine called abemaciclib for people in the UK with a certain type of advanced lung cancer (non-small cell lung cancer) that has a specific gene change (KRAS mutation) and has come back after other treatments. It aims to see how safe and effective abemaciclib is.
Non Small Cell Lung CancerSpain - Active not recruitingPHASE2
Study of Olaparib (MK-7339) in Combination With Pembrolizumab (MK-3475) in the Treatment of Homologous Recombination Repair Mutation (HRRm) and/or Homologous Recombination Deficiency (HRD)-Positive Advanced Cancer (MK-7339-007/KEYLYNK-007)
This study is looking at a new combination treatment, olaparib and pembrolizumab, for adults with advanced cancers. It focuses on specific types of solid tumours that have certain genetic changes or deficiencies in how their cells repair themselves.
Solid TumorsSpain - RecruitingPHASE3
A Study of JNT-517 in Participants With Phenylketonuria (PKU)
This study is looking into a new tablet called JNT-517 for adults with Phenylketonuria (PKU). We want to see if it's safe, how well it works, and how the body handles it. You might take JNT-517 or a dummy pill called a placebo.
PhenylketonuriaSpain - RecruitingPHASE3
Screening for Prostate Cancer Using High Resolution Micro-ultrasound Versus Multiparametric Magnetic Resonance Imaging.
This study compares a new sound wave scan (micro-ultrasound) with the current standard (MRI) for checking the prostate gland in men aged 50-70. It aims to see if the new scan is as good at finding problems, to help decide if a biopsy is needed.
Prostate Cancer ScreeningSpain - Active not recruitingPHASE3
A Study of Guselkumab in Participants With Active Psoriatic Arthritis
This study is looking at a new medicine called guselkumab for people with psoriatic arthritis. It aims to see how well it reduces pain, swelling, and other symptoms compared to a dummy treatment, and if it helps improve their condition.
Arthritis, PsoriaticSpain - RecruitingPHASE2
Study of Futibatinib in Patients With Advanced Cholangiocarcinoma With FGFR2 Fusion or Rearrangement
This study looks at a new drug called futibatinib (also known as TAS-120) for people with advanced bile duct cancer (cholangiocarcinoma). It focuses on patients whose cancer has a specific gene change (FGFR2 fusion or rearrangement) and who have already had standard treatments. The study aims to confirm the drug's benefits at one dose and check a different dose.
Advanced CholangiocarcinomaFGFR2 FusionsGene RearrangementSpain - RecruitingPHASE4
A Study Describing the Efficacy and Safety of Belimumab Administered in Adult Participants With Early Systemic Lupus Erythematosus (SLE)
This study looks at a medicine called Belimumab for people with Systemic Lupus Erythematosus (SLE), also known as lupus. It aims to see how well and how safely it works over three years in people who have had lupus for a short time and whose current treatment isn't fully controlling their symptoms.
Systemic Lupus ErythematosusSpain - Active not recruitingPHASE2
A Rollover Study to Provide Continued Treatment for Participants Previously Enrolled in Studies of Itacitinib
This study is for people already taking the drug itacitinib in other Incyte studies. It allows them to continue getting the treatment if it's helping and they are tolerating it well. It's for conditions like myelofibrosis, lung transplant problems, and chronic graft-versus-host disease.
MyelofibrosisPostlung Transplant (Bronchiolitis Obliterans)Chronic Graft Versus Host DiseaseSpain - Active not recruitingPHASE1
A Study to Test How Well Different Doses of BI 764532 Are Tolerated by People With a Tumour in the Brain That is Positive for DLL3
This study is for adults with a brain tumour called glioma, where previous treatments haven't worked. It's looking to find the safest highest dose of a new drug, BI 764532, which helps your immune system fight the cancer.
GliomaSpain - Active not recruitingPHASE3
Durvalumab With or Without Olaparib as Maintenance Therapy After First-Line Treatment of Advanced and Recurrent Endometrial Cancer
This study is looking into new ways to treat advanced or recurrent womb cancer. We're testing a combination of medicines called durvalumab and olaparib, given after initial chemotherapy, to see if they can help patients live longer and better.
Endometrial NeoplasmsSpain - RecruitingPHASE1, PHASE2
First in Human Study of TUB-030 in Patients With Advanced Solid Tumors
This study is testing a new drug called TUB-030 for adults with advanced solid cancers. Researchers want to see if it's safe, how well it works, and find the right dose. It's a first step to understand if TUB-030 could be a future treatment.
