Can I take Isosorbide mononitrate and Vitamin D together?
Drug interaction guide
Originally published 25 Jan 2026
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There is no known interaction between isosorbide mononitrate (also known by brand names like Carmil or Monomil) and Vitamin D supplements.
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Why this happens
These two substances work in completely different ways in the body. Isosorbide mononitrate relaxes the blood vessels to improve blood flow to the heart, while Vitamin D helps the body absorb calcium and maintain bone health. They do not interfere with each other's absorption, breakdown, or effects.
What you should do
Back to contentsYou can safely take these two medications together. It is usually best to take your heart medication at the same time each day as prescribed by your doctor. If you are taking very high doses of Vitamin D (prescribed for a deficiency), your doctor may monitor your calcium levels, but this is standard practice and not caused by the heart medication.
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Important precautions
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You must not take sildenafil (Viagra), tadalafil (Cialis), or vardenafil (Levitra) while using Isosorbide mononitrate. Combining them can cause a dangerous and potentially fatal drop in blood pressure.
Hypercalcaemia (high blood calcium levels)
Do not take vitamin D supplements if you have high levels of calcium in your blood or urine, as this can lead to serious kidney damage and heart rhythm problems.
Food and drink warnings
Back to contentsAlcohol
It is best to avoid or strictly limit alcohol while taking isosorbide mononitrate. Alcohol can increase the blood pressure-lowering effect of this medicine, which may make you feel dizzy, lightheaded, or faint. It can also increase the risk of headaches.
High-fat meals
Vitamin D is a fat-soluble vitamin. It is best absorbed by your body when taken with a meal that contains some fat (such as eggs, avocado, nuts, or dairy).
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Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Treatment and medication
Can I take Lisinopril and Potassium together?
Taking lisinopril and potassium supplements together can cause the levels of potassium in your blood to become dangerously high (a condition called hyperkalaemia). While your body needs potassium for your heart and muscles to work, too much of it can lead to serious heart rhythm problems or even cause the heart to stop. Symptoms of high potassium can include muscle weakness, tingling sensations, or palpitations, but often there are no symptoms until the level is very high.
Treatment and medication
Can I take Losartan and Rybelsus together?
Taking these two medicines together can sometimes cause your blood sugar levels to drop lower than intended. Additionally, both drugs can affect your kidney function, especially if you become dehydrated.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
25 Jan 2026 | Originally published
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