Can I take Aspirin and Paracetamol together?

Why this happens

Aspirin and paracetamol work in different ways to relieve pain. Aspirin is an anti-inflammatory (NSAID) that blocks certain enzymes (COX-1 and COX-2) throughout the body, while paracetamol is thought to work mainly within the central nervous system. Because they use different pathways, they do not 'compete' with each other, but their pain-relieving effects can add together (an additive effect).

What you should do

It is fine to take these two medicines together for short-term pain relief (such as a headache or fever). Always follow the dosage instructions on the packaging and do not exceed the maximum daily dose for either. If you have a history of stomach ulcers, kidney problems, or asthma, or if you are already taking daily low-dose aspirin for your heart, speak to a pharmacist or doctor before combining them.

Important precautions

Children under 16 years old

Never give aspirin to children under 16 unless prescribed by a doctor, as it can cause Reye’s syndrome, a rare but life-threatening condition affecting the brain and liver.

Asthma

Aspirin can trigger severe asthma attacks or worsening of breathing symptoms in some people with asthma. Do not use if you have a history of aspirin-sensitive asthma.

Liver disease or heavy alcohol use

Paracetamol is processed by the liver; taking more than the recommended dose, or taking it if you have existing liver damage, can cause fatal liver failure. Always check other medicines (like cold and flu remedies) to ensure you are not doubling up on paracetamol.

Food and drink warnings

Alcohol

Drinking alcohol while taking aspirin can increase the risk of stomach irritation and bleeding. It is best to limit alcohol intake or avoid it altogether if you have a history of stomach issues. You should avoid drinking large amounts of alcohol while taking paracetamol. Chronic heavy drinking increases the risk of serious liver damage if you take more than the recommended dose of paracetamol.

Caffeine

Aspirin is sometimes combined with caffeine in 'extra power' painkillers. However, if you are taking aspirin for heart health, be aware that high levels of caffeine can increase blood pressure and may slightly increase the risk of stomach irritation.

Using other medicines

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.