Can I take Lion's mane and Royal sun together?
Drug interaction guide
Originally published 25 Jan 2026
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Both Lion's Mane (Hericium erinaceus) and Royal Sun (Agaricus blazei) may have mild blood-thinning effects and can lower blood sugar levels. Taking them together might increase the risk of bruising or bleeding, and could potentially cause your blood sugar to drop lower than expected.
Why this happens
Both fungi contain compounds that may interfere with blood clotting (anti-platelet activity) and improve insulin sensitivity. When combined, these effects can be additive, meaning they reinforce each other.
What you should do
This combination is usually fine for healthy individuals, but you should use caution if you are already taking blood-thinning medications (like aspirin or warfarin) or diabetes medication. Monitor your blood sugar levels if you are diabetic, and watch for signs of easy bruising or prolonged bleeding from small cuts. If you have a scheduled surgery, stop taking both supplements at least two times weeks beforehand.
Important precautions
Surgery
Stop taking these supplements at least 2 weeks before scheduled surgery as they may increase the risk of bleeding and interfere with blood sugar control during and after the procedure.
Bleeding disorders
These supplements may slow blood clotting and increase the risk of bruising or bleeding, especially if you are already taking anticoagulant or antiplatelet medications.
Diabetes
These mushrooms can lower blood sugar levels. Monitor your blood glucose closely if you take insulin or oral diabetes medications, as a dose adjustment may be necessary to prevent hypoglycaemia.
Food and drink warnings
Alcohol
It is best to avoid or strictly limit alcohol when taking these supplements. Both Lion's Mane and Royal Sun are processed by the liver; combining them with alcohol may increase the strain on your liver and potentially lead to liver damage. Additionally, alcohol can interfere with the immune-modulating effects of these medicinal mushrooms.
Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
Article also available in English, German, Spanish, French, Italian, Portuguese, Hindi, Hebrew, Arabic, and Swedish.
25 Jan 2026 | Originally published

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