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Cyclopentolate eye drops

Mydrilate, Minims Cyclopentolate

Cyclopentolate eye drops allow your doctor to examine your eye more easily.

The drops can cause blurred vision which may last for several hours. Do not drive and do not use tools or machines until your vision is clear again.

At a glance

  • Cyclopentolate eye drops make your pupil larger and relax your eye muscles.

  • They are used to make eye examinations easier or to help treat anterior uveitis.

  • Tell your doctor if you have other medical conditions or take other medicines.

  • Blurred vision is a common side effect and can last for several hours.

  • Do not drive or operate machinery until your vision is clear again.

  • Eye drops in an opened bottle only keep for four weeks.

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About cyclopentolate eye drops

Type of medicine

An antimuscarinic

Used for

To make the pupil of your eye larger and relax the muscles in your eye

Also called

Mydrilate®; Minims® Cyclopentolate Hydrochloride

Available as

Bottles of eye drops and single-dose units (Minims®)

Cyclopentolate makes the pupil of your eye larger and relaxes the muscles in your eye. These things make it easier for your eye to be examined and your vision tested.

Cyclopentolate drops can also be prescribed during the treatment of a condition called anterior uveitis. This is a painful eye condition caused by inflammation within the eye. By making your pupil larger and relaxing the muscles in your eye, it reduces pain and allows the inflamed part of your eye to rest and recover.

To make sure this is the right treatment for you, before you use the drops it is important that your doctor knows:

  • If you have ever had an allergic reaction to any eye drops.

  • If you normally wear contact lenses.

  • If you have been told you have a higher than normal pressure in your eye, or if you have glaucoma.

  • If you have any problems with the way your heart works, such as a fast heart beat or heart failure.

  • If you have epilepsy or you have certain problems with the way your nervous system works, such as ataxia or dementia.

  • If you have an obstruction in your gastrointestinal tract or urinary tract.

  • If you have a condition causing muscle weakness, called myasthenia gravis.

  • If you are taking or using any other medicines. This includes any medicines you are taking which are available to buy without a prescription, as well as herbal and complementary medicines.

  • If you are pregnant or breastfeeding.

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Cyclopentolate eye drops will generally be administered for you but if you are asked to put the drops in yourself, then:

  1. Wash your hands well before you use the drops.

  2. Remove the cap (or twist off the tip of the unit if you are using a Minims® single-dose unit).

  3. Tilt your head back a little and pull the lower lid of your eye out to form a pocket.

  4. Hold the bottle (or single-dose unit) upside down near to your eye. Try not to touch your eye as you do this.

  5. Apply enough pressure to the container to release one drop into your eye. Only use a second drop if the first drop missed going into your eye.

  6. Close your eye for a minute or two and press gently on the side of your nose where the corner of your eye meets your nose. This helps to stop the drop from draining away and keeps it in your eye.

  7. Repeat the process in your other eye if you have been told to use the drops in both eyes. (The contents of one single-dose Minims® are enough for both eyes.)

  8. Replace the cap (or if you are using the single-dose unit, throw it away).

  • Before you start using the eye drops, read the manufacturer's printed information leaflet from the pack. It will give you more information about the drops and will provide you with a full list of the side-effects which you may experience from using them.

  • Take care not to touch your eye, fingers, or any other surface with the dropper of the bottle. This could infect the liquid left in the bottle.

  • Cyclopentolate will cause blurred vision which may last for some time. Make sure you can see clearly again before you drive and before you use tools or machines.

  • If you are using any other eye drops or ointments, leave about ten minutes between applying each one. This is to prevent more liquid going into your eye than it can handle. Otherwise the drops will overflow from your eye and may not have the intended effect.

  • If you normally wear contact lenses, do not wear them again until your doctor advises you do so. There are two reasons for this - using cyclopentolate will mean you are not able to see clearly, and also bottles of eye drops contain a preservative which can affect soft contact lenses.

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Along with their useful effects, eye drops can cause unwanted side-effects although not everyone experiences them. The table below contains the most common ones associated with cyclopentolate eye drops. You will find a full list in the manufacturer's information leaflet supplied with your drops. Unwanted effects often improve as your body adjusts to a new medicine but speak with your doctor or pharmacist if any of the following continue or become troublesome.

Cyclopentolate side-effects

What can I do if I experience this?

Eye irritation such as mild stinging

This should soon pass

Large pupil, blurred vision, difficulty with focusing

These may last for several hours. Do not drive and do not operate machinery until your vision is clear again

Rare side-effects: dry mouth, flushing, dry skin, constipation, difficulties passing urine, and a fast heartbeat

These should soon pass but if you become concerned about any, speak with your doctor

Important: occasionally people can be allergic to eye drops, particularly if the eye drops contain a preservative. If you notice a rash around your eyes, or any swelling or itching, stop using the drops and contact a doctor or pharmacist for advice. Long-term use of preserved eye drops may lead to eye irritation and symptoms of dry eyes. If your eyes or eyelids become red or inflamed after using the drops, contact your doctor for advice.

