Can I take Isosorbide mononitrate and Vitamin D together?

Why this happens

These two substances work in completely different ways in the body. Isosorbide mononitrate relaxes the blood vessels to improve blood flow to the heart, while Vitamin D helps the body absorb calcium and maintain bone health. They do not interfere with each other's absorption, breakdown, or effects.

What you should do

You can safely take these two medications together. It is usually best to take your heart medication at the same time each day as prescribed by your doctor. If you are taking very high doses of Vitamin D (prescribed for a deficiency), your doctor may monitor your calcium levels, but this is standard practice and not caused by the heart medication.

Important precautions

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You must not take sildenafil (Viagra), tadalafil (Cialis), or vardenafil (Levitra) while using Isosorbide mononitrate. Combining them can cause a dangerous and potentially fatal drop in blood pressure.

Hypercalcaemia (high blood calcium levels)

Do not take vitamin D supplements if you have high levels of calcium in your blood or urine, as this can lead to serious kidney damage and heart rhythm problems.

Food and drink warnings

Alcohol

It is best to avoid or strictly limit alcohol while taking isosorbide mononitrate. Alcohol can increase the blood pressure-lowering effect of this medicine, which may make you feel dizzy, lightheaded, or faint. It can also increase the risk of headaches.

High-fat meals

Vitamin D is a fat-soluble vitamin. It is best absorbed by your body when taken with a meal that contains some fat (such as eggs, avocado, nuts, or dairy).

Using other medicines

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.