Latest studies
- RecruitingNot Applicable
Investigating the effects of oral scopolamine on cognition and emotion processing
This study looks at how a low dose of scopolamine, a common travel sickness medicine, affects emotions and thinking in healthy people. The findings could help us understand how to develop new, faster-acting treatments for depression.
Healthy volunteersEngland - Completed
Does removing both ovaries prior to menopause reduce breast cancer risk in BRCA1 and BRCA2 mutation carriers?
This study looks at existing health records to see if removing ovaries and fallopian tubes before menopause reduces breast cancer risk for women with BRCA1 or BRCA2 gene changes. It aims to understand if these operations help prevent cancer in these women.
Breast cancerEngland - RecruitingPhase III
A phase 3 randomized double-blinded, placebo-controlled study of JNJ-78278343, T-Cell redirecting agent targeting Human Kallikrein 2 with best supportive care (BSC) versus placebo with BSC for metastatic castration-resistant prostate cancer_KLK2 comPAS_78278343PCR3001
This study is testing a new drug called pasritamig for men with advanced prostate cancer that has spread and isn't responding to hormone therapy. It aims to see if pasritamig, along with usual care, helps men live longer compared to a dummy drug.
Metastatic Castration-resistant Prostate CancerEngland - Recruiting
Introducing a home-based genomic risk test to screening pathways for abdominal aortic aneurysms
This study asks men aged 60-70 what they think about a home spit test to check their genetic risk for a serious heart condition called an abdominal aortic aneurysm (AAA). Their opinions will help decide if this test should be part of NHS screening.
Abdominal aortic aneurysm population screeningEngland - Recruiting
Emotional and language recovery in aphasia (ELLA)
This study, ELLA, looks at a new therapy for people with language problems (aphasia) after a stroke. It aims to improve their speaking, understanding, confidence, and mood. We want to see if it works well in NHS clinics after good results in our university clinic.
StrokeEngland - Recruiting
A multicomponent evaluation of new restrictions on marketing of less healthy foods in England
This study looks at how new UK rules on advertising unhealthy food and drinks affect what people buy, how companies sell products, and overall health. It also checks what people think about these new rules, which aim to encourage healthier eating.
Unhealthy dietsEngland - Completed
Identifying the most important signs of frailty to predict outcomes after minimally invasive heart valve insertion
This study looks at how frailty affects people having a heart valve replacement (TAVI). Researchers want to use special CT scan measurements and other tests to better predict who will benefit most from the procedure, helping guide future treatment decisions for patients in the UK.
Frailty and its relationship to outcomes in people undergoing transcatheter aortic valve implantationEngland - Completed
Long-term effects of bariatric surgery in women with Polycystic Ovary Syndrome (PCOS), obesity and irregular or absent menstrual periods
This study looks at the long-term health of women who had weight-loss surgery for PCOS and obesity. It checks how the surgery affected their fertility, body, and quality of life over the years. This research helps us understand the lasting benefits of this treatment.
Long-term effects of bariatric surgery in women with Polycystic Ovary Syndrome, obesity and oligomenorrhoea or amenorrhoea.England - Recruiting
AI-based mobile apps for supporting adolescents’ mental health in schools
This study looks at how a smartphone app called MindCraft, which uses AI, can help teenagers in schools with their mental health. It aims to see if personalised tips from the app can make a difference compared to standard advice or just tracking feelings.
Primary and secondary prevention of mental disorders in children and young people.England - RecruitingPhase II
A clinical trial of extended (high) treatment dose antibiotics in combination with methenamine hippurate compared to the standard of care (either prophylactic (low) dose antibiotic treatment or methenamine hippurate) in people with chronic urinary tract infection
This study looks at new ways to treat ongoing bladder infections (chronic UTIs). We're testing if a stronger, longer course of antibiotics combined with a special medicine called methenamine hippurate works better than usual treatments. The goal is to improve symptoms for people with chronic UTIs.