Advanced Solid TumorsHNSCCSCLCNSCLCSpain - RecruitingPHASE2
A Study to Evaluate the Efficacy and Safety of Belantamab Mafodotin in Combination With Standard of Care in Participants With Relapsed-Refractory Multiple Myeloma (RRMM)
This study looks at a new way to give belantamab mafodotin, along with other common medicines, for multiple myeloma that has come back or isn't responding well. We want to see if giving it less often can still work well and cause fewer eye side effects.
Multiple MyelomaSpain - Recruiting
Intelligent Lung Support in the Intensive Care Unit
This study looks at a new AI-powered computer program called IntelliLung. It helps doctors set up breathing machines for very ill patients in intensive care. Researchers want to see how closely doctors' choices match the program's suggestions to help patients breathe better.
Mechanical VentilationIntensive Care MedicineSpain - Active not recruitingPHASE1, PHASE2
A Study of HST-1011 Given as Monotherapy and in Combination With an Anti-PD1 Antibody
This study is looking at a new medicine called HST-1011, sometimes with another medicine called cemiplimab, for adults with advanced solid cancers. It's for people whose cancer hasn't responded to previous treatments or has come back after them.
Solid Tumor, AdultRelapsed CancerRefractory CancerSpain - RecruitingPHASE1, PHASE2
A Study to Assess the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, Immunogenicity and Anti-tumour Activity of IPN01203 in Adults With Locally Advanced or Metastatic Solid Tumours Exposed to Immune Checkpoint Inhibitor Therapies
This study is testing a new drug, IPN01203, for adults with advanced cancers that have spread. We're looking at its safety, best dose, and how well it works, especially for those who've had previous treatments. It's hoped to help control cancer growth.
Advanced Solid TumorMetastatic Solid TumorSpain - Active not recruiting
Post Market Clinical Follow Up of LEGION™ Primary TKS With VERILAST™
This study is looking at how well a new type of knee replacement, called LEGION™ Primary TKS with VERILAST™, works for people with joint problems. It compares its results to older knee replacements to see if it's safe and effective in the long run.
Degenerative Joint DiseaseSpain - Recruiting
Master Framework For Relapse or Refractory Acute Myeloid Leukemia
This study looks at how people with acute myeloid leukaemia (AML) respond to treatment when their cancer comes back or doesn't respond well to initial therapy. It collects important real-world information to help improve care for patients across Europe.
Acute Myeloid Leukemia, in RelapseAcute Myeloid Leukemia RefractorySpain - Active not recruiting
The European Robotic Spinal Instrumentation (EUROSPIN) Study
This study looks at different ways to place screws in your spine for conditions like back pain, slipped discs, or infections. It compares traditional surgery to methods using computer navigation or robotic assistance to see which works best and is safest.
Degenerative Disc DiseaseSpondylolisthesisSpinal StenosisRecurrent Disc HerniationSpain - Active not recruitingPHASE1
A Study to Test KISIMA-02 Vaccine-based Immunotherapy and Ezabenlimab in People With Pancreatic Cancer
This study for advanced pancreatic cancer tests a new treatment. It combines an immunotherapy (a protein alongside a virus that may kill cancer cells) with ezabenlimab, a drug that may boost your immune system. The aim is to find safe doses and see if it helps people live longer.
Pancreatic Ductal AdenocarcinomaSpain - Recruiting
A Non-interventional, Post-authorisation Safety Study of Patients Treated With Efgartigimod Alfa
This study looks at the safety of a new medicine called efgartigimod for people with myasthenia gravis (gMG). Researchers are observing patients as they take the medicine in their everyday lives to understand its effects.
Myasthenia GravisSpain - Recruiting
POS-ARI-ER Observational Study of Acute Respiratory Infections
This study looks at how adults in European hospitals are diagnosed and treated for severe chest and breathing infections. It aims to understand different approaches and what causes these infections, including viruses like flu and coronaviruses, to improve care.
Acute Respiratory InfectionAcute Respiratory Tract InfectionSpain - Recruiting
An Observational Study to Assess the Effectiveness and Safety of a Cemiplimab in Adult Patients With Advanced Non-Small Cell Lung Cancer (NSCLC) in Routine Clinical Practice Settings in Europe
This study looks at how a medicine called cemiplimab (Libtayo®) works for adults with advanced non-small cell lung cancer in everyday healthcare. Researchers want to understand its benefits and safety in real-world use.
