Can I take Maitake and Reishi together?
Drug interaction guide
Originally published 25 Jan 2026
Meets Patient’s editorial guidelines
- DownloadDownload
- Share
- Language
- Discussion
- Audio Version
- Add to preferred sources on Google
Taking maitake and reishi together may increase the risk of bruising or bleeding. Both mushrooms have properties that can slow down blood clotting. Additionally, both may lower blood sugar levels, which could lead to symptoms of low blood sugar (hypoglycaemia) such as dizziness or shakiness.
Why this happens
Both maitake and reishi have 'antiplatelet' effects, meaning they make blood cells less sticky and less likely to form clots. When used together, this effect is additive. They also both possess glucose-lowering properties, which can further reduce blood sugar levels when combined.
What you should do
It is generally safe for healthy individuals to take these together in moderate amounts, but you should use caution. If you are scheduled for surgery, stop taking both at least two weeks beforehand. If you take blood-thinning medications (like warfarin or aspirin) or diabetes medication, speak to your doctor before combining these supplements, as your dosages may need adjusting.
Important precautions
Bleeding disorders or surgery
Both maitake and reishi may slow blood clotting and increase the risk of bleeding. You must stop taking these at least 2 weeks before any scheduled surgery. Use with caution if you are taking blood-thinning medications like warfarin or aspirin.
Diabetes
These supplements can lower blood sugar levels. If you are taking insulin or other diabetes medications, monitor your blood sugar closely as your dose may need adjustment to prevent hypoglycaemia (dangerously low blood sugar).
Auto-immune conditions (e.g., multiple sclerosis, lupus, rheumatoid arthritis)
These supplements can increase immune system activity, which may worsen the symptoms of autoimmune diseases. Avoid use if you have these conditions.
Low blood pressure (Hypotension)
These supplements may lower blood pressure. If you already have low blood pressure or take medication to control high blood pressure, they could cause your blood pressure to drop too low.
Food and drink warnings
Alcohol
It is best to avoid or strictly limit alcohol when taking these supplements. Both Maitake and Reishi can have effects on the liver, and combining them with alcohol may increase the risk of liver strain or damage. Additionally, Reishi can have sedative effects which alcohol may intensify.
Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
Patient picks for Drug interactions

Drug interactions checker
Can I take Guanfacine and Tizanidine together?
Taking these two medicines together can cause your blood pressure to drop too low and make you feel very sleepy or dizzy. You may feel faint, lightheaded, or even pass out, especially when standing up quickly. It can also significantly slow your heart rate.

Drug interactions checker
Can I take Ashwagandha and Vitamin B12 together?
There are no known clinical interactions between ashwagandha and vitamin B12. It is generally considered safe to take these two supplements together.
Article history
The information on this page is written and peer reviewed by qualified clinicians.
Article also available in English, German, Spanish, French, Italian, Portuguese, Hindi, Hebrew, Arabic, and Swedish.
25 Jan 2026 | Originally published

Ask, share, connect.
Browse discussions, ask questions, and share experiences across hundreds of health topics.

Feeling unwell?
Assess your symptoms online for free
Sign up to the Patient newsletter
Your weekly dose of clear, trustworthy health advice - written to help you feel informed, confident and in control.
By subscribing you accept our Privacy Policy. You can unsubscribe at any time. We never sell your data.
More in drug interactions checker
- Can I take Alogliptin and Fibre supplements together?
- Can I take Antibiotics and Paracetamol together?
- Can I take Ashwagandha and Vitamin B12 together?
- Can I take Ashwagandha and Vitamin C together?
- Can I take Ashwagandha and Vitamin D together?
- Can I take Aspirin and Atorvastatin together?
- Can I take Atorvastatin and Lansoprazole together?
- Can I take Cod liver oil and Paracetamol together?
- Can I take Codeine and Morphine together?
- Can I take Devil's claw and Ginger together?
- Can I take Fexofenadine and Sertraline together?
- Can I take Garlic supplements and Ginseng together?
- Can I take Iron supplements and Wellbutrin together?
- Can I take Levothyroxine and Fibre supplements together?
- Can I take Losartan and Paracetamol together?
- Can I take Pancreatin and Morphine together?
- Can I take Ramipril and Vitamin B complex together?
- Can I take Turmeric with black pepper and Vitamin B complex together?
- Can I take Venlafaxine and Vitamin D together?
- Can I take Vitamin B12 and Vitamin B2 together?