Latest studies
- CompletedPhase IV
Can people with cystic fibrosis safely stop taking some of their nebulised treatments if they are established on the new modulator therapy, Kaftrio?
The CF STORM trial is looking at whether people with cystic fibrosis who take the medicine Kaftrio can safely stop their daily mucus-clearing nebulisers. Researchers want to see if reducing these time-consuming treatments keeps lung function steady and makes day-to-day life easier without harming overall health.
Cystic fibrosisEngland - Completed
FReSH START – Looking at new approaches for people who self-harm
The FReSH START study is testing new talking therapies for adults who repeatedly self-harm. Researchers want to see if focusing on positive life goals works better than usual NHS care alone. Participants fill in questionnaires and may be offered up to 12 therapy sessions over six months.
Self harmEngland - Completed
Feasibility of providing additional oxygen in patients with resistant high blood pressure and obstructive sleep apnoea
This UK study looks at whether breathing gentle oxygen at night can help people with high blood pressure and sleep apnoea. Researchers want to see if using an overnight oxygen machine at home for two weeks is practical and acceptable, before planning larger clinical trials to test if it lowers blood pressure.
Obstructive sleep apnoea in patients with difficult-to-treat hypertensionEngland - Completed
A feasibility trial supporting employees with a clinical diagnosis of a mental health complaint and receiving treatment for mental health problems to remain engaged and productive at work
Mental health challenges can make working life tough. This UK study explores whether a specialist worker, called a Mental Health Employment Liaison Worker, can help. By working with both employees receiving NHS care and their managers, the specialist aims to improve communication, reduce stress, and help people stay well at work.
Clinical diagnosis of a mental disorderEngland - CompletedNot Applicable
Testing if the SonoTran Platform can enhance drug delivery in metastatic colorectal cancer
This UK clinical trial is testing a new technology called the SonoTran Platform for bowel cancer that has spread to the liver. It uses microscopic particles and gentle ultrasound over the tummy to help cancer medicines reach deeper into tumours, aiming to make future treatments more effective.
Colorectal cancer liver metastases (CRLM)England - CompletedPhase II
Can restricting the blood supply to part of the stomach lead to weight loss in severely overweight patients?
This UK study tests whether blocking some blood flow to the top of the stomach helps people with severe weight problems lose weight. Doctors use a thin tube to block tiny blood vessels, which may lower hunger hormones. Half the participants receive the treatment, and half receive a pretend procedure.
ObesityEngland - Completed
Development of a web-based health and wellbeing programme to support people preparing for major surgery
Preparing your body and mind before major surgery can help you recover faster. This UK study brings patients and NHS staff together to design and test a simple website and app. The goal is to give people helpful advice on fitness, diet, and wellbeing in the weeks leading up to an operation.
Patients approaching major surgeryEngland - CompletedPhase I
A study evaluating the interaction of the body with (pharmacokinetics), clinical activity, and safety of RO6870810 and atezolizumab (PD-L1 Antibody) in participants with advanced ovarian cancer or triple-negative breast cancer
This study looks at a new drug called RO6870810 given alongside an immunotherapy drug called atezolizumab. Researchers want to find the safest dose and see if this combination helps treat adults with advanced ovarian cancer or triple-negative breast cancer who have limited standard treatment options.
Advanced ovarian cancer, triple negative breast cancerEngland - CompletedNot Applicable
Can we predict which patients with psoriatic arthritis will respond to treatment using precision medicine?
This UK study looks at whether a simple blood test can help doctors choose the best biologic medicine for people with psoriatic arthritis. By checking specific immune cells before treatment starts, researchers hope to match each person to the right drug first time, helping relieve joint pain and swelling much faster.
Arthritis that affects some people with the skin condition psoriasisEngland - RecruitingPhase II
Investigating whether regadenoson is safe and can improve patient outcomes following severe injury and bleeding
This clinical trial is testing whether an injection of a medicine called regadenoson can help men who are bleeding heavily after a serious injury. London's Air Ambulance gives the treatment at the scene alongside standard emergency care. Researchers want to see if the medicine protects the heart and improves survival.