Chronic urinary tract infectionEngland - Recruiting
Helping young people to adapt their internet use and promote mental well-being in a rapidly changing world
This study helps young people aged 12-16 learn healthier ways to use the internet and improve their mental well-being. It uses fun phone apps to teach skills for managing emotions and controlling internet habits, aiming to reduce potential harm from too much screen time.
Problematic usage of the internet in adolescentsEngland - RecruitingNot Applicable
Body surface gastric mapping in patients with para-oesophageal hernias
This study uses a special patch on your skin to measure stomach movement in people who have had surgery for a para-oesophageal hernia. It aims to understand how their stomach works after the operation.
Body surface gastric mapping in paraoesophageal hernia patientsEngland - Recruiting
A feasibility and acceptability study of the SIBS group programme for siblings and parents of children with mental illness
This study looks at a support programme called SIBS for brothers, sisters, and parents of young people with eating disorders. It aims to see if the programme helps families in the UK and if it's easy to run in local mental health services (CAMHS).
Children (referred to as "siblings") aged 8 to 17 years, along with at least one of their parents, who have a child in the family receiving care from CAMHS for an eating disorder.England - Recruiting
Reducing sexually transmitted infections amongst those at highest risk
This study, called Halo, explores a new online tool to help young people aged 16-24 use condoms consistently and reduce sexually transmitted infections (STIs). We want to see if adding Halo to standard advice helps lower chlamydia rates and is good value for money.
Infections with a predominantly sexual mode of transmissionEngland - Recruiting
A study testing two treatments for a type of irregular heartbeat (paroxysmal atrial fibrillation): one using standard vein isolation, and the other combining that with a new technique that targets nerve clusters on the heart using pulsed energy
This study looks at two ways to treat an irregular heartbeat called atrial fibrillation (AF). One uses a standard method, and the other adds a new technique targeting heart nerves with pulsed energy to see if it works better for longer.
Atrial fibrillation treatment using new pulsed field ablationEngland - Recruiting
The investigation of eye tear film proteins to see if there is an association with the stage of an eye condition called Retinopathy of Prematurity (ROP) which can occur in some premature babies; and the investigation of eye nerve development in these babies
This study looks for early signs of an eye condition called Retinopathy of Prematurity (ROP) in premature babies. Researchers will check proteins in tears and how babies' eyes respond to light to find new ways to detect ROP and prevent vision problems early on.
Retinopathy of prematurityEngland - Recruiting
Cough therapy for interstitial lung disease
This study looks at a special type of physiotherapy, called Cough Control Therapy (CCT), for people with Interstitial Lung Disease (ILD) who have a lasting cough. It aims to see if CCT can help reduce coughing and improve their quality of life. Participants attend group sessions over 7 weeks.
Interstitial lung diseaseEngland - RecruitingNot Applicable
Home-based transcranial direct current stimulation for the treatment of major depressive disorder
This study looks at treating depression from home using a gentle electrical brain stimulation device called tDCS. It aims to see if tDCS, along with usual care, helps improve depression more than usual care alone for adults in England and Wales.
Major depressive disorderEngland - Recruiting
Predicting bowel preparation quality before colonoscopy
This study looks at how well people clean their bowels before a colonoscopy. Researchers are checking if photos of poo and health questions can help predict if the bowel is clean enough, hoping to improve colonoscopies for future patients.
Bowel preparation qualityEngland - Recruiting
Pre-eclampsia prevention by timed birth at term 2 (PREVENT-2): a randomised trial
This study, PREVENT-2, looks at whether carefully timed delivery for pregnant women at higher risk of pre-eclampsia can reduce how often it happens and how serious it is. This could help both mothers and babies.
Pre-eclampsiaEngland - CompletedNot Specified
Surgical Techniques: Robotic versus conventional Laparoscopic cholecystectomy IN benign Gallbladder disease (STARLING Trial)
The STARLING trial is comparing two ways to remove gallbladders: robotic surgery and standard keyhole surgery. This study wants to see if robotic surgery is just as safe and effective for people with common gallbladder problems. It will look at recovery, complications, and quality of life.
