Eflornithine cream
Vaniqa
Peer reviewed by Sid DajaniLast updated by Michael Stewart, MRPharmSLast updated 17 Aug 2024
Meets Patient’s editorial guidelines
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Apply a thin layer of eflornithine cream twice a day (eight hours apart). Rub the cream in well.
You can apply cosmetics over the cream, but wait for at least five minutes after applying the cream before you do so.
It can take about eight weeks of using the cream regularly before you see an improvement.
At a glance
Eflornithine cream reduces unwanted facial hair growth in women.
It works by blocking an enzyme in hair follicles that causes hair production.
Apply a thin layer twice a day to affected areas, at least eight hours apart.
It can take about eight weeks to see the full benefit.
Common side-effects include acne or skin irritation.
Speak to your doctor if side-effects continue or become troublesome.
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About eflornithine
Type of medicine | A skin cream to reduce hair growth |
Used for | Reducing unwanted facial hair for women (if caused by a medical condition or treatment) |
Also called | Vaniqa® |
Available as | Cream |
Some hormonal disorders in women can lead to the growth of thick or dark facial hair, called hirsutism. Hirsutism can also be a side-effect of taking some medicines. It occurs either as a result of an increased production of an androgenic hormone (such as the male sex hormone testosterone), or because the skin has become more sensitive to this type of hormone.
When applied to the skin, eflornithine works by blocking the action of an enzyme in hair follicles which is involved in the production of hair. It can be used alongside laser therapy, to help reduce the rate at which unwanted facial hair grows in women who have this problem.
Before using eflornithine cream
Back to contentsTo make sure this is the right treatment for you, before you start using eflornithine cream it is important that your doctor knows:
If you are pregnant, trying for a baby or breastfeeding.
If you are taking any other medicines. This includes any medicines you are taking which are available to buy without a prescription, as well as herbal and complementary medicines.
If you have ever had an allergic reaction to a medicine or skin cream.
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How to use eflornithine cream
Back to contentsBefore you start the treatment, read the manufacturer's printed information leaflet from inside the pack. It will give you more information about eflornithine cream and will provide you with a full list of the side-effects which you may experience from using it.
If you have just used a hair remover or shaved, leave at least five minutes before you apply eflornithine cream. This will help to reduce any stinging or burning, which could otherwise occur.
Apply eflornithine cream twice a day to the areas of your face or chin which are affected. You should leave at least eight hours between the two applications. You only need to apply a thin layer of cream and you should rub it in well (until you can no longer see any cream on your face). Try not to get any cream in or near your eyes or mouth, as it may cause irritation.
After applying the cream, you should wash your hands to remove any cream left on your fingers but, if possible, do not wash your face during the following four hours.
Getting the most from your treatment
Back to contentsEflornithine cream is not a depilatory cream. You may need to continue with your usual hair removal routines. Ways to remove unwanted hair include shaving, plucking, waxing, hair-removing creams, electrolysis, and laser treatments. Your doctor will advise you about which of these are suitable for you to use alongside eflornithine cream.
If you want to apply make-up to the areas of skin that you've applied the cream to, you can do this, but please wait for at least five minutes after applying eflornithine cream before you do so.
It is important that you use the cream regularly. It can take about eight weeks before you start to see the full benefit from using it. If after four months of using the cream there is little improvement, please discuss this with your doctor who will review your treatment.
Eflornithine cream is not intended for use by men, or by girls under 18 years old.
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Can eflornithine cream cause problems?
Back to contentsAlong with their useful effects, medicated skin creams can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with eflornithine cream. You will find a full list in the manufacturer's information leaflet supplied with the cream. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.
Very common eflornithine side-effects (these affect more than 1 in 10 women) | What can I do if I experience this? |
Acne | If troublesome, speak with your doctor |
Common eflornithine side-effects (these affect fewer than 1 in 10 women) | What can I do if I experience this? |
Skin irritation, itching, dryness, redness | Try applying the cream just once a day for a few days to allow your skin to recover. If the irritation continues, speak with your doctor for further advice |
If you experience any other symptoms which you think may be due to the cream, speak with your doctor or pharmacist for further advice.
How to store eflornithine cream
Back to contentsKeep all medicines out of the reach and sight of children.
Store in a cool, dry place, away from direct heat and light.
Any unused cream should be discarded six months after opening. It may be helpful to write the date you opened the cream on to the pharmacy label.
Important information about all medicines
Back to contentsImportant information about all medicines
Eflornithine cream is for use on the skin only. If someone swallows some of it by accident, go to the accident and emergency department of your local hospital. Take the container with you, even if it is empty.
This medicine is for you. Never give it to other people even if their condition appears to be the same as yours.
Do not keep out-of-date or unwanted medicines. Take them to your local pharmacy which will dispose of them for you.
If you have any questions about this medicine, ask your pharmacist.
Report side effects to a medicine or vaccine
If you experience side effects, you can report them online through the Yellow Card website.

