Pimecrolimus cream
Elidel
Peer reviewed by Sid DajaniLast updated by Michael Stewart, MRPharmSLast updated 23 Nov 2022
Meets Patient’s editorial guidelines
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Pimecrolimus cream is for external use only and should be applied thinly to any affected area(s) of skin.
You should see an improvement in your skin within a week or so.
The most common side-effect is a feeling of warmth/burning at the site of application.
Do not drink alcohol - it can make your skin (particularly on your face) become flushed or red, and feel hot.
At a glance
Pimecrolimus cream is an anti-inflammatory cream for eczema and off-licence psoriasis.
It is for short-term use and helps reduce inflammation, redness, and itching.
Apply a thin layer to affected skin twice daily, not under dressings.
Avoid strong sunlight and sunbeds, and use high SPF sun cream.
Do not drink alcohol while using this cream.
Common side-effects include a burning feeling or skin irritation.
See your doctor if your skin does not improve after six weeks.
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Video picks for Skin conditions treatments
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About pimecrolimus cream
Type of medicine | An anti-inflammatory cream |
Used for | Eczema (in adults or in children and infants aged 3 months or older)) |
Also called | Elidel® |
Available as | Skin cream |
Pimecrolimus cream helps reduce inflammatory skin reactions. It is prescribed by doctors who are skin specialists. It is for short-term use.
Pimecrolimus cream is prescribed for people with mild-to-moderate eczema, usually as an alternative to other treatments such as steroid creams or ointments. It is applied on to the skin (topically) to reduce symptoms such as inflammation, redness and itching.
Although pimecrolimus cream is only licensed for use in eczema, it is also prescribed 'off-licence' to people with psoriasis. Current medical practice supports its use, but if you have been prescribed it for this reason and you have any questions about your treatment, it is important that you ask your doctor.
Before using pimecrolimus cream
Back to contentsSome medicines are not suitable for people with certain conditions, and sometimes a medicine can only be used if extra care is taken. For these reasons, before you (or your child) start using pimecrolimus cream it is important that your doctor knows:
If you are pregnant or breastfeeding.
If you have swollen lymph glands or a weakened immune system.
If you have skin cancer.
If you have an inherited skin barrier condition, such as Netherton's syndrome.
If you have ever had an allergic reaction to a medicine.
If you are taking or using any other medicines. This includes any medicines you are taking which are available to buy without a prescription, as well as herbal and complementary medicines.
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How to use pimecrolimus cream
Back to contentsBefore you start the treatment, read the manufacturer's printed information leaflet from inside the pack. It will give you more information about the cream and will provide you with a full list of the side-effects which you could experience from using it.
Apply a thin layer of cream exactly as your doctor tells you to; this is usually twice daily, once in the morning and once in the evening. Rub the cream into your skin gently. You should use it for the shortest time necessary to clear your condition (this may be several weeks). Although the cream is not intended to be used continually over a prolonged period of time, your doctor may suggest that you use it from time to time when your condition flares up.
Apply the cream to the affected areas of your skin only. Do not apply it to any area of skin that could be infected. If you are applying the cream to your face, try to avoid getting it near to your eyes or to the inside of your nose or mouth. If this does happen accidentally, wipe it off straightaway. Remember to wash your hands well after using the cream unless you are treating your hands.
If you forget to use the cream, don't worry, just apply it as soon as you remember, and then continue as before.
Getting the most from your treatment
Back to contentsTry to keep your regular appointments with your doctor. This is so your doctor can check on your progress.
It is important that you don't cover any area of skin treated with pimecrolimus with any dressings or bandages. This is because more of the medicine may be absorbed by your skin than is intended.
You can continue to use moisturising creams and lotions, but you should apply these after you have used pimecrolimus cream.
You should expect to see some improvement in your skin within a week or two of starting treatment. If there is no improvement in your skin after using pimecrolimus cream for six weeks, you should see your doctor again for further advice.
If you are due to have any vaccinations, it may be best to stop using pimecrolimus for a while if the area you are treating with the cream is quite large. If this affects you (or your child), ask your doctor or nurse for further advice.
Your doctor will discuss with you the possibility of a slightly increased risk of cancer (particularly skin cancer) associated with medicines like pimecrolimus. To help reduce this risk, do not use sunbeds, and avoid strong sunlight. On bright days, even if it is cloudy, use a sun cream with a high sun protection factor (an SPF of at least 15).
Do not drink alcohol because it can cause your skin and face to become flushed or red, and feel hot.
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Can pimecrolimus cream cause problems?
Back to contentsAlong with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the more common ones associated with pimecrolimus. The best place to find a full list of the side-effects which can be associated with your medicine, is from the manufacturer's printed information leaflet supplied with the medicine. Alternatively, you can find an example of a manufacturer's information leaflet in the reference section below. Speak with your doctor or pharmacist if any of the following continue or become troublesome.
Very common side-effects (these affect more than 1 in 10 people) | What can I do if I experience this? |
A burning feeling | This generally improves as you get used to the treatment |
Common side-effects (these affect fewer than 1 in 10 people) | What can I do if I experience this? |
Skin infections | Let your doctor know about this |
Skin irritation, itching and redness | This should soon pass, but speak with your doctor if any continue or become troublesome |
If you experience any other symptoms which you think may be due to the cream, speak with your doctor or pharmacist for further advice.
How to store pimecrolimus cream
Back to contentsKeep all medicines out of the reach and sight of children.
Store in a cool, dry place, away from direct heat and light.
Important information about all medicines
Back to contentsImportant information about all medicines
The cream is for use on the skin only. If you suspect that someone has swallowed some of it, go to the accident and emergency department of your local hospital. Take the container with you, even if it is empty.
This medicine is for you. Never give it to other people even if their condition appears to be the same as yours.
If you are having an operation or dental treatment, tell the person carrying out the treatment which medicines you are using.
Do not keep out-of-date or unwanted medicines. Take them to your local pharmacy which will dispose of them for you.
If you have any questions about this medicine ask your pharmacist.
Report side effects to a medicine or vaccine
If you experience side effects, you can report them online through the Yellow Card website.

