Latest studies
- RecruitingPhase III
IIH-Advance: A randomised clinical trial to determine the effects of weight loss, induced by a weight loss drug (Tirzepatide), in adults with active idiopathic intracranial hypertension
This study looks at whether a weight loss drug, Tirzepatide, can help adults with a condition called Idiopathic Intracranial Hypertension (IIH). IIH causes high pressure in the head, leading to headaches and eye problems. We want to see if losing weight with this drug can improve these symptoms.
Idiopathic intracranial hypertensionEngland - Recruiting
Exploring the public's opinion on the use of their data in biobanking, linked to routine medical records, and the use of artificial intelligence in care and medical research
This study wants to hear your thoughts on how your health information and samples are used in research. This includes stored samples, health records, and new computer programs called AI. We want to know what you think about how these are used to improve healthcare, especially for long-term health problems.
Mainly focused on but not exclusive to chronic inflammatory conditions: GI (inflammatory bowel disease), musculoskeletal (inflammatory arthritis such as rheumatoid arthritis, ankylosing spondylitis), skin (psoriasis, eczema, hydradenitis), and liver (autoimmune hepatitis, primary sclerosing cholangitis, primary biliary cirrhosis).England - Completed
Understanding how people shop for soft drinks and alcoholic beverages in grocery stores; understanding drinking experiences at home
This study looks at how calorie labels on alcoholic drinks might change what UK adults buy and drink. Participants will do a pretend shopping trip and track their drinking at home for two weeks. It aims to see if labels help reduce alcohol consumption.
Excessive alcohol consumption in UK adultsEngland - Recruiting
A study to test whether a new website, Sleep Buddy, developed by doctors and psychologists, can help parents and carers of children aged 6-12 years with a diagnosis of ADHD who are experiencing sleep problems to improve their child’s sleep
This study looks at whether a new website called Sleep Buddy can help parents of children aged 6-12 with ADHD improve their child's sleep. Many children with ADHD struggle with sleep, which can affect their daily lives. The website offers advice and tips.
Insomnia and ADHD (attention deficit hyperactivity disorder)England - CompletedPhase I
A study of Pasritamig (JNJ-78278343) in combination with JNJ-86974680 for treatment of prostate cancer
This study is testing two new drugs, Pasritamig and JNJ-86974680, together for men with advanced prostate cancer. Researchers want to find the safest dose and see if it helps fight the cancer. It's a very early-stage trial.
Prostate cancerEngland - RecruitingPhase II
A study to test if LACTIN-V, a type of probiotic made from a specific bacteria (Lactobacillus crispatus CTV-05), is safe and effective in lowering the chances of preterm labour in women who are considered at high risk for giving birth early
This study looks at whether a probiotic called LACTIN-V can help reduce the chance of giving birth too early (preterm labour) in women who are at high risk. It tests if it's safe and if it works to keep babies from being born prematurely.
Preterm labourEngland - Recruiting
The role and impact of same day emergency care
This study looks at how new Same Day Emergency Care (SDEC) services are helping hospitals. Many A&E departments are busy, and SDEC aims to treat patients quickly without them staying overnight. Researchers want to see if SDEC is working well for patients and saving hospital resources.
Emergency careEngland - RecruitingPhase III
Investigating whether prolonged antibiotics can prevent permanent Pseudomonas infection in bronchiectasis
This study looks at whether early, strong antibiotic treatment can stop a lung infection called Pseudomonas from becoming permanent in people with bronchiectasis. We hope to reduce flare-ups and improve health.
BronchiectasisEngland - Recruiting
Improving diversity in clinical research for patients undergoing surgery (PROTECT-DIVERSITY)
This study aims to make sure more people can take part in medical research, especially those having surgery. We're looking at how different consent forms and ways of collecting information can help include a wider range of patients in studies.
Adult patients undergoing elective surgeryEngland - Recruiting
Use of facial monitoring technology for recording vital signs in the emergency department waiting room: a feasibility study
This study looks at whether patients can use their smartphones to check their own vital signs (like heart rate and breathing) in the emergency department waiting room. It also checks if staff and patients think this is a good idea. This could help make care quicker and easier.
Adult walk-in patients in the Emergency Department (ED) and ED staffEngland - CompletedPhase I
A Phase I trial of LY3143921 hydrate in solid tumours
This study looks at a new drug, LY3143921 hydrate, for advanced solid cancers. It aims to find a safe dose and understand its effects, especially in cancers where usual treatments haven't worked or aren't suitable. This is the first time it’s being tested in people.