Critical injury and signs of haemorrhagic shockEngland - Completed
Smoking, nicotine and pregnancy 2 trial
This study looks at whether extra text messages, a website, and a leaflet can help pregnant women stick with nicotine replacement therapy (NRT). The aim is to see if this extra support helps more women successfully quit smoking during pregnancy alongside their regular NHS stop smoking care.
Adherence to nicotine replacement therapy during pregnancyEngland - Recruiting
Multicentre evaluation of sodium bicarbonate in acute kidney injury in critical care (MOSAICC)
This UK study is looking at whether giving sodium bicarbonate through a drip helps critically ill patients in intensive care with sudden kidney failure and high acid levels in their blood. Researchers want to see if this inexpensive medicine saves lives and reduces the need for dialysis machines.
Critically ill patients with metabolic acidosis and acute kidney injuryEngland - Completed
Supporting employees with insomnia and emotional regulation problems
This study tests an online support programme for working adults in the Midlands who struggle with poor sleep, anxiety, or low mood. It combines digital sleep therapy and online sessions with trained specialists to see if improving sleep can boost overall wellbeing and help people feel better at work.
Insomnia, anxiety and depressionEngland - CompletedNot Applicable
The iHOLDS Trial: High Or Low Dose Syntocinon for induction of labour
Around one in three first-time mothers have their labour started artificially (induced). Many need a hormone drip called oxytocin. This UK study compares the standard dose of oxytocin with a higher dose to see if it safely helps women give birth vaginally and reduces the need for an unplanned caesarean section.
Induction of labourEngland - CompletedPhase I/II
A trial of the synthetic cannabinoid ART27.13 to stimulate appetite in patients with cancer anorexia and weight loss
This clinical trial is testing a new medicine called ART27.13 to see if it can help improve appetite and prevent weight loss in people with cancer. Researchers want to find the safest, most effective dose and see if it helps patients regain muscle and body weight.
Cancer patients with anorexia and weight lossEngland - RecruitingPhase II/III
A trial assessing preoperative chemotherapy in patients with locally advanced but operable colon cancer
The FOxTROT trials look at whether giving bowel cancer treatments, such as chemotherapy or immunotherapy, before surgery helps shrink tumours and stops cancer returning. The study tests this approach in people of different ages, fitness levels, and tumour types to see who benefits the most.
Locally advanced but operable colon cancerEngland - CompletedPhase II
Tibial nerve stimulation to improve bladder symptoms in Parkinson's
Bladder problems are common in Parkinson’s disease. This UK clinical trial tests a gentle, stick-on electrical device called Geko. Worn on the lower leg at home, it gently stimulates a nerve linked to the bladder. Researchers want to see if this reduces urgent toilet trips without drug side effects.
Bladder symptoms in Parkinson'sEngland - Recruiting
IBIS-II-O: Observational long-term follow up study of participants from the IBIS-II DCIS and Prevention clinical trials of drugs for breast cancer prevention
The IBIS-II-O study is checking the long-term health of over 3,000 UK women who previously took part in breast cancer prevention trials. Researchers are securely reviewing NHS health records until 2031 to see how well the medicine anastrozole protects against breast cancer over many years, without requiring extra clinic visits.
Breast cancer preventionEngland - CompletedPhase II
Targeted heart rate control using ivabradine to reduce disease in patients undergoing non-cardiac surgery
The FUNNY trial looks at whether a medicine called ivabradine can protect the heart during and after major surgery. Researchers want to see if gently slowing down the heart rate helps people aged 55 and over recover faster, with fewer complications such as heart strain, infections, or kidney problems.
Patients undergoing elective or urgent non-cardiac surgery requiring general and/or regional anaesthesia with sedationEngland - CompletedPhase II
A trial of a clot-busting treatment in livers before transplantation
This study tests whether treating a donor liver with a clot-busting drug before surgery can prevent bile duct scarring. The medicine is added to a special machine holding the liver outside the body. Doctors want to see if this treatment is safe and reduces bleeding and complications after transplant.