Robotic versus conventional laparoscopic cholecystectomy in benign gallbladder diseaseEngland - Recruiting
Exploring the cutaneous immune response to skin massage in early life (CUTIE study)
This study, called CUTIE, explores how regular skin massage affects babies' immune systems. Researchers are looking for healthy babies up to six months old to understand if massage helps their skin's natural defences. It could help us give better advice to parents in the future.
How regular skin massage impacts the immune system in early lifeEngland - Completed
Empowered Together (coordinated social care in prison)
This study, called 'Empowered Together', looks at how to improve support for men in prison who need help with daily tasks like washing or dressing. Researchers will test a new approach to social care to see if it works better than current care, hoping to help prisoners now and in the future.
Social care needs of adult men in prison who are at risk of having unmet needsEngland - RecruitingPhase II
Radiotherapy (miBG) in neuroblastoma combined with chemotherapy (talazoparib)
This study for children and young people with high-risk neuroblastoma tests a new combination of treatments: a targeted radiation therapy (131I-mIBG) and a chemotherapy drug (talazoparib). The goal is to see if this combination works better, especially for patients with certain gene changes.
Relapsed and refractory high-risk neuroblastomaEngland - RecruitingNot Applicable
Testing a new microchip system to detect bowel cancer markers in blood and stool samples
This study is testing a new microchip to find signs of bowel cancer in blood and poo samples. It aims to detect cancer early and help doctors give better, more personal treatments. It’s for adults diagnosed with bowel cancer.
Colorectal cancerEngland - Recruiting
Diet-driven gut microbiome and outcome in patients with early-stage triple-negative breast cancer undergoing neoadjuvant chemotherapy and immunotherapy
This study looks at how the 'good' bacteria in our gut might affect treatment for a type of breast cancer called triple-negative breast cancer. Researchers want to see if changes in diet could help improve how well chemotherapy and immunotherapy work.
Stage I-III Triple Negative Breast CancerEngland - Recruiting
Could a dietetic led supported weight loss programme help people with cystic fibrosis who have excess weight?
This study looks at whether a weight loss program can help adults with cystic fibrosis (CF) who have gained too much weight. It involves special diet support and checks to make sure it's safe and practical, aiming to improve future health for people with CF.
Obesity and other hyperalimentation, Metabolic disordersEngland - Completed
Evaluation of the specialist knowledge for teaching mathematics programme
This study looks at how a special training programme for teachers who don't usually teach maths affects students' maths skills. We want to see if better-trained teachers help 12-13 year olds improve their maths grades. State schools in England can take part.
Examining the effects of a training programme for non-specialist maths teachers on pupil maths attainmentEngland - Recruiting
Artificial intelligence to help healthcare professionals detect cancer in the UK breast screening programme
This study looks at how artificial intelligence (AI) can help find breast cancer in mammograms. It compares AI working with human experts to human experts working alone, hoping to improve breast screening for women across the UK.
Breast cancerEngland - Recruiting
How treatments affect people recently diagnosed with follicular lymphoma. A study over time
This study looks at how treatments affect people newly diagnosed with follicular lymphoma. It will collect information during your usual hospital visits, helping us understand the illness better and hopefully improve future care for patients in the UK and worldwide. You won't have extra tests or treatments.
Malignant neoplasms, stated or presumed to be primary, of lymphoid, haematopoietic and related tissueEngland - Recruiting
Augmented depression therapy adapted for treating depression in adults with autism
This study looks at a new talking therapy called ADepT for autistic adults with depression. It aims to reduce low mood and help build wellbeing. Researchers want to see if it's safe and effective for autistic people before doing a larger study.
Treatment of depression in autistic adultsEngland - RecruitingPhase I
Bleximenib absorption, metabolism, and excretion in participants with acute leukemia
This study looks at a new medicine called bleximenib for blood cancer (acute leukaemia) in adults. Researchers want to understand how the body takes in, uses, and gets rid of this medicine. It's hoped bleximenib could be a new treatment option for those who haven't responded to other therapies.
