Urea is a waste product formed from the breakdown of proteins. Urea is usually passed out in the urine. A high blood level of urea ('uraemia') indicates that the kidneys may not be working properly, or that you have a low body water content (are dehydrated).
Creatinine is a waste product made by the muscles. Creatinine passes into the bloodstream and is usually passed out in urine. A high blood level of creatinine indicates that the kidneys may not be working properly. Creatinine is usually a more accurate marker of kidney function than urea. The effect of muscle mass needs to be taken into account. A person with a lot of muscle and little fat on their body is likely to have a higher creatinine than a person who has a lot of fat and little muscle.
Estimated glomerular filtration rate
Estimated glomerular filtration rate (eGFR) provides a guide to kidney function. Although the level of creatinine in the blood is a useful guide to kidney function, the eGFR is a more accurate measure. Blood creatinine can be used to estimate the eGFR using age, sex and race. This is often calculated by computer and reported with the creatinine blood test. The normal value for eGFR is 90-120 ml/min. An eGFR below 60 ml/min suggests that some kidney damage has occurred. The value becomes lower with increasing severity of kidney damage.
Read more about estimated glomerular filtration rate (eGFR).
Dissolved salts that are routinely measured are sodium, potassium, chloride and bicarbonate. They are sometimes referred to as 'electrolytes'. Abnormal blood levels of any of these may be due to a kidney problem. (Some other conditions may also alter the salt balance in the blood.)
Who has a blood test of kidney function?
Routine kidney function is one of the most commonly performed blood tests. It may be done:
- As part of a general health assessment.
- If you have suspected low body water content (dehydration), when the urea level increases.
- If you have suspected kidney failure. The higher the blood levels of urea and creatinine, the less well the kidneys are working. The level of creatinine is usually used as a marker as to the severity of kidney failure. Creatinine in itself is not harmful but a high level indicates that the kidneys are not working properly. So, many other waste products will not be cleared out of the bloodstream. You normally need treatment with dialysis if the level of creatinine goes higher than a certain value.
- Before and after starting treatment with certain medicines. Some medicines occasionally cause kidney damage as a side-effect. Therefore, kidney function is often checked before and after starting treatment with certain medicines.
Other tests of kidney function
The routine kidney blood test is a general marker of kidney function. If the blood test is abnormal it cannot say what is causing the kidney problem. Therefore, if you have an abnormal result you may need further tests to find the cause of a kidney problem. For example: urine tests, other blood tests, scans, X-rays, kidney biopsy, etc.
Further reading and references
Chronic kidney disease: early identification and management of chronic kidney disease in adults in primary and secondary care; NICE Clinical Guidelines (July 2014)
Hyperphosphataemia in chronic kidney disease; NICE Clinical Guideline (Mar 2013)
Chronic kidney disease: managing anaemia; NICE Clinical Guideline (June 2015).
Sommerer C, Zeier M; Clinical Manifestation and Management of ADPKD in Western Countries. Kidney Dis (Basel). 2016 Oct2(3):120-127. Epub 2016 Oct 6.
Diet in Renal Disease; Edinburgh Renal Unit
Blann A; Routine blood tests 1: why do we test for urea and electrolytes? Nursing Times 110: 5, 19-21, 2014.
Fraser SD, Blakeman T; Chronic kidney disease: identification and management in primary care. Pragmat Obs Res. 2016 Aug 177:21-32. eCollection 2016.
Alaini A, Malhotra D, Rondon-Berrios H, et al; Establishing the presence or absence of chronic kidney disease: Uses and limitations of formulas estimating the glomerular filtration rate. World J Methodol. 2017 Sep 267(3):73-92. doi: 10.5662/wjm.v7.i3.73. eCollection 2017 Sep 26.