Unsure about mixing medicines?
Check for possible interactions between medicines, supplements and foods before taking them together.
Frequently asked questions
What causes the growth of thick or dark facial hair in women?
Thick or dark facial hair, known as hirsutism, can be caused by certain hormonal disorders in women. It can also occur as a side-effect of some medications. This happens either due to an increased production of androgenic hormones, like the male sex hormone testosterone, or because the skin becomes more sensitive to these types of hormones.
How does eflornithine cream work to reduce hair growth?
Eflornithine cream works by blocking the action of a specific enzyme found in hair follicles. This enzyme is involved in the process of hair production. By inhibiting this enzyme, the cream helps to reduce unwanted hair growth.
Can I use eflornithine cream with other hair removal methods?
Yes, eflornithine cream is not a hair removal cream itself, so you will likely need to continue with your usual hair removal routines. Your doctor can advise you on which methods, such as shaving, plucking, waxing, hair-removing creams, electrolysis, or laser treatments, are suitable to use alongside eflornithine cream.
How long will it take to see results from using eflornithine cream?
It is important to use the cream regularly, as it can take about eight weeks before you start to see the full benefit. If you do not notice much improvement after four months of using the cream, you should discuss this with your doctor for a review of your treatment.
Are there any specific instructions for applying make-up after using eflornithine cream?
If you wish to apply make-up to the areas where you've used the cream, you should wait at least five minutes after applying eflornithine cream before doing so.
What should I do if I experience skin irritation from eflornithine cream?
If you experience skin irritation, itching, or redness, which are common side-effects, you can try applying the cream just once a day for a few days to allow your skin to recover. If the irritation continues or becomes troublesome, you should speak with your doctor for further advice.
Can men or girls under 18 use eflornithine cream?
No, eflornithine cream is not intended for use by men or by girls under 18 years old.
How should I dispose of any leftover or expired eflornithine cream?
You should not keep out-of-date or unwanted medicines. Take any leftover or expired eflornithine cream to your local pharmacy, which will dispose of it for you responsibly.
Further reading and references
- Manufacturer's PIL, Vaniqa® 11.5% cream; Almirall Limited, The electronic Medicines Compendium. Dated May 2022.
- Medicines Complete BNF 89th Edition; British Medical Association and Royal Pharmaceutical Society of Great Britain, London.
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About the authorView full bio

Michael Stewart, MRPharmS
Medicine Leaflet Review Manager – Contractor, Pharmacist
BPharm (Hons), MRPharmS
Michael is a community pharmacist practicing in the Midlands and South Yorkshire with more than 20 years’ experience advising on medicines and medical conditions. He has a strong background in healthcare training, having produced and delivered training courses for pharmacy teams and staff of residential care settings, including nurses. He has also contributed to pharmacy advisory boards for the management of low acuity conditions in the community.
About the reviewer

Sid Dajani
Sultan Dajani qualified at the London School of Pharmacy in 1994 and became the youngest elected member of the Royal Pharmaceutical Society council since its founding in 1842.
Article history
The information on this page is written and peer reviewed by qualified clinicians.
Next review due: 24 Aug 2027
17 Aug 2024 | Latest version

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