Non-small Cell Lung CancerSpain - Active not recruitingPHASE3
A Study of Selexipag as Add-On Treatment to Standard of Care in Children With Pulmonary Arterial Hypertension
This study is testing if a medicine called selexipag can help children aged 2-17 with a serious lung condition called pulmonary hypertension. It aims to see if adding selexipag to their usual treatment can slow down the disease compared to a dummy medicine.
Hypertension, PulmonarySpain - RecruitingPHASE2
A Phase 2 Master Protocol Assessing Inebilizumab and Blinatumomab in Autoimmune Diseases
This study looks at new treatments (inebilizumab and blinatumomab) for people with Systemic Lupus Erythematosus (SLE) and Rheumatoid Arthritis (RA). It mainly checks how safe these medicines are and if they help reduce symptoms of these conditions.
Systemic Lupus ErythematosusActive Refractory Rheumatoid ArthritisSpain - RecruitingPHASE3
A Study to Evaluate the Long-term Efficacy and Safety of KarXT + KarX-EC for Agitation in Alzheimer's Disease (ADAGIO-3)
This study looks at a new medicine for agitation in people with Alzheimer's. It aims to see if an experimental drug, given as capsules, is safe and works well over a long time for those who've been in similar studies before.
Alzheimer DiseaseAgitationSpain - Active not recruitingPHASE3
Phase 3b Study to Assess the Efficacy, Safety, and Tolerability of Remibrutinib in Comparison to Placebo, With Omalizumab as Active Control, in Adult CSU Patients, Followed by an Open-label 52-week Optional Extension.
This study looks at a new medicine called remibrutinib for chronic spontaneous urticaria (CSU), comparing it to a dummy treatment (placebo) and another existing medicine, omalizumab. It aims to see if remibrutinib is safe and helps reduce hives and itching in adults whose CSU isn't well controlled by usual allergy medicines.
Chronic Spontaneous UrticariaSpain - Active not recruitingPHASE3
A Study to Assess the Efficacy and Safety of Empasiprubart Versus IVIg in Adults With Multifocal Motor Neuropathy
This study looks at a new medicine called empasiprubart compared to a standard treatment, IVIg, for adults with a rare muscle condition called Multifocal Motor Neuropathy (MMN). It aims to see if empasiprubart is safe and works well.
Multifocal Motor Neuropathy (MMN)MMNSpain - RecruitingPHASE1
Phase 1 Study of INBRX-109 in Subjects With Locally Advanced or Metastatic Solid Tumors Including Sarcomas
This early-stage study is testing a new drug, INBRX-109, for people with advanced solid tumours, including certain types of Ewing sarcoma and bowel cancer. Researchers want to see if it's safe and how well it works, both alone and with standard treatments. This is for patients who haven't responded to previous therapies.
Ewing SarcomaColorectal AdenocarcinomaSpain - RecruitingPHASE1, PHASE2
A Study to Evaluate the Safety and Efficacy of MK-3120 in Participants With Advanced Solid Tumors (MK-3120-002)
This study is looking for new treatment options for people with advanced solid tumors that have spread. Researchers want to see how safe a new medicine called MK-3120 is and if people can tolerate it well. It's a key first step to see if this treatment could help patients.
Advanced Solid TumorsMalignant NeoplasmSpain - RecruitingPHASE2
A Clinical Study to Evaluate DNTH103 in Adults With Multifocal Motor Neuropathy
This study is testing a new medicine, Claseprubart, for adults with Multifocal Motor Neuropathy (MMN). We want to see if it's safe, how it works in the body, and if it can help improve symptoms. Participants will receive either the new medicine or a placebo.
Multifocal Motor NeuropathySpain - Active not recruitingPHASE3
Study of Acalabrutinib (ACP-196) Versus Ibrutinib in Previously Treated Participants With High Risk Chronic Lymphocytic Leukemia (CLL)
This study compares two medicines, Acalabrutinib and Ibrutinib, for people in the UK with a type of blood cancer called Chronic Lymphocytic Leukemia (CLL) that has been treated before. It wants to see which medicine works better at stopping the cancer from getting worse.
Chronic Lymphocytic LeukemiaSpain - Active not recruitingPHASE3
A Study of Remternetug (LY3372993) in Early Alzheimer's Disease (TRAILRUNNER-ALZ 3)
This study, called TRAILRUNNER-ALZ 3, is looking at a new medicine called Remternetug for people in the early stages of Alzheimer's disease. Researchers want to see if it can slow down memory, thinking, or daily living problems compared to a dummy drug (placebo).