If you experience any other symptoms which you think may be due to the eye drops, speak with your doctor or pharmacist for further advice.

  • Keep all medicines out of the reach and sight of children.

  • Some brands of cyclopentolate eye drops should be stored in a fridge; others should be stored in a cool, dry place, away from direct heat and light. Please check the label of the preparation you have been given for details.

  • Eye drops only keep for four weeks once the bottle has been opened so throw away the bottle after this time, even if there is some solution left. Never keep opened bottles of eye drops to use later. This will help to prevent the risk of eye infections.

  • Minims® contain one dose of cyclopentolate only. Do not store or re-use opened units to use at a later time.

Important information about all medicines

If you buy any medicines, always check with a pharmacist that they are safe to use with your other medicines.

Never use more than the recommended dose.

If you suspect that someone has swallowed some of this medicine by accident, contact the accident and emergency department of your local hospital for advice.

If you are having an operation or dental treatment, tell the person carrying out the treatment which medicines you are using.

This medicine is for you. Never give it to other people even if their condition appears to be the same as yours.

Do not keep out-of-date or unwanted medicines. Take them to your local pharmacy which will dispose of them for you.

If you have any questions about this medicine ask your pharmacist.

Report side effects to a medicine or vaccine

If you experience side effects, you can report them online through the Yellow Card website.

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Frequently asked questions

What is the primary purpose of cyclopentolate eye drops for an eye examination?

Cyclopentolate eye drops are used to make the pupil of your eye larger and relax the muscles inside your eye. This combination makes it significantly easier for an optometrist or ophthalmologist to conduct a thorough eye examination and accurately test your vision.

Are there any specific medical conditions that might prevent me from using these eye drops?

Yes, there are several conditions where extra caution is needed or the drops might not be suitable. For example, if you have a history of allergic reactions to eye drops, high eye pressure (glaucoma), certain heart problems like a fast heartbeat or heart failure, epilepsy, specific nervous system disorders such as ataxia or dementia, an obstruction in your gut or urinary tract, or muscle weakness (myasthenia gravis), your doctor needs to be aware before you use these drops.

How long will my vision be affected after using cyclopentolate eye drops?

Cyclopentolate causes blurred vision and can make your pupil large, which may last for several hours. It's important not to drive, cycle, or operate any machinery until your vision has returned to normal and you can see clearly again.

I use other eye drops; how should I manage applying them with cyclopentolate?

If you are using other eye drops or ointments, you should leave approximately ten minutes between applying each type. This allows each drop to be properly absorbed by your eye and prevents too much liquid from overflowing, ensuring each treatment has its intended effect.

What should I do if I experience mild stinging or irritation after using the drops?

Mild stinging or irritation in the eye is a common side-effect that should pass soon. However, if this, or any other side-effect, continues or becomes bothersome, you should speak with your doctor or a pharmacist for advice.

How should I store cyclopentolate eye drops once opened?

Storage instructions can vary between brands, so always check the label on your specific preparation. Some brands need to be stored in a fridge, while others require a cool, dry place away from direct heat and light. Once a bottle of eye drops is opened, it should only be kept for four weeks. After this time, you must throw it away, even if there is liquid remaining, to prevent the risk of eye infections. Single-dose units (Minims®) are for one-time use only and should be discarded immediately after opening.

Can I wear my contact lenses after using cyclopentolate eye drops?

No, if you normally wear contact lenses, you should not wear them again until your doctor advises it. This is for two main reasons: your vision will be blurred, making it unsafe to wear them, and many eye drop bottles contain a preservative that can negatively affect soft contact lenses.

Further reading and references

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About the authorView full bio

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Michael Stewart, MRPharmS

Medicine Leaflet Review Manager – Contractor, Pharmacist

BPharm (Hons), MRPharmS

Michael is a community pharmacist practicing in the Midlands and South Yorkshire with more than 20 years’ experience advising on medicines and medical conditions. He has a strong background in healthcare training, having produced and delivered training courses for pharmacy teams and staff of residential care settings, including nurses. He has also contributed to pharmacy advisory boards for the management of low acuity conditions in the community.

About the reviewer

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Sid Dajani

Sultan Dajani qualified at the London School of Pharmacy in 1994 and became the youngest elected member of the Royal Pharmaceutical Society council since its founding in 1842.

Article history

The information on this page is written and peer reviewed by qualified clinicians.

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