SIX homeobox 5
Last updated 18 Aug 2020
Meets Patient’s editorial guidelines
- DownloadDownload
- Share
- Language
- Discussion
- Audio Version
- Add to preferred sources on Google
The SIX5 gene is part of a group of similar genes known as the SIX gene family. Genes in this family provide instructions for making proteins that bind to DNA and control the activity of other genes. Based on this role, SIX proteins are called transcription factors.
Normal function
The SIX5 gene is part of a group of similar genes known as the SIX gene family. Genes in this family provide instructions for making proteins that bind to DNA and control the activity of other genes. Based on this role, SIX proteins are called transcription factors.
The SIX5 protein interacts with several other proteins, including the protein produced from the EYA1 gene, to regulate the activity of genes that are important for normal development. Before birth, these protein interactions appear to be essential for the normal formation of many tissues. These include the second branchial arch, which gives rise to tissues in the front and side of the neck; the ears; and the kidneys. Researchers have also found the SIX5 protein in the adult brain, heart, eyes, and muscles used for movement (skeletal muscles).
Conditions referring to this gene or chromosome
Other names
BOR2
DM locus-associated homeodomain protein
DMAHP
dystrophia myotonica-associated homeodomain protein
homeobox protein SIX5
sine oculis homeobox homolog 5
SIX5_HUMAN
Related patient information and medicines
Patient information leaflet
Acne treatments
Chemical 'peels' may be purchased – a che... There is not enough evidence to support specific diets for treating acne. Light therapy There are some new treatments that use 'light' to treat acne. You can buy 'light therapy boxes' to use at home. Although there are a lot of online articles about how good they are, the scientific research doesn't.
Patient information leaflet
Loss of taste and smell
How do taste and smell work. Our sense of taste is powered by taste receptors found in the taste buds on our tongues and also in our mouths. The information they collect is sent to the brain. However, the smell of food also hugely influences how we taste. The sense of taste provides five basic different tastes: Sweet. Sour. Salty. Bitter. Umami.
Patient information leaflet
Bedwetting
Bedwetting is common. In time, most children become dry at night without any treatment. However, an option is to use treatment which promotes dry nights sooner rather than later. Treatment is considered for children aged 5 years and over. What is bedwetting. Bedwetting (nocturnal enuresis) means a child passes urine in the night when they are.
Patient information leaflet
Antidepressants
Antidepressant medicines are effective for treating depression. Around half of people with moderate or severe depression feel better within a few weeks of starting treatment. They are also used for other conditions such as recurrent headaches and some forms of pain. A course of antidepressants (used for depression) will be taken for at least six.
Patient information leaflet
Smoking
Smoking-related deaths are mainly due to cancers, chronic obstructive pulmonary disease (COPD) , heart disease (such as heart attacks ) and stroke. If you are a long-term smoker, on average, your life expectancy is about 10 years less than a non-smoker. Put another way, in the UK about 8 in 10 non-smokers live past the age of 70 but only about.
Patient information leaflet
ADHD in adults
Attention deficit hyperactivity disorder (ADHD) causes problems with concentrating (inattention), and being too active and having difficulty staying focused (hyperactivity). The difficulties caused by ADHD vary from mild to severe. Although ADHD starts in childhood, the difficulties often persist into adulthood. Sometimes adults are diagnosed with.
Further reading and references
- SIX homeobox 5; MedlinePlus, National Library of Medicine.
- Hoskins BE, Cramer CH, Silvius D, Zou D, Raymond RM, Orten DJ, Kimberling WJ, Smith RJ, Weil D, Petit C, Otto EA, Xu PX, Hildebrandt F. Transcription factor SIX5 is mutated in patients with branchio-oto-renal syndrome. Am J Hum Genet. 2007 Apr;80(4):800-4. doi: 10.1086/513322. Epub 2007 Feb 22.
- Kirby RJ, Hamilton GM, Finnegan DJ, Johnson KJ, Jarman AP. Drosophila homolog of the myotonic dystrophy-associated gene, SIX5, is required for muscle and gonad development. Curr Biol. 2001 Jul 10;11(13):1044-9. doi: 10.1016/s0960-9822(01)00319-0.
- Krug P, Moriniere V, Marlin S, Koubi V, Gabriel HD, Colin E, Bonneau D, Salomon R, Antignac C, Heidet L. Mutation screening of the EYA1, SIX1, and SIX5 genes in a large cohort of patients harboring branchio-oto-renal syndrome calls into question the pathogenic role of SIX5 mutations. Hum Mutat. 2011 Feb;32(2):183-90. doi: 10.1002/humu.21402.
- Pham YC, Man Nt, Holt I, Sewry CA, Pall G, Johnson K, Morris GE. Characterisation of the transcription factor, SIX5, using a new panel of monoclonal antibodies. J Cell Biochem. 2005 Aug 1;95(5):990-1001. doi: 10.1002/jcb.20454.
Join the conversation
Share your thoughts or experiences with others in our patient communities.
Ask, share, connect.
Browse discussions, ask questions, and share experiences across hundreds of health topics.
Sign up to the Patient newsletter
Your weekly dose of clear, trustworthy health advice - written to help you feel informed, confident and in control.
By subscribing you accept our Privacy Policy. You can unsubscribe at any time. We never sell your data.