Can I take Hydrochlorothiazide and Alogliptin together?

Why this happens

Hydrochlorothiazide can occasionally make the body less sensitive to insulin or cause the body to lose potassium, both of which can slightly raise blood sugar levels. Alogliptin works to lower blood sugar. While 12.5mg is a very low dose of hydrochlorothiazide and unlikely to cause issues, it technically works against the goal of the diabetes medication.

What you should do

You can safely take these medicines together. It is good practice to monitor your blood sugar levels regularly when starting or changing the dose of a diuretic. If you notice your blood sugar readings are consistently higher than usual, mention it to your doctor or pharmacist.

Important precautions

Pancreatitis

Stop taking alogliptin and seek immediate medical help if you experience severe and persistent stomach pain, which may reach through to your back, as this can be a sign of an inflamed pancreas.

Skin cancer risk

Hydrochlorothiazide makes your skin more sensitive to sunlight. Limit sun exposure, use high-factor sunscreen, and regularly check your skin for any new moles or suspicious sores, as long-term use increases the risk of non-melanoma skin cancer.

Sulphonamide allergy

Do not take hydrochlorothiazide if you have a known severe allergy to sulphonamide antibiotics (such as sulfamethoxazole), as you may experience a cross-reactive allergic reaction.

Food and drink warnings

Alcohol

Drinking alcohol while taking hydrochlorothiazide can increase the risk of dizziness or fainting, especially when standing up. This is because both alcohol and the medicine can lower your blood pressure. It is best to limit alcohol intake until you know how the medicine affects you.

Salt substitutes (Potassium-based)

Hydrochlorothiazide can affect the levels of minerals in your blood. While it often lowers potassium, some patients may be advised to use salt substitutes. However, you should check with your doctor before using salt substitutes that contain potassium, as they can significantly alter your mineral balance.

Using other medicines

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.