Can I take Biotin and Isosorbide mononitrate together?
Drug interaction guide
Originally published 25 Jan 2026
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There is no known interaction between biotin and isosorbide mononitrate (also known by brand names like Carmil or Monomil). Biotin is a B-vitamin, and isosorbide mononitrate is a nitrate medication used to prevent chest pain (angina). They work in completely different ways in the body and do not interfere with each other's absorption or effectiveness.
Why this happens
Biotin is a water-soluble vitamin processed by the body's normal metabolic pathways. Isosorbide mononitrate works by relaxing blood vessels. These two substances do not share the same metabolic pathways in the liver, nor do they compete for the same receptors in the body.
What you should do
You can safely take biotin and isosorbide mononitrate together. However, you should always inform your doctor or pharmacist about all supplements you are taking. Note: High doses of biotin can sometimes interfere with certain laboratory blood tests (such as thyroid or heart enzyme tests); if you are having blood work done, tell the nurse or doctor that you take a biotin supplement.
Important precautions
Blood tests (especially heart attack or thyroid tests)
Biotin can cause dangerously misleading results in blood tests. You must stop taking it at least 48 hours before any blood tests and tell your doctor you have been taking it, as it can hide signs of a heart attack or suggest thyroid problems that do not exist.
Erectile dysfunction treatment
Never take isosorbide mononitrate with sildenafil (Viagra), tadalafil (Cialis), or vardenafil (Levitra). Combining these can cause a sudden, life-threatening drop in blood pressure.
Food and drink warnings
Alcohol
You should avoid or strictly limit alcohol while taking isosorbide mononitrate. Alcohol can increase the blood pressure-lowering effect of this medicine, which may lead to dizziness, lightheadedness, fainting, or a rapid heartbeat.
Raw egg whites
Consuming large amounts of raw egg whites over a long period can prevent your body from absorbing biotin. This is because raw egg whites contain a protein called avidin that binds to biotin. Cooked eggs do not cause this issue.
Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
Article also available in English, German, Spanish, French, Italian, Portuguese, Hindi, Hebrew, Arabic, and Swedish.
25 Jan 2026 | Originally published

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