Medical condition: Acute leukaemia Medical condition in lay language: Blood cancer Therapeutic areas: Diseases [C] - Cancer [C04]England - Completed
The effects of helping and supporting an adult who experienced harm in the NHS and/or social care
This study looks at how people who care for a family member or friend are affected when their loved one is somehow harmed within the NHS or social care. Researchers want to understand their experiences and needs to improve support for carers in similar situations.
Carer experiences (e.g. unmet need) and outcomes (e.g. quality of life) when they are supporting a family member or friend (with any type of physical and/or mental health problems) who was harmed in the NHS or social careEngland - RecruitingNot Applicable
A contactless optical stethoscope for murmur detection compared to standard auscultation and using echocardiography as the clinical reference
This study is testing a new device called LightScope that listens to your heart without touching you. It aims to see if LightScope can find heart murmurs as well as a regular stethoscope, using heart scans as a comparison.
Detection of cardiac murmurs associated with normal and valvular heart disease in adult patients undergoing transthoracic echocardiography.England - Completed
Brain response to light stimulation in people with myalgic encephalomyelitis/chronic fatigue syndrome
This study looks at how the brains of people with ME/CFS react to light. We want to see if there are differences in how their brain cells use energy when shown flashing lights, compared to healthy individuals. This could help us understand ME/CFS better.
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)England - Recruiting
Developing and testing approaches to support primary care practices to reduce harmful opioid prescribing (Opioid SMART)
This study looks at ways to help GP practices in Yorkshire reduce how often strong pain medicines, called opioids, are prescribed. It checks if offering special support visits helps practices cut down on these medicines more effectively, aiming to improve patient safety.
Opioid prescribing in primary careEngland - RecruitingPhase III
A randomised Phase III trial to assess whether radiotherapy with radiosensitisers is beneficial in patients with high-risk non-muscle invasive bladder cancer when compared with the standard of care treatment, Bacillus Calmette-Guerin
This study compares two treatments for high-risk bladder cancer that hasn't spread to the muscle: standard treatment (BCG immunotherapy) versus a new approach combining radiotherapy with special drugs. We want to see if the new approach works better to prevent cancer recurrence or progression.
High-risk non-muscle invasive bladder cancerEngland - Completed
Assessing the metabolic effect of sustainable proteins
This study looks at how our bodies digest new, eco-friendly protein foods compared to red meat. We want to see if these alternative proteins can help keep people healthy and prevent diseases like diabetes, and how they are broken down in the body.
Prevention of metabolic disease in currently healthy volunteersEngland - Recruiting
Supermarket voluntary price promotion ban: a public health study
This study looks at what happens when two UK supermarkets stop using special offers on unhealthy foods. Researchers want to see how this affects what people buy, their health, and the businesses involved. It aims to understand if stopping these deals helps people eat better.
The main focus of this work is the prevention of obesity and risk of chronic non-communicable diseases through reduction of consumption of high fat salt sugar foods.England - Completed
Transforming supportive care for people living with lung cancer when you have never smoked
This study wants to hear from people with lung cancer who have never smoked, their close family or friends, and their doctors. It aims to understand their experiences to create better support for them.
Lung cancer in people who have never smoked (LCINS).England - CompletedNot Applicable
Evaluation of digital microfluidic molecular point-of-care testing for the diagnosis of respiratory pathogens
This study compares a new device (Logicore System) to a standard one (Cepheid) for diagnosing breathing infections quickly in the A&E. We want to see if the new device can speed up diagnosis, helping patients get treatment sooner and stopping infections from spreading.
Point-of-care testing for diagnosis of respiratory infections in the Emergency Department setting of Addenbrooke's Hospital.England - RecruitingPhase IV
Goldilocks - determining if personalised drug monitoring of fludarabine in children and young adults with acute lymphoblastic leukaemia who are undergoing CAR-T therapy is feasible and can improve outcome whilst minimising toxicity
This study called 'Goldilocks' looks at how to give the right amount of a medicine called fludarabine to children and young adults with blood cancer (leukaemia) having CAR T-cell therapy. The goal is to make the treatment work better and have fewer side effects.