Colorectal Cancer (CRC), High Grade Serous Ovarian Cancer (HGSOC), Non-Small Cell Lung Cancer (NSCLC; Squamous Cell Variant), Squamous Carcinoma of the Oesophagus, Squamous Carcinoma of the Head and Neck (Human Papillomavirus Negative), Urothelial Cancer, Breast Cancer (Triple Negative Type), Pancreatic CancerEngland - Recruiting
Carbon monoxide screening in ED patients with headache
This study looks at how often carbon monoxide (CO) exposure causes headaches in people visiting the emergency department. It uses simple tests, including a finger sensor and a home monitor, to see if CO could be the cause and help doctors recognise it sooner.
Carbon monoxide screening in ED patients with headacheEngland - Recruiting
Reducing blood clots in donated livers before transplantation
This study looks at whether a special treatment for donor livers can prevent problems after a liver transplant. We're testing if giving a 'clot-buster' medicine to the liver before transplant helps prevent scarring in the bile ducts, which can cause serious problems.
Liver transplantationEngland - Recruiting
How effective are walk-in mental health centers for young people with psychological distress in Europe and Australia?
This study looks at how well 'walk-in' mental health centres, called YEAHs, help young people aged 12-25 with mental health challenges. It checks if they improve mental well-being, are easy to use, and offer good value, comparing them to usual care.
Prevention and early intervention of mental disorders in youth with psychological distressEngland - Recruiting
Effectiveness and public health impact of SELFIE, a blended ecological momentary intervention for improving self-esteem in young people
This study aims to help young people aged 14-25 in the UK and other European countries who have had tough childhoods and now have low self-esteem and mental health problems. It tests a program called SELFIE, combining an app with support from a mental health expert, to see if it can boost self-esteem.
Mental health problemsEngland - RecruitingPhase I/II
A two-part study to investigate the effects in adults of two doses of golexanolone in patients with primary biliary cholangitis with fatigue and cognitive dysfunction
This study looks at a new drug, golexanolone, for people with a liver condition called Primary Biliary Cholangitis (PBC) who also feel very tired and have trouble thinking clearly. Researchers want to see if it's safe, how it works in the body, and if it helps these symptoms.
Patients with primary biliary cholangitis with fatigue and cognitive dysfunctionEngland - RecruitingPhase III
PATHWAYS TRIAL, PATHWAYS HORIZON INTENSIVE, PATHWAYS CONNECT
The PATHWAYS study looks at puberty-stopping medicines for young people with gender incongruence (their gender identity doesn't match their birth sex). It aims to understand how these medicines affect their health and well-being, comparing starting treatment now versus waiting a year.
Gender incongruenceEngland - Recruiting
Mentalisation-based treatment for socially isolated older adults with personality disorder
This study looks at a talking therapy called Mentalisation-Based Treatment (MBT) for older adults (65+) with complex emotional needs. It aims to see if MBT is suitable, helpful, and if older people can take part in this type of research.
Treatment of suicidality, self-harm, personality functioning and loneliness in older adults with personality disorderEngland - CompletedPhase IV
Post-market clinical follow-up study for Zimmer femoral nails
This study looks at how well Zimmer femoral nails work for broken thigh bones. It checks past patient records and asks about recovery. If you've had this surgery and meet certain conditions, you might be asked to take part. It helps improve future care for others.
Femoral shaft fracturesEngland - Recruiting
Hybrid closed loop insulin pumps and early worsening of diabetic retinopathy in Type 1 diabetes
This study looks at how new insulin pumps, called hybrid closed-loop systems, affect the eyes of people with Type 1 diabetes. We want to see if quick blood sugar improvements might temporarily worsen eye health and compare this with other diabetes treatments.
Type 1 diabetesEngland - Recruiting
Perioperative complications and autonomic function assessed by the COMPASS-31 tool
This study looks at how your body's automatic systems, like heart rate, work before and after big operations. We want to see if a special questionnaire can help predict who might have problems and improve care for people having surgery.
Autonomic function in people undergoing major noncardiac surgery under general anaesthesiaEngland - Recruiting
A study exploring a women-only, trauma -informed residential rehabilitation pathway for drug dependent women leaving prison
This study looks at how best to help women leaving prison who have drug problems. It explores if moving them straight into women-only rehab helps them recover and lead better lives, compared to usual support.
Drug-dependent women leaving prisonEngland - RecruitingNot Applicable
Medical utility of artificial intelligence for fracture detection in the emergency department
This study looks at how well a special computer program, called AI, can help doctors find broken bones on X-rays in emergency departments. It aims to see if AI can reduce mistakes and improve care for patients with suspected fractures.
Patients undergoing X-ray for suspected fracture in the emergency department or minor injuries unitEngland - Completed
Wait Less; an online brief psychological intervention to reduce waiting list distress
This study looks at whether an online talking therapy, MyMindWorks (MMW), can help young people aged 12-17 with depression while they wait for NHS mental health services. It aims to see if MMW is helpful and acceptable, and if it could reduce waiting list distress.