Liver transplantationEngland - RecruitingNot Applicable
Trial of local anaesthetic nerve blocks for hip fracture pain relief in prehospital care, compared to usual care (morphine), given by paramedics
Breaking a hip is painful and common in older adults. Paramedics usually give strong painkillers like morphine, which can cause unpleasant side effects. This UK study explores whether trained paramedics giving a targeted numbing injection directly into the hip offers safer, more effective pain relief before a patient reaches hospital.
Pain relief of patients with hip fracture in prehospital careEngland - Completed
A trial comparing the effectiveness of an online sleep behavioural intervention versus standard care in children with rolandic epilepsy
This UK study tests whether an online sleep programme can help children with epilepsy sleep better. Children aged 4 to 12 who have sleep issues take part completely from home. Half use an online sleep programme alongside standard care, while half continue with their usual NHS care alone.
Sleep quality in children with rolandic epilepsyEngland - CompletedNot Applicable
Study evaluating the blood pressure lowering efficacy and safety of a novel self-administered device-based treatment (by stimulating nerves that control blood pressure) in participants with uncontrolled hypertension.
High blood pressure raises the risk of heart attacks and strokes, and tablets do not always keep it under control. This UK study tests a small, gentle ear-clip device that sends tiny electrical pulses to nerves controlling blood pressure, checking if it is safe, easy to use, and effective.
Uncontrolled high blood pressureEngland - Completed
A novel ultrasound method for heart failure detection
Researchers in London are testing a quick, gentle ultrasound scan to spot heart failure earlier. With each heartbeat, pressure waves travel through your arteries. By measuring these waves at the neck, arm, and wrist, doctors hope to diagnose heart problems more easily without needing complex, costly hospital tests.
Heart failure or those with left ventricular diastolic dysfunction but without clinical symptoms or signs of heart failureEngland - Completed
Feasibility study examining the efficacy of brief cognitive therapy for the treatment of panic disorder in adolescents (PANDA)
This UK study tests a short talking therapy for young people aged 11 to 18 who have panic disorder. Researchers want to see if brief cognitive therapy helps teenagers manage sudden fear, racing heartbeats, and breathlessness better than the standard care usually offered by the NHS.
Panic DisorderEngland - Completed
Mapping and evaluating services for children with learning disabilities and behaviours that challenge
This UK study looks at how community services support children with learning disabilities who show behaviours that challenge. Researchers want to find out which types of care work best for children and their families, using questionnaires and interviews to help improve NHS and social care support across England.
Children with learning disabilities and behaviours that challengeEngland - Recruiting
Carbon spectroscopy MRI: a non-invasive tool to detect late-onset Pompe disease (LOPD)
This observational UK study looks at whether a specialised, painless MRI scan can measure sugar build-up in the muscles of people with Pompe disease. Researchers hope this scan will eventually replace muscle biopsies, helping doctors monitor how well treatments work without needing invasive tissue samples.
Pompe disease in adult-onset patientsEngland - Completed
A feasibility study of electron radiotherapy delivered during a surgical operation for rectal cancer
This study looks at giving targeted radiotherapy directly into the pelvis during surgery for rectal cancer. Doctors want to see if treating the area during the operation helps destroy any leftover cancer cells, lowering the chance of the cancer returning while keeping the treatment safe for patients.
Colorectal CancerEngland - Completed
Remote rehabilitation after intensive care
Leaving intensive care can be tough, leaving people physically weak and emotionally drained. This UK study tests a six-week online rehabilitation programme designed to help people recover at home. Researchers want to see if regular remote support, gentle exercises, and recovery advice improve quality of life compared to standard NHS care.
Any condition requiring admission to intensive care and 48 hours of invasive mechanical ventilationEngland - Recruiting
Can screening programmes for abdominal aortic aneurysm safely be made more efficient by targeting them at people at the highest risk of disease?
Currently, the NHS offers abdominal aortic aneurysm (AAA) scans to all 65-year-old men. This computer-based study looks at health records to see if scans could instead be offered only to men at higher risk. The goal is to make screening more efficient while still finding life-threatening swellings early.