Unsure about mixing medicines?
Check for possible interactions between medicines, supplements and foods before taking them together.
Frequently asked questions
Can pimecrolimus cream be used for other skin conditions besides eczema?
While pimecrolimus cream is only licensed for eczema, medical practice supports its 'off-licence' use for psoriasis. If you have been prescribed it for psoriasis and have questions, you should speak with your doctor.
What is the typical duration for using pimecrolimus cream to treat eczema?
You should use pimecrolimus cream for the shortest time necessary to clear your condition, which may be several weeks. It is not intended for continuous, prolonged use, but your doctor might suggest using it occasionally when your eczema flares up.
How long should I wait to see an improvement in my skin after starting pimecrolimus cream?
You should expect to see some improvement in your skin within one to two weeks of starting treatment. If there is no improvement after six weeks, you should contact your doctor for further guidance.
Are there any activities or substances I should avoid while using pimecrolimus cream?
Yes, you should avoid using sunbeds and strong sunlight. On bright days, even if it's cloudy, use a sun cream with a high sun protection factor (at least SPF 15). Also, do not drink alcohol, as it can cause flushing and redness of the skin and face.
What should I do if I accidentally get pimecrolimus cream in my eyes, nose, or mouth?
If you accidentally get the cream near your eyes or inside your nose or mouth, you should wipe it off straightaway.
What should I do if I miss an application of pimecrolimus cream?
If you forget to use the cream, simply apply it as soon as you remember, and then continue with your regular schedule.
Further reading and references
- Manufacturer's PIL, Elidel® 10 mg/g cream; Mylan Products Ltd, The electronic Medicines Compendium. Dated January 2022.
- Medicines Complete BNF 89th Edition; British Medical Association and Royal Pharmaceutical Society of Great Britain, London.
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About the authorView full bio

Helen Allen, MPharm
Pharmacist, Medical Author
MPharm
Helen Allen qualified as a Pharmacist in 1979 and spent 3 years as the drug information leaflets' author for EMIS.
About the reviewer

Sid Dajani
Sultan Dajani qualified at the London School of Pharmacy in 1994 and became the youngest elected member of the Royal Pharmaceutical Society council since its founding in 1842.
Article history
The information on this page is written and peer reviewed by qualified clinicians.
Next review due: 22 May 2027
23 Nov 2022 | Latest version
27 Aug 2013 | Originally published
Authored by:
Helen Allen, MPharm

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