Depression in young people aged 12 to 17 yearsEngland - CompletedPhase I
A study to evaluate the safety and effects on the immune system of a tetanus and diphtheria vaccine which does not need any cold chain distribution or storage
This study is testing a new tetanus and diphtheria jab that doesn't need to be kept cold. It's for healthy adults who've had these jabs before but not in the last 10 years. We want to see if it's safe and works as well as existing jabs.
Prevention of tetanus and diphtheria infection in healthy volunteersEngland - Recruiting
Real-world exploration of digital innovation for managing excess weight
This study looks at how well a digital app helps people in South East London manage their weight compared to usual care. It aims to see if app-based programs can help more people, save money for the NHS, and improve patient experiences without risks.
Specialty: General Practice, Primary sub-specialty: General Practice; Health Category: Cancer and neoplasms, Cardiovascular, Metabolic and Endocrine, Oral and Gastrointestinal, Stroke; Disease/Condition: Obesity and other hyperalimentationEngland - Recruiting
Comparing an easy-to-use swab test and ultrasound for detection of womb cancer
This study compares a new, easy-to-use swab test called WID®-easy with the usual ultrasound scan for detecting womb cancer in women experiencing unusual bleeding. The goal is to see if the new test works better and could be used more widely in the NHS.
Womb cancerEngland - RecruitingPhase III
A study comparing the effect of apalutamide treatment before focal therapy with focal therapy alone in men with prostate cancer that has not spread beyond the prostate
This study looks at treating prostate cancer that is still within the prostate. We're comparing focal therapy alone with focal therapy after a short course of a drug called apalutamide. We want to see if using apalutamide first can make the focal therapy work even better.
Localised prostate cancerEngland - Recruiting
A study to find out if a new blood test (microRNA) can be used to monitor people after surgery for seminoma or dysgerminoma cancer
This study looks at a new blood test to see if cancer has come back in people treated for specific early-stage cancers like seminoma or dysgerminoma. It aims to reduce the need for scans by seeing if a simple blood test can do the job and help find cancer recurrence earlier.
Seminoma and dysgerminomaEngland - Completed
A study of potential treatment-responsive biomarkers and clinical outcomes in Hunter syndrome
This study looked at how Hunter Syndrome affects people over time, including changes in behaviour, thinking abilities, and levels of certain signs in the body. It aimed to understand the condition better and find ways to measure if future treatments are working, without giving any new medicines.
Mucopolysaccharidosis IIEngland - CompletedNot Applicable
Usability and accuracy of the Hormona at-home perimenopause test kit and mobile app
This study looks at how well women aged 40-55 can use the Hormona app and at-home test kit to understand their changing hormones during perimenopause. It aims to make the system easy to use and accurate.
Perimenopause and menopauseEngland - RecruitingNot Applicable
Prospective clinical evaluation of artificial intelligence in radiology
This study looks at how well artificial intelligence (AI) helps NHS doctors read medical scans like X-rays. We're testing AI tools in real hospitals to see if they improve diagnosis and patient care. It aims to make healthcare more accurate and efficient.
Patients undergoing medical imaging as part of routine clinical careEngland - Recruiting
Maximising the impact of speech and language therapy for children with speech sound disorder - Phase 2 England
This study aims to improve speech therapy for children in the UK with speech sound disorder. We're testing a new way to collect information on how well therapy works, so we can find out which treatments are most effective for different children.
Speech sound disorderEngland - Completed
Pilot randomised controlled trial of a shared reading programme to support relationships between children in care and their carers
This study looks at Story Explorers, a fun reading programme for foster families. It aims to see if it helps carers and children aged 2-4 build stronger bonds, improve children's emotional wellbeing, and make them feel more secure. Participants will do online questionnaires and interviews.
attachment difficulties and emotional wellbeing challenges in children in careEngland - Recruiting
The DISC Pilot study: testing if taking extra tissue during breast surgery helps make treatment more successful
This study looks at whether removing a small amount of extra tissue during breast cancer surgery for a specific type called DCIS can reduce the need for a second operation. It also checks cosmetic results and patient experiences.
Breast cancerEngland - Recruiting
Timing of nutrition in emergency laparotomy
This study looks at the best time to give special liquid food directly into a vein to adults having urgent belly surgery. It aims to see if starting this feeding early helps reduce problems and speeds up recovery after the operation.
Hospital complications in adults undergoing emergency laparotomyEngland - Recruiting
Supporting honest and reflective engagement after Mental Health Act assessments
This study wants to improve how people are supported after a Mental Health Act assessment. It aims to create a new way for patients and staff to talk about the experience, helping patients feel heard and prevent future compulsory hospital stays.
Mental healthEngland - Completed
Does use of the MindEar app reduce tinnitus-related distress in patients awaiting tinnitus therapy?