Abdominal aortic aneurysmEngland - RecruitingPhase II
Carbogen for status epilepticus in children trial
When a child has a prolonged epileptic seizure, it is a medical emergency. This UK study looks at whether breathing Carbogen—a safe mix of oxygen and a tiny amount of carbon dioxide—can stop severe seizures faster than pure oxygen, alongside the usual emergency medications.
Severe epileptic seizures in children that are not stopping by themselves and require emergency medication to stop themEngland - Completed
Adaptation and implementation of health Qigong and Tai Chi exercises on quality of life and physical functioning in patients with atrial fibrillation: a feasibility study
This study looks at whether gentle online Tai Chi and Qigong classes can help people with atrial fibrillation (an irregular heartbeat). Researchers want to see if patients enjoy these slow, home-based exercises, find them easy to do, and feel benefits to their everyday wellbeing and physical health.
Tai Chi and Qigong for patients with atrial fibrillation.England - CompletedNot Applicable
Investigating the use of lenzilumab for acute graft versus host disease (when transplanted stem cells attack the body’s cells)
This UK clinical trial is testing a new drug called lenzilumab for acute graft versus host disease (GvHD). GvHD happens when transplanted donor cells attack the patient's body. Researchers want to see if adding lenzilumab to standard steroid treatment is safe and helps patients who have a higher risk of severe illness.
Graft versus host disease following allogeneic stem cell transplantationEngland - Completed
AFTER – Ankle fracture treatment: enhancing rehabilitation trial
The AFTER study explores the best way to help people aged 50 and over recover from a broken ankle. It compares doing exercises at home using a guide and website against having four to six one-to-one sessions with an NHS physiotherapist, to see which approach works best.
Ankle fractureEngland - Completed
MWIQ - AI-powered decision support tool for diabetes clinicians
This study tests a new computer tool called MyWay IQ. It uses artificial intelligence (AI) to help GPs in Greater Manchester choose the best treatments for adults with diabetes. Researchers want to see if the tool is safe, helpful, and easy to use during normal clinic appointments.
DiabetesEngland - CompletedPhase II
A comparison of response to treatment in patients with Myelodysplastic Syndrome/Myeloproliferative Neoplasm (MDS/MPN) Overlap Syndromes taking ASTX727 versus best supportive care
This UK clinical trial is testing a new tablet called ASTX727 for adults with rare bone marrow cancers called MDS/MPN overlap syndromes. Researchers want to find out if taking this tablet at home works better at managing the condition and improving quality of life than standard supportive hospital care.
Myelodysplastic Syndrome/Myeloproliferative Neoplasm (MDS/MPN) Overlap SyndromesEngland - Completed
Urine HPV testing in women over 65 years of age
This UK study explores whether a simple urine test can screen for cervical cancer risk in people aged 65 to 79. Routine screening stops at 65, but risks remain. Researchers want to see if checking for HPV in urine during routine lung health checks is easy, helpful, and acceptable.
Identification of cervical cancer risk in women over 65 years of age using urine HPV testingEngland - CompletedPhase II
Pausing post-COVID fatigue
This UK clinical trial investigates whether a gentle, battery-powered ear stimulation device can reduce ongoing tiredness in adults with Long COVID. Researchers want to see if stimulating a major nerve through the skin of the ear can calm the nervous system and help ease long-term fatigue.
Post-COVID fatigueEngland - Completed
To determine if critically ill patients with acute respiratory failure treated with carbocisteine, hypertonic saline, or both, experience increased hydration of airway mucus.
This study looks at whether medicines called carbocisteine and hypertonic saline help clear thick phlegm from the lungs of critically ill patients on breathing machines. By testing small mucus samples, researchers hope to see how these treatments work to help patients recover and breathe on their own sooner.
Critically ill patients with acute respiratory failure (ARF)England - Completed
Surveillance towards preventing RSV respiratory infection in paediatrics
This UK study looks at how common Respiratory Syncytial Virus (RSV) is in children under three years old. RSV often causes winter chest infections like bronchiolitis. By testing simple nose swabs and surveying parents, researchers want to measure the impact on families and the NHS to help design future vaccines.
