Latest studies
- RecruitingPHASE3
Pembrolizumab With or Without Maintenance Sacituzumab Tirumotecan (Sac-TMT; MK-2870) in Metastatic Squamous Non-small Cell Lung Cancer (NSCLC) [MK-2870-023]
This study looks at new ways to treat advanced squamous non-small cell lung cancer. It combines standard treatment (Pembrolizumab, Carboplatin, Paclitaxel/Nab-paclitaxel) with a new drug, sac-TMT, to see if it helps people live longer.
Non-small Cell Lung CancerNSCLCUnited Arab Emirates - Active not recruitingPHASE3
A Phase 3 Study to Examine the Efficacy and Safety of ZX008 in Subjects With CDKL5 Deficiency Disorder.
This study looks at a new epilepsy medicine, ZX008 (fenfluramine), for children and adults aged 1 to 35 with CDKL5 Deficiency Disorder (CDD). It aims to see if it helps reduce seizures and if it's safe for people whose seizures haven't improved with other treatments.
CDKL5 Deficiency DisorderGeneralized Tonic Clonic SeizureEpileptic SpasmRefractory SeizuresUnited Arab Emirates - RecruitingPHASE3
A Study to Evaluate the Efficacy and Safety of Subcutaneous Amlitelimab on Background Topical Corticosteroids Therapy in Participants Aged 12 Years and Older With Moderate-to-severe AD Who Have Had an Inadequate Response to Prior Biologic Therapy or an Oral JAK Inhibitor
This study looks at a new medicine called amlitelimab for people aged 12 and over with moderate-to-severe eczema. These individuals haven't responded well to other common eczema treatments. Researchers want to see if amlitelimab is safe and helps improve their skin when used with their usual steroid creams.
Dermatitis AtopicUnited Arab Emirates - Active not recruitingPHASE3
An Adjuvant Endocrine-based Therapy Study of Camizestrant (AZD9833) in ER+/HER2- Early Breast Cancer (CAMBRIA-2)
This study is looking at a new drug, camizestrant, for people with a common type of early breast cancer. It aims to see if camizestrant, compared to usual hormone therapy, can better prevent the cancer from coming back.
Breast Cancer, Early Breast CancerUnited Arab Emirates - Active not recruitingPHASE3
Efficacy and Safety Studies of Frexalimab (SAR441344) in Adults With Relapsing Forms of Multiple Sclerosis
This study is looking at a new medicine called frexalimab for people aged 18-55 with certain types of Multiple Sclerosis (MS). It compares frexalimab to an existing MS medicine, teriflunomide, to see how well it stops MS relapses and if it's safe.
Multiple SclerosisUnited Arab Emirates - RecruitingPHASE2
Brivekimig for the Treatment of Moderate to Severe Hidradenitis Suppurativa
This study is testing a new medicine called brivekimig for moderate to severe hidradenitis suppurativa (HS). It compares brivekimig to a dummy medicine (placebo) to see if it's safe and helps reduce HS symptoms.
Hidradenitis SuppurativaUnited Arab Emirates - Enrolling by invitationPHASE3
Selatogrel Outcome Study in Suspected Acute Myocardial Infarction
This study looks at a new treatment called Selatogrel for people who have recently had a heart attack and are at risk of another. It checks if taking Selatogrel when symptoms start can help prevent a second heart attack.
Acute Myocardial InfarctionUnited Arab Emirates - Enrolling by invitationPHASE2, PHASE3
Long-Term Safety and Efficacy Evaluation of Amlitelimab in Participants of Previous Amlitelimab Moderate to Severe Atopic Dermatitis Clinical Trials
This study looks at a medicine called amlitelimab for moderate to severe eczema in people who've already tried it in other studies. We want to see how safe and effective it is over a long time, and if it continues to help.
Dermatitis AtopicUnited Arab Emirates - RecruitingPHASE3
A Study of Dostarlimab vs Placebo After Chemoradiation in Adult Participants With Locally Advanced Unresected Head and Neck Squamous Cell Carcinoma
This study looks at a new drug, Dostarlimab, for adults with a certain type of head and neck cancer. It compares Dostarlimab to a dummy drug (placebo) after standard chemo and radiation, to see if it's safe and effective.
Neoplasms, Head and NeckUnited Arab Emirates - RecruitingPHASE3
Study of Plozasiran in Adults With Severe Hypertriglyceridemia at Risk of Acute Pancreatitis
This study is testing a new medicine, plozasiran, for people with very high triglycerides who have had pancreatitis. It will check if the medicine is safe and helps reduce the risk of future pancreatitis attacks. Participants will get either the study medicine or a dummy medicine.
