Can I take Alogliptin and Empagliflozin together?

Why this happens

Both medicines work in different ways to lower blood glucose: alogliptin increases insulin production after meals, while empagliflozin helps the kidneys remove sugar through urine. Because they both lower blood sugar, their combined effect is stronger than taking either one alone.

What you should do

It is common for these two medicines to be prescribed together, but you should monitor your blood sugar levels regularly as directed by your doctor. Learn to recognise the signs of low blood sugar (such as feeling shaky, sweaty, hungry, or dizzy) and always carry a quick-acting sugar source, like glucose tablets or a sugary drink. Ensure you drink plenty of water to stay hydrated.

Important precautions

Diabetic Ketoacidosis (DKA)

Empagliflozin can cause a serious condition called ketoacidosis even if your blood sugar levels are near normal. Seek immediate medical help if you experience nausea, vomiting, stomach pain, or fruity-smelling breath. Stop taking this medicine if you are fasting for surgery or have a severe illness.

Fournier’s gangrene - empagliflozin

Seek urgent medical attention if you experience pain, tenderness, redness, or swelling in the genital or anal area, especially if accompanied by fever or a general feeling of being unwell.

Acute Pancreatitis

Stop taking alogliptin and contact your doctor immediately if you experience severe and persistent stomach pain, which might reach through to your back, as this may be a sign of an inflamed pancreas.

Food and drink warnings

Alcohol

Drinking alcohol with these medicines can increase the risk of low blood sugar (hypoglycaemia) and, in the case of empagliflozin, may increase the risk of a rare but serious condition called ketoacidosis. It is best to avoid excessive alcohol consumption and never drink on an empty stomach.

Using other medicines

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.