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Can I take Alogliptin and Metformin together?

Drug interaction guide

Taking alogliptin and metformin together is generally safe and very common. However, because both medicines work to lower your blood sugar, there is a slightly higher risk of your blood sugar dropping too low (hypoglycaemia). This is more likely if you are also taking other diabetes medicines like insulin or a sulphonylurea.

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Why this happens

Both drugs work in different ways to lower blood glucose. Alogliptin helps the body release more insulin after eating, while metformin reduces the amount of sugar the liver produces and helps the body use its own insulin better. Together, they have an 'additive' effect, meaning they work as a team to control blood sugar more effectively than either drug alone.

What you should do

You should continue taking both medicines as prescribed by your doctor. It is important to learn the signs of low blood sugar (such as feeling shaky, sweaty, hungry, or dizzy) and always carry a fast-acting sugar source, like glucose tablets or a sugary drink. If you frequently experience symptoms of low blood sugar, speak to your doctor as they may need to adjust your doses.

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Using other medicines

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.

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Article history

The information on this page is written and peer reviewed by qualified clinicians.

  • 25 Jan 2026 | Originally published
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