Severe HypertriglyceridemiaUnited Arab Emirates - RecruitingPHASE3
A Study to Assess the Efficacy and Safety of Induction and Maintenance Therapy With Afimkibart (RO7790121) in Participants With Moderately to Severely Active Crohn's Disease
This study is testing a new medicine called Afimkibart for people with moderately to severely active Crohn's disease. It's a Phase 3 study, which means it's a big step before the medicine might become widely available, looking at how well it works and if it's safe.
Moderately to Severely Active Crohns DiseaseUnited Arab Emirates - RecruitingPHASE2, PHASE3
A Study of Izalontamab Brengitecan Versus Chemotherapy in Participants With Previously Untreated, Locally Advanced, Recurrent Inoperable, or Metastatic Triple-negative Breast Cancer Ineligible for Anti-PD(L)1 Drugs (IZABRIGHT-Breast01)
This study is testing a new drug, iza-bren, for advanced triple-negative breast cancer or ER-low, HER2-negative breast cancer. It compares iza-bren with standard chemotherapy in patients who haven't had previous treatment for advanced disease and can't receive certain immunotherapy drugs.
Breast NeoplasmsUnited Arab Emirates - Active not recruitingPHASE3
Efficacy and Safety of Remibrutinib Compared to Teriflunomide in Participants With Relapsing Multiple Sclerosis (RMS) (REMODEL-1)
This study is comparing a new medication called remibrutinib with an existing treatment, teriflunomide, for people with relapsing multiple sclerosis (RMS). It aims to see how well remibrutinib works and if it's safe to use in managing RMS symptoms.
Relapsing Multiple SclerosisUnited Arab Emirates - RecruitingPHASE2
A Phase 2 Master Protocol Assessing Inebilizumab and Blinatumomab in Autoimmune Diseases
This study looks at new treatments (inebilizumab and blinatumomab) for people with Systemic Lupus Erythematosus (SLE) and Rheumatoid Arthritis (RA). It mainly checks how safe these medicines are and if they help reduce symptoms of these conditions.
Systemic Lupus ErythematosusActive Refractory Rheumatoid ArthritisUnited Arab Emirates - Enrolling by invitation
European TIF2.0 Registry
This study looks at a keyhole procedure called TIF to treat reflux (heartburn and sickness). Doctors want to see how safe and effective it is for people experiencing symptoms like stomach acid coming up and a sore throat, sometimes combined with a small hernia repair.
Gastro -Oesophagal RefluxLaryngo-pharyngeal RefluxUnited Arab Emirates - Active not recruitingPHASE3
A Study to Evaluate the Efficacy and Safety of Giredestrant in Combination With Phesgo (Pertuzumab, Trastuzumab, and Hyaluronidase-zzxf) Versus Phesgo in Participants With Locally Advanced or Metastatic Breast Cancer (heredERA Breast Cancer)
This study looks at a new drug, Giredestrant, combined with an existing treatment called Phesgo, for advanced breast cancer. It aims to see if this new combination is safe and works better than Phesgo alone for people with specific types of breast cancer.
Locally Advanced or Metastatic Breast CancerUnited Arab Emirates - Recruiting
International Collaborative Gaucher Group (ICGG) Gaucher Disease Registry & Pregnancy Sub-registry
This study tracks the health of people with Gaucher disease over time, whether or not they are receiving treatment. There's also a sub-study for pregnant women with Gaucher disease to see how their pregnancies and babies' health progress. It helps doctors learn more about the condition.
Gaucher DiseaseCerebroside Lipidosis SyndromeGlucocerebrosidase Deficiency DiseaseGlucosylceramide Beta-Glucosidase Deficiency DiseaseUnited Arab Emirates - RecruitingNA
Intelligent Vacuum Assisted Biopsy Immediately Before Surgery As an Intra- or Pre-Operative Surrogate for Patient Response to Neoadjuvant Chemotherapy for Breast Cancer
This study looks at a special biopsy method for breast cancer patients who have had chemotherapy before surgery. It aims to see if this biopsy can accurately tell if cancer is gone, potentially helping doctors make better treatment plans after chemo.
Breast CancerUnited Arab Emirates - Not yet recruiting
An International Multicenter Study on Transcatheter Device Closure of Perimembranous Ventricular Septal Defects
This study looks at how well a procedure works to close a hole in the heart called a PmVSD. It gathers information from many hospitals to see how different devices perform in children and adults, focusing on safety and how patients recover.
