Can I take Alogliptin and Metformin together?

Why this happens

Both drugs work in different ways to lower blood glucose. Alogliptin helps the body release more insulin after eating, while metformin reduces the amount of sugar the liver produces and helps the body use its own insulin better. Together, they have an 'additive' effect, meaning they work as a team to control blood sugar more effectively than either drug alone.

What you should do

You should continue taking both medicines as prescribed by your doctor. It is important to learn the signs of low blood sugar (such as feeling shaky, sweaty, hungry, or dizzy) and always carry a fast-acting sugar source, like glucose tablets or a sugary drink. If you frequently experience symptoms of low blood sugar, speak to your doctor as they may need to adjust your doses.

Important precautions

Lactic acidosis

Stop taking metformin and seek urgent medical help if you experience severe vomiting, diarrhoea, or dehydration. This medicine can cause a rare but life-threatening build-up of acid in the blood if you become severely unwell or have kidney problems.

Pancreatitis

Stop taking alogliptin and see a doctor immediately if you develop severe and persistent stomach pain, which may reach through to your back. This can be a sign of an inflamed pancreas.

Contrast X-rays/Scans

You must tell your doctor you take metformin if you are having an X-ray or scan involving an injection of 'contrast' dye. You will need to stop taking metformin for 48 hours to prevent sudden kidney damage.

Food and drink warnings

Alcohol

Drinking alcohol while taking metformin can increase the risk of a rare but serious condition called lactic acidosis. It can also cause your blood sugar levels to drop too low (hypoglycaemia). You should avoid excessive alcohol consumption and binge drinking.

Using other medicines

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.