Alzheimer's DiseaseSpain - Active not recruitingPHASE3
Recombinant Factor VIIa (rFVIIa) for Hemorrhagic Stroke Trial
This study is testing a new treatment for a type of stroke called 'intracerebral haemorrhage' (bleeding in the brain). Doctors want to see if giving a drug called rFVIIa soon after the stroke can reduce bleeding and improve recovery.
Intracerebral HemorrhageSpain - RecruitingPHASE2
A Study to Investigate Efficacy and Safety of AZD1163 in Participants With Rheumatoid Arthritis
This study is testing a new medicine, AZD1163, for people with rheumatoid arthritis (RA) who haven't found enough relief from other treatments. It aims to see if the new medicine is safe and helps reduce RA symptoms.
Rheumatoid ArthritisSpain - RecruitingPHASE3
A Study of Daratumumab
This study offers ongoing access to specific treatments for people with multiple myeloma or smouldering multiple myeloma who have already benefited from them in previous studies. It helps ensure continued care and collects long-term safety information.
Multiple MyelomaSpain - Active not recruitingPHASE2
Study BT8009-230 in Participants With Locally Advanced or Metastatic Urothelial Cancer (Duravelo-2)
This study is testing new treatments for advanced bladder cancer. It compares a new drug, zelenectide pevedotin, alone and with pembrolizumab, against standard chemotherapy. We want to see how well these treatments work and if they are safe for people with bladder cancer that has spread.
Metastatic Urothelial CancerSpain - Active not recruiting
Registry for Patients Undergoing AUS Surgery for Female SUI Due to ISD
This study is looking at how well an operation for bladder leakage works in women. It's collecting information from different hospitals about women who have surgery for stress urinary incontinence caused by a weak bladder valve. They want to see how these women do over several years.
Urinary IncontinenceUrinary Incontinence, StressLower Urinary Tract SymptomsUrination DisordersSpain - Active not recruitingPHASE2
Phase 2b Study of GSK4532990 in Adults With NASH
This study is testing a new medicine, GSK4532990, for people with a serious liver condition called Non-Alcoholic Steatohepatitis (NASH). We want to see if this medicine can improve liver damage and inflammation compared to a dummy medicine.
Nonalcoholic Fatty Liver DiseaseNon-alcoholic Fatty Liver DiseaseSpain - Active not recruitingPHASE3
A Phase 3 Study to Evaluate the Effect of Resmetirom on Clinical Outcomes in Patients With Well-compensated NASH Cirrhosis (MAESTRO-NASH-OUTCOMES)
This study is looking at a new medicine called resmetirom for people with a type of liver scarring called NASH cirrhosis. It aims to see if the medicine can prevent serious liver problems or death over about three years, compared to a dummy pill.
NASHCirrhosis, LiverSpain - RecruitingPHASE2
A Novel COMBinATorial Therapy With Albumin and Enoxaparin in Patients With Decompensated Cirrhosis at High-risk of Poor Outcome (COMBAT Trial).
This study is looking at a new combination treatment for people with severe liver disease (cirrhosis) who have recently been in hospital. We want to see if combining two existing medicines, albumin and enoxaparin, is safe and helps improve outcomes after leaving the hospital.
Liver CirrhosisDecompensated Cirrhosis of LiverAcute on Chronic Liver Failure (ACLF)Spain - Enrolling by invitationNA
Alleviant ALLAY-HF Study
This study is for people with certain types of heart failure where their heart doesn't pump blood as well as it should. It's testing a new device, the Alleviant ALV1, which aims to improve how the heart works. Researchers want to see if it's safe and helps people feel better.
Heart FailureSpain - RecruitingPHASE2, PHASE3
A Study of Izalontamab Brengitecan Versus Chemotherapy in Participants With Previously Untreated, Locally Advanced, Recurrent Inoperable, or Metastatic Triple-negative Breast Cancer Ineligible for Anti-PD(L)1 Drugs (IZABRIGHT-Breast01)
This study is testing a new drug, iza-bren, for advanced triple-negative breast cancer or ER-low, HER2-negative breast cancer. It compares iza-bren with standard chemotherapy in patients who haven't had previous treatment for advanced disease and can't receive certain immunotherapy drugs.
Breast NeoplasmsSpain - RecruitingPHASE1
A Study of LY4256984 in Participants With Sporadic Amyotrophic Lateral Sclerosis
This study looks at a new medicine called LY4256984 for people with ALS, also known as Motor Neurone Disease. We want to see if it's safe, what side effects it might cause, and how the body handles it. It's given as an injection into the spine.
ALS (Amyotrophic Lateral Sclerosis)Spain