cytochrome P450 family 11 subfamily B member 1
Last updated 26 Jul 2023
Meets Patient’s editorial guidelines
- DownloadDownload
- Share
- Language
- Discussion
- Audio Version
- Add to preferred sources on Google
The CYP11B1 gene provides instructions for making an enzyme called 11-beta-hydroxylase. This enzyme is found in the adrenal glands, which are located on top of the kidneys. The 11-beta-hydroxylase enzyme is a member of the cytochrome P450 family of enzymes. These enzymes are involved in the formation and breakdown of various molecules within cells.
Normal function
The CYP11B1 gene provides instructions for making an enzyme called 11-beta-hydroxylase. This enzyme is found in the adrenal glands, which are located on top of the kidneys. The 11-beta-hydroxylase enzyme is a member of the cytochrome P450 family of enzymes. These enzymes are involved in the formation and breakdown of various molecules within cells.
The 11-beta-hydroxylase enzyme helps produce hormones called cortisol and corticosterone. Specifically, the enzyme helps convert a molecule called 11-deoxycortisol to cortisol, and helps convert another molecule called 11-deoxycorticosterone to corticosterone. These processes are triggered by the release of a hormone called adrenocorticotropic hormone (ACTH) by the pituitary gland, located at the base of the brain.
Cortisol helps maintain blood sugar (glucose) levels, protects the body from physical stress, and suppresses inflammation. Corticosterone is converted to the hormone aldosterone by the aldosterone synthase enzyme, which is produced from the nearby CYP11B2 gene. Aldosterone helps control blood pressure by maintaining proper salt and fluid levels in the body.
Conditions referring to this gene or chromosome
Other names
C11B1_HUMAN
CPN1
CYP11B
CYPXIB1
cytochrome P-450c11
cytochrome P450 11B1, mitochondrial
cytochrome P450 11B1, mitochondrial isoform 1 precursor
cytochrome P450 11B1, mitochondrial isoform 2 precursor
cytochrome p450 XIB1
cytochrome P450, family 11, subfamily B, polypeptide 1
cytochrome P450, subfamily XIB (steroid 11-beta-hydroxylase), polypeptide 1
cytochrome P450C11
DKFZp686B05283
FHI
FLJ36771
P450C11
steroid 11-beta-hydroxylase
steroid 11-beta-monooxygenase
Related patient information and medicines
Patient information leaflet
Can I take Black cohosh and Vitamin C together?
I... Why this happens Black cohosh and vitamin C are processed by the body through different pathways. Vitamin C is a water-soluble vitamin that does not significantly interfere with the liver enzymes (such as the Cytochrome P450 system) that process black cohosh. Additionally, they do not have overlapping effects that would cause a dangerous.
Patient information leaflet
Can I take Black cohosh and Glucosamine together?
Why this happens These two substances are processed by the body through different pathways. Glucosamine is an amino sugar used by the body to build cartilage, while black cohosh is a herbal remedy that primarily affects hormonal pathways or neurotransmitters. They do not compete for the same enzymes in the liver (such as the Cytochrome P450.
Patient information leaflet
Find out if you are eligible for a free NHS flu vaccination
Open the flu jab Is the flu vaccine free for you this winter. The flu vaccine is free on the NHS for people most likely to get seriously ill from flu, and for those who could easily pass it on to someone at risk. Whether you qualify depends on your age, your health, and a few other things such as being pregnant or caring for someone. The groups.
Patient information leaflet
Can I take Glucosamine and St John's wort together?
T... It is generally considered safe to take these two supplements together. Why this happens Glucosamine is primarily used by the body to build cartilage and does not significantly affect the liver enzymes (Cytochrome P450) that St John's wort is known to influence. St John's wort works by altering brain chemicals and speeding up the breakdown of.
Patient information leaflet
Can I take Promethazine and Vitamin D3 together?
It is generally considered sa... Why this happens Promethazine is an antihistamine processed primarily by the liver's cytochrome P450 enzymes, while vitamin D3 is a fat-soluble vitamin that undergoes a different metabolic pathway (hydroxylation in the liver and kidneys). They do not interfere with each other's absorption, metabolism, or effects in.
Patient information leaflet
Travelling to remote locations
There could be local unrest or terrorist activity that does not make daily news in the UK but which could be a risk. In addition to political problems, there may be hostility towards travellers or specific advice around dress codes and behaviour. Consider whether to leave jewellery and other valuable items at home. If you will be travelling off.
Further reading and references
- cytochrome P450 family 11 subfamily B member 1; MedlinePlus, National Library of Medicine.
- Martinez-Aguayo A, Fardella C. Genetics of hypertensive syndrome. Horm Res. 2009;71(5):253-9. doi: 10.1159/000208798. Epub 2009 Apr 1.
- Moraitis AG, Rainey WE, Auchus RJ. Gene mutations that promote adrenal aldosterone production, sodium retention, and hypertension. Appl Clin Genet. 2013 Dec 24;7:1-13. doi: 10.2147/TACG.S35571.
- Nimkarn S, New MI. Steroid 11beta- hydroxylase deficiency congenital adrenal hyperplasia. Trends Endocrinol Metab. 2008 Apr;19(3):96-9. doi: 10.1016/j.tem.2008.01.002. Epub 2008 Feb 21.
- Parajes S, Loidi L, Reisch N, Dhir V, Rose IT, Hampel R, Quinkler M, Conway GS, Castro-Feijoo L, Araujo-Vilar D, Pombo M, Dominguez F, Williams EL, Cole TR, Kirk JM, Kaminsky E, Rumsby G, Arlt W, Krone N. Functional consequences of seven novel mutations in the CYP11B1 gene: four mutations associated with nonclassic and three mutations causing classic 11beta-hydroxylase deficiency. J Clin Endocrinol Metab. 2010 Feb;95(2):779-88. doi: 10.1210/jc.2009-0651. Epub 2010 Jan 20.
- Peter M. Congenital adrenal hyperplasia: 11beta-hydroxylase deficiency. Semin Reprod Med. 2002 Aug;20(3):249-54. doi: 10.1055/s-2002-35389.
- Quack I, Vonend O, Rump LC. Familial hyperaldosteronism I-III. Horm Metab Res. 2010 Jun;42(6):424-8. doi: 10.1055/s-0029-1246187. Epub 2010 Feb 3.
- Stowasser M, Gordon RD. Familial hyperaldosteronism. J Steroid Biochem Mol Biol. 2001 Sep;78(3):215-29. doi: 10.1016/s0960-0760(01)00097-8.
- Stowasser M, Gordon RD. Monogenic mineralocorticoid hypertension. Best Pract Res Clin Endocrinol Metab. 2006 Sep;20(3):401-20. doi: 10.1016/j.beem.2006.07.008.
- Stowasser M, Gunasekera TG, Gordon RD. Familial varieties of primary aldosteronism. Clin Exp Pharmacol Physiol. 2001 Dec;28(12):1087-90. doi: 10.1046/j.1440-1681.2001.03574.x.
- Williams SS. Advances in genetic hypertension. Curr Opin Pediatr. 2007 Apr;19(2):192-8. doi: 10.1097/MOP.0b013e32801e217c.
Join the conversation
Share your thoughts or experiences with others in our patient communities.
Ask, share, connect.
Browse discussions, ask questions, and share experiences across hundreds of health topics.
Sign up to the Patient newsletter
Your weekly dose of clear, trustworthy health advice - written to help you feel informed, confident and in control.
By subscribing you accept our Privacy Policy. You can unsubscribe at any time. We never sell your data.