Respiratory syncytial virus (RSV)England - CompletedPhase III
Symptoms, trajectory, inequalities and management: understanding Long COVID to address and transform existing integrated care pathways
This UK study tests different ways to treat Long COVID. Researchers want to see if existing medicines, specialised body scans, and a recovery app can help reduce ongoing symptoms. The goal is to discover which treatments work best so the NHS can provide clearer, more equal care for everyone.
COVID-19 (SARS-CoV-2 infection)England - Completed
Early rehabilitation promoting motor recovery from spinal cord injury
This study tests whether using an arm-pedal bike soon after a spinal cord injury can help people regain better torso control and sitting balance. Researchers want to see if exercising working arm muscles can stimulate nerve repair to the chest and stomach muscles, helping people become more independent.
Traumatic and non-traumatic cervical and thoracic spinal cord injury.England - Recruiting
CAMELOT - Continuous rectus sheath Analgesia in eMErgency LaparOTomy
The CAMELOT study tests a new pain relief method for people having emergency tummy surgery. It looks at whether placing two tiny numbing tubes into the stomach wall during surgery helps control pain better, reduces the need for strong morphine painkillers, and helps patients recover more quickly.
Use of rectus sheath catheters (RSCs) in patients undergoing emergency bowel surgery.England - Completed
A parenting course to reduce behavioural difficulties and improve the quality of life for families of those diagnosed with fetal alcohol spectrum disorders
This UK study tests 'SPECIFIC', a new seven-week online parenting course designed for families raising children with foetal alcohol spectrum disorder (FASD). Researchers want to see if the course helps boost parental confidence, reduces stress, and improves day-to-day family life before running a much larger national trial.
Stress reduction in families diagnosed with fetal alcohol spectrum disorderEngland - Completed
Specialist pre-hospital redirection for ischaemic stroke thrombectomy (SPEEDY)
The SPEEDY study tests whether paramedics can take stroke patients straight to specialist hospitals for an emergency clot-removal procedure called a thrombectomy. By phoning hospital specialists from the ambulance, paramedics hope to cut out transfer delays, helping patients receive life-saving care faster and recover with fewer long-term disabilities.
Suspected and confirmed acute strokeEngland - RecruitingPhase I
The first-in-human trial of MDX-124 in patients with advanced cancer
This clinical trial is testing a new drug called MDX-124 for adults with advanced solid cancers. It is the first time this medicine is being given to humans. Doctors want to find out what dose is safe, how well the body copes with it, and what side effects it causes.
Locally advanced, unresectable or metastatic solid malignanciesEngland - Completed
Retrospective analysis of vital signs data from patients with COVID-19 using the 'virtual high dependency unit' monitoring system
This study looks back at anonymised health data from hospital patients with COVID-19. Researchers want to see how wearable sensors, which continuously tracked heart rate, breathing, and blood pressure, helped monitor patient health. The goal is to discover how these devices can help doctors spot early warning signs of illness.
COVID-19 (SARS-CoV-2 infection)England - Completed
Does nocturnal haemodialysis improve heart disease for patients on dialysis?
This study looks at whether having dialysis overnight for 6 to 8 hours is gentler on the heart than standard daytime dialysis. Standard dialysis can cause heart scarring. Researchers want to see if slower, longer overnight treatment protects the heart and improves health for people with kidney failure.
Haemodialysis, kidney failureEngland - Completed
SMART Schools Study: An evaluation of the impact of school policies restricting daytime use of smartphones and social media on adolescent mental wellbeing
This UK study looks at how school smartphone rules affect teenagers' mental wellbeing. Researchers are comparing schools that ban phones during the school day with those that allow them at break times. The goal is to see how these rules influence pupils' mood, sleep, physical activity, and learning.
Smartphones, social media and adolescent mental wellbeingEngland - Completed
IGLOo: Sickness absence and sustainable return to work pilot study
Taking long-term sick leave can be stressful and isolating. The IGLOo study tests whether an online support toolkit can help employees on sick leave feel better supported by their managers, return to work smoothly when ready, and stay well in their jobs. It is taking place across large UK workplaces.
Mental healthEngland