Can I take St john's wort and Vitamin c together?
Drug interaction guide
Originally published 25 Jan 2026
Meets Patient’s editorial guidelines
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There is no known interaction between St John's Wort and Vitamin C. It is generally considered safe to take these two supplements together.
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Why this happens
Vitamin C (ascorbic acid) and St John's Wort (Hypericum perforatum) are processed by the body through different pathways. Vitamin C is water-soluble and does not interfere with the liver enzymes (specifically the CYP450 system) that St John's Wort is known to affect. Furthermore, they do not have overlapping effects on the body's systems that would cause a conflict.
What you should do
You can continue to take both supplements as directed. However, always inform your doctor or pharmacist about all supplements you are taking, as St John's Wort interacts with many prescription medicines, such as the contraceptive pill, blood thinners, and antidepressants.
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Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
25 Jan 2026 | Originally published

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