Perimembranous Ventricular Septal DefectUnited Arab Emirates - Active not recruiting
A Real-World Study to Gain Clinical Insights Into Roche Ophthalmology Products
This study looks at how well certain eye medicines from Roche work for conditions like wet macular degeneration and diabetic eye disease in real patients. It's about understanding long-term results and why doctors choose specific treatments, without changing how patients are usually cared for.
Neovascular Age-related Macular DegenerationDiabetic Macular EdemaRetinal Vein OcclusionBranch Retinal Vein OcclusionUnited Arab Emirates - Recruiting
Neurovascular Product Surveillance Registry
This study looks at how well Medtronic treatments work for brain aneurysms and strokes. It's a way to keep track of these medical devices after they're used to help patients. Doctors watch how people recover over time to make sure the treatments are safe and effective.
Intracranial AneurysmStroke, IschemicUnited Arab Emirates - Recruiting
Abbott Vascular Medical Device Registry
This study looks at how well Abbott medical devices, like stents and catheters, work in real life. It aims to confirm their safety and performance, making sure they continue to help patients effectively. It's for adults having procedures involving these devices.
Acute Myocardial InfarctionRestenoses, CoronaryCoronary Artery LesionsVenous EmbolismUnited Arab Emirates - RecruitingPHASE2
Safety & Efficacy of DCR-PHXC in Patients With PH1 and ESRD
This study is testing a new medicine, DCR-PHXC, for people with a rare kidney disease called Primary Hyperoxaluria Type 1 (PH1) who also have severe kidney problems. It aims to see how safe and effective the medicine is.
Primary Hyperoxaluria Type 1End Stage Renal DiseaseUnited Arab Emirates - Active not recruitingPHASE3
A Study to Investigate Tolerability and Efficacy of Asciminib (Oral) Versus Nilotinib (Oral) in Adult Participants (≥18 Years of Age) With Newly Diagnosed Philadelphia Chromosome Positive Chronic Myelogenous Leukemia in Chronic Phase (Ph+ CML-CP)
This study compared two oral medications, asciminib and nilotinib, for adults newly diagnosed with a type of blood cancer called Philadelphia chromosome-positive chronic myeloid leukemia (CML). It looked at how well people tolerated each drug.
Philadelphia Chromosome-Positive Chronic Myeloid LeukemiaUnited Arab Emirates - Active not recruiting
Observational Study of Patients Receiving Dupixent® for Atopic Dermatitis (AD)
This study looks at how Dupixent (a medicine for eczema) works for people with eczema in their everyday lives. Researchers want to understand who uses it, how they use it, and how effective and safe it is over time.
Dermatitis AtopicUnited Arab Emirates - Active not recruitingPHASE3
A Study to Evaluate Ocrelizumab Treatment in Participants With Progressive Multiple Sclerosis
This study looks at a medicine called ocrelizumab for people with progressive multiple sclerosis (PMS). It aims to see how well it works and if it's safe. Everyone in the study will receive the medicine, and doctors will watch their progress closely.
Progressive Multiple Sclerosis (PMS)United Arab Emirates - Active not recruitingPHASE3
A Study Evaluating the Efficacy and Safety of Mitapivat in Participants With Non-Transfusion-Dependent Alpha- or Beta-Thalassemia (α- or β-NTDT)
This study looked at a new drug, mitapivat, for people aged 18 and over with a type of blood disorder called thalassemia that doesn't need regular blood transfusions. It aimed to see if mitapivat could help reduce anaemia compared to a dummy pill.
Non-Transfusion-dependent Alpha-ThalassemiaNon-Transfusion-dependent Beta-ThalassemiaUnited Arab Emirates - Active not recruitingPHASE3
A Study Evaluating the Efficacy and Safety of Mitapivat in Participants With Transfusion-Dependent Alpha- or Beta-Thalassemia (α- or β-TDT)
This study looks at a new medicine called mitapivat for people with severe types of thalassemia who need regular blood transfusions. It aims to see if mitapivat can reduce how often they need transfusions compared to a dummy treatment.
Transfusion-dependent Alpha-ThalassemiaTransfusion-dependent Beta-ThalassemiaUnited Arab Emirates - Active not recruiting
Evaluating Effectiveness and Long Term Safety of Damoctocog Alfa Pegol in Patients, Who Have Been Diagnosed With Hemophilia A
This study looks at how a medicine called Jivi (damoctocog alfa pegol) works for people with haemophilia A in their daily lives. It checks its long-term safety and how happy patients and doctors are with it.
Hemophilia AUnited Arab Emirates - Active not recruiting
A Study to Assess Real-World Use, Safety, and Effectiveness of Oral Upadacitinib in Adult and Adolescent (>=12 Years Old) Participants With Atopic Dermatitis
This study looks at how a medicine called upadacitinib (for a skin condition called atopic dermatitis or eczema) is used in real life. It checks how safe and effective it is for people aged 12 and over, seeing how long the good effects last outside of strict trial conditions.