This study looks at whether a phone app called MindEar can help people with tinnitus feel better while they wait for specialist NHS care. Participants will either use the app or not, and share how they are feeling.
TinnitusEngland - Recruiting
Discontinuation of hormone replacement therapy: TAPER study
This study looks at why women stop Hormone Replacement Therapy (HRT) and why some choose to restart it. It also explores how healthcare professionals support these decisions. The goal is to better understand experiences and improve care for women going through menopause.
Use of Hormone Replacement TherapyEngland - Completed
Exploring cannabidiol’s impact on behaviour in adults with intellectual disabilities and epilepsy (CANABID-LD)
This study looks at how a medicine called Epidyolex, used for seizures, might also help adults with intellectual disabilities who have certain types of epilepsy (Dravet, Lennox-Gastaut, Tuberous Sclerosis Complex) with challenging behaviours. It follows people already prescribed the medicine.
Adults with Intellectual Disability with Lennox-Gastaut syndrome, Dravet syndrome and tuberous sclerosis complexEngland - Recruiting
Supporting people with long-term health conditions and disabilities at work: a feasibility study of the Co-Manage self-management support programme
This study tests an online toolkit called Co-Manage to help people with long-term health conditions and disabilities manage their health better at work. It aims to support employees, managers, and employers to create healthier workplaces.
Any long-term condition or disability requiring ongoing management for ≥12 months.England - Completed
An international cohort study of wound closure and surgical site infection prevention strategies in abdominal surgery
This study looks at how different ways of closing wounds and preventing infections after tummy surgery affect how well people recover. It aims to improve future surgical care worldwide by gathering information from adults undergoing these operations.
Adult patients (age 18 years and above) undergoing general or colorectal surgical procedures using any type of abdominal incision measuring at least 5 cm (including extraction sites)England - Recruiting
A study of home-use brain stimulation to treat bipolar depression
This study looks at whether a home-use device using mild electrical current can help people with bipolar depression. It aims to see if it's effective, safe, and easy to use at home, compared to a dummy treatment.
Bipolar Disorder; Mental healthEngland - Completed
Effects of short-term consumption of retail-available fermented foods on cognition, mood, and the gut microbiome: an exploratory pilot study.
This study looks at how everyday fermented foods might improve mood, thinking, and gut health in healthy adults. Researchers want to see if these foods change the good bacteria in our gut and how that affects us.
No health conditions, healthy cohort only, not obese.England - Recruiting
Understanding what Social Care organisations do to bring more young people into care roles and keep them in the job
This study looks at how social care organisations attract and keep young people in vital care roles. Researchers will identify successful organisations, interview their senior staff, and share good ideas across the country to help strengthen the social care workforce for the future.
Adult social care workforceEngland - Recruiting
The effectiveness of a cardiovascular ‘health check’ in a workplace setting
This study checks how well a workplace health check works. You'll repeat a home 'Healthy Heart' test you did a year ago, measuring cholesterol. It helps see if these remote checks are a good way to monitor heart health, potentially replacing some traditional NHS checks.
Cardiovascular diseasesEngland - Recruiting
A global study of pleural infection causes, management, and outcomes
This global study, INTERMITTENT, aims to understand why and how lung infections (pleural infections) happen, how they're treated around the world, and what helps patients recover best. Researchers hope to improve care for this serious condition.
Pleural infectionEngland - RecruitingPhase II
A study to explore the effect of immunotherapy drug, tebentafusp, on patients with clear cell sarcoma (ultra-rare, aggressive type of soft tissue sarcoma that primarily affects young adults)
This study looks at a medicine called tebentafusp for a rare cancer called clear cell sarcoma. Researchers want to see if the drug works and how long its effects last. It's for adults with advanced clear cell sarcoma.
Clear cell sarcomaEngland - RecruitingPhase I
First in woman safety and ease of use assessment of 400 mg progesterone Callavid in women with luteal phase progesterone insufficiency
This study looks at a new progesterone treatment for women who have had miscarriages and have low progesterone. We want to see if it’s safe and easy to use, comparing it to an existing treatment. It aims to help improve our understanding of fertility.
Women who have had at least one miscarriage and have luteal phase progesterone insufficiencyEngland - RecruitingPhase III
A flexible initiative to test therapies for Alzheimer’s disease
This study, AD-SMART, is testing if two existing medicines, atomoxetine and metformin, can help people with Alzheimer's disease. Researchers want to see if these drugs improve daily life and memory for about four years, hoping to find better treatments.
Medical condition: Symptomatic Alzheimer’s Disease (Mild Cognitive Impairment, Mild Dementia, Moderate Dementia) Medical condition in lay language: Alzheimer’s disease (AD) Therapeutic areas: Diseases [C] - Nervous System Diseases [C10]England