factor interacting with PAPOLA and CPSF1
Last updated 5 Jul 2022
Meets Patient’s editorial guidelines
- DownloadDownload
- Share
- Language
- Discussion
- Audio Version
- Add to preferred sources on Google
The FIP1L1 gene provides instructions for making part of a protein complex named cleavage and polyadenylation specificity factor (CPSF). This complex of proteins plays an important role in processing molecules called messenger RNAs (mRNAs), which serve as the genetic blueprints for making proteins. The CPSF protein complex helps add a string of the RNA building block adenine to the mRNA, creating a polyadenine tail or poly(A) tail. The poly(A) tail is important for stability of the mRNA and for protein production from the blueprint.
Normal function
The FIP1L1 gene provides instructions for making part of a protein complex named cleavage and polyadenylation specificity factor (CPSF). This complex of proteins plays an important role in processing molecules called messenger RNAs (mRNAs), which serve as the genetic blueprints for making proteins. The CPSF protein complex helps add a string of the RNA building block adenine to the mRNA, creating a polyadenine tail or poly(A) tail. The poly(A) tail is important for stability of the mRNA and for protein production from the blueprint.
Conditions referring to this gene or chromosome
Other names
FIP1-like 1 protein
FIP1_HUMAN
hFip1
pre-mRNA 3'-end-processing factor FIP1
Rhe
Related patient information and medicines
Patient information leaflet
Check your medicines for interactions
Use this medicine and drug interaction checker to see whether your medicines, supplements, vitamins, foods, or certain health conditions may interact with each other. It can help you understand potential risks, avoid unwanted side effects, and decide when it’s impo... What is a drug interaction. A drug interaction occurs when one medicine affects.
Patient information leaflet
Can I take Allopurinol and Atenolol together?
There is a potential for these two medicines to interact, which may lead to an increased risk of allergic reactions or a slight change in how your kidneys handle the medication. While most people take this co... Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to.
Patient information leaflet
Can I take Amlodipine and Lansoprazole together?
Why this happens Amlodipine (a blood pressure medicine) and lansoprazole (a stomach acid reducer) are processed by different pathways in the body and do not interfere with how the other works. Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together..
Patient information leaflet
Can I take St John's wort and Vitamin C together?
There is no known interaction between St John's Wort and Vitamin C. Why this happens Vitamin C (ascorbic acid) and St John's Wort (Hypericum perforatum) are processed by the body through different pathways. Simply search for you... Disclaimer This information is for general educational purposes only and should not be relied upon as a substitute.
Patient information leaflet
Can I take Atorvastatin and Fibre supplements together?
...supplements at the same time as atorvastatin can lower the amount of medicine your body absorbsOur Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them. Disclaimer.
Patient information leaflet
Can I take Atorvastatin and Lansoprazole together?
There is no significant harmful interaction between atorvastatin and lansoprazole. Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them. ...or professional medical.
Further reading and references
- factor interacting with PAPOLA and CPSF1; MedlinePlus, National Library of Medicine.
- Bain BJ. Relationship between idiopathic hypereosinophilic syndrome, eosinophilic leukemia, and systemic mastocytosis. Am J Hematol. 2004 Sep;77(1):82-5. doi: 10.1002/ajh.20088.
- Buitenhuis M, Verhagen LP, Cools J, Coffer PJ. Molecular mechanisms underlying FIP1L1-PDGFRA-mediated myeloproliferation. Cancer Res. 2007 Apr 15;67(8):3759-66. doi: 10.1158/0008-5472.CAN-06-4183.
- Cools J, DeAngelo DJ, Gotlib J, Stover EH, Legare RD, Cortes J, Kutok J, Clark J, Galinsky I, Griffin JD, Cross NC, Tefferi A, Malone J, Alam R, Schrier SL, Schmid J, Rose M, Vandenberghe P, Verhoef G, Boogaerts M, Wlodarska I, Kantarjian H, Marynen P, Coutre SE, Stone R, Gilliland DG. A tyrosine kinase created by fusion of the PDGFRA and FIP1L1 genes as a therapeutic target of imatinib in idiopathic hypereosinophilic syndrome. N Engl J Med. 2003 Mar 27;348(13):1201-14. doi: 10.1056/NEJMoa025217.
- Fukushima K, Matsumura I, Ezoe S, Tokunaga M, Yasumi M, Satoh Y, Shibayama H, Tanaka H, Iwama A, Kanakura Y. FIP1L1-PDGFRalpha imposes eosinophil lineage commitment on hematopoietic stem/progenitor cells. J Biol Chem. 2009 Mar 20;284(12):7719-32. doi: 10.1074/jbc.M807489200. Epub 2009 Jan 14.
- Kaufmann I, Martin G, Friedlein A, Langen H, Keller W. Human Fip1 is a subunit of CPSF that binds to U-rich RNA elements and stimulates poly(A) polymerase. EMBO J. 2004 Feb 11;23(3):616-26. doi: 10.1038/sj.emboj.7600070. Epub 2004 Jan 29.
- Roufosse FE, Goldman M, Cogan E. Hypereosinophilic syndromes. Orphanet J Rare Dis. 2007 Sep 11;2:37. doi: 10.1186/1750-1172-2-37.
Join the conversation
Share your thoughts or experiences with others in our patient communities.
Ask, share, connect.
Browse discussions, ask questions, and share experiences across hundreds of health topics.
Sign up to the Patient newsletter
Your weekly dose of clear, trustworthy health advice - written to help you feel informed, confident and in control.
By subscribing you accept our Privacy Policy. You can unsubscribe at any time. We never sell your data.