Atopic DermatitisUnited Arab Emirates - Active not recruiting
Study Evaluating LDL-C Change and Adherence to Inclisiran Lipid-lowering Therapy in ASCVD
This study looks at how well a medicine called inclisiran works for people with high cholesterol and helps prevent heart problems. We want to see if it lowers bad cholesterol and if people stick to taking it as part of their usual care.
Primary HypercholesterolemiaMixed DyslipidemiaUnited Arab Emirates - Active not recruiting
A Study Investigating the Outcomes and Safety of Atezolizumab Under Real-World Conditions in Patients Treated in Routine Clinical Practice
This study looks at how a cancer drug called atezolizumab works in real patients. Researchers want to see its effects and safety under normal hospital care, for different types of cancer it's approved for.
Urothelial CarcinomaNon-Small Cell Lung CancerSmall Cell Lung CancerHepatocellular CarcinomaUnited Arab Emirates - Recruiting
A Study Observing Everyday Effectiveness and Safety of the Drug Elafibranor in Participants With Primary Biliary Cholangitis Who Are Receiving Ongoing Treatment
This study looks at how a drug called elafibranor works for people with a rare liver disease called Primary Biliary Cholangitis (PBC) in everyday life. Researchers will check its effects, how safe it is, and how well people tolerate it over about five years.
Primary Biliary CholangitisUnited Arab Emirates - Recruiting
Exploring the hidden burden of living with Glanzmann thrombasthenia
This study wants to hear from people living with Glanzmann thrombasthenia (GT) and their caregivers. We want to understand the daily challenges and feelings of those affected. Your stories can help improve support and understanding for everyone with GT.
Glanzmann thrombastheniaUnited Arab Emirates - Active not recruitingPHASE2, PHASE3
An International, Multicenter, Randomized, Double-Blind, Parallel Group, Vehicle-Controlled, Phase 2/3 Study With Open-Label Extension Evaluating the Efficacy and Safety of Diacerein 1% Ointment for the Treatment of Generalized Epidermolysis Bullosa Simplex (EBS)
This study tests a special cream (AC-203) for a skin condition called Epidermolysis Bullosa Simplex (EBS). It looks at how well the cream works to reduce blistering and how safe it is for people with widespread EBS, including children.
Generalized Epidermolysis Bullosa SimplexUnited Arab Emirates - Active not recruiting
Real World Observational Study of Poteligeo in Adult Patients With MF and SS (PROSPER)
This study looks at how people with Mycosis Fungoides (MF) and Sézary Syndrome (SS) are doing on a treatment called Poteligeo. It collects real-world experiences from patients and their carers, helping us understand the treatment's impact on their daily lives.
Mycosis Fungoides and Sézary SyndromeUnited Arab Emirates - Recruiting
eUltra 10k - Biofreedom Ultra
This study is gathering real-world information on the BioFreedom Ultra stent, a small tube used to keep blood vessels open. It's for people aged 18 and over who have this stent, helping researchers understand how it works in everyday medical care.
Post Market Clinical Follow up (PMCF)United Arab Emirates - RecruitingPHASE2
Safety and Tolerability of Difelikefalin in Adolescents on Haemodialysis With Moderate-to-Severe Pruritus
This study looks at a medicine called difelikefalin for teenagers (12-17) on dialysis who have very itchy skin from kidney disease. It checks if the medicine is safe and how much gets into their blood. We hope to find a new way to help young people with this problem.
PruritusChronic Kidney DiseasesUnited Arab Emirates - Active not recruitingPHASE3
A Study to Assess the Change in Disease Activity in Adult Participants With Moderate to Severe Ulcerative Colitis Treated With Risankizumab Compared to Vedolizumab
This study compares two approved medicines, risankizumab and vedolizumab, for adults with moderate to severe ulcerative colitis who haven't tried similar treatments before. It looks at how safe and effective they are. Around 530 people will take part worldwide.
Ulcerative ColitisUnited Arab Emirates - Active not recruiting
Observational Study of Oral Atogepant to Evaluate Real-World Effectiveness in Adult Participants With Migraine
This study looks at how well a medication called atogepant works for adults with migraine in everyday life. If you're prescribed atogepant, you might be asked to join. It simply involves attending your usual doctor's appointments and won't add extra hassle.