Acute lymphoblastic leukaemiaEngland - RecruitingPhase III
Benzodiazepine intervention in adults receiving opioid agonist treatment
This study looks at whether providing a steady supply of prescribed diazepam, along with extra support, can help people on opioid addiction treatment reduce their use of street benzodiazepines. Street versions of these drugs can be very dangerous.
Medical condition: Adults enrolled in OAT (Opioid Agonist Treatment) with DSM-5-diagnosed substance (benzodiazepine) use disorder with toxicologically verified non-prescription benzodiazepine use in the previous month. Medical condition in lay language: Adults who are enrolled in Opioid Agonist Treatment programme (methadone or buprenorphine) who are using non-prescribed (street) benzodiazepine. Therapeutic areas: Psychiatry and Psychology [F] - Behaviours [F01]England - RecruitingPhase III
Study evaluating the efficacy of icotrokinra in ulcerative colitis
This study is testing a new medicine, icotrokinra, for ulcerative colitis (UC) in adults and teenagers. It aims to see if icotrokinra can help reduce UC symptoms and keep the disease under control by targeting inflammation.
Ulcerative colitisEngland - Recruiting
Adapting ENGAGE-PD physical activity coaching for individuals newly diagnosed with Parkinson’s: perspectives of healthcare professionals using Nominal Group Technique consensus
This study asks NHS staff who help people with Parkinson's for their ideas. They want to create a UK version of a programme called ENGAGE-PD. This programme helps people with newly diagnosed Parkinson's be more physically active, which can be very beneficial for their condition.
Perspectives of UK National Health Service (NHS) staff working in neurology and/or healthcare of the elderly services providing NHS physiotherapy rehabilitation services for people with Parkinson's.England - Recruiting
Cash for families
This study looks at whether giving money to families involved with social services can help improve children's mental health and wellbeing. Families either get extra financial support or continue with usual services. Researchers want to see if this helps reduce stress and improve home life.
Mental health and wellbeing of children with social care input (i.e. Child in Need (CiN) or Child Protection Plan (CPP) status)England - Recruiting
Using an NHS walking app to support physical activity in older adults during NHS health-checks: a feasibility study
This study looks at whether an NHS walking app helps people over 55 who don't move much to become more active. Half the people will use the app and the other half get an exercise leaflet. It's a small study to prepare for a larger one.
Prevention of physical inactivity among older adultsEngland - RecruitingPhase III
IIH-Advance: A randomised clinical trial to determine the effects of weight loss, induced by a weight loss drug (Tirzepatide), in adults with active idiopathic intracranial hypertension
This study looks at whether a weight loss drug, Tirzepatide, can help adults with a condition called Idiopathic Intracranial Hypertension (IIH). IIH causes high pressure in the head, leading to headaches and eye problems. We want to see if losing weight with this drug can improve these symptoms.
Idiopathic intracranial hypertensionEngland - Recruiting
Exploring the public's opinion on the use of their data in biobanking, linked to routine medical records, and the use of artificial intelligence in care and medical research
This study wants to hear your thoughts on how your health information and samples are used in research. This includes stored samples, health records, and new computer programs called AI. We want to know what you think about how these are used to improve healthcare, especially for long-term health problems.
Mainly focused on but not exclusive to chronic inflammatory conditions: GI (inflammatory bowel disease), musculoskeletal (inflammatory arthritis such as rheumatoid arthritis, ankylosing spondylitis), skin (psoriasis, eczema, hydradenitis), and liver (autoimmune hepatitis, primary sclerosing cholangitis, primary biliary cirrhosis).England - RecruitingNot Applicable
A multi-centre study testing a new imaging app to help diagnose systemic sclerosis using nailfold capillaroscopy
This study tests a new app called CapilyticsAcquisition to help doctors diagnose conditions like Raynaud's and systemic sclerosis. It takes pictures of tiny blood vessels near fingernails to assist with earlier and more accurate diagnosis. Participants are adults and children aged 6+.
Systemic sclerosis spectrum disordersEngland