Can I take Lions mane and White button together?
Drug interaction guide
Originally published 25 Jan 2026
Meets Patient’s editorial guidelines
- DownloadDownload
- Share
- Language
- Discussion
There are no known harmful interactions between Lion's Mane (Hericium erinaceus) and White Button mushrooms (Agaricus bisporus). Both are edible fungi that are commonly consumed as food or supplements.
In this article:
It is safe to consume Lion's Mane and White Button mushrooms together.
These two types of mushrooms do not interfere with each other's absorption or breakdown in the body. They work through different pathways and do not have overlapping side effects that would cause concern when taken together.
As with any supplement, if you are trying Lion's Mane for the first time, start with a small amount to ensure you do not have an individual sensitivity or allergy.
Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
Patient picks for Drug interactions

Treatment and medication
Can I take Omeprazole and Simvastatin together?
Taking omeprazole and simvastatin together can increase the amount of simvastatin in your blood. This may increase the risk of side effects, particularly muscle pain, weakness, or a rare but serious condition called rhabdomyolysis (muscle breakdown).

Treatment and medication
Can I take Amlodipine and Paracetamol together?
There is no known interaction between amlodipine and paracetamol. It is generally considered safe to take these two medicines together.
Article history
The information on this page is written and peer reviewed by qualified clinicians.
25 Jan 2026 | Originally published

Ask, share, connect.
Browse discussions, ask questions, and share experiences across hundreds of health topics.

Feeling unwell?
Assess your symptoms online for free
Sign up to the Patient newsletter
Your weekly dose of clear, trustworthy health advice - written to help you feel informed, confident and in control.
By subscribing you accept our Privacy Policy. You can unsubscribe at any time. We never sell your data.