MigraineUnited Arab Emirates - Active not recruiting
A Prospective, Non-interventional, Multinational, Observational Study With Isatuximab in Patients With Relapsed and/or Refractory Multiple Myeloma (RRMM)
This study looks at how a medicine called isatuximab works for people in the UK with a type of blood cancer called multiple myeloma that has come back or not responded to previous treatments. It checks how well it works and if it's safe in real-world settings.
Plasma Cell MyelomaUnited Arab Emirates - Active not recruitingPHASE2
A Platform Study of Novel Immunotherapy Combinations in Participants With Previously Untreated, Advanced/Metastatic Non-Small-Cell Lung Cancer
This study is looking at new combinations of medicines for advanced lung cancer that hasn't been treated before. We want to see how safe these new treatments are and how well they work together. It's for people whose cancer shows high levels of a specific marker called PD-L1.
Lung Cancer, Non-Small CellUnited Arab Emirates - Active not recruiting
The SPECTRUM Study: An Observational Study to Learn More About How Well Aflibercept 8 mg Works in Treating Visual Impairment Due to Neovascular Age-related Macular Degeneration or Diabetic Macula Edema
The SPECTRUM Study is looking at how well a new eye medicine called aflibercept 8 mg works for vision problems caused by wet AMD or diabetic macular oedema. Researchers will collect information from patients who are already prescribed this medicine by their doctor.
Visual ImpairmentNeovascular Age-related Macular Degeneration (nAMD)Diabetic Macula Edema (DME)United Arab Emirates - Not yet recruitingPhase II
A study testing two targeted medicines, bomedemstat, which helps normalise blood cell development, and momelotinib, which reduces symptoms and anaemia, to see whether the combination is safe and effective for people with myelofibrosis
This study looks at combining two medicines, bomedemstat and momelotinib, for people with myelofibrosis. It aims to see if this combination is safe and helps more than momelotinib alone, especially for those whose first treatment isn't working well.
MyelofibrosisUnited Arab Emirates - Active not recruitingPHASE4
Study Assessing the Long-term Effect of Dupilumab on Prevention of Lung Function Decline in Adult Patients With Uncontrolled Moderate to Severe Asthma
This study is looking at whether a medicine called dupilumab can help adults with moderate to severe asthma keep their lungs working better over time. It compares dupilumab to standard asthma care to see if it can prevent lung function from getting worse. It's a long-term study.
AsthmaUnited Arab Emirates - RecruitingPHASE1, PHASE2
A Study of EP0031 (Lunbotinib) in Patients With Advanced RET-altered Malignancies
This study is testing a new medicine called EP0031 for advanced cancers caused by problems with a gene called RET. It aims to see if EP0031 is safe, what side effects it causes, and how well it works, especially for a type of lung cancer called NSCLC.
NSCLCUnited Arab Emirates - Active not recruitingPHASE3
A Study to Assess Adverse Events and Change in Disease Activity of Risankizumab Subcutaneous Induction Treatment for Moderately to Severely Active Crohn's Disease.
This study is looking at a new way to give risankizumab, a medicine for Crohn's disease, as an injection under the skin. It aims to see how well it works and if it's safe for adults with moderate to severe Crohn's disease.
Crohn's DiseaseUnited Arab Emirates - RecruitingPHASE3
A Study to Compare the Efficacy and Safety of Golcadomide in Combination With Rituximab (Golca + R) vs Investigator's Choice in Participants With Relapsed/Refractory Follicular Lymphoma Who Have Received at Least 1 Prior Line of Systemic Therapy (GOLSEEK-4)
This study looks at a new drug, golcadomide, combined with rituximab, for people with follicular lymphoma that has come back or not responded to previous treatments. It compares this new combination to standard treatments chosen by doctors.
Follicular LymphomaUnited Arab Emirates - Active not recruitingPHASE3
A Study to Assess Efficacy and Safety of Efgartigimod PH20 SC in Adults With Ocular Myasthenia Gravis
This study looks at a new medicine for adults with a type of muscle weakness affecting the eyes called ocular myasthenia gravis. Researchers want to see if the medicine, Efgartigimod, is safe and helps improve eye symptoms. Some people will get the active medicine, and others will get a dummy treatment.
Myasthenia Gravis, OcularUnited Arab Emirates - Active not recruiting
An Observational Study to Assess Change in Disease Activity and Adverse Events of Upadacitinib in Adult Participants With Moderate to Severe Ulcerative Colitis (UC) in Real-World Practice
This study looks at how a medicine called upadacitinib works for adults with moderate to severe Ulcerative Colitis in everyday life. Researchers will check its safety and how well it helps manage the condition, following about 1000 people over three years.
Ulcerative ColitisUnited Arab Emirates