chloride voltage-gated channel Ka
Last updated 20 Mar 2023
Meets Patient’s editorial guidelines
- DownloadDownload
- Share
- Language
- Discussion
- Audio Version
- Add to preferred sources on Google
The CLCNKA gene belongs to the CLC family of genes, which provide instructions for making chloride channels. These channels, which transport negatively charged chlorine atoms (chloride ions), play a key role in a cell's ability to generate and transmit electrical signals. Some CLC channels regulate the flow of chloride ions across cell membranes, while others transport chloride ions within cells.
Normal function
The CLCNKA gene belongs to the CLC family of genes, which provide instructions for making chloride channels. These channels, which transport negatively charged chlorine atoms (chloride ions), play a key role in a cell's ability to generate and transmit electrical signals. Some CLC channels regulate the flow of chloride ions across cell membranes, while others transport chloride ions within cells.
The CLCNKA gene provides instructions for making a chloride channel called ClC-Ka. These channels are found predominantly in the kidneys. ClC-Ka is one of several proteins that work together to regulate the movement of ions into and out of kidney cells. The transport of chloride ions by ClC-Ka channels is part of the mechanism by which the kidneys reabsorb salt (sodium chloride or NaCl) from the urine back into the bloodstream. The retention of salt affects the body's fluid levels and helps maintain blood pressure.
ClC-Ka channels are also located in the inner ear, where they play a role in normal hearing.
Conditions referring to this gene or chromosome
Other names
chloride channel Ka
chloride channel protein ClC-Ka
chloride channel, kidney, A
chloride channel, voltage-sensitive Ka
ClC-K1
CLCK1
CLCKA_HUMAN
hClC-Ka
Related patient information and medicines
Patient information leaflet
Can I take Atorvastatin and Candesartan together?
Salt substitutes (potassium-based) Candesartan can increase the levels of potassium in your blood. Many 'low-sodium' salt substitutes contain potassium chloride. Using these while taking candesartan can lead to dangerously high potassium levels (hyperkalaemia). Check with your pharmacist before using salt substitutes. Using other medicines Taking.
Patient information leaflet
Swollen lymph glands
Swollen lymph glands (also called lymph nodes) are usually a sign that your body is fighting infection, but they can have other causes. Common areas for swollen glands include the neck, under the chin, in the armpits and in the groin. Swollen lymph glands caused by infection usually get better on their own within two weeks. In this leaflet we.
Patient information leaflet
Can I take Lisinopril and Potassium together?
Stomach or intestinal blockages Potassium tablets can cause severe irritation or ulcers in the digestive tract; they must be taken with a ... Food and drink warnings Salt substitutes and low-sodium salts (e.g., LoSalt) These products often contain potassium chloride. Taking them alongside lisinopril or potassium supplements can cause your blood.
Patient information leaflet
Routine kidney function blood test
When doctors talk about a blood test for the kidneys, they usually mean a single blood test that measures the following four things: Urea. Creatinine. Sodium. Potassium. Some laboratories also measure chloride and bicarbonate routinely, whereas in other labs these are only done if the clinician specifically asks for them. These blood tests are.
Patient information leaflet
Cystic fibrosis
Cystic fibrosis is an inherited disease which mainly affects the lungs and pancreas but can involve other organs. Symptoms usually begin in early childhood and include persistent cough, wheeze, repeated chest infections, difficulty digesting food and general ill health. Treatments include antibiotics, physiotherapy, medicines for thinning mucus,.
Patient information leaflet
Sweaty feet
It may lead to smelly feet, and nobody likes stinky feet. This leaflet explains why feet sweat (which is normal) and how to stop your feet from being sweaty or smelly. Why do feet sweat. Sweating is normal. It has three main functions: Heat regulation - sweating cools the body by wetting the surface of the skin. Excretion - another way for the.
Further reading and references
- chloride voltage-gated channel Ka; MedlinePlus, National Library of Medicine.
- Barlassina C, Dal Fiume C, Lanzani C, Manunta P, Guffanti G, Ruello A, Bianchi G, Del Vecchio L, Macciardi F, Cusi D. Common genetic variants and haplotypes in renal CLCNKA gene are associated to salt-sensitive hypertension. Hum Mol Genet. 2007 Jul 1;16(13):1630-8. doi: 10.1093/hmg/ddm112. Epub 2007 May 17.
- Kieferle S, Fong P, Bens M, Vandewalle A, Jentsch TJ. Two highly homologous members of the ClC chloride channel family in both rat and human kidney. Proc Natl Acad Sci U S A. 1994 Jul 19;91(15):6943-7. doi: 10.1073/pnas.91.15.6943.
- Kramer BK, Bergler T, Stoelcker B, Waldegger S. Mechanisms of Disease: the kidney-specific chloride channels ClCKA and ClCKB, the Barttin subunit, and their clinical relevance. Nat Clin Pract Nephrol. 2008 Jan;4(1):38-46. doi: 10.1038/ncpneph0689.
- Nozu K, Inagaki T, Fu XJ, Nozu Y, Kaito H, Kanda K, Sekine T, Igarashi T, Nakanishi K, Yoshikawa N, Iijima K, Matsuo M. Molecular analysis of digenic inheritance in Bartter syndrome with sensorineural deafness. J Med Genet. 2008 Mar;45(3):182-6. doi: 10.1136/jmg.2007.052944.
- Schlingmann KP, Konrad M, Jeck N, Waldegger P, Reinalter SC, Holder M, Seyberth HW, Waldegger S. Salt wasting and deafness resulting from mutations in two chloride channels. N Engl J Med. 2004 Mar 25;350(13):1314-9. doi: 10.1056/NEJMoa032843. No abstract available.
Join the conversation
Share your thoughts or experiences with others in our patient communities.
Ask, share, connect.
Browse discussions, ask questions, and share experiences across hundreds of health topics.
Sign up to the Patient newsletter
Your weekly dose of clear, trustworthy health advice - written to help you feel informed, confident and in control.
By subscribing you accept our Privacy Policy. You can unsubscribe at any time. We never sell your data.