Can I take Alogliptin and Empagliflozin together?
Drug interaction guide
Originally published 25 Jan 2026
Meets Patient’s editorial guidelines
- DownloadDownload
- Share
- Language
- Discussion
Taking alogliptin and empagliflozin together can increase the risk of your blood sugar levels dropping too low (hypoglycaemia). While both drugs are designed to lower blood sugar, using them at the same time has an additive effect. You may also have a slightly higher risk of dehydration or urinary tract infections.
In this article:
Continue reading below
Why this happens
Both medicines work in different ways to lower blood glucose: alogliptin increases insulin production after meals, while empagliflozin helps the kidneys remove sugar through urine. Because they both lower blood sugar, their combined effect is stronger than taking either one alone.
What you should do
It is common for these two medicines to be prescribed together, but you should monitor your blood sugar levels regularly as directed by your doctor. Learn to recognise the signs of low blood sugar (such as feeling shaky, sweaty, hungry, or dizzy) and always carry a quick-acting sugar source, like glucose tablets or a sugary drink. Ensure you drink plenty of water to stay hydrated.
Continue reading below
Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
Patient picks for Drug interactions

Treatment and medication
Can I take Clarithromycin and Rosuvastatin together?
Taking these two medicines together can significantly increase the amount of rosuvastatin in your blood. This increases the risk of serious muscle damage (rhabdomyolysis), which can lead to kidney problems. Symptoms to watch for include unexplained muscle pain, tenderness, or weakness, especially if you also feel generally unwell or have a fever.

Treatment and medication
Can I take Evana heavy period relief and Mefenamic acid together?
Taking these two medicines together significantly increases your risk of serious stomach problems, such as stomach ulcers, bleeding, or irritation of the stomach lining. It can also put extra strain on your kidneys.
Continue reading below
Article history
The information on this page is written and peer reviewed by qualified clinicians.
25 Jan 2026 | Originally published

Ask, share, connect.
Browse discussions, ask questions, and share experiences across hundreds of health topics.

Feeling unwell?
Assess your symptoms online for free
Sign up to the Patient newsletter
Your weekly dose of clear, trustworthy health advice - written to help you feel informed, confident and in control.
By subscribing you accept our Privacy Policy. You can unsubscribe at any time. We never sell your data.